ISRN pediatrics最新文献

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Regional variation on rates of bronchopulmonary dysplasia and associated risk factors. 支气管肺发育不良发病率的地区差异及相关风险因素。
ISRN pediatrics Pub Date : 2012-01-01 Epub Date: 2012-07-05 DOI: 10.5402/2012/685151
María Ximena Rojas, Mario Augusto Rojas, Juan Manuel Lozano, Martín Alonso Rondón, Laura Patricia Charry
{"title":"Regional variation on rates of bronchopulmonary dysplasia and associated risk factors.","authors":"María Ximena Rojas, Mario Augusto Rojas, Juan Manuel Lozano, Martín Alonso Rondón, Laura Patricia Charry","doi":"10.5402/2012/685151","DOIUrl":"10.5402/2012/685151","url":null,"abstract":"<p><p>Background. An abnormally high incidence (44%) of bronchopulmonary dysplasia with variations in rates among cities was observed in Colombia among premature infants. Objective. To identify risk factors that could explain the observed high incidence and regional variations of bronchopulmonary dysplasia. Study Design. A case-control study was designed for testing the hypothesis that differences in the disease rates were not explained by differences in city-of-birth specific population characteristics or by differences in respiratory management practices in the first 7 days of life, among cities. Results. Multivariate analysis showed that premature rupture of membranes, exposure to mechanical ventilation after received nasal CPAP, no surfactant exposure, use of rescue surfactant (instead of early surfactant), PDA, sepsis and the median daily FIO(2), were associated with a higher risk of dysplasia. Significant differences between cases and controls were found among cities. Models exploring for associations between city of birth and dysplasia showed that being born in the highest altitude city (Bogotá) was associated with a higher risk of dysplasia (OR 1.82 95% CI 1.31-2.53). Conclusions. Bronchopulmonary dysplasia was manly explained by traditional risk factors. Findings suggest that altitude may play an important role in the development of this disease. Prenatal steroids did not appear to be protective at high altitude.</p>","PeriodicalId":73521,"journal":{"name":"ISRN pediatrics","volume":"2012 ","pages":"685151"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30787421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urinary tract infection prophylaxis in children with neurogenic bladder with cranberry capsules: randomized controlled trial. 蔓越莓胶囊预防神经源性膀胱患儿尿路感染:随机对照试验。
ISRN pediatrics Pub Date : 2012-01-01 Epub Date: 2012-07-01 DOI: 10.5402/2012/317280
Hatice Mutlu, Zelal Ekinci
{"title":"Urinary tract infection prophylaxis in children with neurogenic bladder with cranberry capsules: randomized controlled trial.","authors":"Hatice Mutlu,&nbsp;Zelal Ekinci","doi":"10.5402/2012/317280","DOIUrl":"https://doi.org/10.5402/2012/317280","url":null,"abstract":"<p><p>Objectives. The aim of this randomized controlled prospective study is to evaluate the efficacy of cranberry capsules for prevention of UTI in children with neurogenic bladder caused by myelomeningocele. Patients and Methods. To be eligible for this study, patients had to be diagnosed as neurogenic bladder caused by myelomeningocele, evaluated urodynamically, followed up with clean intermittent catheterization and anticholinergic drugs. Intervention. Six months of treatment with placebo; after a week of wash-out period treatment of cranberry extract tablets (1 capsule/day) for an additional 6 months. Randomization was performed sequentially. Patients and care givers were blinded to drug assignment. Main outcome measure was infection rate. Group comparisons were performed with Wilcoxon test. Results. The study population included 20 (F/M: 13/7) patients with neurogenic bladder with the mean age of 7.25 ± 3.49 (4, 18) years. The median UTI rate was 0.5/year during placebo usage whereas 0/year during cranberry capsule usage. Decrease in infection rate was significant with cranberry capsule usage (P = 0.012). Decrease in the percentage of the pyuria was also recorded as significant (P = 0.000). Any adverse events or side effects were not recorded. Conclusion. We concluded that cranberry capsules could be an encouraging option for the prevention of recurrent UTI in children with neurogenic bladder caused by myelomeningocele.</p>","PeriodicalId":73521,"journal":{"name":"ISRN pediatrics","volume":"2012 ","pages":"317280"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/317280","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30774041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Cow's Milk Allergy Is a Major Contributor in Recurrent Perianal Dermatitis of Infants. 牛奶过敏是婴儿复发性肛周皮炎的主要原因。
