International journal of dermatology and venereology最新文献

Impact of 30% supramolecular salicylic acid combined with ultra-pulse carbon dioxide fractional laser therapy on facial atrophic acne scars 30% 超分子水杨酸联合超脉冲二氧化碳点阵激光疗法对面部萎缩性痤疮疤痕的影响

International journal of dermatology and venereology Pub Date : 2024-07-11 DOI: 10.1097/jd9.0000000000000394

Xiu-Feng Liu, Man-Chang Yu

{"title":"Impact of 30% supramolecular salicylic acid combined with ultra-pulse carbon dioxide fractional laser therapy on facial atrophic acne scars","authors":"Xiu-Feng Liu, Man-Chang Yu","doi":"10.1097/jd9.0000000000000394","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000394","url":null,"abstract":"\u0000 \u0000 To assess the impact of 30% supramolecular salicylic acid (SSA) combined with ultra-pulse carbon dioxide (CO2) fractional laser therapy on facial atrophic acne scars.\u0000 \u0000 \u0000 \u0000 This retrospective study included patients with atrophic acne scars treated from June 2020 to June 2022. The patients were divided into the combination group (SSA combined with ultra-pulse CO2 fractional laser therapy) and the laser group (ultra-pulse CO2 fractional laser therapy alone). Four treatment sessions were conducted for each group. Follow-up visits were performed every 2 months after each treatment and included assessments of the Échelle d'Évaluation clinique des cicatrices d'acné (ECCA) score, effective rate, and visual analogue scale score.\u0000 \u0000 \u0000 \u0000 The combination and laser groups comprised 72 and 61 patients, respectively. There were no significant differences in sex, age, or baseline ECCA score between the two groups. The effective rate (95.8% vs. 67.2%, P < 0.001) was higher and the pain scores (during and after the intervention) were lower in the combination group than in the laser group (P < 0.001). The severity of erythema, edema, and crusting was milder in the combination group (P < 0.001). The proportion of highly satisfied patients was higher (73.6% vs. 31.2%, P < 0.001) and the Dermatology Life Quality Index showed greater improvement (0.15 ± 0.40 vs. 1.39 ± 1.53, P < 0.001) in the combination group than in the laser group.\u0000 \u0000 \u0000 \u0000 The combination of ultra-pulse CO2 fractional laser therapy and 30% supramolecular SSA had improved efficacy in treating facial atrophic acne scars without increasing pain or inducing adverse reactions.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"124 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141656846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Content Validity of Health Games for children with Atopic Dermatitis 特应性皮炎儿童健康游戏的设计和内容有效性

International journal of dermatology and venereology Pub Date : 2024-07-08 DOI: 10.1097/jd9.0000000000000396

Mariana Muzzolon, Mariana A Pasa Morgan, R. Imoto, Vânia O de Carvalho

{"title":"Design and Content Validity of Health Games for children with Atopic Dermatitis","authors":"Mariana Muzzolon, Mariana A Pasa Morgan, R. Imoto, Vânia O de Carvalho","doi":"10.1097/jd9.0000000000000396","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000396","url":null,"abstract":"\u0000 \u0000 The success of managing atopic dermatitis (AD) largely depends on patient adherence to treatment. Achieving adherence requires more than knowledge transfer; it also requires a change in patients’ health behavior. Therefore, we conducted this study to develop and validate the content of health games for the pediatric population with AD.\u0000 \u0000 \u0000 \u0000 This study focused on developing and validating the content of health games about AD. Among these were the book Oli e o Grande Desafio da Coceira™ (“Oli and the Great Itching Challenge”) and the games Dermatrilha™ (“Dermatrail”) and Caixinha Surpresa da Dermatite™ (“Dermatitis Surprise Box”). The instrument development process consisted of five stages: planning of the instruments, development of the instruments, development of content validation questionnaires, evaluation by an expert committee, and a pre-test with the target audience.\u0000 \u0000 \u0000 \u0000 The expert committee comprised 20 professionals: 5 pediatric dermatologists, 5 hospital psychologists, 5 illustrators/designers, and 5 early childhood education teachers. The target audience comprised 25 children with AD aged 5 to 12 years. The content validity index was 0.94 in the evaluation by the expert committee and 0.95 in the evaluation by the target audience. Among the games, the general content validity index was 0.95 among the members of the expert committee and 0.92 among the target audience, being higher than 0.80 for all items.\u0000 \u0000 \u0000 \u0000 The health games evaluated in this study are useful psychoeducational tools with high content validity for use in the therapeutic education of children with AD.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":" October","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognosis and immune infiltration analysis of m6A RNA methylation regulators in cutaneous melanoma and differential analysis with cuproptosis related genes 皮肤黑色素瘤 m6A RNA 甲基化调节因子的预后和免疫浸润分析以及与杯突症相关基因的差异分析

