Itch (Philadelphia, Pa.)最新文献_第4页

A systematic review of animal models and sex as a variable in itch research 动物模型和性别作为瘙痒研究变量的系统综述

Itch (Philadelphia, Pa.) Pub Date : 2020-07-01 DOI: 10.1097/itx.0000000000000040

Joshua J. Wheeler, Katherine Allen-Moyer, John M. Davis, S. Mishra

{"title":"A systematic review of animal models and sex as a variable in itch research","authors":"Joshua J. Wheeler, Katherine Allen-Moyer, John M. Davis, S. Mishra","doi":"10.1097/itx.0000000000000040","DOIUrl":"https://doi.org/10.1097/itx.0000000000000040","url":null,"abstract":"Introduction: Pruritus (or itch) research has gained momentum in the last decades and use of animal models to study itch behavior are a vital part of the research. Recent studies have found that many fields using animal models, including neuroscience, are predisposed toward using male animals in preclinical research. To address sex bias in animal research, the National Institutes of Health (NIH) began requiring researchers to include sex as a variable beginning in June 2015. Here, we test whether researchers studying itch are biased toward using males in preclinical research. Methods: The NIH’s PubMed database was searched for primary research articles written between August 2007 and December 2018 using the words “Itch” and “Pruritus.” The following information was extracted from articles fitting our inclusion criteria: type of itch (acute or chronic), the animal model and the sex of the animals used, and whether researchers considered sex as a variable. z-Tests, binomial tests, and the Cochran-Armitage test for trend were used to explore relationships between animal models and the usage of both sexes. Results: We found 5.3%±1.2% of papers in a given year used 1 of our 4 animal models. Mice were the most frequently used animal model, followed by rats, nonhuman primates, and dogs. Overall, researchers used male animals regardless of the animal model used. In preclinical research conducted on both male and female animals, sex was not considered a variable in a majority of these studies. Finally, since 2015, there has not been a change in the usage of male or female mice. Briefly, the incidence of papers utilizing both sexes has not changed. Discussion: We have found that itch researchers have a bias towards males in animal research. This bias has not changed since the NIH’s mandate to include sex as a variable in preclinical research.","PeriodicalId":73523,"journal":{"name":"Itch (Philadelphia, Pa.)","volume":"5 1","pages":"e40 - e40"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44778671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A review of the management of uremic pruritus: current perspectives and future directions 尿毒症瘙痒症的治疗综述：现状与发展方向

Itch (Philadelphia, Pa.) Pub Date : 2020-07-01 DOI: 10.1097/itx.0000000000000038

E. Westby, K. Purdy, K. Tennankore

{"title":"A review of the management of uremic pruritus: current perspectives and future directions","authors":"E. Westby, K. Purdy, K. Tennankore","doi":"10.1097/itx.0000000000000038","DOIUrl":"https://doi.org/10.1097/itx.0000000000000038","url":null,"abstract":"Uremic pruritus (UP) is a common and distressing symptom experienced by up to half of all patients with end-stage renal disease (ESRD) receiving dialysis. It is associated with multiple health-related quality of life impairments and has been independently associated with mortality. Despite the prevalence and associated impact on quality of life, UP remains a difficult symptom to treat because of the relative lack of existing high quality evidence on which to base recommendations and the sheer volume of poorly studied therapeutic options. This review outlines the existing data of available treatment options including topical therapy, systemic therapy, and phototherapy as well as explore emerging data on therapies that are targeting novel pruritus pathways including the cannabinoid and opioid pathways. Overall, neuromodulators, in particular gabapentin, appear to have the most robust data in the treatment of UP. In individuals who cannot tolerate oral systemic therapy or in those with refractory generalized UP, ultraviolet phototherapy, specifically broad-band UVB, has shown significant promise. However, access is often a limiting factor. Lastly, the emergence of new therapies targeting a peripheral acting κ-opioid agonist, difelikefalin, has demonstrated effect in both early phase 2 and 3 clinical trials.","PeriodicalId":73523,"journal":{"name":"Itch (Philadelphia, Pa.)","volume":"5 1","pages":"e38 - e38"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/itx.0000000000000038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41380163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Sex differences in the perception of itch and quality of life in patients with chronic pruritus in the United States 美国慢性瘙痒症患者瘙痒感和生活质量的性别差异

