International journal of clinical endocrinology and metabolism最新文献

Relationship of insulin resistance with microvascular and macrovascular complications, death rate and other factors in patients with type 2 diabetes: A case-control study 胰岛素抵抗与 2 型糖尿病患者微血管和大血管并发症、死亡率及其他因素的关系：病例对照研究

International journal of clinical endocrinology and metabolism Pub Date : 2024-07-04 DOI: 10.17352/ijcem.000060

Čypaitė Gabrielė, Šimonienė Diana, Rudminaitė Emilė

{"title":"Relationship of insulin resistance with microvascular and macrovascular complications, death rate and other factors in patients with type 2 diabetes: A case-control study","authors":"Čypaitė Gabrielė, Šimonienė Diana, Rudminaitė Emilė","doi":"10.17352/ijcem.000060","DOIUrl":"https://doi.org/10.17352/ijcem.000060","url":null,"abstract":"Abstract: There is a lack of studies analyzing Severe Insulin Resistance (SIR) forms, especially from clinical aspects. The main objective of this research was to assess the relationship between micro- and macrovascular complications and the death rate of patients with SIR. Methods: It was a partially prospective case-control study of 120 participants with T2DM. Patients with doses of insulin >1 IU/kg/day were considered to have SIR (case group), with an insulin requirement of <1 IU/kg/day - control group. Statistical analyses were performed. Results: Regarding microvascular complications, an association was found between insulin doses and the rate of Diabetic Nephropathy (DN) in the case group compared with the control group (138 vs. 170 IU/day), p = 0.002. Men with T2DM and SIR were more likely to present with myocardial infarction than women (39.3% vs. 13.3%); p = 0.036. Subjects of the case group with lower eGDR (2.44 vs. 1.35) (or higher insulin resistance) were more likely to suffer a stroke, p = 0.003. Case group males were more likely than females to undergo coronary artery bypass graft surgery (21.4% vs. 3.3%); p = 0.048. Higher mortality was observed in the case group of patients with lower eGDR (1.01 vs. 1.85); p = 0.031. Conclusion: As for microvascular outcomes, the rate of DP and DR was similar in both control and case groups. Only the rate of DN in the case group was associated with higher insulin doses. Macrovascular complications such as stroke, myocardial infarction, and bypass surgery were related to the male gender and SIR, as well as higher mortality according to eGDR.","PeriodicalId":73435,"journal":{"name":"International journal of clinical endocrinology and metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating polymorphisms in genes encoding TGF-β1, IL-10, and IL-6 and their associations with type 1 diabetes mellitus TGF-β1、IL-10和IL-6编码基因多态性及其与1型糖尿病的关系研究

International journal of clinical endocrinology and metabolism Pub Date : 2023-10-20 DOI: 10.17352/ijcem.000058

Alghamdi Ahmed H, El-Refaei Mohamed F, Shatla Ibrahim M, El-Sherbini Sherif M

{"title":"Investigating polymorphisms in genes encoding TGF-β1, IL-10, and IL-6 and their associations with type 1 diabetes mellitus","authors":"Alghamdi Ahmed H, El-Refaei Mohamed F, Shatla Ibrahim M, El-Sherbini Sherif M","doi":"10.17352/ijcem.000058","DOIUrl":"https://doi.org/10.17352/ijcem.000058","url":null,"abstract":"Many cytokines play a role in the pathogenesis of Type 1 Diabetes (T1D), and gene polymorphisms could possibly contribute to the disease’s genetic predisposition because they can affect cytokine production or function. The purpose of this study was to investigate the role of the gene polymorphisms TGF-β1 (+869T/C), (+915G/C), IL-10 {-1082 G/A), (-819 C/T), and (-592 A/C), and IL-6 (-174 G/C) in hereditary vulnerability to T1D. The Polymerase Chain Reaction with Sequence-Specific Primers (PCR-SSP) was used to analyze the polymorphisms. According to their genotypes, individuals were divided into the low-, high-, or intermediate-producer phenotypes predicted for these cytokines polymorphisms. Our findings revealed that the production of TGF-β1 was significantly higher in control than in T1D participants whereas the IL-6 genotype with low IL-6 production was significantly increased in the cases compared to the control. A significant association was evident between TGF-β1 and IL-6 low production and the incidence of T1D, thereby confirming the importance of TGF-β1 and IL-6 polymorphism as a genetic factor contributing to the incidence of T1D. By contrast, the involvement of IL-10 in the incidence of T1D was not as clear. Although some evidence supports a relationship, no statistically significant association has been verified between IL-10 and T1D. This type of measurement could be beneficial in determining the susceptibility and severity of the T1D condition while also taking into consideration the prediction of T1D incidence.","PeriodicalId":73435,"journal":{"name":"International journal of clinical endocrinology and metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135666286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omega-3/omega-6 fatty acids: The effects on the psychophysical well-being of adolescents and adults Omega-3/omega-6脂肪酸:对青少年和成人身心健康的影响

