IJC metabolic & endocrine最新文献

{"title":"Serum levels of free T3 are associated with ApoA1 and ApoA2, whereas free T4 levels are associated with ApoB and LDL-cholesterol in euthyroid cardiovascular patients","authors":"Hidekazu Takeuchi","doi":"10.1016/j.ijcme.2015.04.001","DOIUrl":"10.1016/j.ijcme.2015.04.001","url":null,"abstract":"<div><h3>Background</h3><p>There are a few papers reporting the association between thyroid hormones, cholesterol and lipoprotein in euthyroid cardiovascular patients.</p></div><div><h3>Objective</h3><p>Our objective was to investigate the relationship between thyroid hormones, cholesterol and lipoprotein in euthyroid cardiovascular patients.</p></div><div><h3>Methods</h3><p>The study population consisted of 73 consecutive euthyroid cardiovascular patients. The average age of the patients was 57<!--> <!-->±<!--> <!-->16<!--> <!-->years, and 52% were male. The serum levels of free 3,3′,5′-triiodo-<span>l</span>-thyronine (FT3), free thyroxine (3,5,3′,5′-tetraiodo-<span>l</span>-thyronine; FT4), thyroxine stimulating hormone (TSH), apolipoprotein, fatty acids and cholesterol were assessed.</p></div><div><h3>Results</h3><p>We found a strong, significant positive correlation between the serum levels of FT4 and low-density lipoprotein cholesterol (LDL-C) (r<!--> <!-->=<!--> <!-->0.442, p<!--> <!-->&lt;<!--> <!-->0.01), the serum levels of FT4 and apolipoprotein B (ApoB) (r<!--> <!-->=<!--> <!-->0.402, p<!--> <!-->&lt;<!--> <!-->0.01), the serum levels of FT3 and apolipoprotein A2 (ApoA2) (r<!--> <!-->=<!--> <!-->0.549, p<!--> <!-->&lt;<!--> <!-->0.01) and the serum level of TSH and high-density lipoprotein cholesterol (HDL-C) (r<!--> <!-->=<!--> <!-->0.503, p<!--> <!-->&lt;<!--> <!-->0.01). There were significant positive correlations between the serum levels of TSH and ApoA1 (r<!--> <!-->=<!--> <!-->0.267, p<!--> <!-->&lt;<!--> <!-->0.05), and the serum levels of TSH and apolipoprotein E (ApoE) (r<!--> <!-->=<!--> <!-->0.302, p<!--> <!-->&lt;<!--> <!-->0.01). By contrast, there were significant negative correlations between the serum levels of TSH and triglyceride (TG) (r<!--> <!-->=<!--> <!-->−<!--> <!-->0.315, p<!--> <!-->&lt;<!--> <!-->0.01) and the serum levels of TSH and docosahexaenoic acid (DHA) (r<!--> <!-->=<!--> <!-->−<!--> <!-->0.274, p<!--> <!-->&lt;<!--> <!-->0.05).</p></div><div><h3>Conclusions</h3><p>This is the first report demonstrating a significant correlation between the serum levels of FT3 and both ApoA1 and ApoA2; the serum levels of FT4 and ApoA2, ApoB, TC and LDL-C; and the serum levels of TSH and ApoA1, ApoE, DHA, TG and HDL-C.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"8 ","pages":"Pages 1-6"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2015.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81269551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart failure as a strong independent predictor of delirium after pacemaker operations","authors":"Haruhiko Higashi ,&nbsp;Shinji Inaba ,&nbsp;Makoto Saito ,&nbsp;Manami Yamaoka ,&nbsp;Rikako Yanagimoto ,&nbsp;Nami Okiura ,&nbsp;Yuka Gen ,&nbsp;Yumiko Kojima ,&nbsp;Takumi Sumimoto","doi":"10.1016/j.ijcme.2015.07.003","DOIUrl":"10.1016/j.ijcme.2015.07.003","url":null,"abstract":"<div><h3>Background</h3><p>Postoperative delirium is a common and serious condition in the clinical setting that has been linked to increased mortality and worse outcomes. Some patients after pacemaker operations may suffer from delirium; however, this condition has not been clarified. The aim of this study was to investigate the prevalence and predictors of delirium after pacemaker operations such as initial permanent pacemaker implantation or pacemaker generator replacement.</p></div><div><h3>Methods</h3><p>We retrospectively evaluated 192 consecutive patients who underwent pacemaker operations. According to the Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV) criteria, patients were divided into two groups: patients with delirium and patients without delirium after pacemaker operation. The two groups were compared in terms of patient characteristics, clinical settings, and environmental factors.</p></div><div><h3>Results</h3><p>Forty patients (20.8%) suffered from delirium after pacemaker operations and were significantly older than patients without delirium (85.3<!--> <!-->±<!--> <!-->6.4<!--> <!-->years vs. 80.8<!--> <!-->±<!--> <!-->8.4<!--> <!-->years, p<!--> <!-->=<!--> <!-->0.0014). Temporary pacing before permanent pacemaker implantation (30% vs. 11%, p<!--> <!-->=<!--> <!-->0.0019) and intensive care unit admission (28% vs. 12%, p<!--> <!-->=<!--> <!-->0.014) were more common in patients with delirium. Moreover, patients with delirium had more frequent heart failure than patients without delirium (78% vs. 41%, p<!--> <!-->&lt;<!--> <!