International journal of dermatology and venereology最新文献

{"title":"Integrated skin microbiome and metabolome analyses reveal altered bacterial community composition and metabolites in psoriasis","authors":"Rong Tao, Zhe Wan, Ruo-Yu Li, Ruo-Jun Wang","doi":"10.1097/jd9.0000000000000350","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000350","url":null,"abstract":"Objective: Current theories highlight the role of the microbiome in the pathogenesis of psoriasis. Additionally, abnormal metabolism can alter disease processes in terms of occurrence, progression, and prognosis. Therefore, an integrative microbiome and metabolome analysis of the skin may aid in understanding the disease pathogenesis and identify therapeutic targets for psoriasis. Methods: We recruited 22 patients with psoriasis and 22 age- and sex-matched healthy controls. Skin swabs were collected from the participants’ scalps. All samples underwent amplicon sequencing of the ITS1 and V3V4 16S rRNA regions and metabolome analysis. Results: The psoriatic lesions were characterized by higher bacterial diversity, significantly higher abundances of Corynebacterium and Staphylococcus , and a lower abundance of Cutibacterium compared with healthy controls. However, no significant alterations in the fungal diversity or fungal taxonomies were detected. Metabolome analysis revealed that prostaglandin-related metabolites, nucleotides, and cysteine- and methionine-related metabolites were significantly enriched in patients with psoriasis, and these metabolites were positively correlated with the disease-associated bacteria Staphylococcus and Corynebacterium . Conclusions: We demonstrated significant alterations in the skin microbiome and metabolome in patients with psoriasis compared with healthy controls.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136182868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-Rich Plasma for Androgenetic Alopecia: What the Dermatologist Needs to Know","authors":"Shivali Devjani, Ogechi Ezemma, Kristen J. Kelley, Maryanne Makredes Senna","doi":"10.1097/jd9.0000000000000348","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000348","url":null,"abstract":"Devjani, Shivali1; Ezemma, Ogechi1; Kelley, Kristen J.1; Senna, Maryanne Makredes1,2 Author Information","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"180 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136058030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Climatic Factors on Varicella-Zoster Viral Infection","authors":"Sarah-Jane Dempsey, Louise K. Andersen, Sarah J. Coates, Mark D.P. Davis","doi":"10.1097/jd9.0000000000000347","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000347","url":null,"abstract":"Dempsey, Sarah-Jane; Andersen, Louise K. MD; Coates, Sarah J. MD; Davis, Mark D.P. MD Author Information","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136313170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An extensive review of vitiligo-associated conditions","authors":"Madhavi Premkumar, Iyshwarya Bhaskar Kalarani, Vajagathali Mohammed, Ramakrishnan Veerabathiran","doi":"10.1097/jd9.0000000000000346","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000346","url":null,"abstract":"Vitiligo is an autoimmune disorder caused by the destruction of melanocytes in various body regions. Numerous diseases may accompany vitiligo. The prevalence of vitiligo varies among geographical regions and shows no relation to sex or age. However, vitiligo most commonly affects people aged 10 to 30 years. The clinical symptoms of vitiligo include irregular patches on the skin and various diseases associated with this disorder. The present review focuses on the clinical effects and risk factors of vitiligo-associated conditions and the current therapeutics for treating vitiligo. This systematic review was performed based on the PRISMA guidelines and articles published from 2000 to 2023 in several electronic databases (Web of Science, PubMed, PsycINFO, and others). The most clinically significant diseases associated with vitiligo are alopecia areata, autoimmune thyroid disease, Addison's disease, and type 1 diabetes mellitus. No targeted population is specifically prone to vitiligo; it does not affect any particular race or sex. Hence, awareness of the diseases associated with vitiligo is necessary to control them through various medical and surgical treatments with the proper facilities.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135152885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophilic panniculitis associated with myelodysplastic syndrome/myeloproliferative neoplasm: a case report and literature review.","authors":"Alexa J Cohen, Laura K Gleason, Safiyyah A Bhatti, Neda Nikbakht","doi":"10.1097/jd9.0000000000000286","DOIUrl":"10.1097/jd9.0000000000000286","url":null,"abstract":"<p><strong>Introduction: </strong>Neutrophilic panniculitis (NP) is a rare subtype of neutrophilic dermatosis, a group of neutrophil-rich inflammatory skin disorders that can present in association with myeloid neoplasms. NP is defined by the presence of a neutrophilic infiltrate in the fat lobules of the subcutis in the absence of either infection or vasculitis. We herein describe a 65-year-old woman with a recent diagnosis of myelodysplastic syndrome/myeloproliferative neoplasm overlap syndrome (MDS/MPN) who abruptly developed painful, pruritic nodules consistent with NP.</p><p><strong>Case presentation: </strong>A 65-year-old woman with MDS/MPN presented for evaluation of painful and pruritic nodules on her upper and lower extremities. A biopsy revealed a lobular neutrophilic infiltrate in the subcutis without evidence of microorganisms or vasculitis. The patient was diagnosed with NP and treated with oral prednisone. Within 1 month of treatment, she reported complete resolution of the nodules.</p><p><strong>Discussion: </strong>Similar to other neutrophilic dermatoses, NP may arise in association with hematologic malignancies of myeloid origin, such as MDS/MPN. A literature review revealed that most cases of NP associated with MDS occur after the onset of MDS and respond to systemic corticosteroids, not antibiotics. Infection should be ruled out before initiating treatment with systemic steroids.