JACC. Asia最新文献_第8页

Unveiling the Complexities of Peripartum Cardiomyopathy 揭示围产期心肌病的复杂性

JACC. Asia Pub Date : 2025-04-01 DOI: 10.1016/j.jacasi.2025.03.001

Beatriz Fernandez-Campos MD, Candice K. Silversides MD

引用次数: 0

Hemodynamic Patterns and Left Ventricular Function Recovery in Peripartum Cardiomyopathy 围产期心肌病的血流动力学模式和左心室功能恢复

JACC. Asia Pub Date : 2025-04-01 DOI: 10.1016/j.jacasi.2024.11.019

Valery Meledin MD, PhD , Hawani Sasmaya Prameswari MD , Sara Shimoni MD , Roni Ramon-Gonen PhD , Melawati Hasan MD , Jacob George MD , Sorel Goland MD

{"title":"Hemodynamic Patterns and Left Ventricular Function Recovery in Peripartum Cardiomyopathy","authors":"Valery Meledin MD, PhD , Hawani Sasmaya Prameswari MD , Sara Shimoni MD , Roni Ramon-Gonen PhD , Melawati Hasan MD , Jacob George MD , Sorel Goland MD","doi":"10.1016/j.jacasi.2024.11.019","DOIUrl":"10.1016/j.jacasi.2024.11.019","url":null,"abstract":"<div><h3>Background</h3><div>The influence of hemodynamic changes at presentation on the recovery of left ventricular (LV) function in peripartum cardiomyopathy (PPCM) patients remains uncertain.</div></div><div><h3>Objectives</h3><div>This study aims to identify hemodynamic patterns in individuals with PPCM.</div></div><div><h3>Methods</h3><div>This study included women with PPCM from 2 databases in Israel and Indonesia. Conventional echocardiography, 2-dimensional strain, myocardial work, and noninvasive pressure-volume loop analysis were performed with subsequent data clustering.</div></div><div><h3>Results</h3><div>Among 89 women (median age 32 years, IQR: 8.7 years; LV ejection fraction [EF] 36.0%, IQR: 11.5%), 63 (70.8%) experienced LV function recovery (LVEF ≥50%) during 6 months of follow-up. Gestation hypertension/pre-eclampsia and LVEF >35% and LVDD ≤55 mm at presentation were associated with LV recovery. Significant hemodynamic variability was observed, indicating a nonuniform PPCM pattern. Cluster analysis of 43 patients identified 3 hemodynamic subtypes. In cluster 1, patients exhibited the lowest rate of LV recovery (12.5%), profound contractility impairment, severe LV remodeling, and reduced cardiac output (CO). Cluster 2 showed a high LV recovery rate of 78.6%, prevalent in Southeast Asian patients with gestational hypertension. These patients displayed decreased CO and extremely elevated afterload. Load-dependent contractility indexes, like LVEF and global longitudinal strain, were markedly reduced, while load-independent end-systolic elastance remained unaffected, indicating afterload-dependent contractility impairment. All patients in cluster 3 recovered LVEF, presenting mildly reduced contractility indexes, mild ventricular dilatation, slightly increased afterload, and preserved CO.</div></div><div><h3>Conclusions</h3><div>PPCM exhibits heterogeneous hemodynamic patterns, with 3 distinct phenotypes displaying varying rates of LV recovery. Understanding the heterogeneity in PPCM hemodynamic phenotypes can guide optimal treatment.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 554-564"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Onerous Burden of Cardiometabolic Disease Among Asian Emigrants 亚洲移民心脏代谢疾病的沉重负担

JACC. Asia Pub Date : 2025-04-01 DOI: 10.1016/j.jacasi.2025.02.003

Feiming Ye MD, PhD, Jian’an Wang MD, PhD

引用次数: 0

Association Between Periprocedural Anticoagulation in Ventricular Tachycardia Ablation and Postprocedural Stroke and Intracranial Hemorrhage 室性心动过速消融术中围术期抗凝与术后卒中及颅内出血的关系

