IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium最新文献_第2页

Accelerated blood clearance of targeted ultrasound contrast reduced molecular imaging signal intensity: Secreted Frizzled Related Protein-2 signal remained significantly higher than signal from either Vascular Endothelial Growth Factor Receptor-2 or alpha_Vbeta₃ integrin. 靶向超声造影剂加速血液清除降低分子成像信号强度:分泌的卷曲相关蛋白-2信号仍显著高于血管内皮生长因子受体-2或α vbeta3整合素的信号。

IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium Pub Date : 2019-10-01 Epub Date: 2019-12-09 DOI: 10.1109/ultsym.2019.8925919

James Tsuruta, Rachel White, Nancy Klauber-DeMore, Paul A Dayton

{"title":"Accelerated blood clearance of targeted ultrasound contrast reduced molecular imaging signal intensity: Secreted Frizzled Related Protein-2 signal remained significantly higher than signal from either Vascular Endothelial Growth Factor Receptor-2 or alphaVbeta3 integrin.","authors":"James Tsuruta, Rachel White, Nancy Klauber-DeMore, Paul A Dayton","doi":"10.1109/ultsym.2019.8925919","DOIUrl":"https://doi.org/10.1109/ultsym.2019.8925919","url":null,"abstract":"Multiple doses of polyethylene glycol (PEG) decorated pharmaceuticals cause accelerated blood clearance (ABC) due to the generation of antibodies reactive to the PEG moiety. Using molecular imaging to monitor response to therapy could be complicated by the ABC effect due to PEG chains in microbubble lipid shells. Our objective was to measure the half-life of targeted contrast flowing through non-tumor tissue during longitudinal imaging studies, and to determine which targeted agent returned the highest signal intensity within tumors. The molecular imaging signals from contrast agents targeted to three distinct molecular targets, Secreted Frizzled-Related Protein-2 (SFRP2), Vascular Endothelial Growth Factor Receptor-2 (VEGFR2), AlphaVBeta3 Integrin (avb3) were all significantly correlated to contrast half-life. The molecular imaging signal from SFRP2 remained significantly higher than the signal returned by ultrasound contrast targeted to either VEGFR2 or avb3 before and after restricting analyses to imaging exams with similar half-lives. We hypothesize that increasing immune clearance rates during our longitudinal studies limited the amount of targeted contrast able to perfuse tumor vasculature, and that this resulted in a global dose-dependent decrease in molecular imaging signals. Molecular imaging may underestimate biomarker levels as longitudinal studies progress and as contrast half-lives decrease, unless contrast dosing is normalized by the amount of contrast able to reach the tumor and surrounding tissue rather than by the injected dosage.","PeriodicalId":73288,"journal":{"name":"IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium","volume":" ","pages":"407-410"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/ultsym.2019.8925919","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39520882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contrast-enhanced ultrasound imaging of acute changes in pancreatic cancer following targeted hyaluronan treatment. 透明质酸靶向治疗后胰腺癌急性变化的对比增强超声成像。

IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium Pub Date : 2019-10-01 Epub Date: 2019-12-08 DOI: 10.1109/ultsym.2019.8925558

Ipek Oezdemir, Kulsoom Javed, Girdhari Rijal, Kenneth Hoyt

{"title":"Contrast-enhanced ultrasound imaging of acute changes in pancreatic cancer following targeted hyaluronan treatment.","authors":"Ipek Oezdemir, Kulsoom Javed, Girdhari Rijal, Kenneth Hoyt","doi":"10.1109/ultsym.2019.8925558","DOIUrl":"10.1109/ultsym.2019.8925558","url":null,"abstract":"The purpose of this study was to monitor acute changes in pancreatic tumor perfusion with contrast-enhanced ultrasound (CEUS) imaging following targeted hyaluronan (HA) treatment. Intratumoral accumulation of HA is one of contributing factors that can lead to an increased tumor interstitial pressure (TIP). These elevated TIP levels can hinder delivery of chemotherapeutic drugs and cause treatment failure. For this study, pancreatic cancer-bearing mice were imaged at baseline and again at 2 h after intravenous administration of physiological saline (control group) or PEGPH20, which targets HA (therapy group). CEUS data were collected for 5 min and the temporal sequence was first analyzed using a singular value filter (SVF) to remove any background clutter signal. Given the time history of contrast agent flow, a tumor perfusion parametric analysis was performed. A series of morphological image operations was applied to quantify structural features of the tumor angiogenic network including vessel count, density, length, diameter, tortuosity, and branching points. After imaging, animals were euthanized, and tumors excised for histological processing. Acute microvascular changes were found at 2 h after drug administration as confirmed by CEUS imaging. Further, histologic analysis of tumor sections revealed lower HA accumulation in the therapy group animals. Overall, these findings suggest that CEUS imaging of acute changes in tumor perfusion may help identify an optimal window whereby follow-up chemotherapeutic drug dosing would be more effective.","PeriodicalId":73288,"journal":{"name":"IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium","volume":"2019 ","pages":"2303-2306"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743975/pdf/nihms-1855372.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10361985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonic Implant Localization for Wireless Power Transfer: Active Uplink and Harmonic Backscatter. 无线电力传输的超声植入定位:有源上行和谐波反向散射。

IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium Pub Date : 2019-10-01 Epub Date: 2019-12-09

Max L Wang, Ting Chia Chang, Amin Arbabian

引用次数: 0

3-D Motion Correction for Volumetric Super-Resolution Ultrasound Imaging. 容积超分辨率超声成像的三维运动校正。

IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium Pub Date : 2019-02-25 eCollection Date: 2018-01-01 DOI: 10.1109/ULTSYM.2018.8580145

Sevan Harput, Kirsten Christensen-Jeffries, Jemma Brown, Jiaqi Zhu, Ge Zhang, Robert J Eckersley, Chris Dunsby, Meng-Xing Tang

引用次数: 0

Machine learning to improve breast cancer diagnosis by multimodal ultrasound. 机器学习提高乳腺癌多模态超声诊断。

IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium Pub Date : 2018-10-01 Epub Date: 2018-12-20 DOI: 10.1109/ultsym.2018.8579953

Laith R Sultan, Susan M Schultz, Theodore W Cary, Chandra M Sehgal

{"title":"Machine learning to improve breast cancer diagnosis by multimodal ultrasound.","authors":"Laith R Sultan, Susan M Schultz, Theodore W Cary, Chandra M Sehgal","doi":"10.1109/ultsym.2018.8579953","DOIUrl":"https://doi.org/10.1109/ultsym.2018.8579953","url":null,"abstract":"Despite major advances in breast cancer imaging there is compelling need to reduce unnecessary biopsies by improving characterization of breast lesions. This study demonstrates the use of machine learning to enhance breast cancer diagnosis with multimodal ultrasound. Surgically proven solid breast lesions were studied using quantitative features extracted from grayscale and Doppler ultrasound images. Statistically different features from the logistic regression classifier were used train and test lesion differentiation by leave-one-out cross-validation. The area under the ROC curve (AUC) of the grayscale morphologic features was 0.85 (sensitivity = 87, specificity = 69). The diagnostic performance improved (AUC = 0.89, sensitivity = 79, specificity = 89) when Doppler features were added to the analysis. Reliability of the individual training cycles of leave-one-out cross-validation was tested by measuring dispersion from the mean model. Significant dispersion from the mean, representing weak learning, was observed in 11.3% of cases. Pruning the high-dispersion cases improved the diagnostic performance markedly (AUC 0.96, sensitivity = 92, specificity = 95). These results demonstrate the effectiveness of dispersion to identify weakly learned cases. In conclusion, machine learning with multimodal ultrasound including grayscale and Doppler can achieve high performance for breast cancer diagnosis, comparable to that of human observers. Identifying weakly learned cases can markedly enhance diagnosis.","PeriodicalId":73288,"journal":{"name":"IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium","volume":"2018 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/ultsym.2018.8579953","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39210919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Dissolved Oxygen Scavenging by Acoustic Droplet Vaporization using Intravascular Ultrasound. 血管内超声声滴汽化清除溶解氧的研究。

IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium Pub Date : 2017-09-01 Epub Date: 2017-11-02 DOI: 10.1109/ULTSYM.2017.8091704

Kevin J Haworth, Bryan H Goldstein, Karla P Mercado-Shekhar, Rohan Srivastava, P Arunkumar, Haili Su, Ellena M Privitera, Christy K Holland, Andrew N Redington

