Immunology and immunogenetics insights最新文献_第2页

The Immune System as Drug Target 免疫系统作为药物靶点

Immunology and immunogenetics insights Pub Date : 2013-01-01 DOI: 10.4137/III.S12145

D. Flower

引用次数: 3

Sequence of Rabbit (Oryctolagus Cuniculus) DNA from the OryCun2.0 Donor does not Confirm a Frameshift in Exon 2 of IL4 来自OryCun2.0供体的兔(Oryctolagus Cuniculus) DNA序列未确认IL4外显子2的移码

Immunology and immunogenetics insights Pub Date : 2012-01-01 DOI: 10.4137/III.S9557

R. Mage, M. Mage

引用次数: 4

Bioinformatics-Based Predictions of Peptide Binding to Disease-Associated HLA Proteins Suggest Explanation for Shared Autoimmunity 基于生物信息学的多肽结合疾病相关HLA蛋白的预测为共同自身免疫提供了解释

Immunology and immunogenetics insights Pub Date : 2011-01-01 DOI: 10.4137/III.S6558

J. Glutting, P. Reche, M. Fridkis-Hareli

{"title":"Bioinformatics-Based Predictions of Peptide Binding to Disease-Associated HLA Proteins Suggest Explanation for Shared Autoimmunity","authors":"J. Glutting, P. Reche, M. Fridkis-Hareli","doi":"10.4137/III.S6558","DOIUrl":"https://doi.org/10.4137/III.S6558","url":null,"abstract":"Aim This study was designed to examine the immunogenetic basis for shared autoimmunity, resulting in autoantigen presentation that leads to the production of two or more disease-specific autoantibodies. Methods A bioinformatics approach based on peptide binding predictions to disease-associated HLA determinants has been developed and tested here using 11 disease associations between autoimmune systemic and mucocutaneous blistering disorders. Various HLAs associated with antigens within a given “disease model” (set of HLA class II and protein sequences known to be associated with a specific autoimmune disease) were tested and ranked against the antigenic proteins, first with proteins they are known to associate with and then with proteins known to be implicated in a second disease model. In every case binding predictions were compared for different proteins binding to the same HLA. Subsequently, disease-related autoantigens have been tested for their binding affinity against each disease-specific HLA class II protein. Results For a single HLA haplotype, several binders have been generated from a related autoantigen with the variable binding score. In most cases, the binding score corresponding to the interactions between the autoantigen-derived epitope and the HLA associated with one disease was similar or lower than the interactions between the epitope from proteins associated with the second disease and the same HLA. Notably, there was no compelling promiscuity in peptide binding to each of the HLA molecules, in spite of the promiscuous nature of HLA class II binding. Conclusions The data suggest that, in susceptible individuals, shared autoimmunity might be initiated by two types of HLA/peptide interaction; first between an autoantigen-derived epitope and its disease-associated HLA molecules, and second, between a different peptide of the same autoantigen and HLA proteins specific for the second disease.","PeriodicalId":73345,"journal":{"name":"Immunology and immunogenetics insights","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/III.S6558","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70704405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of genome sequences of the Th2 cytokine region of rabbit (Oryctolagus cuniculus) with those of nine different species. 兔(Oryctolagus cuniculus) Th2细胞因子区基因组序列与9个不同物种的比较分析。

Immunology and immunogenetics insights Pub Date : 2011-01-01 DOI: 10.4137/III.S7236

E Michael Gertz, Richa Agarwala, Rose G Mage, Alejandro A Schäffer

引用次数: 9

Cytokine-mediated Regulation of CX3CL1 in Osteoblasts from Patients with Rheumatoid Arthritis 细胞因子介导的CX3CL1在类风湿关节炎患者成骨细胞中的调节作用

Immunology and immunogenetics insights Pub Date : 2010-01-01 DOI: 10.4137/III.S4970