Itch (Philadelphia, Pa.) Pub Date : 2020-07-01 DOI: 10.1097/itx.0000000000000041

C. Kursewicz, E. Fowler, J. Rosen, D. Castillo, Y. Chan, L. Nattkemper, G. Yosipovitch

引用次数: 2

Loss of S1PR3 attenuates scratching behaviors in mice in the imiquimod model of psoriasis, but not in the MC903 model of atopic dermatitis S1PR3的缺失减轻了咪喹莫特银屑病模型小鼠的抓挠行为，但在MC903特应性皮炎模型中没有

Itch (Philadelphia, Pa.) Pub Date : 2020-04-01 DOI: 10.1097/itx.0000000000000035

Rose Z. Hill, Ziad Rifi, Cliff Vuong, D. Bautista

引用次数: 3

Itch intensity and characteristics in fibromyalgia patients in an outpatient rheumatology clinic 风湿病门诊纤维肌痛患者的瘙痒强度和特征

Itch (Philadelphia, Pa.) Pub Date : 2020-04-01 DOI: 10.1097/itx.0000000000000033

S. Shah, R. S. Golpanian, T. Hashimoto, J. Rosen, L. Nattkemper, C. Albornoz, Y. Chan, G. Yosipovitch

引用次数: 0

Nonpharmacologic interventions for chronic pruritus 慢性瘙痒的非药物干预

Itch (Philadelphia, Pa.) Pub Date : 2020-01-01 DOI: 10.1097/itx.0000000000000031

J. Bonchak, P. Lio

{"title":"Nonpharmacologic interventions for chronic pruritus","authors":"J. Bonchak, P. Lio","doi":"10.1097/itx.0000000000000031","DOIUrl":"https://doi.org/10.1097/itx.0000000000000031","url":null,"abstract":"Chronic pruritus, traditionally defined as itch persisting for >6 weeks, is a common affliction that can be associated with cutaneous or systemic disease, or may be idiopathic in nature. It affects patients of all ages and backgrounds and seems to have no predilection for sex or socioeconomic status. The lifetime prevalence has been estimated between 22% and 26%. It accounts for millions of outpatient clinic encounters every year. Pruritus is associated with significant morbidity ranging from sleep disturbance to suicidal ideation in both pediatric and adult patients. The pathophysiology of pruritus is complex and multifactorial. An intricate and incompletely understood interplay between cytokines, sensory neurons, and a variety of cutaneous and central nervous system receptors and effector cells are responsible for the development of itch. Scores of therapies exist, with enormous variation in efficacy, for the amelioration of itch. Drugs aimed at virtually all of the aforementioned pathogenic factors in pruritus have been trialed or are being developed. Nonpharmacologic therapies for chronic pruritus encompass a variety of methods for altering itch signaling or for changing the patient’s perception of pruritus. Although some of these interventions may be used as monotherapy, they are usually best utilized in combination with more conventional pharmacologic antipruritic therapies. This review evaluates the current understanding of the mechanisms and efficacy of these nonpharmacologic interventions and serves to expand the dermatologist's armamentarium against chronic pruritus.","PeriodicalId":73523,"journal":{"name":"Itch (Philadelphia, Pa.)","volume":"5 1","pages":"e31 - e31"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/itx.0000000000000031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41928914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Measurement tools for chronic pruritus: assessment of the symptom and the associated burden: a review 慢性瘙痒的测量工具:症状和相关负担的评估:综述

Itch (Philadelphia, Pa.) Pub Date : 2019-10-01 DOI: 10.1097/itx.0000000000000029

M. Pereira, S. Ständer

{"title":"Measurement tools for chronic pruritus: assessment of the symptom and the associated burden: a review","authors":"M. Pereira, S. Ständer","doi":"10.1097/itx.0000000000000029","DOIUrl":"https://doi.org/10.1097/itx.0000000000000029","url":null,"abstract":"Chronic pruritus is a subjective, multidimensional and highly impairing symptom of difficult assessment. Its clinical features and secondary burdens may vary substantially between affected individuals and within the same patient across time. Standardized scales and questionnaires have been developed to assess the various dimensions of chronic pruritus. Instruments addressing the intensity, distribution, qualities of associated symptoms, skin status and course over time are available for clinical trials. In addition, patient-oriented questionnaires on reactive conditions, including sleep disorders, anxiety, depression, and impairment of quality of life can be used. Assessing the individual patient’s needs before and throughout the treatment is valuable in directing therapeutic priorities and maximizing patient’s satisfaction. Along with a detailed medical history and a comprehensive physical examination, these instruments should be implemented in the clinical routine to achieve a comprehensive assessment of each patient. European experts of the European Academy of Dermatology and Venereology (EADV) considered a priority the use of intensity scales and questionnaires on quality of life. Harmonization of the assessment procedures should be aimed for across attending physicians. New technologies including electronic diaries or the use of tablet computers to complete assessment tools constitute helpful aids in the clinical practice by facilitating data collection and saving time.","PeriodicalId":73523,"journal":{"name":"Itch (Philadelphia, Pa.)","volume":"4 1","pages":"e29 - e29"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/itx.0000000000000029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44999313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Placebo and nocebo effects on itch: a review of experimental methods 安慰剂和反安慰剂对瘙痒的影响:实验方法综述

