International archives of medicine最新文献

{"title":"Dohi's Reticulated Acropigmentation: a Case Report","authors":"Adriana Kamilly Leitão Pitman Machado, Danielle Oliveira de Sousa, Miguel Saraty de Oliveira, Débora Bacellar Cruz Nunes, Michelle Fonseca Goiabeira, B. P. Casagrande, W. Loureiro, Samira Oliveira Silveira, C. Mainardi, F. Carneiro","doi":"10.3823/2544","DOIUrl":"https://doi.org/10.3823/2544","url":null,"abstract":"Background: Dohi's Reticulated Acropigmentation is a rare autosomal dominant genodermatosis with high penetrance, characterized by small, irregular, hypo and hyperpigmented macules on the dorsal surface of the distal extremities. \u0000Case: The authors report a case of Dohi’s Reticulated Acropigmentation in a 61 years old female patient. The patient complained of spots on hands, feet and posteriorly face involvement since she was 7 years old. \u0000Conclusion: Dohi's Reticulated Acropigmentation is a rare clinical condition, which usually appear in childhood and commonly interrupt their onset before adolescence. The diagnosis is based on clinical data, physical examination and histopathological findings. The treatment is unsatisfactory and still no therapy is proposed.","PeriodicalId":73409,"journal":{"name":"International archives of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42851332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transverse myelitis associated with Zika virus infection: a Case Report","authors":"B. P. Casagrande, Danielle Oliveira de Sousa, Adriana Kamilly Leitão Pitman Machado, C. Mainardi, Carolina Barros Kahwage","doi":"10.3823/2543","DOIUrl":"https://doi.org/10.3823/2543","url":null,"abstract":"Title: Transverse myelitis associated with Zika virus infection: a Case Report.: The zika virus belongs to the family flaviviridae, and is transmitted by the arthropod Aedes aegypt. Its major importance is related to the several debilitating neurological manifestations associated with it, such as transverse myelitis. \u0000Case: The authors report a case of transverse myelitis in a patient with a previous diagnosis of Zika virus infection. After the image exams and serology, the diagnosis was confirmed and treatment with prednisone was performed with an unsatisfactory clinical outcome. \u0000Conclusion: Brazil is the country of greatest concern worldwide due to the thousands of Zika cases with associated neurological complications, causing sequels and physical disabilities. However, cases worldwide have increased substantially.","PeriodicalId":73409,"journal":{"name":"International archives of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48913413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness in the performance of organ transplants in the State of Paraná, Brazil","authors":"Iriana Oliveira, C. M. D. Souza, M. Galdino, Paloma de Souza Cavalcante Pissinati, L. G. D. Silva, M. Vannuchi, M. Haddad","doi":"10.3823/2542","DOIUrl":"https://doi.org/10.3823/2542","url":null,"abstract":"Objective: To analyze the effectiveness of organ transplants in the state of Parana, Brazil. Methods: A cross-sectional quantitative study was conducted with data from 2,036 solid organ transplants performed in the state between 2011 and 2015. Three indicators were calculated, per capita transplants, meeting the demands of the population and the demand for transplants, which demonstrated the effectiveness and the disparities in the process. The association between the variables was verified by Pearson's Chi-Square test and Fisher's exact test. Results: Most transplants were performed in philanthropic hospitals, male, funded by public funding, and there was an annual increase in the number of transplants per capita and in the productivity of kidney, liver and heart transplantation teams. Although renal transplantation is the most performed in absolute numbers, it served a maximum of 2.2% of its demand. Conclusion: It is necessary to devise strategies to meet the demand for organ transplants, above all, to consolidate the process of donating organs in the state under study.","PeriodicalId":73409,"journal":{"name":"International archives of medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70307625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment For Chronic Eosinophilic Leukemia (CEL) With Imatinib Mesylate","authors":"Rayane da Silva Souza, N. A. C. Tavares, Martina Bragante Fernandes Pimenta, Marcelle Bragante Fernandes Pimenta, Matheus Cartaxo Eloy Fialho, Ary Santos, A. Paz, F. Pimenta","doi":"10.3823/2539","DOIUrl":"https://doi.org/10.3823/2539","url":null,"abstract":"We report a case of a patient with Chronic Eosinophilic Leukemia (CEL) with mutation in alfa PDGFR gene exhibiting a satisfactory response to treatment with imatinib mesylate. A 25-year-old man presented in a hematology service with a persistent cough and hemogram alterations. His blood count showed a hemoglobin level of 12.5 g/dL and a white blood cell count of 94,030/mm3, eosinophils were 68% of all cells. Bone marrow aspiration and biopsy showed hypercellularity with marked eosinophilia (77%) and erythroid differentiation series was hypocellular with normoblast maturation. The immunohistochemically of