International journal of dermatology and venereology Pub Date : 2024-06-03 DOI: 10.1097/jd9.0000000000000387

Cui-cui Tian, Hao-ze Shi, Cong-cong Zhang, Yingjie Kong, Hao Chen

{"title":"Prognosis and immune infiltration analysis of m6A RNA methylation regulators in cutaneous melanoma and differential analysis with cuproptosis related genes","authors":"Cui-cui Tian, Hao-ze Shi, Cong-cong Zhang, Yingjie Kong, Hao Chen","doi":"10.1097/jd9.0000000000000387","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000387","url":null,"abstract":"\u0000 \u0000 N6-methyladenosine (m6A) modification and cuproptosis play essential roles in the pathogenesis of various malignant tumors. However, the predictive role of m6A regulators and cuproptosis-related genes in cutaneous melanoma (CM) remains unclear. In this study, the aim was not only to explore the role of m6A modification in CM, but also to investigate the differential expression of cuproptosis-related genes in different risk group.\u0000 \u0000 \u0000 \u0000 We obtained transcriptome data from the XENA and GTEx databases. Univariate Cox regression analysis was performed to investigate the relationship between m6A-related genes and the outcomes of CM. LASSO regression analysis was utilized to construct a risk model. Moreover, we analyzed immune cell infiltration using CIBERSORT algorithms. Finally, we evaluated the expression levels of cuproptosis-related genes in CM samples and performed RT-qPCR to validate the expression of cuproptosis-associated genes in melanoma cells after YTHDF3 knockdown.\u0000 \u0000 \u0000 \u0000 All m6A-related genes differed in melanoma tissues and normal tissues and a prognostic signature was developed. Immune infiltration revealed that low-risk group patients had a higher level of CD8 + T cells, memory activated CD4 + T cells, activated NK cells and M1 Macrophages than high-risk group (P<0.05). Moreover, the cuproptosis-related genes MTF-1, PDHB and FDX1 were significantly negatively associated with risk score (P=0.0007, P=0.0057 and P=0.04, respectively). We also found that downregulation YTHDF3 in melanoma cells affected the expression of cuproptosis-related genes. (P<0.01 and P<0.05).\u0000 \u0000 \u0000 \u0000 Our study demonstrated the prognostic value of m6A-related genes and cuproptosis-related genes in CM, providing new predictive models and potential therapeutic targets for CM.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141272055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on ultrastructure of Treponema pallidum subspecies pallidum 苍白螺旋体亚种超微结构的研究进展

International journal of dermatology and venereology Pub Date : 2024-05-09 DOI: 10.1097/jd9.0000000000000386

Si-Ning Wang, Rui-Li Zhang

引用次数: 0

Impact of the COVID-19 pandemic on the epidemiology of hand-foot-and-mouth disease and varicella in a general hospital in Guangzhou, China COVID-19 大流行对中国广州某综合医院手足口病和水痘流行病学的影响

International journal of dermatology and venereology Pub Date : 2024-04-15 DOI: 10.1097/jd9.0000000000000383

Hui-Hui Wu, Hang Li, Juan-Hua Liu, Lu-Li Song, D. Luo, Yu-Kun Zhao

{"title":"Impact of the COVID-19 pandemic on the epidemiology of hand-foot-and-mouth disease and varicella in a general hospital in Guangzhou, China","authors":"Hui-Hui Wu, Hang Li, Juan-Hua Liu, Lu-Li Song, D. Luo, Yu-Kun Zhao","doi":"10.1097/jd9.0000000000000383","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000383","url":null,"abstract":"We retrospectively reviewed the medical records of patients with hand-foot-and-mouth disease (HFMD) and varicella treated in a general hospital in Guangzhou, China between 2017 and 2023 to evaluate the effect of the coronavirus disease 2019 (COVID-19) on the epidemiology of HFMD and varicella in Guangzhou. The epidemiological characteristics of HFMD and varicella before (2017–2019), during (2020–2022), and after (2023) the pandemic were compared. In total, 1731 cases of HFMD and 1043 cases of varicella were reported before the COVID-19 pandemic (2017–2019), with average reporting rates of 0.08% and 0.05%, respectively. During the COVID-19 pandemic (2020–2022), the number of reported cases of HFMD and varicella decreased to 571 and 389, respectively, with average reporting rates of 0.03% and 0.02%, respectively, which were significantly different from those in the pre-pandemic period (P < 0.001). In the post-pandemic period (2023), the reporting rate of HFMD was 0.07%, showing a marked increase compared with that in 2022 (P < 0.001). However, the difference in the reporting rate of varicella in 2023 did not differ significantly from that in 2022 (P =0.204). These results suggest that non-pharmaceutical interventions implemented during the COVID-19 pandemic might be helpful in preventing the spread of HFMD and varicella.","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"50 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140701180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eruptive pseudoangiomatosis and parvovirus: exclusive clinical findings 爆发性假血管瘤病和副病毒：独有的临床发现