ISRN pediatrics Pub Date : 2012-01-01 Epub Date: 2012-09-03 DOI: 10.5402/2012/408769
Mostafa Abdel-Aziz El-Hodhod, Ahmad Mohamed Hamdy, Marwa Talaat El-Deeb, Mohamed O Elmaraghy
{"title":"Cow's Milk Allergy Is a Major Contributor in Recurrent Perianal Dermatitis of Infants.","authors":"Mostafa Abdel-Aziz El-Hodhod,&nbsp;Ahmad Mohamed Hamdy,&nbsp;Marwa Talaat El-Deeb,&nbsp;Mohamed O Elmaraghy","doi":"10.5402/2012/408769","DOIUrl":"https://doi.org/10.5402/2012/408769","url":null,"abstract":"<p><p>Background. Recurrent perianal inflammation has great etiologic diversity. A possible cause is cow's milk allergy (CMA). The aim was to assess the magnitude of this cause. Subjects and Methods. This follow up clinical study was carried out on 63 infants with perianal dermatitis of more than 3 weeks with history of recurrence. Definitive diagnosis was made for each infant through medical history taking, clinical examination and investigations including stool analysis and culture, stool pH and reducing substances, perianal swab for different cultures and staining for Candida albicans. Complete blood count and quantitative determination of cow's milk-specific serum IgE concentration were done for all patients. CMA was confirmed through an open withdrawal-rechallenge procedure. Serum immunoglobulins and CD markers as well as gastrointestinal endoscopies were done for some patients. Results. Causes of perianal dermatitis included CMA (47.6%), bacterial dermatitis (17.46%), moniliasis (15.87%), enterobiasis (9.52%) and lactose intolerance (9.5%). Predictors of CMA included presence of bloody and/or mucoid stool, other atopic manifestations, anal fissures, or recurrent vomiting. Conclusion. We can conclude that cow's milk allergy is a common cause of recurrent perianal dermatitis. Mucoid or bloody stool, anal fissures or ulcers, vomiting and atopic manifestations can predict this etiology.</p>","PeriodicalId":73521,"journal":{"name":"ISRN pediatrics","volume":"2012 ","pages":"408769"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/408769","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30913706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Prevalence of toxoplasma infection in Mexican newborns and children: a systematic review from 1954 to 2009. 墨西哥新生儿和儿童弓形虫感染流行:1954年至2009年的系统回顾
ISRN pediatrics Pub Date : 2012-01-01 Epub Date: 2012-09-25 DOI: 10.5402/2012/501216
Ma de la Luz Galvan-Ramírez, Rogelio Troyo-Sanroman, Sonia Roman, Rosamaría Bernal-Redondo, José Luís Vázquez Castellanos
{"title":"Prevalence of toxoplasma infection in Mexican newborns and children: a systematic review from 1954 to 2009.","authors":"Ma de la Luz Galvan-Ramírez,&nbsp;Rogelio Troyo-Sanroman,&nbsp;Sonia Roman,&nbsp;Rosamaría Bernal-Redondo,&nbsp;José Luís Vázquez Castellanos","doi":"10.5402/2012/501216","DOIUrl":"https://doi.org/10.5402/2012/501216","url":null,"abstract":"<p><p>Introduction. Recent studies in Mexico have shown that from 20/10,000 to 58/10,000 newborns with Toxoplasma infection could be undetected. The aim of this study was to determine the weighed prevalence of T. gondii infection and describe the epidemiological transition of infection in newborns. Methods. Research literature reporting Toxoplasma infection prevalence in Mexican newborns and children were searched in five international databases. Weighted prevalence was calculated by inverse variance-weighted method in asymptomatic and symptomatic study groups, and the epidemiological transition was estimated by a lineal regression analysis. Results. The weighed prevalence in 4833 asymptomatic newborns was 0.616%, CI95% (0.396%-0.835%) (P < 0.001), whereas, among 895 symptomatic newborns, the weighed prevalence was 3.02%, CI 95% (1.91%-4.1%) (P < 0.001). A downward trend of 0.25%/year represented an accumulated decrease of -13,75% in the prevalence in the symptomatic newborns throughout 55 years, whereas, in the asymptomatic children, the prevalence was similar over the course of the years. Conclusion. The high-weighted prevalence of congenital Toxoplasma infection in newborns justifies that Toxoplasma gondii testing be included in the screening programs for women during pregnancy and newborns in Mexico. A rapid diagnosis and treatment strategy could aid in limiting a potential damage to the newborns.</p>","PeriodicalId":73521,"journal":{"name":"ISRN pediatrics","volume":"2012 ","pages":"501216"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/501216","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30965710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Validation of advanced paediatric life support formulas for weight calculation in a multiethnic population. 多民族人口中用于体重计算的先进儿科生命支持公式的验证。
