JACC. AsiaPub Date : 2025-04-01DOI: 10.1016/j.jacasi.2025.03.001
Beatriz Fernandez-Campos MD, Candice K. Silversides MD
{"title":"Unveiling the Complexities of Peripartum Cardiomyopathy","authors":"Beatriz Fernandez-Campos MD, Candice K. Silversides MD","doi":"10.1016/j.jacasi.2025.03.001","DOIUrl":"10.1016/j.jacasi.2025.03.001","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 565-567"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. AsiaPub Date : 2025-04-01DOI: 10.1016/j.jacasi.2024.11.019
Valery Meledin MD, PhD , Hawani Sasmaya Prameswari MD , Sara Shimoni MD , Roni Ramon-Gonen PhD , Melawati Hasan MD , Jacob George MD , Sorel Goland MD
{"title":"Hemodynamic Patterns and Left Ventricular Function Recovery in Peripartum Cardiomyopathy","authors":"Valery Meledin MD, PhD , Hawani Sasmaya Prameswari MD , Sara Shimoni MD , Roni Ramon-Gonen PhD , Melawati Hasan MD , Jacob George MD , Sorel Goland MD","doi":"10.1016/j.jacasi.2024.11.019","DOIUrl":"10.1016/j.jacasi.2024.11.019","url":null,"abstract":"<div><h3>Background</h3><div>The influence of hemodynamic changes at presentation on the recovery of left ventricular (LV) function in peripartum cardiomyopathy (PPCM) patients remains uncertain.</div></div><div><h3>Objectives</h3><div>This study aims to identify hemodynamic patterns in individuals with PPCM.</div></div><div><h3>Methods</h3><div>This study included women with PPCM from 2 databases in Israel and Indonesia. Conventional echocardiography, 2-dimensional strain, myocardial work, and noninvasive pressure-volume loop analysis were performed with subsequent data clustering.</div></div><div><h3>Results</h3><div>Among 89 women (median age 32 years, IQR: 8.7 years; LV ejection fraction [EF] 36.0%, IQR: 11.5%), 63 (70.8%) experienced LV function recovery (LVEF ≥50%) during 6 months of follow-up. Gestation hypertension/pre-eclampsia and LVEF >35% and LVDD ≤55 mm at presentation were associated with LV recovery. Significant hemodynamic variability was observed, indicating a nonuniform PPCM pattern. Cluster analysis of 43 patients identified 3 hemodynamic subtypes. In cluster 1, patients exhibited the lowest rate of LV recovery (12.5%), profound contractility impairment, severe LV remodeling, and reduced cardiac output (CO). Cluster 2 showed a high LV recovery rate of 78.6%, prevalent in Southeast Asian patients with gestational hypertension. These patients displayed decreased CO and extremely elevated afterload. Load-dependent contractility indexes, like LVEF and global longitudinal strain, were markedly reduced, while load-independent end-systolic elastance remained unaffected, indicating afterload-dependent contractility impairment. All patients in cluster 3 recovered LVEF, presenting mildly reduced contractility indexes, mild ventricular dilatation, slightly increased afterload, and preserved CO.</div></div><div><h3>Conclusions</h3><div>PPCM exhibits heterogeneous hemodynamic patterns, with 3 distinct phenotypes displaying varying rates of LV recovery. Understanding the heterogeneity in PPCM hemodynamic phenotypes can guide optimal treatment.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 554-564"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. AsiaPub Date : 2025-04-01DOI: 10.1016/j.jacasi.2025.02.003
Feiming Ye MD, PhD, Jian’an Wang MD, PhD
{"title":"Onerous Burden of Cardiometabolic Disease Among Asian Emigrants","authors":"Feiming Ye MD, PhD, Jian’an Wang MD, PhD","doi":"10.1016/j.jacasi.2025.02.003","DOIUrl":"10.1016/j.jacasi.2025.02.003","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 603-606"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. AsiaPub Date : 2025-04-01DOI: 10.1016/j.jacasi.2024.12.012
Qinyi Bao MD , Zhuo Wang MD , Jian’an Wang MD, PhD , Yixin Ruan MD, PhD
{"title":"Epidemiology of Ischemic Heart Disease Burden Attributable to High Temperature in Asia From GBD 2021","authors":"Qinyi Bao MD , Zhuo Wang MD , Jian’an Wang MD, PhD , Yixin Ruan MD, PhD","doi":"10.1016/j.jacasi.2024.12.012","DOIUrl":"10.1016/j.jacasi.2024.12.012","url":null,"abstract":"<div><h3>Background</h3><div>Ischemic heart disease (IHD) posed the highest global disease burden in 2021, with regional disparities in Asia. Moreover, climate change is exacerbating population exposure to high temperatures (Hi-Tem).</div></div><div><h3>Objectives</h3><div>This study aimed to systematically assess the burden of IHD attributed to Hi-Tem in Asia, considering geographic and demographic factors.</div></div><div><h3>Methods</h3><div>The Global Burden of Disease Study 2021 tools evaluated the IHD burden from Hi-Tem in Asia, and decomposition analysis was conducted to further explore the potential burden drivers.