JACC. Asia最新文献

{"title":"Epidemiology of Ischemic Heart Disease Burden Attributable to High Temperature in Asia From GBD 2021","authors":"Qinyi Bao MD ,&nbsp;Zhuo Wang MD ,&nbsp;Jian’an Wang MD, PhD ,&nbsp;Yixin Ruan MD, PhD","doi":"10.1016/j.jacasi.2024.12.012","DOIUrl":"10.1016/j.jacasi.2024.12.012","url":null,"abstract":"<div><h3>Background</h3><div>Ischemic heart disease (IHD) posed the highest global disease burden in 2021, with regional disparities in Asia. Moreover, climate change is exacerbating population exposure to high temperatures (Hi-Tem).</div></div><div><h3>Objectives</h3><div>This study aimed to systematically assess the burden of IHD attributed to Hi-Tem in Asia, considering geographic and demographic factors.</div></div><div><h3>Methods</h3><div>The Global Burden of Disease Study 2021 tools evaluated the IHD burden from Hi-Tem in Asia, and decomposition analysis was conducted to further explore the potential burden drivers.</div></div><div><h3>Results</h3><div>Asia witnessed a significant increase in IHD burden caused by Hi-Tem, with 88,450 (95% UI: 15,815-188,816) deaths and 2,112,025.42 (95% UI: 456,758.65-4,325,643.47) disability-adjusted life years in 2021. Over the past 3 decades, the burden increased annually by 1.63% (95% CI: 1.25%-2.01%) in age-standardized mortality rate and by 1.60% (95% CI: 1.21%-1.99%) in age-standardized rate of disability-adjusted life years. Notably, South Asia bore the heaviest burden, whereas high-income Asia Pacific had the lightest. Men and older persons consistently faced a higher IHD burden from Hi-Tem. Despite generally balanced contributions from population growth, aging, and epidemiological changes, regional disparities may persist.</div></div><div><h3>Conclusions</h3><div>Our study provides a comprehensive overview of the demographic and geographic characteristics of the IHD burden attributable to Hi-Tem in Asia from 1990 to 2021. In summary, Asia's IHD burden caused by Hi-Tem rose significantly, with the greater impact on men and older populations.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 528-540"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CGAS-STING1 Pathway as a Mediator of Innate Immune Response in Cardiovascular Disease","authors":"Leila Rouhi MD, PhD,&nbsp;Priyatansh Gurha PhD,&nbsp;Ali J. Marian MD","doi":"10.1016/j.jacasi.2025.01.005","DOIUrl":"10.1016/j.jacasi.2025.01.005","url":null,"abstract":"<div><div>The innate immune response, a rapid and cell-autonomous response of the cell to the pathogens, recognizes the external as well as the internal pathogens, such as self-DNA, released from the damaged cells. The response activates a set of molecules that induce the expression of proinflammatory cytokines and chemokines and leads to inflammation, fibrosis, and cell death. The innate immune response comprised of DNA-sensing protein cyclic guanosine monophosphate–adenosine monophosphate synthase (CGAS) and its downstream molecules, the stimulator of interferon genes 1 (STING1), TANK-binding kinase 1 (TBK1), interferon regulatory factor 3 (IRF3), and nuclear factor kappa B (NFκB), are activated in several cardiovascular diseases, including hereditary cardiomyopathies, myocardial infarction, hypertension, atherosclerosis, and aortic aneurysm. The genetic deletion of key molecules in this pathway, such as CGAS, STING1, and interferon regulatory factor 3, affords salubrious effects, including improving survival and cardiac dysfunction, rendering the CGAS-STING1 pathway an attractive therapeutic target in cardiovascular disease.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 516-527"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in IV Thrombolysis for Acute Ischemic Stroke","authors":"Rahul Mahajan MD, PhD","doi":"10.1016/j.jacasi.2025.02.006","DOIUrl":"10.1016/j.jacasi.2025.02.006","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 593-594"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S2772-3747(25)00159-0","DOIUrl":"10.1016/S2772-3747(25)00159-0","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages I-CX"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Option for Self-Expanding Transcatheter Pulmonary Valve","authors":"Chun-An Chen MD, PhD ,&nbsp;Jou-Kou Wang MD, PhD","doi":"10.1016/j.jacasi.2025.02.007","DOIUrl":"10.1016/j.jacasi.2025.02.007","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 582-583"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multicenter Feasibility and Safety Study of a Novel Hybrid IVUS-OCT Imaging System","authors":"Qinhua Jin MD ,&nbsp;Zhenhong