-->0.0001). Multiple regression models showed heart failure as an independent predictor of delirium after pacemaker implantation.</p></div><div><h3>Conclusions</h3><p>Delirium after pacemaker operations was not uncommon and heart failure was a strong independent predictor of such a condition.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"8 ","pages":"Pages 42-45"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2015.07.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88185991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Overweight and Obesity in Turkey","authors":"Cihangir Erem","doi":"10.1016/j.ijcme.2015.07.002","DOIUrl":"10.1016/j.ijcme.2015.07.002","url":null,"abstract":"<div><p>Obesity is a major public health problem affecting an important proportion of the Turkish population. The prevalence of obesity has significantly increased among adult Turkish population over the past 20<!--> <!-->years. In 1990, 18.8% of the adult population was obese (28.5% among women and 9% among men), and the prevalence increased to 36% in 2010 (44% among women and 27% among men). From the data, we found that the prevalence of obesity in Turkey has increased steadily from 1990 to 2010 in both genders. Adult obesity-associated risk factors are age, gender, hypertension, hyperlipidemia, smoking cessation, alcohol consumption, high household income, low education level and physical activity, occupation, marital status and a family of selected medical conditions (e.g. obesity, diabetes and hypertension). To control obesity, necessary precautions should urgently be taken. The precautions include serious public health education encouraging a well-balanced diet and increasing physical activity.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"8 ","pages":"Pages 38-41"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2015.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74138976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accumulation of epicardial adipose tissue increases coronary morbidity in non-obese patients with suspected coronary artery disease","authors":"Hideya Yamamoto ,&nbsp;Toshiro Kitagawa ,&nbsp;Eiji Kunita ,&nbsp;Hiroshi Tsushima ,&nbsp;Fuminari Tatsugami ,&nbsp;Kazuo Awai ,&nbsp;Yasuki Kihara","doi":"10.1016/j.ijcme.2015.04.002","DOIUrl":"10.1016/j.ijcme.2015.04.002","url":null,"abstract":"<div><h3>Background</h3><p>We explored the relationship between epicardial adipose tissue (EAT) volume, body mass index (BMI) and the incidence of major coronary events in non-obese patients with suspected coronary artery disease (CAD).</p></div><div><h3>Methods</h3><p>We measured EAT volume in a cohort of 722 patients who had undergone coronary computed tomography, and recorded subsequent occurrences of major coronary events (cardiac death and acute coronary syndrome), simultaneously evaluating all coronary events and all-cause death.</p></div><div><h3>Results</h3><p>Eighteen patients experienced major coronary events: there were five cardiac deaths and 13 cases of acute coronary syndrome. BMI was inversely predictive of major coronary events (hazard ratio [HR], 0.74; 95% confidence interval [CI], 0.63–0.87; <em>p</em> <!-->&lt;<!--> <!-->0.001), but not for all-cause death. EAT volume predicted all coronary events (HR per 10<!--> <!-->mL, 1.11; 95% CI, 1.03–1.19; <em>p</em> <!-->=<!--> <!-->0.003). Although there was a trend suggestive of an inverse association with major coronary events, this was not statistically significant (HR per 10<!--> <!-->mL, 1.10; 95% CI; 1.00–1.21; <em>p</em> <!-->=<!--> <!-->0.059), and there was no significant relationship with all-cause death. When stratified by the first quartile (QI) of BMI (≤<!--> <!-->21.4<!--> <!-->kg/m²) and median EAT volume (107<!--> <!-->mL), the event rates in the high EAT volume and BMI QI group were significantly higher than those of other groups (adjusted HR, 5.45; 95% CI, 1.51–25.3 <em>p</em> <!-->=<!--> <!-->0.009, compared with the low EAT volume and BMI QI group).</p></div><div><h3>Conclusion</h3><p>Our findings suggest that suspected CAD patients with low BMI but high EAT volume are at an increased risk of major coronary events, but not all-cause death.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"8 ","pages":"Pages 7-12"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2015.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90832989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-density lipoprotein cholesterol and left atrial or left atrial appendage thrombus in non-valvular atrial fibrillation patients","authors":"Lijun Cui ,&nbsp;Liju Han ,&nbsp;Zhao Li,&nbsp;Junwei Ma,&nbsp;Xianghong Ma,&nbsp;Changyu Zhou,&nbsp;Guangping Li","doi":"10.1016/j.ijcme.2015.01.001","DOIUrl":"10.1016/j.ijcme.2015.01.001","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"8 ","pages":"Pages 24-25"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2015.