International journal of biomedical engineering and clinical science最新文献

Safety Evaluation of Recombinant Bovine Lactoferrin as a Novel Biomaterial 重组牛乳铁蛋白作为新型生物材料的安全性评估

International journal of biomedical engineering and clinical science Pub Date : 2024-03-07 DOI: 10.11648/j.ijbecs.20241001.11

Jiamiao Sun, Sumin Zhang, Yong Wang, Jinchi Wei, Yonghui Teng, Binghua Quan, Xiaoming Pang, Honghong Deng, Chiming Wei

{"title":"Safety Evaluation of Recombinant Bovine Lactoferrin as a Novel Biomaterial","authors":"Jiamiao Sun, Sumin Zhang, Yong Wang, Jinchi Wei, Yonghui Teng, Binghua Quan, Xiaoming Pang, Honghong Deng, Chiming Wei","doi":"10.11648/j.ijbecs.20241001.11","DOIUrl":"https://doi.org/10.11648/j.ijbecs.20241001.11","url":null,"abstract":"This study introduces the physical principles and safety evaluation of recombinant bovine lactoferrin (fusion factor) as an innovative biomaterial. Fusion factor is a recombinant lactoferrin expressed by fusing lactoferrin, which has natural biological defense function, with other peptide segments through sequence optimization. It is named fusion factor. Its molecular weight is about 36kDa, which is much greater than the 1kDa molecular weight limit of macromolecular transdermal absorption, so it is not absorbed when used externally on the epithelial mucosa. The lactoferrin based biological defense functional peptide segment in the fusion factor can neutralize the virus by binding to viral protein nucleic acid through the physical action of charge adsorption, and can also compete with cell receptors to inhibit virus infection in cells. The molar ratio of the transmembrane peptide (Pep-1) fragment to the carrier protein is 1:1, so only the transport protein is anchored to the cell surface, forming a physical isolation protein protective wall against viruses and bacteria, without penetrating the cell or damaging the cell membrane. The fusion factor and its derived vaginal bacteria blocking gel have no significant toxicity, sensitization, anaphylaxis or delayed hypersensitivity in vitro cell experiments, in vivo animal experiments and clinical observation tests, and have no side effects with highly safety.\u0000","PeriodicalId":73426,"journal":{"name":"International journal of biomedical engineering and clinical science","volume":"11 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140261163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of Neonatal Outcomes for Preterm Infants Admitted to the Neonatal Intensive Care Unit at Ndola Teaching Hospital in Ndola District, Zambia 赞比亚恩多拉地区恩多拉教学医院新生儿重症监护室收治的早产儿新生儿结局的决定因素

International journal of biomedical engineering and clinical science Pub Date : 2023-12-06 DOI: 10.11648/j.ijbecs.20230904.12

Nsululu Hyascinth Mbulo, Siwale Mwaba Chileshe, Kwaleyela Namukolo Concepta

引用次数: 0

Predicative Meaning of Radioiodine Pharmacokinetics Indices for Evaluation of Radioablation Efficacy of Thyroid Residuum in Patients with Differentiated Thyroid Cancer 放射性碘药代动力学指标对分化型甲状腺癌患者甲状腺残留放射消融疗效评价的预测意义

International journal of biomedical engineering and clinical science Pub Date : 2023-07-20 DOI: 10.11648/j.ijbecs.20230903.14

D. Dzhuzha

引用次数: 0

The Effectiveness of Three-Dimensional Planning and Augmented Reality Navigation-Assisted Total Hip Arthroplasty: A Systematic Review and Meta-Analysis 三维规划和增强现实导航辅助全髋关节置换术的有效性:系统回顾和荟萃分析

International journal of biomedical engineering and clinical science Pub Date : 2023-07-13 DOI: 10.11648/j.ijbecs.20230903.13

Huiyang Kong, Shuyi Wang, Hua Xing

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Epidemiology and Diagnostic Methods of Foot-and-Mouth Disease: A Review 口蹄疫流行病学与诊断方法综述

International journal of biomedical engineering and clinical science Pub Date : 2023-07-13 DOI: 10.11648/j.ijbecs.20230903.12

Betelihem Yirdaw, Dessie Abera

引用次数: 0

Effect of Educational Intervention on Oxygen Therapy Knowledge and Prescription Practices in an Inpatient Community Hospital: A Quality Improvement Initiative 教育干预对社区住院病人氧疗知识和处方实践的影响:一项质量改进举措

International journal of biomedical engineering and clinical science Pub Date : 2023-07-06 DOI: 10.11648/j.ijbecs.20230903.11

Adebola Oluwabusayo Adetiloye, Farhana Alladin, Abida Naz, K. Ghosh, O. Badero, O. Adewuya, A. Poor

引用次数: 0

Optimum Sterilization Department Design in Low-Medium Healthcare Facilities 中低等医疗机构消毒部门的最佳设计

International journal of biomedical engineering and clinical science Pub Date : 2023-06-21 DOI: 10.11648/j.ijbecs.20230902.12