the bone biopsy was positive for myeloperoxidase and negative for CD34/CD99, consistent with CEL. Fluorescence in situ hybridization (FISH) for the beta-fraction of platelet-derived growth factor (PDGFRβ) and Philadelphia chromosome (Ph 1) were negative and the alfa PDGFR (Platelet-Derived Growth Factor) was positive and showed heterozygosis in c.2531T>C on 18 Exon and homozygous in C.2562+1G>A at the region of the splicing site at the 18 intron. Treatment was initiated and maintained by administering 400mg/day imatinib mesylate. Laboratory findings returned to normal ranges, with clinical improvement and a hematological response observed after the second month of therapy. Currently, the patient’s blood count shows the white blood cell count (5,400 total leukocytes), eosinophils (8.6/mm3), hemoglobin (15.5 g/dl), hematocrit (45.4%) and platelets (298,000/mm3) within normal ranges. The mutation search was negative in in peripheral blood one year after the initial treatment. Our work corroborates other studies on the efficacy of imatinib mesylate in the treatment of patients with CSF PDGFR alpha positive. We emphasize the importance of molecular studies, considering its relevance for the correct staging of the disease. Since CEL is a rare disease, it is important to define its etiology and anticipate its treatment, thus minimizing the damage induced by the disease.","PeriodicalId":73409,"journal":{"name":"International archives of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49627760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Are The Benefits In The Association Of SGLT2 Inhibitors And Other Drugs","authors":"Deici Aparecida Gomes Rodrigues, I. Alves, Isabelly de Oliveira Pinheiro, Élida Camilla Nunes Valões, Erich Pires Lisboa","doi":"10.3823/2540","DOIUrl":"https://doi.org/10.3823/2540","url":null,"abstract":"The SGLT2 inhibitors are a class of drugs that blocks the sodium-glucose co-transport, which is responsible for 90% of the nephron glucose. Objective: To show the benefits of the SGLT2 inhibitors in monotherapy and in association with other drugs. Results: The association of SGLT2 inhibitors and other drugs has shown several additional benefits after their interaction, including weight loss, reduction of body fat, reduction of triglycerides level, decrease of glycated hemoglobin, decrease in postprandial glucose level, reduction of arterial pressure, decrease of hypoglycemia risk and improvement of glucose metabolism. Therefore, this is a promising interaction for type 2 diabetes.","PeriodicalId":73409,"journal":{"name":"International archives of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45048850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are There Scientific Evidences that the Stem Cell Use Is Benefic to Patient with Dilated Cardiomyopathy","authors":"Isabelly de Oliveira Pinheiro, I. Alves, Élida Camilla Nunes Valões, Deici Aparecida Gomes Rodrigues, Ângelo Roncalli Ramalho Sampaio","doi":"10.3823/2541","DOIUrl":"https://doi.org/10.3823/2541","url":null,"abstract":"The dilated cardiomyopathy (DCM) is one of the most important causes of cardiac insufficiency, leading to morbidity and mortality augment, due to therapeutic restriction. Objective: To search scientific evidences about the treatment of dilated cardiomyopathy with stem cells use. Results: The stem cells use in this pathology has shown benefits through human and animals experiments, verified through images and laboratorial exams. Conclusion: Even with positive results, this treatment requires deeper studies that can show consistent vantages of this therapy in humans.","PeriodicalId":73409,"journal":{"name":"International archives of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44160494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Duplication Of Parotid Duct. A Rare Anatomical Variation","authors":"Humberto Ferreira Arquez","doi":"10.3823/2537","DOIUrl":"https://doi.org/10.3823/2537","url":null,"abstract":"Background: The paired parotid glands are the largest of the major salivary glands and produces mainly serous secretions. The secretion of this gland reaches the oral cavity through single parotid duct (Stensen’s duct). The parotid duct begins at the anterior border of the gland, crosses the masseter muscle, and then pierces the buccinator muscle to reach the mucosa lining the mouth at the level of the cheek. The purpose of this study is determine the morphologic features of the parotid duct and describe an anatomical variation until now unreported. \u0000Methods and Findings: A total of 17 cadavers were used for this study in the Morphology Laboratory at the University of Pamplona. In a cadaver were findings: The main parotid duct originated two conducts: Left superior parotid duct and Left inferior parotid duct, is observed the criss-cross of the ducts, and then perforated the buccinator muscle and entered the oral cavity at a double parotid papilla containing a double opening, separated from each other in 0,98 mm. In the remaining  33 parotid regions (97.06%) the parotid duct is conformed to the classical descriptions given in anatomical textbooks. \u0000Conclusions: The parotid duct anatomy is important