International journal of clinical endocrinology and metabolism Pub Date : 2023-01-19 DOI: 10.17352/ijcem.000057

Perrotta Giulio

{"title":"Omega-3/omega-6 fatty acids: The effects on the psychophysical well-being of adolescents and adults","authors":"Perrotta Giulio","doi":"10.17352/ijcem.000057","DOIUrl":"https://doi.org/10.17352/ijcem.000057","url":null,"abstract":"Background: Fatty acids of the omega-3/omega-6 groups are used especially in cases of pregnancy, lactation, and malnutrition. In recent decades, pediatrics has been trying to find out whether the use of omega-3/omega-6 has effects on human growth and neurodevelopment. Aims: Check the state of the art on the use of omega-3/omega-6 type fatty acids in the diet, in adolescent and adult populations. Materials and methods: A total of 72 original articles on the topic of human growth and nutrition in pediatrics have been selected on PubMed through September 2022. Results: In literature, the use of omega-3/omega-6, with greater prevalence in the former group than the latter group, appears to be most effective in hypertension hypothesis, dyslipidemia, and high C-reactive protein values, cardiovascular risk, and neuropathic pain, while appearing to have less impact on neurodegenerative (except in multiple sclerosis) and mental disorders (except in depression). Interesting benefits can be detected when combining omega-3/omega-6 with spirulina algae, chitosan, probiotics, vitamin D, fiber and plant extracts. Conclusion: Significant evidence emerges on the importance of omega-3 and omega-6 fatty acid supplementation, but important structural shortcomings of research designs still emerge from the published studies; moreover, many studies assume that fatty acid supplementation can have a curative effect on already active diseases, when in fact such prescriptions should be considered as adjuvant therapies to prevent or promote symptomatic regression, precisely because of their anti-inflammatory, antioxidant and immunomodulating virtues. However, there is no concrete and robust evidence of the positive impact on psychological well-being. Future research that can resolve the critical issues highlighted is hoped to promote a better approach to the topic of omega-3/omega-6 supplementation in human health.","PeriodicalId":73435,"journal":{"name":"International journal of clinical endocrinology and metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89665408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 diseases, understanding and treatments COVID-19疾病、认识和治疗

International journal of clinical endocrinology and metabolism Pub Date : 2023-01-18 DOI: 10.17352/ijcem.000056