Fu MD ,&nbsp;Yupeng Wang MD ,&nbsp;Yong Zeng MD ,&nbsp;Xiaoling Zhang MD ,&nbsp;Yicong Ye MD ,&nbsp;Yida Tang MD ,&nbsp;Xinye Xu MD ,&nbsp;Yundai Chen MD, PhD","doi":"10.1016/j.jacasi.2025.01.009","DOIUrl":"10.1016/j.jacasi.2025.01.009","url":null,"abstract":"<div><div>Currently, precise stent manipulation and placement in percutaneous coronary intervention remain compromised. Intravascular imaging techniques are often limited by either spatial resolution or depth of penetration. A hybrid intravascular ultrasound (IVUS)-optical coherence tomography (OCT) system would be a better choice for interventional cardiologists. To validate the image quality and safety of the novel IVUS-OCT system for guiding coronary intervention in Chinese patients, a total of 114 cases were included. The proportion of clear imaging length was 96.21% ± 10.16%. Device success rate was 99.1%, technical success rate was 98.2%, and excellent image rate was 96.5%. No catheter-related adverse events occurred, and the incidence of device defects was 0.9%. This study preliminarily verified the image quality and safety of the novel Hybrid IVUS and OCT imaging system. (The StUdy to Evaluate the Performance and safEty of the Novasight HybRid System Using Objective PeRformance Criteria [SUPERIOR]; <span><span>NCT04617899</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 3","pages":"Pages 396-400"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S2772-3747(25)00072-9","DOIUrl":"10.1016/S2772-3747(25)00072-9","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 3","pages":"Pages I-LXXII"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Tricuspid Valve Repair on Less Than Moderate Tricuspid Regurgitation After Degenerative Mitral Repair","authors":"Jinren Du MD ,&nbsp;Yichen Zhao MD ,&nbsp;Kemin Liu MD,&nbsp;Qing Ye MD,&nbsp;Cheng Zhao MD,&nbsp;Jie Han MD,&nbsp;Xu Meng MD,&nbsp;Fei Meng MD,&nbsp;Tiange Luo MD,&nbsp;Baiyu Tian MD,&nbsp;Jiangang Wang MD","doi":"10.1016/j.jacasi.2025.01.012","DOIUrl":"10.1016/j.jacasi.2025.01.012","url":null,"abstract":"<div><h3>Background</h3><div>Whether tricuspid valve (TV) repair should be performed during degenerative mitral valve repair in patients with less than moderate regurgitation remains controversial.</div></div><div><h3>Objectives</h3><div>This study aimed to explore the clinical outcomes of degenerative mitral valve repair for less than moderate tricuspid regurgitation (TR).</div></div><div><h3>Methods</h3><div>Between 2010 and 2019, 541 patients with less than moderate TR underwent mitral valve repair for degenerative mitral disease at the Beijing Anzhen Hospital. Among these patients, 255 underwent concomitant TV repair. The median follow-up was 8 years (Q1-Q3: 6-11 years). The primary endpoint was the development of moderate TR. The secondary endpoint was death, recurrent mitral regurgitation (MR), reoperation for MR or TR, new-onset atrial fibrillation, and permanent pacemaker implantation. Propensity score matching was performed to reduce selection bias.</div></div><div><h3>Results</h3><div>After baseline adjustment, propensity score matching analysis identified 207 pairs. There were no significant differences in the primary endpoints between the patients who underwent simultaneous TV repair and those who did not. Mortality, recurrent MR, permanent pacemaker implantation, and reoperation for MR or TR did not differ significantly between groups. Concomitant TV repair only contributed to new-onset atrial fibrillation, with 24 (11.6%) in the TV-repair group and 7 (3.4%) in the no-repair group (<em>P =</em> 0.001).</div></div><div><h3>Conclusions</h3><div>Considering its minimal effects on the development of TR and potential contributions to postoperative new-onset atrial fibrillation during follow-up among these patients, more aggressive TV repair is not encouraged among patients with less than moderate TR during MV surgery.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 3","pages":"Pages 467-475"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter Tricuspid Annuloplasty in Tricuspid Regurgitation Patients With Right Ventricular-Pulmonary Arterial Uncoupling","authors":"Dawei Lin MD ,&nbsp;Qinchun Jin MD ,&nbsp;Jiaxin Miao MD,&nbsp;Zhenzhen Li MB,&nbsp;Jianing Fan MB,&nbsp;Wanjiao Chen MD,&nbsp;Wenzhi Pan MD,&nbsp;Daxin Zhou MD,&nbsp;Xiaochun Zhang MD,&nbsp;Junbo Ge MD","doi":"10.1016/j.jacasi.2025.01.004","DOIUrl":"10.1016/j.jacasi.2025.01.004","url":null,"abstract":"<div><h3>Background</h3><div>There is limited evidence regarding evidence of transcatheter tricuspid annuloplasty using K-Clip (Huihe Medical Technology) in tricuspid regurgitation (TR) patients with right ventricular-pulmonary arterial (RV-PA) uncoupling.