for duct endoscopy, lithotripsy, sialography and trans-ductal facial nerve stimulation in the early stage of facial palsy in some cases. The anatomical variations also has clinical importance for parotid gland surgery and facial cosmetic surgery. To keep in mind the parotid duct variation will reduce iatrogenic injury risks and improve diagnosis of parotid duct injury.","PeriodicalId":73409,"journal":{"name":"International archives of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46215363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical Variation Of The Submandibular Gland Duct. A Unreported Anomaly","authors":"Humberto Ferreira Arquez","doi":"10.3823/2538","DOIUrl":"https://doi.org/10.3823/2538","url":null,"abstract":"Background: The submandibular gland is the second largest major salivary gland and weighs 7–16 gr. The gland is located in both sides of the face, at the same level of the body of the jaw, in the submandibular triangle, The submandibular duct or Wharton’s duct exits anteriorly, coursing deep to the lingual nerve and medial to the sublingual gland, the main excretory duct of the submandibular gland, whose diameter is of 2 to 3mm and approximately 4–5 cm long. It empties lateral to the lingual frenulum through a papilla in the floor of the mouth behind the lower incisor tooth. The purpose of this study is determine the morphologic features and describe an unusual anatomical variation of the path of the submandibular duct. Methods and Findings: A total of 17 cadavers were used for this study in the Morphology Laboratory at the University of Pamplona. In a cadaver were findings: The excretory duct of the left submandibular gland had an external location that ascends and crosses vertically off the body of the mandible, in its termination it is divided in four ducts that had separate openings into the oral cavity upon a small papillas independent, opposites to the first and second lower molar Crown. Conclusions: Awareness of potential variations of the excretory ducts of the salivary glands can aid in the accurate diagnosis and treatment of patients with salivary conditions as well as help surgeons avoid further complications or duct lacerations during surgical procedures.","PeriodicalId":73409,"journal":{"name":"International archives of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49028970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nervous Communications In The Upper Limb. A Cadaveric Study","authors":"Humberto Ferreira Arquez","doi":"10.3823/2536","DOIUrl":"https://doi.org/10.3823/2536","url":null,"abstract":"Background: Anatomical variations of the terminal branches of the brachial plexus in terms of communication between nerves at the level of upper limb have been reported, these communications were median and musculocutaneous nerve, median and ulnar nerve, radial and ulnar nerve (at level humeral), but communications between the radial and ulnar nerve at level of the forearm are very rare. \u0000Methods and Findings: 34 upper extremities of 15 male and 2 females embalmed adults cadavers in the laboratory of Morphology of the University of Pamplona. The upper limbs were studied serially during the years 2013-2016. Of the 34 upper limbs studied in the Laboratory of Mor­phology of the University of Pamplona, in a 75 year-old male cadaver anatomical variations were found, dissected carefully and morphological details were photographed, these variations consisted of nervous communications between median and musculocutaneous nerve in the arm, median and ulnar nerve in the forearm, radial and ulnar nerve in the forearm. \u0000Conclusions: Knowledge of these communications is of clinical significance. Surgical, therapeutic and diagnostically invasive procedures require extreme caution to prevent lesions of the anastomotic branches.","PeriodicalId":73409,"journal":{"name":"International archives of medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70308009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Behavior Associated to Death from External Causes in Elderly People in Brazil","authors":"Eliana Barreto Fixina, E. Maia, Dario de Queiroz Ribeiro","doi":"10.3823/2535","DOIUrl":"https://doi.org/10.3823/2535","url":null,"abstract":"METHODS: This is an ecological study that aimed to understand the behaviour of deaths from external causes in the population older than 60 years old in all Brazilian states. The data was collected using the Brazilian Mortality Information System and the population data from the Brazilian Institute of Geography and Statistics and from the SUS Informatics Department organized in historic series from 1995 to 2010. \u0000RESULTS AND CONCLUSIONS: It is not possible to deny that deaths from external causes in elder citizens is not in an increasing and statistically significant tendency in most Brazilian states. This brings preoccupation about the issue, since discussions on the subjects are limited in the country, which makes this study good for future references in the field.","PeriodicalId":73409,"journal":{"name":"International archives of medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48628158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}