T. Isozaki, Michihito Sato, R. Takahashi, K. Wakabayashi, T. Odai, N. Yajima, Y. Miwa, Masakazu Tezuka, T. Kasama

{"title":"Cytokine-mediated Regulation of CX3CL1 in Osteoblasts from Patients with Rheumatoid Arthritis","authors":"T. Isozaki, Michihito Sato, R. Takahashi, K. Wakabayashi, T. Odai, N. Yajima, Y. Miwa, Masakazu Tezuka, T. Kasama","doi":"10.4137/III.S4970","DOIUrl":"https://doi.org/10.4137/III.S4970","url":null,"abstract":"Introduction CX3CL1 (fractalkine), a membrane-bound chemokine that induces both the adhesion and migration of leukocytes, is involved in the recruitment of cells to tissues undergoing inflammatory responses. To explore the regulation of CX3CL1 in inflammatory bone diseases, we examined CX3CL1 expression in osteoblasts. Methods Human osteoblasts isolated from the femora of rheumatoid arthritis patients were incubated in the presence or absence of various inflammatory stimuli. Culture supernatants were collected, and soluble CX3CL1 levels were determined with an enzyme-linked immunosorbent assay (ELISA). The expression of CX3CL1 mRNA transcripts in osteoblasts was examined using the quantitative TaqMan real-time polymerase chain reaction. Results The combination of tumor necrosis factor (TNF)-α and interferon (IFN)-γ induced dramatic increases in levels of both soluble CX3CL1 protein and mRNA transcripts. CX3CL1 expression in osteoblasts was decreased by the addition of interleukin(IL)-4 or IL-17 but was increased when stimulation by IFN-γ and IL-17 was supplemented with IL-1β In addition, expression was decreased when TNF-α was added. Conclusions Multiple cytokines, including IL-17, are able to either increase or decrease the expression of CX3CL1 by human osteoblasts.","PeriodicalId":73345,"journal":{"name":"Immunology and immunogenetics insights","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/III.S4970","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70704507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro and In Vivo Phagocytic Ability of Mouse B-1 Cells 小鼠B-1细胞体内外吞噬能力的研究

Immunology and immunogenetics insights Pub Date : 2010-01-01 DOI: 10.4137/III.S6156

R. N. E. Brito, B. Cortéz, GM Machado-Santelli, P. Xander, B. De Lorenzo, H. Oliveira, F. Thies, E.S. Kioshima, J. Maricato, J. Lopes, M. Mariano

引用次数: 18

Relationship between Celiac Disease Markers and Gastrointestinal Disease in Children with Autism 自闭症儿童乳糜泻标志物与胃肠道疾病的关系

Immunology and immunogenetics insights Pub Date : 2010-01-01 DOI: 10.4137/III.S3662

A.J. Russo

{"title":"Relationship between Celiac Disease Markers and Gastrointestinal Disease in Children with Autism","authors":"A.J. Russo","doi":"10.4137/III.S3662","DOIUrl":"https://doi.org/10.4137/III.S3662","url":null,"abstract":"Aim This study was designed to determine if there is a relationship between celiac disease (CD) and the presence of gastrointestinal disease (GI) disease in children with autism. Subjects and Methods One hundred twenty-two children were tested for IgG and IgA anti-transglutaminase autoantibodies (55 autistic children with GI disease, 28 non autistic children with no GI disease, 30 autistic children with no GI disease, and 9 non autistic children with GI Disease). We also compared the presence/level of these autoantibodies to presence of anti-neutrophil cytoplasmic antibodies (ANCA) and level of Alpha-1 Antitrypsin (AAT). Results We did not find a significant difference in the level of anti-transglutaminase IgG or IgA in autistic children with GI disease compared to controls. However, we found a significant relationship between the presence of ANCA and low-level IgG anti-transglutaminase IgG in children with autism and GI disease. Discussion Although there appears to be no relationship between these celiac disease markers and the presence of GI disease in autistic children, these results suggest a possible association between sub diagnostic levels of anti-transglutaminase IgG and the presence of ANCA, and therefore, supports the hypothesis that there is a generalized autoimmune dysfunction in autistic children with GI disease.","PeriodicalId":73345,"journal":{"name":"Immunology and immunogenetics insights","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/III.S3662","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70703709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chronic Periodontitis as a Risk Marker for Systemic Diseases with Reference to Cardiometabolic Disorders: Common Pathways in their Progression 慢性牙周炎是与心脏代谢紊乱相关的全身性疾病的危险标志:其进展的共同途径

