What Are The Benefits In The Association Of SGLT2 Inhibitors And Other Drugs

Deici Aparecida Gomes Rodrigues, I. Alves, Isabelly de Oliveira Pinheiro, Élida Camilla Nunes Valões, Erich Pires Lisboa
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Abstract

The SGLT2 inhibitors are a class of drugs that blocks the sodium-glucose co-transport, which is responsible for 90% of the nephron glucose. Objective: To show the benefits of the SGLT2 inhibitors in monotherapy and in association with other drugs. Results: The association of SGLT2 inhibitors and other drugs has shown several additional benefits after their interaction, including weight loss, reduction of body fat, reduction of triglycerides level, decrease of glycated hemoglobin, decrease in postprandial glucose level, reduction of arterial pressure, decrease of hypoglycemia risk and improvement of glucose metabolism. Therefore, this is a promising interaction for type 2 diabetes.
SGLT2抑制剂和其他药物联合使用的益处是什么
SGLT2抑制剂是一类阻断钠-葡萄糖共转运的药物,钠-葡萄糖共转运负责90%的肾单位葡萄糖。目的:显示SGLT2抑制剂在单药治疗和与其他药物联合治疗中的益处。结果:SGLT2抑制剂与其他药物相互作用后显示出一些额外的益处,包括体重减轻、体脂减少、甘油三酯水平降低、糖化血红蛋白水平降低、餐后血糖水平降低、动脉压降低、低血糖风险降低和葡萄糖代谢改善。因此,这是一种很有前景的治疗2型糖尿病的相互作用。
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