ISRN pediatrics Pub Date : 2012-01-01 Epub Date: 2012-09-25 DOI: 10.5402/2012/869634
Colette Seddon, Laurell Lockitt, Sacha Dhanjal, Michael Eisenhut
{"title":"Validation of advanced paediatric life support formulas for weight calculation in a multiethnic population.","authors":"Colette Seddon,&nbsp;Laurell Lockitt,&nbsp;Sacha Dhanjal,&nbsp;Michael Eisenhut","doi":"10.5402/2012/869634","DOIUrl":"https://doi.org/10.5402/2012/869634","url":null,"abstract":"<p><p>Introduction. The aims of this study were to validate the new formulas for weight calculation introduced by the advanced life support group (alsg) of the United Kingdom in 2011 and compare their performance to the formula currently used by the European Resuscitation Council (ERC) and other formulas and to check whether performance of formulas for weight calculation is affected by ethnic group and gender. Methods. Prospective audit of weight versus calculated weight comparing alsg formula with ERC, Luscombe, Argall, and Best Guess formulas analysed for gender, age, and ethnic groups. Results. Prospectively 599 children were included: 157 Asian, 268 Caucasian, and 174 children from other origin. In infants there was no difference between actual weight and alsg formula calculated weight. There was a progressively increased underestimation of weight year by year from 1 to 10 years of age using the ERC formula. In the 6-10 year age group the ERC formula underestimated the weight by a mean of 6.5 kg (21.8%, P < 0.001) with the alsg and Luscombe formulas performing best. In 11-12 year old children the alsg formula estimated well. Conclusion. In one- to ten-year-old children, the Luscombe formula provided a better weight estimate than alsg and ERC formulas in a multiethnic population.</p>","PeriodicalId":73521,"journal":{"name":"ISRN pediatrics","volume":"2012 ","pages":"869634"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/869634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30965711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Primary Closure without Diversion in Management of Operative Blunt Duodenal Trauma in Children. 儿童钝性十二指肠手术创伤的初步闭合治疗。
ISRN pediatrics Pub Date : 2012-01-01 Epub Date: 2012-11-05 DOI: 10.5402/2012/298753
Katherine Smiley, Tiffany Wright, Sean Skinner, Joseph A Iocono, John M Draus
{"title":"Primary Closure without Diversion in Management of Operative Blunt Duodenal Trauma in Children.","authors":"Katherine Smiley,&nbsp;Tiffany Wright,&nbsp;Sean Skinner,&nbsp;Joseph A Iocono,&nbsp;John M Draus","doi":"10.5402/2012/298753","DOIUrl":"https://doi.org/10.5402/2012/298753","url":null,"abstract":"<p><p>Background. Operative blunt duodenal trauma is rare in pediatric patients. Management is controversial with some recommending pyloric exclusion for complex cases. We hypothesized that primary closure without diversion may be safe even in complex (Grade II-III) injuries. Methods. A retrospective review of the American College of Surgeons' Trauma Center database for the years 2003-2011 was performed to identify operative blunt duodenal trauma at our Level 1 Pediatric Trauma Center. Inclusion criteria included ages <14 years and duodenal injury requiring operative intervention. Duodenal hematomas not requiring intervention and other small bowel injuries were excluded. Results. A total of 3,283 hospital records were reviewed. Forty patients with operative hollow viscous injuries and seven with operative duodenal injuries were identified. The mean Injury Severity Score was 10.4, with injuries ranging from Grades I-IV and involving all duodenal segments. All injuries were closed primarily with drain placement and assessed for leakage via fluoroscopy between postoperative days 4 and 6. The average length of stay was 11 days; average time to full feeds was 7 days. No complications were encountered. Conclusion. Blunt abdominal trauma is an uncommon mechanism of pediatric duodenal injuries. Primary repair with drain placement is safe even in more complex injuries.</p>","PeriodicalId":73521,"journal":{"name":"ISRN pediatrics","volume":"2012 ","pages":"298753"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/298753","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31100503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Childhood Convulsion: Inquiry about the Concerns and Home Management among Mothers in Tegbesun, a Periurban Community in Ilorin, Nigeria. 儿童痉挛:尼日利亚伊洛林郊区Tegbesun社区母亲的担忧和家庭管理调查。
