IPEM-translation最新文献

National radiotherapy dosimetry audit in the UK – A vision and roadmap 英国全国放射治疗剂量测量审计--愿景和路线图

IPEM-translation Pub Date : 2024-09-25 DOI: 10.1016/j.ipemt.2024.100032

Sarah Misson , Antony L Palmer , Patricia Diez , Mohammed Hussein , Catharine H Clark

{"title":"National radiotherapy dosimetry audit in the UK – A vision and roadmap","authors":"Sarah Misson , Antony L Palmer , Patricia Diez , Mohammed Hussein , Catharine H Clark","doi":"10.1016/j.ipemt.2024.100032","DOIUrl":"10.1016/j.ipemt.2024.100032","url":null,"abstract":"<div><div>Radiotherapy dosimetry audit is an important element in the overall quality assurance of radiotherapy delivery and has become established as best practice prior to implementation of new equipment, techniques or clinical trials.</div><div>The Institute of Physics and Engineering in Medicine (IPEM) Interdepartmental Dosimetry Audit group (IDA) facilitates regional audits across the UK through a network of 8 regional chairs. This is a well-established and successful network utilising local staff resources and dosimetry equipment from each region to conduct audits for new radiotherapy equipment, techniques and annual reference audits. All dosimeters used are traceable to the National Physical Laboratory's (NPL) primary standard.</div><div>NPL and the National Radiotherapy Trials Quality Assurance Group (RTTQA) perform audits for new techniques and clinical trials in the UK. The IPEM IDA, NPL and RTTQA have a joint vision of a national audit network so that comprehensive audits can be offered to all UK centres and bring together all UK dosimetry audit data within a centralised database to facilitate coordinated national audits. This will also allow centres to access and review their data for anonymous benchmarking against other UK centres to support quality improvement.</div><div>Increasing the frequency and complexity of national audits to reflect current clinical practice is often inhibited by the cost of purchasing appropriate equipment. IPEM have now funded two phantoms that will enable national audits of gynae brachytherapy and head and neck external beam treatments through 2024–25.</div><div>The aim of this Position Paper is to provide an update on the activities of the IPEM IDA and present the future vision and roadmap for the three UK dosimetry audit groups.</div></div>","PeriodicalId":73507,"journal":{"name":"IPEM-translation","volume":"12 ","pages":"Article 100032"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the clinical value of mechanical ventilators and extracorporeal membrane oxygenation (ECMO) equipment 机械呼吸机和体外膜氧合（ECMO）设备的临床价值回顾

IPEM-translation Pub Date : 2024-08-15 DOI: 10.1016/j.ipemt.2024.100031

David Stell , Dr Man Ting Kwong , Robert Megwa , Dr Tom Bashford , Dr. Emmanuel Akinluyi , Prof. P. John Clarkson

{"title":"A review of the clinical value of mechanical ventilators and extracorporeal membrane oxygenation (ECMO) equipment","authors":"David Stell , Dr Man Ting Kwong , Robert Megwa , Dr Tom Bashford , Dr. Emmanuel Akinluyi , Prof. P. John Clarkson","doi":"10.1016/j.ipemt.2024.100031","DOIUrl":"10.1016/j.ipemt.2024.100031","url":null,"abstract":"<div><div>Acute healthcare providers operate large, diverse medical equipment inventories. Resources for managing these inventories is frequently scarce so must be prioritised such that maximum benefit is conferred per unit of expenditure.</div><div>This review identifies publications which have discussed the clinical value conferred by mechanical ventilation (MV) and by extra corporeal membrane oxygenation (ECMO). Respectively, mechanical ventilators and ECMO units are necessary to deliver these therapies. Systematic searches for publications which discuss the clinical value conferred by MV and by ECMO were conducted.</div><div>The identified articles included reviews, prospective studies, retrospective studies, and models. Most presented findings in terms of the cost-effectiveness ratio. The patient populations studied, and analytical methods used varied widely. The clinical value conferred by MV varied with dependencies on several factors including the age- and disease- profile of the patient population. It was not possible to infer these dependencies from the literature which exists for ECMO.</div><div>More relevant literature existed for MV, the more mature technology, than did for ECMO. The ECMO literature also tended to be more recent and included more modelling studies and fewer prospective studies. The data extracted could inform estimates of the clinical value likely to be delivered by mechanical ventilators operated by a specific institution. Estimates for ECMO are likely to carry greater uncertainty than those for MV.</div></div>","PeriodicalId":73507,"journal":{"name":"IPEM-translation","volume":"12 ","pages":"Article 100031"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of solar film elements on a neonate manikin surface to estimate the received output power of neonatal phototherapy lamp systems 利用新生儿人体模型表面的太阳膜元件估算新生儿光疗灯系统的接收输出功率

