International journal of chronic diseases & therapy最新文献

Occupational Contact Dermatitis in the Food Industry 食品工业中的职业性接触性皮炎

International journal of chronic diseases & therapy Pub Date : 2021-11-23 DOI: 10.19070/2572-7613-2100024

F. Rahimpour

引用次数: 0

Vulnerability Among Multi-Racial Families 多种族家庭的脆弱性

International journal of chronic diseases & therapy Pub Date : 2019-11-07 DOI: 10.19070/2572-7613-1900017

E. Aurelus

引用次数: 0

Influence of Mental Health on Preventive Behavior towards Premature - Sexual Intercourse among Junior High School Students in Thailand 心理健康对泰国初中生过早性行为预防的影响

International journal of chronic diseases & therapy Pub Date : 2019-03-25 DOI: 10.19070/2572-7613-1900016

Pramote Wongsawat

{"title":"Influence of Mental Health on Preventive Behavior towards Premature - Sexual Intercourse among Junior High School Students in Thailand","authors":"Pramote Wongsawat","doi":"10.19070/2572-7613-1900016","DOIUrl":"https://doi.org/10.19070/2572-7613-1900016","url":null,"abstract":"This study aimed to identify influence of mental health on preventive behavior towards premature-sexual intercourse among junior high school students in Thailand. A cross-sectional survey, consisting of a questionnaire was self-administered to 260 junior high school students randomly selected by stratified sampling technique. Stepwise multiple regression analysis was performed to determine the factors included mental health affecting preventive behavior towards sexual intercourse among junior high school students. Seven factors were statistically significant with preventive behavior towards sexual intercourse among junior high school students and were found to make a unique contribution to this prediction. Correlation for regression was significantly different with R2 at 0.422. The adjusted R2 value of 0.407 indicated that 40.7% of the variability in mental health affected on preventive behavior towards sexual intercourse among junior high school students. The seven factors were normal level of mental health (Beta = 0.482), sex values (Beta = 0.431), knowledge of sex education (Beta = 0.247) which associated positively towards preventive behavior in premature-sexual intercourse, junior high school students, who had alcohol drinking, had less preventive behavior towards premature-sexual intercourse than those who had not (Beta = -0.159), junior high school students, who had money saving, had less preventive behavior towards premature-sexual intercourse than those who had not (Beta = -0.153), being taught about sex education by parents affected negatively to preventive behavior towards premature-sexual intercourse among the students (Beta = .142), and the students, who had boy or girl friend, had less preventive behavior towards premature-sexual intercourse than those who had not (Beta = -0.112). With respect to recommendations, junior high school students should be promoted mental health in order to increase preventive behavior towards premature-sexual intercourse.","PeriodicalId":73432,"journal":{"name":"International journal of chronic diseases & therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74179189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Chronic Diseases on the Quality of Life among Elderly Survivors from Earthquake in- Northern Thailand 慢性疾病对泰国北部地震中老年幸存者生活质量的影响

International journal of chronic diseases & therapy Pub Date : 2018-09-30 DOI: 10.19070/2572-7613-1800015

Sudnongbua S

{"title":"The Impact of Chronic Diseases on the Quality of Life among Elderly Survivors from Earthquake in- Northern Thailand","authors":"Sudnongbua S","doi":"10.19070/2572-7613-1800015","DOIUrl":"https://doi.org/10.19070/2572-7613-1800015","url":null,"abstract":"Recently, all nations in the world are faced with the growth of number and proportion of aged people [1]. United Nations Population Fund reported that elderly population built up 12.3% of the world population, and that that number will rise to approximately 22% per cent by 2050 [2]. According to the increase of aged population, health status score among elders in each country in the world has declined with age, as expected. Elderly women have lived longer than elderly men on average, but have had poorer health status. In addition, the number of disabled people in most developing countries seems to rise as the number of elder people continues to grow [3]. With regard to climate change, most countries in the world are concerned with disaster. In 2015, World Conference on Disaster Reduction with convening support from the UN International Strategy for Disaster Reduction (UNISDR) was held in order to focus on world awareness and commitment to address the landscape alteration of natural disasters [4]. According to the disaster preparedness from the UN, government sectors and networks of individuals are strategized on how to improve the preparation for disasters. However, in Thailand the disaster preparedness had not been strategized, until the earthquake occurred in Northern Thailand in 2014 [5]. On 5th May 2014, the 6.3 magnitude quake battered the Northern part of Thailand, Abstract","PeriodicalId":73432,"journal":{"name":"International journal of chronic diseases & therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86727748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BRCA1 Mutation Leads to Deregulated Ubc9 Levels which Triggers Proliferation and Migration of Patient-Derived High Grade Serous Ovarian Cancer and Triple Negative Breast Cancer Cells BRCA1突变导致Ubc9水平失调，引发患者源性高级别浆液性卵巢癌和三阴性乳腺癌细胞的增殖和迁移