Immunology and immunogenetics insights Pub Date : 2010-01-01 DOI: 10.4137/III.S5795

M. Soory

{"title":"Chronic Periodontitis as a Risk Marker for Systemic Diseases with Reference to Cardiometabolic Disorders: Common Pathways in their Progression","authors":"M. Soory","doi":"10.4137/III.S5795","DOIUrl":"https://doi.org/10.4137/III.S5795","url":null,"abstract":"Periodontitis, an inflammatory condition of the supporting structures of teeth resulting from dental plaque biofilm attached to tooth surfaces is potentially an important nidus of systemic inflammation and its sequelae. Relevant risk markers common to periodontitis co-existing with coronary heart disease and diabetes mellitus play an important role in their pathogeneses and abate in response to treatment. An over-exuberant host-response to periodontal pathogen- mediated inflammation, triggers a cycle of events which is not dissimilar to an autoimmune response in a cohort of susceptible individuals. Some variation in documented findings regarding correlations with co-morbidities and periodontitis could be explained by the lack of uniformity in studies with regard to stipulation of periodontal inflammatory status in the context of risk factors examined. There are several genetic and environmental factors which influence the progression of inflammatory periodontitis in response to plaque biofilm, also relevant to associated cardiometabolic disorders in the same subject. Some common mechanisms in the pathogeneses of periodontitis and cardiometabolic disorders based on regulation of inflammation are addressed in this review. There is some evidence of an improved systemic inflammatory profile in response to periodontal treatment which emphasizes the importance of periodontal management for systemic health in relevant cases.","PeriodicalId":73345,"journal":{"name":"Immunology and immunogenetics insights","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70704146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Characteristics of Activated Monocyte Phenotype Support R5-Tropic Human Immunodeficiency Virus. 激活单核细胞表型支持r5 -回归线人类免疫缺陷病毒的特征。

Immunology and immunogenetics insights Pub Date : 2009-01-01 DOI: 10.4137/iii.s2011

Sody M Munsaka, Melissa Agsalda, David Troelstrup, Ningjie Hu, Qigui Yu, Bruce Shiramizu

{"title":"Characteristics of Activated Monocyte Phenotype Support R5-Tropic Human Immunodeficiency Virus.","authors":"Sody M Munsaka, Melissa Agsalda, David Troelstrup, Ningjie Hu, Qigui Yu, Bruce Shiramizu","doi":"10.4137/iii.s2011","DOIUrl":"https://doi.org/10.4137/iii.s2011","url":null,"abstract":"<p><p>BACKGROUND: Microbial translocation has been recognized as an important factor in monocyte activation and contributing to AIDS pathogenesis with elevated plasma lipopolysaccharide (LPS) levels, as a marker for microbial translocation, seen in advanced HIV disease. Therefore, the current study was undertaken to assess monocyte activation in vitro by LPS and to determine its impact on monocyte phenotype. METHODS: Monocytes from non-HIV-infected donors were analyzed for CD14, CD16, CD69, TNFα, and CCR5 by flow cytometry pre- and post-stimulation with LPS. In-vitro cultures were then set up to expose non-activated and activated monocytes to R5-, X4-, and dual (R5/X4)-tropic viruses; and the amount of HIV present on the cells was assayed. RESULTS: Non-HIV-infected monocytes, after LPS stimulation, were confirmed to have an activated phenotype with increase in CD16 and CD69 surface expressions (p<0.05). The activation phenotype was supported by increase in TNFα production, p<0.05. The activated monocytes had increased surface CCR5 (from 21% to 98%; p=0.05); and were found to have more R5-tropic virus than non-activated monocytes (p<0.05). CONCLUSIONS: Following activation by LPS, non-HIV-infected monocytes were found to have increase in surface CCR5. These activated monocytes, when exposed to R5-tropic virus, were found to have more virus compared to non-activated monocytes. The significance of the findings could lie in explaining how microbial translocation plays a role in HIV progression; and possibly promoting CCR5-directed strategies in treating HIV.</p>","PeriodicalId":73345,"journal":{"name":"Immunology and immunogenetics insights","volume":"1 ","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/iii.s2011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28583483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15