JACC. Asia Pub Date : 2025-04-01 DOI: 10.1016/j.jacasi.2025.01.010

Hisaki Makimoto MD, PhD , Hayato Yamana MD, MPH, PhD , Toshiaki Isogai MD, MPH , Hiroki Matsui MPH, PhD , Kiyohide Fushimi MD, PhD , Hideo Yasunaga MD, PhD , Takahide Kohro MD, PhD

引用次数: 0

Epidemiology of Ischemic Heart Disease Burden Attributable to High Temperature in Asia From GBD 2021 2021年亚洲GBD高温引起的缺血性心脏病负担的流行病学研究

JACC. Asia Pub Date : 2025-04-01 DOI: 10.1016/j.jacasi.2024.12.012

Qinyi Bao MD , Zhuo Wang MD , Jian’an Wang MD, PhD , Yixin Ruan MD, PhD

{"title":"Epidemiology of Ischemic Heart Disease Burden Attributable to High Temperature in Asia From GBD 2021","authors":"Qinyi Bao MD , Zhuo Wang MD , Jian’an Wang MD, PhD , Yixin Ruan MD, PhD","doi":"10.1016/j.jacasi.2024.12.012","DOIUrl":"10.1016/j.jacasi.2024.12.012","url":null,"abstract":"<div><h3>Background</h3><div>Ischemic heart disease (IHD) posed the highest global disease burden in 2021, with regional disparities in Asia. Moreover, climate change is exacerbating population exposure to high temperatures (Hi-Tem).</div></div><div><h3>Objectives</h3><div>This study aimed to systematically assess the burden of IHD attributed to Hi-Tem in Asia, considering geographic and demographic factors.</div></div><div><h3>Methods</h3><div>The Global Burden of Disease Study 2021 tools evaluated the IHD burden from Hi-Tem in Asia, and decomposition analysis was conducted to further explore the potential burden drivers.</div></div><div><h3>Results</h3><div>Asia witnessed a significant increase in IHD burden caused by Hi-Tem, with 88,450 (95% UI: 15,815-188,816) deaths and 2,112,025.42 (95% UI: 456,758.65-4,325,643.47) disability-adjusted life years in 2021. Over the past 3 decades, the burden increased annually by 1.63% (95% CI: 1.25%-2.01%) in age-standardized mortality rate and by 1.60% (95% CI: 1.21%-1.99%) in age-standardized rate of disability-adjusted life years. Notably, South Asia bore the heaviest burden, whereas high-income Asia Pacific had the lightest. Men and older persons consistently faced a higher IHD burden from Hi-Tem. Despite generally balanced contributions from population growth, aging, and epidemiological changes, regional disparities may persist.</div></div><div><h3>Conclusions</h3><div>Our study provides a comprehensive overview of the demographic and geographic characteristics of the IHD burden attributable to Hi-Tem in Asia from 1990 to 2021. In summary, Asia's IHD burden caused by Hi-Tem rose significantly, with the greater impact on men and older populations.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 528-540"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The CGAS-STING1 Pathway as a Mediator of Innate Immune Response in Cardiovascular Disease CGAS-STING1通路作为心血管疾病先天免疫反应的中介