International journal of chronic diseases & therapy Pub Date : 2016-06-23 DOI: 10.19070/2572-7613-160006

Jingyao Xu, A. Footman, Yunlong Qin, K. Aysola, S. Black, V. Reddy, Karan P. Singh, William E. Grizzle, S. You, D. Moellering, E. Reddy, Y. Fu, Veena Rao

{"title":"BRCA1 Mutation Leads to Deregulated Ubc9 Levels which Triggers Proliferation and Migration of Patient-Derived High Grade Serous Ovarian Cancer and Triple Negative Breast Cancer Cells","authors":"Jingyao Xu, A. Footman, Yunlong Qin, K. Aysola, S. Black, V. Reddy, Karan P. Singh, William E. Grizzle, S. You, D. Moellering, E. Reddy, Y. Fu, Veena Rao","doi":"10.19070/2572-7613-160006","DOIUrl":"https://doi.org/10.19070/2572-7613-160006","url":null,"abstract":"Women who carry a germline mutation in BRCA1 gene typically develop triple negative breast cancers (TNBC) and high grade serous ovarian cancers (HGSOC). Previously, we reported that wild type BRCA1 proteins, unlike the disease-associated mutant BRCA1 proteins to bind the sole sumo E2-conjugating enzyme Ubc9. In this study, we have used clinically relevant cell lines with known BRCA1 mutations and report the in-vivo association of BRCA1 and Ubc9 in normal mammary epithelial cells but not in BRCA1 mutant HGSOC and TNBC cells by immunofluorescence analysis. BRCA1-mutant HGSOC/TNBC cells and ovarian tumor tissues showed increased expression of Ubc9 compared to BRCA1 reconstituted HGSOC, normal mammary epithelial cells and matched normal ovarian tissues. Knockdown of Ubc9 expression resulted in decreased proliferation and migration of BRCA1 mutant TNBC and HGSOC cells. This is the first study demonstrating the functional link between BRCA1 mutation, high Ubc9 expression and increased migration of HGSOC and TNBC cells. High Ubc9 expression due to BRCA1 mutation may trigger an early growth and transformation advantage to normal breast and ovarian epithelial cells resulting in aggressive cancers. Future work will focus on studying whether Ubc9 expression could show a positive correlation with BRCA1 linked HGSOC and basal like TNBC phenotype.","PeriodicalId":73432,"journal":{"name":"International journal of chronic diseases & therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77580271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Home-Telemonitoring Lung Cancer Intervention in Appalachia: A Pilot Study 阿巴拉契亚地区家庭远程监测肺癌干预:一项试点研究

International journal of chronic diseases & therapy Pub Date : 2016-05-25 DOI: 10.19070/2572-7613-160005