Itch (Philadelphia, Pa.) Pub Date : 2019-07-01 DOI: 10.1097/itx.0000000000000027

Joseph S. Blythe, K. Peerdeman, D. Veldhuijzen, A. V. Van Laarhoven, A. Evers

引用次数: 15

Signs of chronic itch in the mouse imiquimod model of psoriasiform dermatitis: sex differences and roles of TRPV1 and TRPA1. 银屑病样皮炎小鼠咪喹莫特模型的慢性瘙痒症状:TRPV1和TRPA1的性别差异和作用

Itch (Philadelphia, Pa.) Pub Date : 2019-07-01 DOI: 10.1097/itx.0000000000000025

Taylor Follansbee, Yan Zhou, Xuesong Wu, Jeremy Delahanty, Amanda Nguyen, Dan Domocos, Mirela Iodi Carstens, Samuel T Hwang, Earl Carstens

{"title":"Signs of chronic itch in the mouse imiquimod model of psoriasiform dermatitis: sex differences and roles of TRPV1 and TRPA1.","authors":"Taylor Follansbee, Yan Zhou, Xuesong Wu, Jeremy Delahanty, Amanda Nguyen, Dan Domocos, Mirela Iodi Carstens, Samuel T Hwang, Earl Carstens","doi":"10.1097/itx.0000000000000025","DOIUrl":"https://doi.org/10.1097/itx.0000000000000025","url":null,"abstract":"<p><p>Plaque psoriasis is a chronic inflammatory skin disease that affects a substantial proportion of the world population. This disorder is characterized by scaly, thick skin, intense ongoing itch, and itch from light touch (such as clothing contacting skin, called \"alloknesis\"). Imiquimod is a topical treatment for basal cell carcinomas and warts that has been used to create a mouse model of plaque psoriasis. Imiquimod-treated male, but not female, wildtype B6 mice showed significant increases in spontaneous scratching, while both sexes exhibited increased alloknesis, indicative of chronic itch. TRPV1 and TRPA1 knockout (KO) mice all exhibited numeric increases in spontaneous scratching which were significant for TRPV1KO mice and TRPA1KO males. Female TRPV1KO and TRPA1KO mice exhibited imiquimod-induced increases in alloknesis scores that did not significantly differ from wildtypes, while alloknesis scores in imiquimod-treated male TRPV1KO and TRPA1KO mice were significantly lower compared with wildtypes, suggesting that these ion channels are necessary for the development of alloknesis in males but not females in this model. Curiously, none of the groups exhibited any significant overall change in chloroquine-evoked scratching following imiquimod treatment, indicating that hyperknesis does not develop in this mouse model. Overall, the data indicate that there are sex differences in this mouse model of psoriasis, and that TRPV1 and TRPA1 ion channels have a small role in promoting the development of itch sensitization. This contrasts with the far greater role these channels play in the manifestation of skin changes in psoriatic dermatitis.</p>","PeriodicalId":73523,"journal":{"name":"Itch (Philadelphia, Pa.)","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/itx.0000000000000025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39121773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

MrgprX1 Mediates Neuronal Excitability and Itch Through Tetrodotoxin-Resistant Sodium Channels. MrgprX1通过抗河豚毒素钠通道介导神经元兴奋性和瘙痒。

Itch (Philadelphia, Pa.) Pub Date : 2019-07-01 Epub Date: 2019-08-01 DOI: 10.1097/itx.0000000000000028

Pang-Yen Tseng, Qin Zheng, Zhe Li, Xinzhong Dong

引用次数: 17