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73081768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"64-slice multidetector computed tomography may assess resistance of antiplatelet drugs in some vivo cases","authors":"Hidekazu Takeuchi","doi":"10.1016/j.ijcme.2015.03.001","DOIUrl":"10.1016/j.ijcme.2015.03.001","url":null,"abstract":"","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"7 ","pages":"Pages 1-2"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2015.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78121389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiology of oxygen uptake kinetics: Insights from incremental cardiopulmonary exercise testing in the Study of Health in Pomerania","authors":"Anthony J. Barron ,&nbsp;Niti M. Dhutia ,&nbsp;Sven Gläser ,&nbsp;Beate Koch ,&nbsp;Ralf Ewert ,&nbsp;Anne Obst ,&nbsp;Marcus Dörr ,&nbsp;Henry Völzke ,&nbsp;Darrel P. Francis ,&nbsp;Roland Wensel","doi":"10.1016/j.ijcme.2015.02.002","DOIUrl":"10.1016/j.ijcme.2015.02.002","url":null,"abstract":"<div><h3>Background</h3><p>Cardiopulmonary exercise testing allows for assessment of cardiac and respiratory limitation, but is often affected by patient effort. Indices of oxygen kinetics, including the oxygen uptake efficiency slope (OUES), oxygen uptake–work-rate slope (VO₂–WR slope) and the heart rate–oxygen uptake slope (HR–VO₂ slope) are relatively effort independent but may be affected by patient characteristics.</p><p>The objective of this study is to identify the impact of factors, such as age, gender, body size, respiratory function, smoking and beta-blockade on these parameters, as well as generate predictive equations.</p></div><div><h3>Methods</h3><p>1708 volunteers from the population-based Study of Health in Pomerania underwent an incremental bicycle exercise protocol. Markers of oxygen kinetics were calculated. Participants with structural heart disease, echocardiographic or lung function pathology were excluded, leaving 577 males and 625 females. Age, height, weight, smoking, forced expiratory volume in 1<!--> <!-->s (FEV₁) and beta-blockers were analysed for their influencing power by gender. Quantile regression analysis determined the reference equations for each parameter.</p></div><div><h3>Results</h3><p>Age, gender, height, weight and FEV₁ (but not percent predicted FEV₁) are strongly related to OUES. Participants using beta-blockers and male smokers had significantly lower OUES values. VO₂–WR slope was minimally affected by age, gender, weight and FEV₁. Gender, height, weight and beta-blocker use, but not FEV₁ and smoking status, were related to the HR–VO₂ slope whilst age was only related in females.</p></div><div><h3>Conclusions</h3><p>Markers of oxygen kinetics are differentially affected by patient characteristics. This study provides normal reference values for these variables thereby facilitating interpretation of oxygen uptake kinetics in health and disease.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"7 ","pages":"Pages 3-9"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2015.02.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33977702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes after hypertensive crisis: Comparison between diabetics and nondiabetics","authors":"Rashed Al Bannay ,&nbsp;Aysha Husain ,&nbsp;Michael Böhm ,&nbsp;Stefan Wagenpfeil","doi":"10.1016/j.ijcme.2015.03.003","DOIUrl":"10.1016/j.ijcme.2015.03.003","url":null,"abstract":"<div><p>To study the long-term cardiovascular and non-cardiovascular outcomes among patients admitted with hypertensive crisis. A total of 297 (145 diabetics, 152 nondiabetics) patients with hypertensive crisis were followed up for a median of 30 months. Fatal and nonfatal events were tracked. The traced events defined as hypertensive urgency, acute coronary syndrome, left ventricular failure, atrial fibrillation, cerebrovascular or renal failure were consecutively analyzed during the follow-up.Overall, 140 (47%) patients had nonfatal clinical events (115 diabetics and 25 nondiabetics); 37 (12%) patients had fatal clinical events (26 diabetics and 11 nondiabetics). The rate of fatal and nonfatal events was significantly higher in diabetics. The mean time of survival was 25.7 months, with the shortest periods for stroke and left ventricular failure. For nondiabetic participants, the mean time of survival was 31 months. Cox regression analysis identified diabetes mellitus, acute left ventricular failure, stroke and renal impairment as predictors of mortality. In conclusion, hypertensive crisis is associated with a markedly increased risk for subsequent cardiovascular morbidity and mortality, especially among diabetics who present with heart failure.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"7 ","pages":"Pages 25-30"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2015.