</div></div><div><h3>Results</h3><div>Asia witnessed a significant increase in IHD burden caused by Hi-Tem, with 88,450 (95% UI: 15,815-188,816) deaths and 2,112,025.42 (95% UI: 456,758.65-4,325,643.47) disability-adjusted life years in 2021. Over the past 3 decades, the burden increased annually by 1.63% (95% CI: 1.25%-2.01%) in age-standardized mortality rate and by 1.60% (95% CI: 1.21%-1.99%) in age-standardized rate of disability-adjusted life years. Notably, South Asia bore the heaviest burden, whereas high-income Asia Pacific had the lightest. Men and older persons consistently faced a higher IHD burden from Hi-Tem. Despite generally balanced contributions from population growth, aging, and epidemiological changes, regional disparities may persist.</div></div><div><h3>Conclusions</h3><div>Our study provides a comprehensive overview of the demographic and geographic characteristics of the IHD burden attributable to Hi-Tem in Asia from 1990 to 2021. In summary, Asia's IHD burden caused by Hi-Tem rose significantly, with the greater impact on men and older populations.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 528-540"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. AsiaPub Date : 2025-04-01DOI: 10.1016/j.jacasi.2025.01.005
Leila Rouhi MD, PhD, Priyatansh Gurha PhD, Ali J. Marian MD
{"title":"The CGAS-STING1 Pathway as a Mediator of Innate Immune Response in Cardiovascular Disease","authors":"Leila Rouhi MD, PhD, Priyatansh Gurha PhD, Ali J. Marian MD","doi":"10.1016/j.jacasi.2025.01.005","DOIUrl":"10.1016/j.jacasi.2025.01.005","url":null,"abstract":"<div><div>The innate immune response, a rapid and cell-autonomous response of the cell to the pathogens, recognizes the external as well as the internal pathogens, such as self-DNA, released from the damaged cells. The response activates a set of molecules that induce the expression of proinflammatory cytokines and chemokines and leads to inflammation, fibrosis, and cell death. The innate immune response comprised of DNA-sensing protein cyclic guanosine monophosphate–adenosine monophosphate synthase (CGAS) and its downstream molecules, the stimulator of interferon genes 1 (STING1), TANK-binding kinase 1 (TBK1), interferon regulatory factor 3 (IRF3), and nuclear factor kappa B (NFκB), are activated in several cardiovascular diseases, including hereditary cardiomyopathies, myocardial infarction, hypertension, atherosclerosis, and aortic aneurysm. The genetic deletion of key molecules in this pathway, such as CGAS, STING1, and interferon regulatory factor 3, affords salubrious effects, including improving survival and cardiac dysfunction, rendering the CGAS-STING1 pathway an attractive therapeutic target in cardiovascular disease.</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 516-527"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. AsiaPub Date : 2025-04-01DOI: 10.1016/j.jacasi.2025.02.006
Rahul Mahajan MD, PhD
{"title":"Advances in IV Thrombolysis for Acute Ischemic Stroke","authors":"Rahul Mahajan MD, PhD","doi":"10.1016/j.jacasi.2025.02.006","DOIUrl":"10.1016/j.jacasi.2025.02.006","url":null,"abstract":"","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 4","pages":"Pages 593-594"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JACC. AsiaPub Date : 2025-03-01DOI: 10.1016/j.jacasi.2025.01.009
Qinhua Jin MD , Zhenhong Fu MD , Yupeng Wang MD , Yong Zeng MD , Xiaoling Zhang MD , Yicong Ye MD , Yida Tang MD , Xinye Xu MD , Yundai Chen MD, PhD
{"title":"A Multicenter Feasibility and Safety Study of a Novel Hybrid IVUS-OCT Imaging System","authors":"Qinhua Jin MD , Zhenhong Fu MD , Yupeng Wang MD , Yong Zeng MD , Xiaoling Zhang MD , Yicong Ye MD , Yida Tang MD , Xinye Xu MD , Yundai Chen MD, PhD","doi":"10.1016/j.jacasi.2025.01.009","DOIUrl":"10.1016/j.jacasi.2025.01.009","url":null,"abstract":"<div><div>Currently, precise stent manipulation and placement in percutaneous coronary intervention remain compromised. Intravascular imaging techniques are often limited by either spatial resolution or depth of penetration. A hybrid intravascular ultrasound (IVUS)-optical coherence tomography (OCT) system would be a better choice for interventional cardiologists. To validate the image quality and safety of the novel IVUS-OCT system for guiding coronary intervention in Chinese patients, a total of 114 cases were included. The proportion of clear imaging length was 96.21% ± 10.16%. Device success rate was 99.1%, technical success rate was 98.2%, and excellent image rate was 96.5%. No catheter-related adverse events occurred, and the incidence of device defects was 0.9%. This study preliminarily verified the image quality and safety of the novel Hybrid IVUS and OCT imaging system. (The StUdy to Evaluate the Performance and safEty of the Novasight HybRid System Using Objective PeRformance Criteria [SUPERIOR]; <span><span>NCT04617899</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":73529,"journal":{"name":"JACC. Asia","volume":"5 3","pages":"Pages 396-400"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}