Yj Chen, G. Narsavage, K. Frick, T. Petitte

{"title":"Home-Telemonitoring Lung Cancer Intervention in Appalachia: A Pilot Study","authors":"Yj Chen, G. Narsavage, K. Frick, T. Petitte","doi":"10.19070/2572-7613-160005","DOIUrl":"https://doi.org/10.19070/2572-7613-160005","url":null,"abstract":"Benefits of home-telemonitoring for rural dwelling cancer patients are largely unknown. This study examined the effectiveness of home-telemonitoring surveillance with nurse coaching for self-management to improve lung cancer outcomes in mountainous Appalachia where health care access/ service is limited. This randomized clinical trial pilot study compared patient outcomes for telemonitoring versus routine care. A convenience sample (N = 47) was enrolled/ randomized (Telemonitored: 26/ Control: 21) from a university hospital and cancer center. Physiologic parameters and symptoms were collected in the telemonitored group for two weeks; all participants were studied for 60 days after the index treatment/ discharge. The telemonitored group showed greater improvement for both functional status (Wald X2 = 3.78, p = .05) and quality of life (QOL) (Wald X2 = 7.25, p = .007) from baseline to 60 days post-discharge. Compared to controls, telemonitored patients survived longer; had more scheduled medical visits (96% vs. 75%); made more unplanned calls to doctors/ nurses (32% vs. 30% & 64% vs. 50%); had fewer rehospitalizations (28% vs. 40%); and had more ER utilization (36% vs. 30%). The telemonitored group had relative improvements for health utility (.09 on a scale where 0 = death/ 1= perfect health) and QOL (15 on 0–100 VAS). Differences in health care utilization and cost were not significantly different (p > .05), likely due to the sample size. Telemonitoring group satisfaction with care was high and recommended by patients and caregivers. Results suggest that it is possible to improve patient outcomes with home-telemonitoring for self-management in rural areas. Short-term, telemonitoring-based coaching is feasible and offers a promising option to develop patient self-management knowledge and skills.","PeriodicalId":73432,"journal":{"name":"International journal of chronic diseases & therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80393744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

BRCA1 Mutation Leads to Deregulated Ubc9 Levels which Triggers Proliferation and Migration of Patient-Derived High Grade Serous Ovarian Cancer and Triple Negative Breast Cancer Cells. BRCA1突变导致Ubc9水平失调，引发患者源性高级别浆液性卵巢癌和三阴性乳腺癌细胞的增殖和迁移。

International journal of chronic diseases & therapy Pub Date : 2016-01-01

J Xu, A Footman, Y Qin, K Aysola, S Black, V Reddy, K Singh, W Grizzle, S You, D Moellering, E S Reddy, Y Fu, V N Rao

{"title":"BRCA1 Mutation Leads to Deregulated Ubc9 Levels which Triggers Proliferation and Migration of Patient-Derived High Grade Serous Ovarian Cancer and Triple Negative Breast Cancer Cells.","authors":"J Xu, A Footman, Y Qin, K Aysola, S Black, V Reddy, K Singh, W Grizzle, S You, D Moellering, E S Reddy, Y Fu, V N Rao","doi":"","DOIUrl":"","url":null,"abstract":"Women who carry a germline mutation in BRCA1 gene typically develop triple negative breast cancers (TNBC) and high grade serous ovarian cancers (HGSOC). Previously, we reported that wild type BRCA1 proteins, unlike the disease-associated mutant BRCA1 proteins to bind the sole sumo E2-conjugating enzyme Ubc9. In this study, we have used clinically relevant cell lines with known BRCA1 mutations and report the in-vivo association of BRCA1 and Ubc9 in normal mammary epithelial cells but not in BRCA1 mutant HGSOC and TNBC cells by immunofluorescence analysis. BRCA1-mutant HGSOC/TNBC cells and ovarian tumor tissues showed increased expression of Ubc9 compared to BRCA1 reconstituted HGSOC, normal mammary epithelial cells and matched normal ovarian tissues. Knockdown of Ubc9 expression resulted in decreased proliferation and migration of BRCA1 mutant TNBC and HGSOC cells. This is the first study demonstrating the functional link between BRCA1 mutation, high Ubc9 expression and increased migration of HGSOC and TNBC cells. High Ubc9 expression due to BRCA1 mutation may trigger an early growth and transformation advantage to normal breast and ovarian epithelial cells resulting in aggressive cancers. Future work will focus on studying whether Ubc9 expression could show a positive correlation with BRCA1 linked HGSOC and basal like TNBC phenotype.","PeriodicalId":73432,"journal":{"name":"International journal of chronic diseases & therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9885547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0