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Mechanical scratch injury on differentiated motor neuron of NSC-34 cells as an in vitro model for evaluation of neuroregeneration potential of NeuroAiD II (MLC901) 将 NSC-34 细胞分化运动神经元上的机械划痕损伤作为评估 NeuroAiD II (MLC901) 神经再生潜力的体外模型
In vitro models Pub Date : 2024-04-22 DOI: 10.1007/s44164-024-00070-7
A. Anjum, Muhammad Da'in Yazid, Muhammad Fauzi Daud, Jalilah Idris, Angela Min Hwei Ng, A. S. Naicker, Ohnmar Htwe Ismail, Ramesh Kumar Athi Kumar, Y. Lokanathan
{"title":"Mechanical scratch injury on differentiated motor neuron of NSC-34 cells as an in vitro model for evaluation of neuroregeneration potential of NeuroAiD II (MLC901)","authors":"A. Anjum, Muhammad Da'in Yazid, Muhammad Fauzi Daud, Jalilah Idris, Angela Min Hwei Ng, A. S. Naicker, Ohnmar Htwe Ismail, Ramesh Kumar Athi Kumar, Y. Lokanathan","doi":"10.1007/s44164-024-00070-7","DOIUrl":"https://doi.org/10.1007/s44164-024-00070-7","url":null,"abstract":"","PeriodicalId":73357,"journal":{"name":"In vitro models","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140674250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids 利用三维人体视网膜器官组织模拟早期糖尿病视网膜病变中的神经变性和炎症反应
In vitro models Pub Date : 2024-03-25 DOI: 10.1007/s44164-024-00068-1
Luisa de Lemos, Pedro Antas, Inês S. Ferreira, Inês Paz Santos, Beatriz Felgueiras, Catarina M. Gomes, Catarina Brito, Miguel C. Seabra, Sandra Tenreiro
{"title":"Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids","authors":"Luisa de Lemos, Pedro Antas, Inês S. Ferreira, Inês Paz Santos, Beatriz Felgueiras, Catarina M. Gomes, Catarina Brito, Miguel C. Seabra, Sandra Tenreiro","doi":"10.1007/s44164-024-00068-1","DOIUrl":"https://doi.org/10.1007/s44164-024-00068-1","url":null,"abstract":"","PeriodicalId":73357,"journal":{"name":"In vitro models","volume":" 1234","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140382660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the neuroinflammatory network: insights from diverse cell models 神经炎症网络导航：不同细胞模型的启示
In vitro models Pub Date : 2024-03-12 DOI: 10.1007/s44164-024-00067-2
L. C. S. Castellanos, Mayra Micaela Montes, Georgina Oriana Mingolo Malnati, Carina Weissmann
{"title":"Navigating the neuroinflammatory network: insights from diverse cell models","authors":"L. C. S. Castellanos, Mayra Micaela Montes, Georgina Oriana Mingolo Malnati, Carina Weissmann","doi":"10.1007/s44164-024-00067-2","DOIUrl":"https://doi.org/10.1007/s44164-024-00067-2","url":null,"abstract":"","PeriodicalId":73357,"journal":{"name":"In vitro models","volume":"98 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140250557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological characterization of breast cancer spheroid formed by fast fabrication method 用快速制造法形成的乳腺癌球形体的生物学特征
In vitro models Pub Date : 2024-02-13 DOI: 10.1007/s44164-024-00066-3
Yuta Iijima, Norino Uenaka, Mayu Morimoto, Daiki Sato, Satomi Hirose, N. Sakitani, Masahiro Shinohara, Kenichi Funamoto, Gen Hayase, Daisuke Yoshino
{"title":"Biological characterization of breast cancer spheroid formed by fast fabrication method","authors":"Yuta Iijima, Norino Uenaka, Mayu Morimoto, Daiki Sato, Satomi Hirose, N. Sakitani, Masahiro Shinohara, Kenichi Funamoto, Gen Hayase, Daisuke Yoshino","doi":"10.1007/s44164-024-00066-3","DOIUrl":"https://doi.org/10.1007/s44164-024-00066-3","url":null,"abstract":"","PeriodicalId":73357,"journal":{"name":"In vitro models","volume":"150 ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139839833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological characterization of breast cancer spheroid formed by fast fabrication method 用快速制造法形成的乳腺癌球形体的生物学特征
In vitro models Pub Date : 2024-02-13 DOI: 10.1007/s44164-024-00066-3
Yuta Iijima, Norino Uenaka, Mayu Morimoto, Daiki Sato, Satomi Hirose, N. Sakitani, Masahiro Shinohara, Kenichi Funamoto, Gen Hayase, Daisuke Yoshino
{"title":"Biological characterization of breast cancer spheroid formed by fast fabrication method","authors":"Yuta Iijima, Norino Uenaka, Mayu Morimoto, Daiki Sato, Satomi Hirose, N. Sakitani, Masahiro Shinohara, Kenichi Funamoto, Gen Hayase, Daisuke Yoshino","doi":"10.1007/s44164-024-00066-3","DOIUrl":"https://doi.org/10.1007/s44164-024-00066-3","url":null,"abstract":"","PeriodicalId":73357,"journal":{"name":"In vitro models","volume":"7 11","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139779863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of mechanical engineering innovations in biomedical advancements 机械工程创新对生物医学进步的影响
In vitro models Pub Date : 2024-01-25 DOI: 10.1007/s44164-024-00065-4
Senthil Maharaj Kennedy, A. Vasanthanathan, R.B. Jeen Robert, A. Vignesh Moorthi Pandian