Khaled Sayed Ahmed, Fayroz Farouk Shereif

引用次数: 0

The Decoction of Cymbopogon citratus (Poaceae) Exerts Anxiolytic and Antioxidant Effects in Mice on Stress Paradigm Tests 在应激模式试验中，香茅汤对小鼠具有抗焦虑和抗氧化作用

International journal of biomedical engineering and clinical science Pub Date : 2023-05-10 DOI: 10.11648/j.ijbecs.20230902.11

Jean Pierre Omam Omam, André Hamadou, Antoine Kavaye Kandeda, J. Koubé, Djibrilla Mana Moussa, Brice Kevin Tchoupe Djoumsie, Mireille Delphine Minkoulou Ze, Roger Sébastien Ndjock, E. Ngo Bum

引用次数: 0

Therapy Against COVID-19: Medicinal Plant Extracts Can Be a Solution 治疗COVID-19:药用植物提取物可能是一种解决方案

International journal of biomedical engineering and clinical science Pub Date : 2023-03-31 DOI: 10.11648/j.ijbecs.20230901.12

Bouopda Tamo Sylvain Parfait, Mundene-Timothee Junior Lawrence

{"title":"Therapy Against COVID-19: Medicinal Plant Extracts Can Be a Solution","authors":"Bouopda Tamo Sylvain Parfait, Mundene-Timothee Junior Lawrence","doi":"10.11648/j.ijbecs.20230901.12","DOIUrl":"https://doi.org/10.11648/j.ijbecs.20230901.12","url":null,"abstract":": Coronavirus disease 2019 (COVID-19) was declared by the World Health Organization (WHO) as a pandemic on March 11, 2020. Despite the development of anti-COVID-19 vaccine, the disease continues to kill thousands of people, mainly due to a lack of sufficient doses for all populations and to the prioritization of populations to be vaccinated. According to epidemiological data from April 06, 2022, the COVID-19 pandemic has already killed more than 6,184,299 people around the world with nearly 494,286,073confirmed cases. To date, no antiviral drug has been officially approved to fight this pandemic. Medical professionals and researchers all over the globe are in pursuit for the discovery therapies against this disease. One of the strategies is the use of medicinal plants. Indeed, plant extracts can inhibit viral growth and their effectiveness has been demonstrated on many viruses encountered in human pathology including SARS-CoV-1, poliovirus, varicella-zoster virus, HIV, human papillomavirus, HSV-1, HSV-2, influenza virus, cytomegalovirus and many others. Besides, it has been shown that plant extracts can regulate immune system and make the body able to prevent the establishment of viral infection or to fight against its deleterious effects. The exploration of plant extracts with anti-viral and immunostimulatory properties could be exploitable in the development of drug against COVID-19. This review promotes medicinal plant extracts as potential anti-COVID-19 drugs.","PeriodicalId":73426,"journal":{"name":"International journal of biomedical engineering and clinical science","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86526249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A NEW ALGORITHM FOR MEASURING PULSE TRANSIT TIME FROM ECG AND PPG SIGNALS 一种测量心电和心电信号脉冲传递时间的新算法

International journal of biomedical engineering and clinical science Pub Date : 2023-01-30 DOI: 10.5121/ijbes.2023.10101

Radjef Lilia, Omari Taha

{"title":"A NEW ALGORITHM FOR MEASURING PULSE TRANSIT TIME FROM ECG AND PPG SIGNALS","authors":"Radjef Lilia, Omari Taha","doi":"10.5121/ijbes.2023.10101","DOIUrl":"https://doi.org/10.5121/ijbes.2023.10101","url":null,"abstract":"Pulse transit Time (PTT) is a physiological parameter that is based on characteristics of the pulse waveform, a direct indicator of Cardiovascular Diseases (CVD). The (PTT) is defined as the time taken for the arterial pulse to travel from the heart to a peripheral site. It is commonly derived from Electrocardiogram (ECG) and Photoplethysmogram (PPG) signal calculations and is calculated as the interval between the peak of the electrocardiogram (ECG) R-wave and a time point on the photoplethysmogram (PPG). In this study, we propose a new and lowcomplexity algorithm for the Pulse transit time (PTT) measurement, using these two signals and detecting (PTT- foot) and (PTT- peak). We built a 37 subjects dataset containing a simultaneous recording of the (ECG) and (PPG). The calculation of (PTT) consists of detecting the peak and foot points of a (PPG) and the R-peak of the (ECG) signal. Intermediate operations such as normalization and thresholding to detect the local maxima and minima, are processed on noisy signals, this algorithm is improved by a windowing temporal analysis. The obtained results are promising for the first step. The average sensitivity (SEN) and accuracy (ACC) obtained were (97.5%, and 96.82%) respectively for R-peaks detection and respectively (97.77%, and 97.64%) for (PPG-peak) detection. The sensitivity (SEN) and accuracy (ACC) of (PPG- foot) detection were (98.33%, and 94.14%).","PeriodicalId":73426,"journal":{"name":"International journal of biomedical engineering and clinical science","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135599731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0