Choi Youngah, Jin Hyun-Ju, Song Eun-Hyang, Kim Bu-Yeon, Park Shin-Ae

{"title":"COVID-19 diseases, understanding and treatments","authors":"Choi Youngah, Jin Hyun-Ju, Song Eun-Hyang, Kim Bu-Yeon, Park Shin-Ae","doi":"10.17352/ijcem.000056","DOIUrl":"https://doi.org/10.17352/ijcem.000056","url":null,"abstract":"Seobuk Hospital is a hospital directly operated by the Seoul Metropolitan Government and has mainly served as a tuberculosis hospital. It is a Seoul city governmental public hospital which primarily provides inpatients and out patients treatment to the elderly, many of them suffering from dementia patients and the marginalized, such as the homeless and the disabled. From March 2nd, 2020, to May 31th, 2022 Seobuk hospital was appointed to treat COVID-19 patients that required stationary treatment. South Korea’s COVID-19 mortality rate has below 0.1% while in other countries such as the United States and in Europe the mortality rate varies between 1 and 2 %. We believe that it is due to the quarantine system which was put in place right from the start of the COVID-19 pandemic in Febuary 2020. Patients testing positive for COVID-19 were hospitalized free of charge and they were hospitalized usually in early period (2 - 3 days after COVID -19 testing) of COVID-19 disease. In this paper we analyzed the disease patterns of patients hospitalized with COVID-19 using the data from the 4,531 patients charts which received treatment in Seobuk hospital between March 2nd, 2020 and May 31st, 2022 by looking at their clinical features and medication history and medications for treatment. The key element of the guideline of our treatment was to administer Veklury (Remdesivir) or Paxlovid despite its high cost in the early period of the COVID-19 disease when oxygen saturation dropped below 94%. Nowadays we administer Veklury and Paxlovid right after COVID-19 is daignosed free of charge for the proper patient. It is believed that the current quarantine system in South Korea which allows patients to be treated with Veklury (Remdesivir) in hospitals at the initial stage of the infection and with an early Paxlovid administration in home treatment has contributed to lowering the death rate in South Korea.","PeriodicalId":73435,"journal":{"name":"International journal of clinical endocrinology and metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79968253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Teriparatide in a patient with severe osteoporosis, hypoparathyroidism and thalassemia major 特立帕肽治疗严重骨质疏松、甲状旁腺功能减退和地中海贫血1例

International journal of clinical endocrinology and metabolism Pub Date : 2022-12-22 DOI: 10.17352/ijcem.000055

A. Graziani, M. Cannito, M. Putti, V. Camozzi

{"title":"Teriparatide in a patient with severe osteoporosis, hypoparathyroidism and thalassemia major","authors":"A. Graziani, M. Cannito, M. Putti, V. Camozzi","doi":"10.17352/ijcem.000055","DOIUrl":"https://doi.org/10.17352/ijcem.000055","url":null,"abstract":"β-Thalassemia Major (TM) is a form of beta-thalassemias. TM complications include, among others, osteoporosis, whose frequency, among TM patients, varies from 13.6% to 50%. The overall etiological mechanisms of TM-related osteoporosis remain unclarified. The primary approach to osteoporosis in patients with TM is the management of TM and its complications and the use of antiresorptive agents, such as Bisphosphonates (BPs), as the first line-drug of treatment. In this article, we present the case of 45 years old-woman with TM and severe osteoporosis, with multiple fractures, albeit the assumption of BPs for many years. The anti-fracture efficacy and safety of BPs are not well-established in TM patients. Data suggest that etidronate and zoledronic acid should be considered as first-line agents in the management of TM- associated osteoporosis. Regarding Teriparatide (TP), there are only a few case reports published about its use in TM patients. It is also noticed that, at the dismission of TP therapy, its benefits are rapidly lost. Finally, regarding romosozumab, our patient presents a significant cardiovascular risk due to the presence of insulin-treated Diabetes Mellitus (DM) and TM-related cardiomyopathy, suggesting we avoid this drug. This case report shows that the therapy of osteoporosis in patients with TM remains an open problem. TM patients often present multiple comorbidities which create limitations to osteoporosis’s treatment. Moreover, these comoboridites are often unavoidable risk factors for osteoporosis.","PeriodicalId":73435,"journal":{"name":"International journal of clinical endocrinology and metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90299053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes and bacterial infection 糖尿病和细菌感染

International journal of clinical endocrinology and metabolism Pub Date : 2022-09-24 DOI: 10.17352/ijcem.000054

Kang Tae-Bong, Hisham Yasmin, Lee Youngmin, Jhun Hyunjhung, Kim, Joohee, Kim Soohyun