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89644495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting outcome in patients under extracorporeal membrane oxygenation due to cardiogenic shock through dynamic change of lymphocytes and interleukins","authors":"Tsai-Hsia Hong ,&nbsp;Fu-Chang Hu ,&nbsp;Shuenn-Wen Kuo ,&nbsp;Wen-Je Ko ,&nbsp;Lu-Ping Chow ,&nbsp;Li-Ming Hsu ,&nbsp;Shu-Chien Huang ,&nbsp;Sung-Liang Yu ,&nbsp;Yih-Sharng Chen","doi":"10.1016/j.ijcme.2014.11.001","DOIUrl":"10.1016/j.ijcme.2014.11.001","url":null,"abstract":"<div><h3>Objectives</h3><p>Peripheral blood parameters implicating the irreversible damages of cardiogenic shock under extracorporeal membrane oxygenation (ECMO) support patients were investigated.</p></div><div><h3>Methods</h3><p>The blood was collected from 23 cardiogenic shock cases at the time of ECMO installation, and 2, 6, 12, and 24<!--> <!-->h after oxygenation. Plasma levels of IL-2, IL-6, IL-7, IL-8, IL-10, IFN-γ, MCP-1, and carbonic anhydrase IX (CA IX) were determined by ELISA. Reactive oxygen species were measured by luminol and lucigenin and leukocyte subpopulations were analyzed by flow cytometry. Generalized additive models (GAMs) were performed to identify the death ranges of every variable and the variables were further discretized at each time point. The combination of predictors was selected from both original and discretized covariates by the generalized linear model (GLM) at each time point.</p></div><div><h3>Results</h3><p>Plasma IL-10 level was the most distinct biomarker between survivors and non-survivors after oxygenation. IL-10 sequentially partnered with IL-6, IL-7, and lymphocyte percentage at 2<!--> <!-->h, with CD3⁺CD4⁺ T cells at 6<!--> <!-->h, with CA IX at 12<!--> <!-->h, and CD3⁺ T lymphocytes at 24<!--> <!-->h predicted death with AUCs 1.000, 0.975, 0.992, and 0.992, respectively.</p></div><div><h3>Conclusions</h3><p>Combination of the GAM plots and GLM models overcame the complexity of different disease categories. The systemic irreversible damages from cardiogenic shock ECMO cases might be detected from several peripheral blood parameters.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"7 ","pages":"Pages 36-44"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2014.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77457366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac safety profile of etamicastat, a novel peripheral selective dopamine-β-hydroxylase inhibitor in non-human primates, human young and elderly healthy volunteers and hypertensive patients","authors":"Manuel Vaz-da-Silva ,&nbsp;José-Francisco Rocha ,&nbsp;Pierre Lacroix ,&nbsp;Amílcar Falcão ,&nbsp;Luís Almeida ,&nbsp;Patrício Soares-da-Silva","doi":"10.1016/j.ijcme.2015.03.002","DOIUrl":"10.1016/j.ijcme.2015.03.002","url":null,"abstract":"<div><p>The aim of this work was to evaluate the cardiac risk for etamicastat, a peripheral reversible dopamine-β-hydroxylase inhibitor. Etamicastat blocked the hERG current amplitude with an IC₅₀ value of 44<!--> <!-->μg/ml. Etamicastat had no substantial effects on arterial blood pressure, heart rate and the PR interval in male <em>Cynomolgus</em> monkeys when administered orally up to 90<!--> <!-->mg/kg. Administered orally at 15 and 45<!--> <!-->mg/kg/day in female and male <em>Cynomolgus</em> monkey for 91<!--> <!-->days, etamicastat had no effect on heart rate and the waveform or intervals of the electrocardiogram. At the highest dose level of 45<!--> <!-->mg/kg, mean plasma concentrations of etamicastat ranged from 1875 to 3145<!--> <!-->ng/ml on Day 1 and Day 91 of treatment, respectively. The effect of age on the tolerability and pharmacokinetics of etamicastat in elderly (≥<!--> <!-->65<!--> <!-->years) and young adult (18–45 years) subjects showed that supine systolic (SBP) and diastolic (DBP) blood pressure, ECG heart rate, PR interval, QRS duration and QTcF interval were not affected following once-daily administration of 100<!--> <!-->mg/day etamicastat for 7<!--> <!-->days. In hypertensive patients the decrease of blood pressure tended to be more important in subjects who had received etamicastat (50, 100 and 200<!--> <!-->mg) than in subjects who had received placebo. No clinically significant out-of-range values in vital signs or ECG parameters, ECG heart rate, PR interval, QRS duration and QTcF interval were observed in hypertensive subjects following once-daily administration of etamicastat for 10<!--> <!-->days. In conclusion, etamicastat is not likely to prolong the QT interval at therapeutic doses.</p></div>","PeriodicalId":73333,"journal":{"name":"IJC metabolic & endocrine","volume":"7 ","pages":"Pages 10-24"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcme.2015.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90798720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}