Intensive care research最新文献

{"title":"O-GlcNAcylation Modification in Immune Cells: Potential Therapeutic Implications of Sepsis","authors":"Zhenzhen Huang, YuanMei Qin","doi":"10.1007/s44231-023-00048-1","DOIUrl":"https://doi.org/10.1007/s44231-023-00048-1","url":null,"abstract":"","PeriodicalId":73403,"journal":{"name":"Intensive care research","volume":"3 1","pages":"204 - 214"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45138896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Procalcitonin Combined with C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Patients After Lung Transplantation","authors":"Chenhao Xuan, Dapeng Wang, Song Wang, Jiayue Zhang, Jiawei Li, Xiaowan Li, Min Liu, Jingyu Chen, Hong-yang Xu","doi":"10.1007/s44231-023-00043-6","DOIUrl":"https://doi.org/10.1007/s44231-023-00043-6","url":null,"abstract":"","PeriodicalId":73403,"journal":{"name":"Intensive care research","volume":"3 1","pages":"221 - 228"},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44405554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian Randomization Study of the Relationship Between Serum Matrix Metalloproteinases and the Occurrence of Sepsis","authors":"Changzhen Yang, Chun Long, Qian Zhang, Dehua He, Hongying Bi, Xu Liu","doi":"10.1007/s44231-023-00047-2","DOIUrl":"https://doi.org/10.1007/s44231-023-00047-2","url":null,"abstract":"","PeriodicalId":73403,"journal":{"name":"Intensive care research","volume":"3 1","pages":"215 - 220"},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48689138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of the Ratio of Hemoglobin to Red Blood Cell Distribution Width in Patients with Out-of-Hospital Cardiac Arrest: A Retrospective Study","authors":"Hong Wang, Yao Luo, Tangjuan Zhang, Qing Lv, Liu Yang, Xinya Jia, Yan Zhou, Renjie Li, Xingqiang Zhu, Ruyi Lei, Chao Lan","doi":"10.1007/s44231-023-00046-3","DOIUrl":"https://doi.org/10.1007/s44231-023-00046-3","url":null,"abstract":"","PeriodicalId":73403,"journal":{"name":"Intensive care research","volume":"3 1","pages":"229 - 236"},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46481014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedation Weaning in a Patient with a Substance Abuse and Psychiatric History","authors":"Anna V Jones, Alana Shunnarah, Andrew Gwaltney, Marilyn N Bulloch, Grier Stewart","doi":"10.1007/s44231-023-00044-5","DOIUrl":"https://doi.org/10.1007/s44231-023-00044-5","url":null,"abstract":"","PeriodicalId":73403,"journal":{"name":"Intensive care research","volume":"3 1","pages":"237 - 244"},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49233601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the Timing of Amubarvimab/Romlusevimab (BRII-196/198) Administration on Progression to Severe Disease in Elderly Patients with COVID-19 Infection: A Retrospective Cohort Study.","authors":"Yonghao Xu,&nbsp;Ying Liu,&nbsp;Ruiqiang Zheng,&nbsp;Shujie Si,&nbsp;Yin Xi,&nbsp;Xilong Deng,&nbsp;Gang Wang,&nbsp;Liang Zhou,&nbsp;Manshu Li,&nbsp;Ya Wang,&nbsp;Shuo Zhang,&nbsp;Jianfeng Xie,&nbsp;Xiaoqing Liu,&nbsp;Yi Yang,&nbsp;Xiaoping Tang","doi":"10.1007/s44231-023-00040-9","DOIUrl":"10.1007/s44231-023-00040-9","url":null,"abstract":"<p><strong>Objective: </strong>Early intervention with neutralizing antibodies is considered to be effective in preventing disease progression in patients with mild to moderate COVID-19 infection. Elderly patients are the most susceptible and at a higher risk of COVID-19 infection. The present study aimed to assess the necessity and possible clinical benefits of the early administration of Amubarvimab/Romlusevimab (BRII-196/198) in the elderly population.</p><p><strong>Methods: </strong>The present study was designed as a retrospective, multi-center cohort study conducted with 90 COVID-19 patients aged over 60, who were divided into two groups based on the timing of the administration of BRII-196/198 (administration at ≤ 3 days or > 3 days from the onset of infection symptoms).</p><p><strong>Results: </strong>The ≤ 3 days group exhibited a greater positive effect (HR 5.94, 95% CI, 1.42-24.83; <i>P</i> < 0.01), with only 2 patients among 21 patients (9.52%) exhibiting disease progression, compared to the 31 patients among the 69 patients (44.93%) of the > 3 days group who exhibited disease progression. The multivariate Cox regression analysis revealed low flow oxygen support prior to BRII-196/198 administration (HR 3.53, 95% CI 1.42-8.77, <i>P</i> < 0.01) and PLT class (HR 3.68, 95% CI 1.37-9.91, <i>P</i> < 0.01) as independent predictors of disease progression.</p><p><strong>Conclusions: </strong>In elderly patients with mild or moderate COVID-19 disease, who do not require oxygen support and had the risk factors for disease progression to severe COVID-19 disease, the administration of BRII-196/198 within 3 days resulted in a beneficial trend in terms of preventing disease progression.