{"title":"Diabetes and bacterial infection","authors":"Kang Tae-Bong, Hisham Yasmin, Lee Youngmin, Jhun Hyunjhung, Kim, Joohee, Kim Soohyun","doi":"10.17352/ijcem.000054","DOIUrl":"https://doi.org/10.17352/ijcem.000054","url":null,"abstract":"People with diabetes are at increased risk of infection and are worried about biological agents such as bacteria. Particularly, foot infections, urinary tract infections, pneumonia, and skin diseases are due to bacterial infections that make diabetic patients suffer from clinical difficulties. Although antibiotics, one of the bacterial therapies, have been used, the emergence of multidrug-resistant bacteria is now in demand for alternative therapies. Although, many studies reported that antibiotic-resistant for bacterial infections and their rate have increased significantly in the diabetic patient population. Still, there is no report that directly compares the prevalence of antibiotic-resistant infections in diabetes types. In this review, we described the diverse types of diabetes with their bacterial infection and the reported resistance. Generally, diabetic patients are susceptible to vancomycin-resistant enterococcal infections, extended-spectrum β-lactamase-producing intestinal bacteria, carbapenem-resistant intestinal bacteria, and unfermented gram-negative bacilli. Thus, early detection of diabetes and prompt treatment are important to control chronic infections in diabetic patients.","PeriodicalId":73435,"journal":{"name":"International journal of clinical endocrinology and metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90682265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Primary hyperparathyroidism 原发性甲状旁腺功能亢进

International journal of clinical endocrinology and metabolism Pub Date : 2020-06-06 DOI: 10.17352/ijcem.000045

Cetin Zeynep

引用次数: 0

Association between LHβR gene variant and infertility LHβR基因变异与不孕症的关系

International journal of clinical endocrinology and metabolism Pub Date : 2020-01-13 DOI: 10.17352/ijcem.000042

E. Yılmaz, A. Özdemir, M. Önal, D. Güven, S. Tural, İ. Koçak

引用次数: 1

Metformin use and the Risk of Gastrointestinal Malignancies in Diabetic Populations: A Meta-Analysis. 糖尿病人群使用二甲双胍和胃肠道恶性肿瘤的风险:一项荟萃分析。

International journal of clinical endocrinology and metabolism Pub Date : 2020-01-01 DOI: 10.17352/ijcem.000052

Gil Hevroni, Samara Skwiersky, Angelina Zhyvotovska, Samy I McFarlane

{"title":"Metformin use and the Risk of Gastrointestinal Malignancies in Diabetic Populations: A Meta-Analysis.","authors":"Gil Hevroni, Samara Skwiersky, Angelina Zhyvotovska, Samy I McFarlane","doi":"10.17352/ijcem.000052","DOIUrl":"https://doi.org/10.17352/ijcem.000052","url":null,"abstract":"Background: Metformin use has been associated with a decreased risk of cancer and improvement in overall cancer survival rates. However, scant data available regarding metformin's role in the risk of Gastrointestinal (GI) malignancies in patients with type II diabetes. Our study aimed to conduct a meta-analysis to evaluate the association of metformin use and GI cancer risk.Methods: We conducted electronic search by two independent investigators using the PubMed and Cochrane library databases. Studies were assessed for design and quality, and a meta-analysis was conducted to quantify the effect of metformin on the odds of developing specific GI malignancies. The final papers that met our prespecified inclusion criteria included 4 case-control studies that address metformin's effect on pancreatic cancer, and 4 case-control studies that address metformin's effect on colorectal cancer in patients with type II DM.Results: Of 2258 articles screened, 8 eligible studies were identified comprising 483,561 participants diagnosed with DM. Our analysis showed that metformin use was not associated with a significant effect on the odds of developing pancreatic cancer (OR .98; 95% CI 0.82-1.17, P=0. 83). Metformin use was associated with significantly lower odds of having Colorectal Cancer (CRC); (OR 0.84; 95% CI 0.81-0.87, p < 0.01). Sufficient data were not available to conduct analyses on the impact of metformin dose and duration.Conclusion: Our findings suggest that metformin could be a useful neoadjuvant agent for CRC cancer and as a possible preventive therapy for other inflammatory conditions related to colorectal pathologies such as adenomatous polyps and inflammatory bowel disease. Further research is warranted to elucidate the role of metformin on the risk of developing pancreatic cancer, given the complex nature of the organ's regulation on insulin production.","PeriodicalId":73435,"journal":{"name":"International journal of clinical endocrinology and metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9109488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Apparent mineralocorticoid excess: A case of hypertension in a child with delayed diagnosis leading to stroke 明显的矿化皮质激素过量:一例儿童高血压延迟诊断导致中风

International journal of clinical endocrinology and metabolism Pub Date : 2019-11-12 DOI: 10.17352/ijcem.000041

I. Kochar, Rakhi Jain, Smita Ramachandran

引用次数: 1