ISRN pediatrics Pub Date : 2012-01-01 Epub Date: 2012-11-20 DOI: 10.5402/2012/209609
Emmanuel Ademola Anigilaje, Omolara Olufunmilayo Anigilaje
{"title":"Childhood Convulsion: Inquiry about the Concerns and Home Management among Mothers in Tegbesun, a Periurban Community in Ilorin, Nigeria.","authors":"Emmanuel Ademola Anigilaje,&nbsp;Omolara Olufunmilayo Anigilaje","doi":"10.5402/2012/209609","DOIUrl":"10.5402/2012/209609","url":null,"abstract":"<p><p>Background. The fear and panic felt by most parents when their child convulsed made them apply all sorts of management. Objective. This study evaluated the concerns and home management of childhood convulsions among mothers in Tegbesun, a periurban community in Ilorin, Nigeria. Methods. A ten-week cross-sectional study comprising 500 mothers interviewed using a structured questionnaire. Results. Fear of death was the commonest concern (450, 90%) among mothers. For a witnessed convulsion, the majority took the child to the hospital (414, 82.8%). Cow's urine concoction (74, 87.1%) was the most common item administered to a convulsing child. Putting the hand and/or a spoon into the mouth of the convulsing child was the commonest unwholesome practice (74, 61.2%). None of the subjects safely put the convulsing child on his/her side. Conclusions. Maternal concerns are precursors of mismanagement of childhood convulsions, and health education was undertaken at the end of the study.</p>","PeriodicalId":73521,"journal":{"name":"ISRN pediatrics","volume":"2012 ","pages":"209609"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/209609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31100502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Peer-mediated multimodal intervention program for the treatment of children with ADHD in India: one-year followup. 同伴介导的多模式干预方案在印度治疗多动症儿童:一年随访。
ISRN pediatrics Pub Date : 2012-01-01 Epub Date: 2012-12-20 DOI: 10.5402/2012/419168
Sagar Mehta, Devesh Shah, Kushal Shah, Sanjiv Mehta, Neelam Mehta, Vivek Mehta, Vijay Mehta, Vaishali Mehta, Smita Motiwala, Naina Mehta, Devendra Mehta
{"title":"Peer-mediated multimodal intervention program for the treatment of children with ADHD in India: one-year followup.","authors":"Sagar Mehta,&nbsp;Devesh Shah,&nbsp;Kushal Shah,&nbsp;Sanjiv Mehta,&nbsp;Neelam Mehta,&nbsp;Vivek Mehta,&nbsp;Vijay Mehta,&nbsp;Vaishali Mehta,&nbsp;Smita Motiwala,&nbsp;Naina Mehta,&nbsp;Devendra Mehta","doi":"10.5402/2012/419168","DOIUrl":"https://doi.org/10.5402/2012/419168","url":null,"abstract":"<p><p>The objective was to assess the efficacy of a one-year, peer-mediated interventional program consisting of yoga, meditation and play therapy maintained by student volunteers in a school in India. The population consisted of 69 students between the ages of 6 and 11 years, previously identified as having attention deficit hyperactivity disorder (ADHD). A program, known as Climb-Up, was initially embedded in the school twice weekly. Local high school student volunteers were then trained to continue to implement the program weekly over the period of one year. Improvements in ADHD symptoms and academic performance were assessed using Vanderbilt questionnaires completed by both parents and teachers. The performance impairment scores for ADHD students assessed by teachers improved by 6 weeks and were sustained through 12 months in 46 (85%) of the enrolled students. The improvements in their Vanderbilt scores assessed by parents were also seen in 92% (P < 0.0001, Wilcoxon). The Climb-Up program resulted in remarkable improvements in the students' school performances that were sustained throughout the year. These results show promise for a cost-effective program that could easily be implemented in any school.</p>","PeriodicalId":73521,"journal":{"name":"ISRN pediatrics","volume":"2012 ","pages":"419168"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/419168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31160024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Diagnostic value of exhaled carbon monoxide as an early marker of exacerbation in children with chronic lung diseases. 呼出一氧化碳作为慢性肺部疾病加重早期标志物的诊断价值。