JACC. Asia Pub Date : 2025-04-01 DOI: 10.1016/j.jacasi.2025.01.005

Leila Rouhi MD, PhD, Priyatansh Gurha PhD, Ali J. Marian MD

{"title":"The CGAS-STING1 Pathway as a Mediator of Innate Immune Response in Cardiovascular Disease","authors":"Leila Rouhi MD, PhD, Priyatansh Gurha PhD, Ali J. Marian MD","doi":"10.1016/j.jacasi.2025.01.005","DOIUrl":"10.1016/j.jacasi.2025.01.005","url":null,"abstract":"<div><div>The innate immune response, a rapid and cell-autonomous response of the cell to the pathogens, recognizes the external as well as the internal pathogens, such as self-DNA, released from the damaged cells. The response activates a set of molecules that induce the expression of proinflammatory cytokines and chemokines and leads to inflammation, fibrosis, and cell death. The innate immune response comprised of DNA-sensing protein cyclic guanosine monophosphate–adenosine monophosphate synthase (CGAS) and its downstream molecules, the stimulator of interferon genes 1 (STING1), TANK-binding kinase 1 (TBK1), interferon regulatory factor 3 (IRF3), and nuclear factor kappa B (NFκB), are activated in several cardiovascular diseases, including hereditary cardiomyopathies, myocardial infarction, hypertension, atherosclerosis, and aortic aneurysm. The genetic deletion of key molecules in this pathway, such as CGAS, STING1, and interferon regulatory factor 3, affords salubrious effects, including improving survival and cardiac dysfunction, rendering the CGAS-STING1 pathway an attractive therapeutic target in cardiovascular disease.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 516-527"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Advances in IV Thrombolysis for Acute Ischemic Stroke 急性缺血性脑卒中静脉溶栓治疗进展

JACC. Asia Pub Date : 2025-04-01 DOI: 10.1016/j.jacasi.2025.02.006

Rahul Mahajan MD, PhD

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Full Issue PDF 完整版PDF

JACC. Asia Pub Date : 2025-04-01 DOI: 10.1016/S2772-3747(25)00159-0

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A New Option for Self-Expanding Transcatheter Pulmonary Valve 经导管自扩张肺动脉瓣的新选择

JACC. Asia Pub Date : 2025-04-01 DOI: 10.1016/j.jacasi.2025.02.007

Chun-An Chen MD, PhD , Jou-Kou Wang MD, PhD

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A Multicenter Feasibility and Safety Study of a Novel Hybrid IVUS-OCT Imaging System 一种新型混合IVUS-OCT成像系统的多中心可行性和安全性研究

JACC. Asia Pub Date : 2025-03-01 DOI: 10.1016/j.jacasi.2025.01.009

Qinhua Jin MD , Zhenhong Fu MD , Yupeng Wang MD , Yong Zeng MD , Xiaoling Zhang MD , Yicong Ye MD , Yida Tang MD , Xinye Xu MD , Yundai Chen MD, PhD

{"title":"A Multicenter Feasibility and Safety Study of a Novel Hybrid IVUS-OCT Imaging System","authors":"Qinhua Jin MD , Zhenhong Fu MD , Yupeng Wang MD , Yong Zeng MD , Xiaoling Zhang MD , Yicong Ye MD , Yida Tang MD , Xinye Xu MD , Yundai Chen MD, PhD","doi":"10.1016/j.jacasi.2025.01.009","DOIUrl":"10.1016/j.jacasi.2025.01.009","url":null,"abstract":"<div><div>Currently, precise stent manipulation and placement in percutaneous coronary intervention remain compromised. Intravascular imaging techniques are often limited by either spatial resolution or depth of penetration. A hybrid intravascular ultrasound (IVUS)-optical coherence tomography (OCT) system would be a better choice for interventional cardiologists. To validate the image quality and safety of the novel IVUS-OCT system for guiding coronary intervention in Chinese patients, a total of 114 cases were included. The proportion of clear imaging length was 96.21% ± 10.16%. Device success rate was 99.1%, technical success rate was 98.2%, and excellent image rate was 96.5%. No catheter-related adverse events occurred, and the incidence of device defects was 0.9%. This study preliminarily verified the image quality and safety of the novel Hybrid IVUS and OCT imaging system. (The StUdy to Evaluate the Performance and safEty of the Novasight HybRid System Using Objective PeRformance Criteria [SUPERIOR]; <span><span>NCT04617899</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 3","pages":"Pages 396-400"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0