</p><p><strong>Conclusion: </strong>Although the mechanism is still unknown, it is important for clinicians to be aware that NP is associated with MDS; thus, hematological malignancies should be investigated upon diagnosis of NP. Once diagnosed, NP is easily treated and has an excellent response to systemic corticosteroids.</p>","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"6 3","pages":"168-171"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Whole Blood Zinc Levels, CD4 Cell Count, Disease Stage, and Dermatologic Manifestations Among HIV Patients: A Single Center Experience in Philippines: Erratum","authors":"","doi":"10.1097/jd9.0000000000000322","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000322","url":null,"abstract":"","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135434197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of leprosy in China, 2021: an update","authors":"Ying Shi, Pei-Wen Sun, Le Wang, Hong-Sheng Wang, Mei-Wen Yu, Heng Gu","doi":"10.1097/jd9.0000000000000344","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000344","url":null,"abstract":"Objective: To describe the epidemiological characteristics of leprosy in China in 2021 and provide essential information for future national leprosy control and prevention strategies. Methods: We collected epidemiological data of leprosy from 31 provinces, autonomous regions, and municipalities of China (except for Hong Kong, Macao, and Taiwan) provided by the Leprosy Management Information System. We performed a comparative analysis of the epidemiological features of patients with leprosy including age, sex, geographical distribution, and grade of disability. Results: In total, 374 newly detected leprosy cases were reported nationwide in China in 2021, giving an incidence rate of 0.27 per million population, which represented a decrease of 7.9% compared with 2020. Among the population with leprosy in 2021 that comprised 238 males (63.6%) and 136 females (36.4%), 1.9% (7/374) were children younger than 15 years, 92.8% (347/374) had multibacillary leprosy, and 18.2% (68/374) had grade 2 disability. More than half of the new leprosy cases (54.8%, 205/374) were distributed in southwest China. There were 33 relapsed leprosy cases reported in 2021. By the end of 2021, there were 1,897 registered leprosy cases reported nationwide, giving a prevalence rate of 1.35 per million population. Conclusion: The leprosy epidemic in China shows a downward trend in terms of the prevalence and incidence rates. However, the high prevalence of leprosy in southwest China is still a matter of concern.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135990885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of three different biologics on mental health and health-related quality of life in patients with psoriasis: a repeated cross-sectional survey of Chinese patients","authors":"Jie Liu, Xuan Wang, Xiao-Ling Yu, Zhi-Miao Lin, Li-Yan Yuan, Bin Yang","doi":"10.1097/jd9.0000000000000343","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000343","url":null,"abstract":"Objective: Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health. While biologics have been shown to be effective in treating psoriatic lesions, thus improving QoL, real-life data regarding such effects remain scant. We administered a repeated cross-sectional survey to assess the effects of 8 weeks of biologics treatment on the QoL and mental health status of patients with moderate-to-severe plaque psoriasis. Methods: From March to May 2022, patients with moderate-to-severe plaque psoriasis were enrolled and treated with biologics in the outpatient clinic at the Dermatology Hospital of Southern Medical University. Assessments were performed before treatment and after 4 and 8 weeks of treatment with biologics. Psoriasis severity, QoL, and mental health status were evaluated using the Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), 36-Item Short Form Health Survey (SF-36), and Hospital Anxiety and Depression Scale (HADS). A multivariate generalized estimating equations (GEE) analysis was used to account for repeated measures and to determine the effects of treatment duration and type of biological agent on relevant indicators. Results: Among the 78 enrolled patients, the ranges of pretreatment scores were 4.6–46.8 for the PASI, 1–30 for the DLQI, 31.5–100 for the physical component score (PCS) of the SF-36, 16.6–100 for the mental component score (MCS) of the SF-36, 0–15 for the HADS-A, and 0–17 for the HADS-D. After 8 weeks of biologics treatment, 98.7% (77/78) of patients had obtained PASI 75. All assessed scores changed over time (GEE, P < 0.05). Moreover, there were group-by-time interaction effects for the DLQI score (GEE, P = 0.023) and PCS (GEE, P = 0.029). The HADS-A and HADS-D scores were both decreased at week 8 compared with pretreatment values. Correlation analyses revealed that higher DLQI scores were associated with lower levels of QoL and higher levels of anxiety or depression. Conclusion: Biologics are not only effective in the treatment of skin lesions, but also exert beneficial effects upon the QoL and mental health of patients with psoriasis as determined in the short-term assessments conducted in this study.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136239510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Stress Affects the Occurrence and Development of Psoriasis Through Neuroendocrine-Immune Regulation: A Narrative Review","authors":"","doi":"10.1097/jd9.0000000000000342","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000342","url":null,"abstract":"This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135715939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Genetic Predisposition to Numerous Large Ulcerating Basal Cell Carcinomas and Response to Immune Therapy: Erratum.","authors":"","doi":"10.1097/JD9.0000000000000184","DOIUrl":"https://doi.org/10.1097/JD9.0000000000000184","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/JD9.0000000000000170.].</p>","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"6 2","pages":"106"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/57/jd9-6-106.PMC10309099.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}