ISRN pediatrics Pub Date : 2012-01-01 Epub Date: 2012-09-11 DOI: 10.5402/2012/859873
Karima A Abd El Khalek, Magda Y El Seify, Omneya I Youssef, Mona M Badr
{"title":"Diagnostic value of exhaled carbon monoxide as an early marker of exacerbation in children with chronic lung diseases.","authors":"Karima A Abd El Khalek,&nbsp;Magda Y El Seify,&nbsp;Omneya I Youssef,&nbsp;Mona M Badr","doi":"10.5402/2012/859873","DOIUrl":"https://doi.org/10.5402/2012/859873","url":null,"abstract":"<p><p>Chronic airways infection and inflammation are leading causes of morbidity and mortality in chronic lung diseases (CLD). Pulmonary exacerbations are major causes of morbidity in CLD. Exhaled carbon monoxide (eCO) is a product of endogenous metabolic processes whose presence in exhaled breath is considered an index of inflammatory processes. Objective. To evaluate carbon monoxide (eCO) as inflammatory marker for early detection of acute exacerbation in CLD. Methods. Case control study included 40 children with CLD (twenty in exacerbation, group I and twenty in quiescent period, group II) recruited from the Chest Clinic, Children's Hospital, Ain Shams University. Twenty apparently healthy children were included as controls (group III). Results. Patients' mean age was 9.98 ± 3.29 years: 24 (60%) males and 16 (40%) females. The mean eCO level among patients during exacerbation was 5.35 ± 1.35 (ppm) compared to 2.65 ± 0.49 (ppm) in quiescent stage and 1.30 ± 0.47 (ppm) in controls. eCO cutoff value discriminating cases and control was 1.5 (ppm) (sensitivity; 100% and specificity 70%) and cutoff value discriminating group I from group II was 3 (ppm) (sensitivity: 100% and specificity: 100%). Conclusion. Exhaled CO can be considered a noninvasive early marker of acute exacerbation of CLD.</p>","PeriodicalId":73521,"journal":{"name":"ISRN pediatrics","volume":"2012 ","pages":"859873"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/859873","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30921779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Therapeutic role of mobilized bone marrow cells in children with nonischemic dilated cardiomyopathy. 动员骨髓细胞在儿童非缺血性扩张型心肌病中的治疗作用。
ISRN pediatrics Pub Date : 2012-01-01 Epub Date: 2012-10-21 DOI: 10.5402/2012/927968
Nevin M Habeeb, Omneya I Youssef, Eman S El Hadidi
{"title":"Therapeutic role of mobilized bone marrow cells in children with nonischemic dilated cardiomyopathy.","authors":"Nevin M Habeeb,&nbsp;Omneya I Youssef,&nbsp;Eman S El Hadidi","doi":"10.5402/2012/927968","DOIUrl":"https://doi.org/10.5402/2012/927968","url":null,"abstract":"<p><p>Dilated cardiomyopathy is an important cause of congestive cardiac failure in infants and children. Mobilizing hematopoietic progenitor cells is a promising intervention to this deadly disease. Aim. Evaluate granulocyte colony stimulating factor (GCSF) as therapeutic modality in children with idiopathic dilated cardiomyopathy (IDCM). Subjects and Methods. This case-control prospective study was conducted on 20 children with IDCM following up at Cardiology Clinic Children's Hospital, Ain Shams University (group 1) who were compared to another 10 age-, sex-, duration-of-illness-, and systolic-function-matched children with IDCM as control (group 2). They were subjected to history taking, clinical examination, echocardiography, and peripheral blood CD34+ cell assessment before and one week after GCSF intake for 5 consecutive days (by group 1 but not group 2). Results. A significant improvement in echocardiographic data and CD34+-T-cell increase was found in group 1 one week after GCSF intake and for the next 6 months CD34+ T cells percentage of change showed no significant correlation with the that of the left ventricular dimensions and systolic function. Conclusion. Administration of GCSF to children with IDCM resulted in clinical and echocardiographic improvement not correlated to mobilized CD34+ T cells, implying involvement of additional mechanisms over simple stem cell mobilization.</p>","PeriodicalId":73521,"journal":{"name":"ISRN pediatrics","volume":"2012 ","pages":"927968"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/927968","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31048668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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