{"title":"Impact of mechanical engineering innovations in biomedical advancements","authors":"Senthil Maharaj Kennedy, A. Vasanthanathan, R.B. Jeen Robert, A. Vignesh Moorthi Pandian","doi":"10.1007/s44164-024-00065-4","DOIUrl":"https://doi.org/10.1007/s44164-024-00065-4","url":null,"abstract":"","PeriodicalId":73357,"journal":{"name":"In vitro models","volume":"25 23","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139597199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microfluidic model of the alternative vasculature in neuroblastoma 神经母细胞瘤替代血管的微流控模型
In vitro models Pub Date : 2024-01-15 DOI: 10.1007/s44164-023-00064-x
Aranzazu Villasante, M. J. Lopez-Martinez, Gema Quiñonero, Andrea García-Lizarribar, Xiaofeng Peng, Josep Samitier
{"title":"Microfluidic model of the alternative vasculature in neuroblastoma","authors":"Aranzazu Villasante, M. J. Lopez-Martinez, Gema Quiñonero, Andrea García-Lizarribar, Xiaofeng Peng, Josep Samitier","doi":"10.1007/s44164-023-00064-x","DOIUrl":"https://doi.org/10.1007/s44164-023-00064-x","url":null,"abstract":"","PeriodicalId":73357,"journal":{"name":"In vitro models","volume":"8 3","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139529716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and prediction of molecular factors associated with ischemic stroke: an integrative analysis of DEGs, TFs, and PPI networks 缺血性中风相关分子因素的识别与预测：DEGs、TFs 和 PPI 网络的综合分析
In vitro models Pub Date : 2023-12-01 DOI: 10.1007/s44164-023-00063-y
Mehran Radak, Hossein Fallahi
{"title":"Identification and prediction of molecular factors associated with ischemic stroke: an integrative analysis of DEGs, TFs, and PPI networks","authors":"Mehran Radak, Hossein Fallahi","doi":"10.1007/s44164-023-00063-y","DOIUrl":"https://doi.org/10.1007/s44164-023-00063-y","url":null,"abstract":"","PeriodicalId":73357,"journal":{"name":"In vitro models","volume":" 19","pages":"307 - 315"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138612831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging mesoporous silica nanomaterial for optimal immunotherapeutics against cancer 利用介孔二氧化硅纳米材料的最佳免疫治疗癌症
In vitro models Pub Date : 2023-11-13 DOI: 10.1007/s44164-023-00061-0
K. C. Ashitha, Gopinath M, Sasirekha N.R, Balakumar S, Rajashree P
{"title":"Leveraging mesoporous silica nanomaterial for optimal immunotherapeutics against cancer","authors":"K. C. Ashitha, Gopinath M, Sasirekha N.R, Balakumar S, Rajashree P","doi":"10.1007/s44164-023-00061-0","DOIUrl":"https://doi.org/10.1007/s44164-023-00061-0","url":null,"abstract":"Cancer represents a significant cause of morbidity and mortality. Definitive chemotherapy, surgery and radiotherapy treatment have not improved the “5-year survival period” and have shown recurrence. Currently, cancer immunotherapy is reported to be a promising therapeutic modality that aims to potentiate immune response against cancer by employing immune checkpoint inhibitors, cancer vaccines and immunomodulators. Inhibition of immune checkpoints such as PD-1/PDL1, CTLA and TIM molecules using monoclonal antibodies, ligands or both are proven to be the most successful anticancer immunotherapy. But the application of immunotherapy involves critical challenges such as non-responsiveness and systemic toxicity due to the administration of high dose. To mitigate the above challenges, nanomaterial-based delivery and therapy have been adopted to inhibit the immune checkpoints and induce an anticancer immune response. Specifically, mesoporous silica-based materials for cancer therapy are shown to be versatile materials for the above purpose. Mesoporous silica nanoparticle (MSN) based cancer immunotherapy overcomes numerous challenges and offers novel strategies for improving conventional immunotherapies. MSN has a high surface area, porosity and biocompatibility; it also has natural immune-adjuvant properties, which have been reported to be the best candidate material for immunotherapeutic delivery. This review will focus on the use of MSN as carriers for delivering immune checkpoint inhibitors and their efficacy in cancer combination therapy.","PeriodicalId":73357,"journal":{"name":"In vitro models","volume":"61 43","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136283763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Special issue: recent trends in bionanomaterials for health care applications 特刊:医疗保健应用生物纳米材料的最新趋势
In vitro models Pub Date : 2023-11-07 DOI: 10.1007/s44164-023-00062-z
Subramaina Balakumar, Vijayakumari Sugumaran
{"title":"Special issue: recent trends in bionanomaterials for health care applications","authors":"Subramaina Balakumar, Vijayakumari Sugumaran","doi":"10.1007/s44164-023-00062-z","DOIUrl":"https://doi.org/10.1007/s44164-023-00062-z","url":null,"abstract":"","PeriodicalId":73357,"journal":{"name":"In vitro models","volume":"14 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135480576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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