IPEM-translation Pub Date : 2024-06-01 DOI: 10.1016/j.ipemt.2024.100029

D.M. Clarkson , P. Satodia

{"title":"The use of solar film elements on a neonate manikin surface to estimate the received output power of neonatal phototherapy lamp systems","authors":"D.M. Clarkson , P. Satodia","doi":"10.1016/j.ipemt.2024.100029","DOIUrl":"https://doi.org/10.1016/j.ipemt.2024.100029","url":null,"abstract":"<div><p>The work described was undertaken to develop a means to estimate the delivered power over the exposed body surface of a neonate receiving phototherapy. Previous work of the group had involved the use of discrete photodiodes distributed over a newborn manikin surface. It was considered that improved accuracy of sensing over curved surfaces would be provided with the use of flexible solar cell elements. A group of products based on amorphous silicon was identified as potentially suitable and a range of its properties investigated. These included the wavelength sensitivity, the relative sensitivity of similar elements and the cosine response of elements. It was identified that with selection of elements of matched sensitivity, specific element types were appropriate for intended use. A total of 44 discrete solar cell elements of three separate sizes was used to cover the previously used manikin surface and a dedicated interface circuit was designed and constructed. A handheld calibrated spectroradiometer provided a means to relate incident irradiance values within specific wavelength bands to corresponding optical power over the manikin surface. Initial use of the system is described together with future potential developments in relation to clinical applications and testing standards for neonatal phototherapy devices.</p></div>","PeriodicalId":73507,"journal":{"name":"IPEM-translation","volume":"10 ","pages":"Article 100029"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667258824000074/pdfft?md5=bc417a771e4cef07d67fba1c25ac294a&pid=1-s2.0-S2667258824000074-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141543793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental measurement of dosimetric parameters relevant to radioactive needlestick injury 放射性针刺伤相关剂量参数的实验测量

IPEM-translation Pub Date : 2024-06-01 DOI: 10.1016/j.ipemt.2024.100028

Niamh Banks , Luke Collett , Farnoosh Zananiri

{"title":"Experimental measurement of dosimetric parameters relevant to radioactive needlestick injury","authors":"Niamh Banks , Luke Collett , Farnoosh Zananiri","doi":"10.1016/j.ipemt.2024.100028","DOIUrl":"10.1016/j.ipemt.2024.100028","url":null,"abstract":"<div><p>Nuclear medicine healthcare workers are exposed to the risk of radioactive needlestick injury. To quantify the severity of this risk, the activity deposited into the skin and the injury depth have been experimentally measured for input into skin dosimetry program VARSKIN+. Agar test objects were pierced by hand with a needle containing Tc-99m Hydroxymethylene Diphosphonate (HMDP). The deposited activity was measured by contamination monitor and converted into deposited volume. Injury depth was measured with a ruler by piercing the test objects with visible dye.</p><p>The median volume deposited into test objects without gloves was 100 ± 50 nl (standard error) (interquartile range (IQR): 50–320 nl). Through one glove, this was reduced to 50 ± 20 nl (IQR: 30 - 140 nl), however, the difference was not significant (<em>p</em> > 0.1). The volume deposited through two gloves was highly variable due to the increased force required to puncture. The median injury depth was 4.0 ± 0.4 mm (standard error).</p><p>Decontamination efficacy was investigated by rinsing alone, with hand soap and by application of decontamination agent RadiacWash. All decontamination methods were found to significantly decrease the activity deposited (<em>p</em> < 0.001). Test objects rinsed for 60 s had a mean reduction of 42 % ± 6 % (95 % confidence interval). There was no significant difference observed between decontamination methods. This may be due to differences in absorption time between the sample groups.</p><p>Skin dose estimates have been calculated in VARSKIN+ using the results of the experiment. For injuries without gloves, involving 1011 MBq/ml of Tc-99m HMDP, a skin dose of 11 ± 5 mSv (propagated standard error) was calculated. Immediate decontamination under running water is recommended to reduce the dose. Further research is encouraged to investigate the protection offered by gloves.</p></div>","PeriodicalId":73507,"journal":{"name":"IPEM-translation","volume":"10 ","pages":"Article 100028"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667258824000062/pdfft?md5=f490824380cb9e54cb70612b6cbf15a8&pid=1-s2.0-S2667258824000062-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141139494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Coriolis flow measurement technology in validation of model of syringe driver performance 科里奥利流量测量技术在验证注射器驱动器性能模型中的作用