</p>","PeriodicalId":73403,"journal":{"name":"Intensive care research","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10091879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Sivelestat in the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis.","authors":"Qiongli Ding,&nbsp;Yi Wang,&nbsp;Chunbo Yang,&nbsp;Dilireba Tuerxun,&nbsp;Xiangyou Yu","doi":"10.1007/s44231-023-00032-9","DOIUrl":"10.1007/s44231-023-00032-9","url":null,"abstract":"<p><strong>Background: </strong>The efficacy of neutrophil elastase inhibitor sivelestat in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remains controversial. A systematic review and meta-analysis were performed in accordance with the PRISMA guidelines assess the effect of sivelestat on ALI/ARDS patients, different studies were included.</p><p><strong>Methods: </strong>Electronic databases, National Knowledge Infrastructure (CNKI), Wan fang data, VIP, PubMed, Embase, Springer, Ovid and the Cochrane Library were searched using the following key words: (\"Sivelestat\" OR \"Elaspol\") AND (\"ARDS\" OR \"adult respiratory distress syndrome\" OR \"acute lung injury\"). All databases published from January 2000 to August 2022. The treatment group was treated with sivelestat and the control group was given normal saline. The outcome measurements include the mortality of 28-30 days, mechanical ventilation time, ventilation free days, intensive care unit (ICU) stays, oxygenation index (PaO₂/FiO₂) on day 3, the incidence of adverse events. The literature search was conducted independently by 2 researchers using standardized methods. We used the Cochrane risk-of-bias tool to assess the quality of the included studies. Mean difference (MD), Standardized mean difference (SMD) and relative risk (RR) were calculated using random effects model or fixed effects model. All statistical analyses were performed using RevMan software 5.4.</p><p><strong>Results: </strong>A total of 2050 patients were enrolled in 15 studies, including 1069 patients in treatment group and 981 patients in the control group. The results of the meta-analysis showed that: compared with the control group, sivelestat can reduce the mortality of 28-30 days (RR = 0.81, 95% CI = 0.66-0.98, <i>p</i> = 0.03) and the incidence of adverse events (RR = 0.91, 95% CI = 0.85-0.98, <i>p</i> = 0.01), shortened mechanical ventilation time (SMD = - 0.32, 95% CI = - 0.60 to - 0.04, <i>p</i> = 0.02) and ICU stays (SMD = - 0.72, 95% CI = - 0.92 to - 0.52, <i>p</i> < 0.00001), increased the ventilation free days (MD = 3.57, 95% CI = 3.42-3.73, <i>p < </i>0.00001) and improve oxygenation index (PaO₂/FiO₂) on day 3 (SMD = 0.88, 95% CI = 0.39-1.36, <i>p</i> = 0.0004).</p><p><strong>Conclusions: </strong>Sivelestat can not only reduce the mortality of ALI/ARDS patients within 28-30 days and the incidence of adverse events, shorten the mechanical ventilation time and ICU stays, increase ventilation free days, but also improve the oxygenation index of patients on days 3, which has a good effect on the treatment of ALI/ARDS. These findings need to be verified in large-scale trials.</p>","PeriodicalId":73403,"journal":{"name":"Intensive care research","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9769385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Study on the Effect of Blood Purification Therapy with Dual-Cannula in Jugular-Femoral Venous: A Report of 2 Cases","authors":"Yi Ran He, Zhunyong Gu, Yi Mei Liu, Hong-yu He, Bo Shen, M. Ju","doi":"10.1007/s44231-023-00042-7","DOIUrl":"https://doi.org/10.1007/s44231-023-00042-7","url":null,"abstract":"","PeriodicalId":73403,"journal":{"name":"Intensive care research","volume":"3 1","pages":"245 - 249"},"PeriodicalIF":0.0,"publicationDate":"2023-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48442846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent Intensive Care Unit: Current and Future Trends.","authors":"Zhi Mao,&nbsp;Chao Liu,&nbsp;Qinglin Li,&nbsp;Yating Cui,&nbsp;Feihu Zhou","doi":"10.1007/s44231-023-00036-5","DOIUrl":"10.1007/s44231-023-00036-5","url":null,"abstract":"<p><p>There is a growing demand for intensive care units, but there is a relative shortage of medical staff. Intensive care work is heavy and stressful. Optimizing the working conditions and processes of the intensive care unit is of great significance for improving the work efficiency and the level of diagnosis and treatment in the intensive care unit. The intelligent intensive care unit is a new ward management model gradually developed on the basis of modern science and technology such as communication technology, internet of things, artificial intelligence, robots, and big data. Under this model, the potential risks caused by human factors are greatly reduced, and the monitoring and treatment of patients has been significantly improved. This paper reviews the progress in related fields.</p>","PeriodicalId":73403,"journal":{"name":"Intensive care research","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10073698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features of Herpes Simplex Encephalitis and Risk Factors for Post-Encephalitic Epilepsy in Children","authors":"Guangshuai Wei, Jiandong Wang, Yao Wang, Yu Zhang, Guang Chen, Huaili Wang","doi":"10.1007/s44231-023-00041-8","DOIUrl":"https://doi.org/10.1007/s44231-023-00041-8","url":null,"abstract":"","PeriodicalId":73403,"journal":{"name":"Intensive care research","volume":"3 1","pages":"189 - 194"},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43351393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}