</div></div><div><h3>Objectives</h3><div>This study sought to explore the role of transcatheter tricuspid annuloplasty in patients with RV-PA uncoupling.</div></div><div><h3>Methods</h3><div>This was a retrospective observational study, including patients who underwent transcatheter annular repair successfully using the K-Clip device with RV-PA uncoupling at 9 centers in China. RV-PA uncoupling was characterized by a tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (PASP) ratio &lt;0.55. Baseline information, imaging results, and their subsequent follow-up data were collected.</div></div><div><h3>Results</h3><div>All 81 patients (29 men, 72.6 ± 6.9 years of age) underwent successful intervention were enrolled in this study. During 30 days and 6 months follow-up, patients showed significant improvement in tricuspid annular plane systolic excursion/PASP rate (baseline vs 30 days: 0.40 ± 0.07 vs 0.50 ± 0.18; <em>P</em> &lt; 0.001; baseline vs 6 months: 0.40 ± 0.07 vs 0.44 ± 0.11; <em>P =</em> 0.007) and decline in PASP comparing to those at baseline; patients with RV-PA uncoupling showed sustained improvement in TR status with significant improvement in life quality (NYHA functional class, Kansas City Cardiomyopathy Questionnaire scores); 3 noncardiovascular deaths were documented, and the rate of adverse events during follow-up was acceptable.</div></div><div><h3>Conclusions</h3><div>Transcatheter tricuspid annuloplasty showed a significant and durable improvement in TR in patients with RV-PA uncoupling. Significant improvement and decline are observed in RV-PA ratio and PASP, respectively. All-cause mortality and adverse event rates were acceptable, with sustained improvements in quality of life.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 3","pages":"Pages 424-433"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Height Exponents on the Diagnosis and Prognosis of LVH","authors":"Clement Lee MBBS ,&nbsp;Ryan Chan MBBS ,&nbsp;Desiree-Faye Toh MSc ,&nbsp;Michelle Kui MBBS ,&nbsp;Vivian Lee MSc ,&nbsp;Jennifer A. Bryant PhD ,&nbsp;Redha Boubertakh PhD ,&nbsp;Chi-Hang Lee MBBS, MD ,&nbsp;Thu-Thao Le PhD ,&nbsp;Calvin W.L. Chin MD, PhD","doi":"10.1016/j.jacasi.2024.12.006","DOIUrl":"10.1016/j.jacasi.2024.12.006","url":null,"abstract":"<div><h3>Background</h3><div>Left ventricular hypertrophy (LVH) is a strong predictor of adverse outcomes. Although normalizing LV mass (LVM) to height exponents reduced variability from body size, specific recommendations for height exponents are lacking due to a scarcity of normal cohorts to define appropriate height exponents.</div></div><div><h3>Objectives</h3><div>The authors aimed to show the diagnostic and prognostic implications of establishing height exponents specific to sex, ethnicity, and imaging modality.</div></div><div><h3>Methods</h3><div>Nonoverweight/nonobese Asian healthy volunteers (n = 416) were used to establish appropriate height exponents. The impact of these height exponents was examined in a separate cohort of Asian subjects with hypertension (n = 878). All individuals underwent standardized cardiovascular magnetic resonance imaging. The primary outcome was a composite of acute coronary syndrome, heart failure hospitalization, stroke, and cardiovascular mortality.</div></div><div><h3>Results</h3><div>The height exponents for healthy female subjects and male subjects were 1.57 and 2.33, respectively. LVH was present in 27% of individuals with hypertension when indexed to body surface area and 47% when indexed to sex-specific height exponents. Most individuals reclassified to LVH with height exponents were overweight or obese. There were 37 adverse events over 60 months (37-73 months) of follow-up. Regardless of indexing method, LVH was independently associated with increased adverse events (height exponent HR: 2.80 [95% CI: 1.25-6.29; <em>P</em> = 0.013]; body surface area HR: 5.43 [95% CI: 2.49-11.8; <em>P</em> &lt; 0.001]).</div></div><div><h3>Conclusions</h3><div>Reference ranges specific to ethnicity, sex, and imaging modality are necessary to establish appropriate height exponents. Although using height exponents resulted in more LVH reclassification, this did not translate to a notable improvement in event prediction.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 3","pages":"Pages 350-357"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}