IPEM-translation Pub Date : 2024-04-12 DOI: 10.1016/j.ipemt.2024.100027

D.M. Clarkson , M. Tshangini

{"title":"Role of Coriolis flow measurement technology in validation of model of syringe driver performance","authors":"D.M. Clarkson , M. Tshangini","doi":"10.1016/j.ipemt.2024.100027","DOIUrl":"10.1016/j.ipemt.2024.100027","url":null,"abstract":"<div><p>The development of a flow/pressure measurement system in association with Bronkhorst High-Tech B.V. incorporating a Coriolis flow transducer, provided an opportunity to observe the flow/pressure dynamics of syringe drivers. A model of flow/pressure performance of syringe drivers was established where key variable factors included the compliance of the connected system and the associated line resistance. It was identified that the flow/pressure dynamics observed with the flow measurement system incorporating the Coriolis transducer matched that of the model. In this consideration the dominant compliance contribution related to that of the syringe. The model operates by considering the notional volume change in the residual fluid volume in the syringe with inflow from stepper motor action and outflow in the interval between sequential pulses. While many of the observations in the literature of syringe driver function are qualitative, the model allows a more precise prediction of associated device performance.</p></div>","PeriodicalId":73507,"journal":{"name":"IPEM-translation","volume":"10 ","pages":"Article 100027"},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667258824000050/pdfft?md5=9f630e933b3b9c89566642af5e2ed2d5&pid=1-s2.0-S2667258824000050-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140790237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoplethysmogram-based heart rate and blood pressure estimation with hypertension classification 基于照相血压计的心率和血压估算与高血压分类

IPEM-translation Pub Date : 2024-03-01 DOI: 10.1016/j.ipemt.2024.100024

Aditta Chowdhury , Diba Das , Abdelrahman B.M. Eldaly , Ray C.C. Cheung , Mehdi Hasan Chowdhury

{"title":"Photoplethysmogram-based heart rate and blood pressure estimation with hypertension classification","authors":"Aditta Chowdhury , Diba Das , Abdelrahman B.M. Eldaly , Ray C.C. Cheung , Mehdi Hasan Chowdhury","doi":"10.1016/j.ipemt.2024.100024","DOIUrl":"https://doi.org/10.1016/j.ipemt.2024.100024","url":null,"abstract":"<div><p>A photoplethysmogram (PPG) is an optically-derived signal that records the variation in blood volume within the microvasculature. Certain cardiovascular diseases (CVDs) are symptomatic of damaged blood vessels and problems in blood flow, including hypertension. While software implementations for heart rate and blood pressure estimation exist, point-of-care systems demand hardware-based implementations for real-time estimations to be useful for CVD detection. In this study, digital field programmable gate array (FPGA) based systems are developed for heart rate and blood pressure estimation from PPG signals by means of linear regression. In addition to the blood pressure estimation system, we present a prototype hypertension level detection system that achieves 92.42% accuracy while consuming 0.364 W of power. The Mean Absolute Error (MAE) <span><math><mo>±</mo></math></span> Standard Deviation (SD) for heart rate estimation is 3.17 ± 2.79 beat per minute. The corresponding results for systolic and diastolic blood-pressure estimation are 4.75 ± 2.78 and 3.34 ± 2.60, respectively. The prototype can be further extended to wearable devices and medical equipment in the future.</p></div>","PeriodicalId":73507,"journal":{"name":"IPEM-translation","volume":"9 ","pages":"Article 100024"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667258824000025/pdfft?md5=6f5c7e4d5072d04f8f45d83d1cdd8008&pid=1-s2.0-S2667258824000025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140180578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Realistic phantoms for quantitative MR: the need and a proposal (the B1 sleeve) 定量 MR 的真实模型：需求与建议（B1 套筒）

IPEM-translation Pub Date : 2024-03-01 DOI: 10.1016/j.ipemt.2024.100026

Paul S Tofts

{"title":"Realistic phantoms for quantitative MR: the need and a proposal (the B1 sleeve)","authors":"Paul S Tofts","doi":"10.1016/j.ipemt.2024.100026","DOIUrl":"https://doi.org/10.1016/j.ipemt.2024.100026","url":null,"abstract":"<div><p>Quantitative MR (qMR) has offered direct access to <em>in-vivo</em> biology and physiology for over three decades, yet it has failed to translate into the clinic. Why is this? The development of suitable phantoms is a key stage in the evolution of qMR, and here a systematic categorisation is proposed. Currently there is much attention paid to creating simple head phantoms containing materials with metrologically traceable values of MR quantities. However these are usually unrealistic; many of the disrupting phenomena present in clinical imaging are absent. Good performance with a simple traceable phantom is a necessary but not sufficient requirement for the establishment of good <em>in-vivo</em> measurement performance. There is therefore a premium on developing <em>realistic</em> phantoms. A proposal made for a more realistic body phantom that includes RF B<sub>1</sub> imperfections. It consists of lossy annuli placed around a standard head phantom. Other confounding phenomena could be identified, possibly built into an appropriate annulus around a simple head phantom, to form realistic phantoms; these would enable validation of qMR methods and translation to the clinic. The concept is probably applicable to other quantitative diagnostic imaging modalities.</p></div>","PeriodicalId":73507,"journal":{"name":"IPEM-translation","volume":"9 ","pages":"Article 100026"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667258824000049/pdfft?md5=66e3d7644488924b67b7aef8cf57afeb&pid=1-s2.0-S2667258824000049-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140533344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards clinical translation of 7 Tesla MRI in the human brain 实现 7 特斯拉核磁共振成像在人脑中的临床转化