International journal of dermatology and venereology Pub Date : 2024-04-15 DOI: 10.1097/jd9.0000000000000384

F. Gaudiello, S. Spennato, F. Cillo, Maria Teresa Cantelli, Maria Vastarella, M. Scalvenzi

引用次数: 0

Macrophage Polarization and Crosstalk between Macrophages and Other Cells in Hidradenitis Suppurativa 化脓性扁桃体炎中巨噬细胞的极化以及巨噬细胞与其他细胞之间的相互影响

International journal of dermatology and venereology Pub Date : 2024-03-25 DOI: 10.1097/jd9.0000000000000382

Qiujing Zhang, Yibo Feng, Xiang Chen, Xiaohui Mo, Qiong Wu, Qiang Ju

引用次数: 0

Serum 25-Hydroxyvitamin D Level Might Be a Useful Indicator of Disease Severity in Obese Children With Atopic Dermatitis: A Case-Control Study 血清 25-羟维生素 D 水平可能是特应性皮炎肥胖儿童疾病严重程度的有效指标：病例对照研究

International journal of dermatology and venereology Pub Date : 2024-03-01 DOI: 10.1097/jd9.0000000000000366

Jing-Jing Chen, Xiao-Kai Fang, Xiu-Mei Liu, Xiao-Chun Liu, Xu Yao

{"title":"Serum 25-Hydroxyvitamin D Level Might Be a Useful Indicator of Disease Severity in Obese Children With Atopic Dermatitis: A Case-Control Study","authors":"Jing-Jing Chen, Xiao-Kai Fang, Xiu-Mei Liu, Xiao-Chun Liu, Xu Yao","doi":"10.1097/jd9.0000000000000366","DOIUrl":"https://doi.org/10.1097/jd9.0000000000000366","url":null,"abstract":"\u0000 \u0000 To assess the relationship between the severity of atopic dermatitis (AD) in children of varying weight categories and their serum 25-hydroxyvitamin D [25(OH)D] levels.\u0000 \u0000 \u0000 \u0000 The study population comprised 899 patients with AD and 854 age- and sex-matched controls. The Mann-Whitney U test and Kruskal-Wallis H tests were used to assess differences between groups, and Spearman correlation analysis was used to test correlation.\u0000 \u0000 \u0000 \u0000 The 25(OH)D level in the AD group was M (Q\u0000 25, Q\u0000 75), 24.0 (19.7, 28.4) ng/mL, which was significantly lower than the control group (26.4 [23.6, 29.9] ng/mL; Z = −3.34, P = 0.001). 25(OH)D levels in children with AD were negatively correlated with body mass index (r = −0.30, P < 0.001), Severity scoring of Atopic Dermatitis (SCORAD; r = −0.14, P < 0.001), total immunoglobulin E (r = −0.13, P < 0.001), and eosinophil (r = −0.08, P = 0.017). There were statistically significant differences in 25(OH)D (H = 18.46, P < 0.001), total immunoglobulin E (H = 9.13, P = 0.010), eosinophil (H = 67.17, P < 0.001), and SCORAD (H = 10.49, P = 0.005) among groups with different body mass index classification. The 25(OH)D levels were 22.3 (17.5, 27.1) ng/mL in the overweight AD group and 22.3 (17.6, 25.7) ng/mL in the obese AD group, which were significantly lower than those in the normal-weight AD group (24.7 [20.4, 25.5] ng/mL; P = 0.003, P = 0.004). 25(OH)D levels were negatively correlated with SCORAD in obese AD patients (r = −0.25, P = 0.010).\u0000 \u0000 \u0000 \u0000 Vitamin D insufficient or deficient is obvious in children AD patients. The 25(OH)D levels in the overweight/obese AD group are significantly lower than those in the normal-weight AD group. Vitamin D level is negatively correlated with SCORAD in obese children with AD.\u0000","PeriodicalId":73440,"journal":{"name":"International journal of dermatology and venereology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140399774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eccrine Spiradenoma of the Forehead: A Case Report 额部棘细胞瘤：病例报告

International journal of dermatology and venereology Pub Date : 2024-02-06 DOI: 10.1097/jd9.0000000000000375

引用次数: 0

A novel small deletion in the ATP2A2 gene in a patient with sporadic Darier’s disease and concomitant depression: a case report 一名散发性达里尔病患者的 ATP2A2 基因小缺失并伴有抑郁症：病例报告

International journal of dermatology and venereology Pub Date : 2024-02-06 DOI: 10.1097/jd9.0000000000000371

引用次数: 0