IPEM-translation Pub Date : 2024-03-01 DOI: 10.1016/j.ipemt.2024.100025

Graeme A. Keith , Rosemary A. Woodward , Tracey Hopkins , Sarah Allwood-Spiers , Jon Trinder , Keith W. Muir , David A. Porter , Natasha E. Fullerton

{"title":"Towards clinical translation of 7 Tesla MRI in the human brain","authors":"Graeme A. Keith , Rosemary A. Woodward , Tracey Hopkins , Sarah Allwood-Spiers , Jon Trinder , Keith W. Muir , David A. Porter , Natasha E. Fullerton","doi":"10.1016/j.ipemt.2024.100025","DOIUrl":"10.1016/j.ipemt.2024.100025","url":null,"abstract":"<div><p>Clinical translation of 7 tesla (T) MRI of the brain promises high image quality and potentially improved clinical diagnosis for patients compared to current standard lower field-strength MRI at 1.5 and 3T.</p><p>Here we describe how physics principles underlying ultra-high field (UHF) strength MRI affect 7T image quality, and how these can be exploited to translate 7T brain imaging into clinical practice. UHF MRI profits from higher inherent signal-to-noise ratio (SNR) and a resultant increase in achievable spatial resolution or acceleration factors; increase in sensitivity to magnetic susceptibility differences and a higher amplitude of the Blood Oxygen Level Dependent (BOLD) signal; increase in longitudinal relaxation time; and increased frequency dispersion and spectral resolution in MR spectroscopy.</p><p>Examples are presented of different brain pathologies, which are better illustrated on 7T compared to lower field strength by applying sequences and imaging techniques that exploit these intrinsic strengths of 7T MRI. This includes imaging of various vascular pathologies, epilepsy and brain tumours.</p></div>","PeriodicalId":73507,"journal":{"name":"IPEM-translation","volume":"9 ","pages":"Article 100025"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667258824000037/pdfft?md5=ab93932573339e7644a6ba9484e810bd&pid=1-s2.0-S2667258824000037-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140276801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards a locally constructed multi-element ultrasound imaging transducer for resource poor environments 为资源贫乏环境开发本地制造的多元件超声波成像传感器。

IPEM-translation Pub Date : 2024-02-14 DOI: 10.1016/j.ipemt.2024.100023

A.J. Wilson , R.W. Taylor , S.E. Burrows , S.M. Dixon

{"title":"Towards a locally constructed multi-element ultrasound imaging transducer for resource poor environments","authors":"A.J. Wilson , R.W. Taylor , S.E. Burrows , S.M. Dixon","doi":"10.1016/j.ipemt.2024.100023","DOIUrl":"10.1016/j.ipemt.2024.100023","url":null,"abstract":"<div><p>This paper investigates techniques and materials for making a multi-element ultrasound imaging transducer with craft-based techniques available in resource poor environments. The transducer housing can be conveniently divided into three parts: the body supporting the piezoelectric (PZT) elements and other components; the matching layer between the PZT elements and the human body; and the backing layer behind the PZT elements. Low-cost 3D printing systems based on photopolymers were found to be suitable for manufacturing the body. Finite Element Modelling (FEM) showed that the material characteristics of the backing layer and the thickness of the matching layer were much less critical than predicted by ultrasound plane wave theory and transmission line theory, respectively. The backing and matching layers are normally made from epoxy-tungsten composites that are pourable in the uncured state. However, the composite required for the backing layer was putty-like when uncured. When the tungsten was allowed to settle under gravity during curing, a 20 % by volume uncured tungsten-epoxy composite gave a 30 % by volume concentration of tungsten at the bottom when cured at 20–30 °C. These findings, when coupled with the findings from the FEM modelling, suggests that constructing a multi-element ultrasound imaging transducer using craft-based techniques is feasible.</p></div>","PeriodicalId":73507,"journal":{"name":"IPEM-translation","volume":"9 ","pages":"Article 100023"},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667258824000013/pdfft?md5=2a3b6a3d10cb4d9ed4c4f796bcfba694&pid=1-s2.0-S2667258824000013-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139827649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards a locally constructed multi-element ultrasound imaging transducer for resource poor environments. 为资源贫乏环境开发本地制造的多元件超声波成像传感器。

IPEM-translation Pub Date : 2024-02-01 DOI: 10.1016/j.ipemt.2024.100023

A.J. Wilson, R.W. Taylor, S.E. Burrows, S.M. Dixon

引用次数: 0