{"title":"Dissolved Oxygen Scavenging by Acoustic Droplet Vaporization using Intravascular Ultrasound.","authors":"Kevin J Haworth, Bryan H Goldstein, Karla P Mercado-Shekhar, Rohan Srivastava, P Arunkumar, Haili Su, Ellena M Privitera, Christy K Holland, Andrew N Redington","doi":"10.1109/ULTSYM.2017.8091704","DOIUrl":"https://doi.org/10.1109/ULTSYM.2017.8091704","url":null,"abstract":"Modification of dissolved gas content by acoustic droplet vaporization (ADV) has been proposed for several therapeutic applications. Reducing dissolved oxygen (DO) during reperfusion of ischemic tissue during coronary interventions could inhibit reactive oxygen species production and rescue myocardium. The objective of this study was to determine whether intravascular ultrasound (IVUS) can trigger ADV and reduce DO. Perfluoropentane emulsions were created using high-speed shaking and microfluidic manufacturing. High-speed shaking resulted in a polydisperse droplet distribution ranging from less than 1 micron to greater than 16 microns in diameter. Microfluidic manufacturing produced a narrower size range of droplets with diameters between 8.0 microns and 9.6 microns. The DO content of the fluids was measured before and after ADV triggered by IVUS exposure. Duplex B-mode and passive cavitation imaging was performed to assess nucleation of ADV. An increase in echogenicity indicative of ADV was observed after exposure with a clinical IVUS system. In a flow phantom, a 20% decrease in DO was measured distal to the IVUS transducer when droplets, formed via high-speed shaking, were infused. In a static fluid system, the DO content was reduced by 11% when droplets manufactured with a microfluidic chip were exposed to IVUS. These results demonstrate that a reduction of DO by ADV is feasible using a clinical IVUS system. Future studies will assess the potential therapeutic efficacy of IVUS-nucleated ADV and methods to increase the magnitude of DO scavenging.","PeriodicalId":73288,"journal":{"name":"IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium","volume":"2017 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/ULTSYM.2017.8091704","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36229261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Blind Source Separation - Based Motion Detector for Sub-Micrometer, Periodic Displacement in Ultrasonic Imaging. 基于盲源分离的亚微米运动检测器，超声成像中的周期性位移。

IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium Pub Date : 2016-09-01 Epub Date: 2016-11-03 DOI: 10.1109/ULTSYM.2016.7728880

Md Murad Hossain, Diwash Thapa, Justin Sierchio, Amy Oldenburg, Caterina Gallippil

{"title":"Blind Source Separation - Based Motion Detector for Sub-Micrometer, Periodic Displacement in Ultrasonic Imaging.","authors":"Md Murad Hossain, Diwash Thapa, Justin Sierchio, Amy Oldenburg, Caterina Gallippil","doi":"10.1109/ULTSYM.2016.7728880","DOIUrl":"https://doi.org/10.1109/ULTSYM.2016.7728880","url":null,"abstract":"Sub-micrometer, periodic motion detection using blind source separation (BSS) via principal component analysis (PCA) is presented in the context of magnetomotive ultrasound (MMUS) imaging and Shearwave Dispersion Ultrasound Vibrometry (SDUV). In MMUS, an oscillating external magnetic field displaces tissue loaded with superparamagnetic iron oxide (SPIO) particles, whereas in SDUV, periodic tissue motion is induced using acoustic radiation force (ARF) to measure visco-elastic properties. BSS motion detection performance in MMUS imaging and SDUV was compared against frequency-phase locked (FPL) and normalized cross-correlation (NCC) motion detectors, respectively, in silico and in experimental phantoms. Parametric MMUS phantom images constructed using the BSS method had nearly twice the SNR of the corresponding images constructed using FPL method when a 0.043 mm or smaller kernel size was used. In FEM models of SDUV, the error in the BSS-estimated viscoelastic properties of simulated materials was < 10%, whereas the error was > 20% using NCC when the simulated SNR was 15 dB. In a calibrated elasticity phantom, the amplitude of the motion was ≤ 0.5 μm for a scanner power level ≤ 20%. The median percent error in BSS-derived shear modulus of the phantom was -6.8%, -1.55%, -17.11% for power level of 20%, 15%, and 10%, respectively. The corresponding NCC-derived errors were 29.90%, 127.1%, and 244.70%. These results suggest the relevance of using BSS for the detection of sub-micrometer, periodic motion in MMUS and SDUV imaging, particularly when SNR is less than 15 dB and/or induced displacements are less than 0.5 μm.","PeriodicalId":73288,"journal":{"name":"IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium","volume":"2016 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/ULTSYM.2016.7728880","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35240816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Acoustic Radiation Force of a Quasi-Gaussian Beam on an Elastic Sphere in a Fluid. 流体中弹性球上准高斯光束的声辐射力。

IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium Pub Date : 2016-09-01 Epub Date: 2016-11-03 DOI: 10.1109/ULTSYM.2016.7728608

A V Nikolaeva, O A Sapozhnikov, M R Bailey

{"title":"Acoustic Radiation Force of a Quasi-Gaussian Beam on an Elastic Sphere in a Fluid.","authors":"A V Nikolaeva, O A Sapozhnikov, M R Bailey","doi":"10.1109/ULTSYM.2016.7728608","DOIUrl":"https://doi.org/10.1109/ULTSYM.2016.7728608","url":null,"abstract":"Acoustic radiation force has many applications. One of the related technologies is the ability to noninvasively expel stones from the kidney. To optimize the procedure it is important to develop theoretical approaches that can provide rapid calculations of the radiation force depending in stone size and elastic properties, together with ultrasound beam diameter, intensity, and frequency. We hypothesize that the radiation force nonmonotonically depends on the ratio between the acoustic beam width and stone diameter because of coupling between the acoustic wave in the fluid and shear waves in the stone. Testing this hypothesis by considering a spherical stone and a quasi-Gaussian beam was performed in the current work. The calculation of the radiation force was conducted for elastic spheres of two types. Dependence of the magnitude of the radiation force on the beam diameter at various fixed values of stone diameters was modeled. In addition to using real material properties, speed of shear wave in the stone was varied to reveal the importance of shear waves in the stone. It was found that the radiation force reaches its maximum at the beamwidth comparable to the stone diameter; the gain in the force magnitude can reach 40% in comparison with the case of a narrow beam.","PeriodicalId":73288,"journal":{"name":"IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium","volume":"2016 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/ULTSYM.2016.7728608","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35069426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In vivo imaging of ocular blood flow using high-speed ultrasound. 高速超声在体眼血流成像。

IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium Pub Date : 2016-09-01 Epub Date: 2016-11-03 DOI: 10.1109/ULTSYM.2016.7728578

Jeffrey A Ketterling, Raksha Urs, Ronald H Silverman

{"title":"In vivo imaging of ocular blood flow using high-speed ultrasound.","authors":"Jeffrey A Ketterling, Raksha Urs, Ronald H Silverman","doi":"10.1109/ULTSYM.2016.7728578","DOIUrl":"https://doi.org/10.1109/ULTSYM.2016.7728578","url":null,"abstract":"Clinical ophthalmic ultrasound is currently performed with mechanically scanned, single-element probes, but these are unable to provide useful information about blood flow with Doppler techniques. Linear arrays are well-suited for the detection of blood flow, but commercial systems generally exceed FDA ophthalmic safety limits. A high-speed plane-wave ultrasound approach with an 18-MHz linear array was utilized to characterize blood flow in the orbit and choroid. Acoustic intensity was measured and the plane-wave mode was within FDA limits. Data were acquired for up to 2 sec and up to 20,000 frames/s with sets of steered plane-wave transmissions that spanned 2*θ degrees where 0 degrees was normal to the array. Lateral resolution was characterized using compounding from 1 to 50 transmissions and -6-dB lateral beamwidths ranged from 320 to 180 μm, respectively. Compounded high-frame-rate data were post-processed using a singular value decomposition spatiotemporal filter and then flow was estimated at each pixel using standard Doppler processing methods. A 1-cm diameter rotating scattering phantom and a 2-mm diameter tube with a flow of blood-mimicking fluid were utilized to validate the flow-estimation algorithms. In vivo data were obtained from the posterior pole of the human eye which revealed regions of flow in the choroid and major orbital vessels supplying the eye.","PeriodicalId":73288,"journal":{"name":"IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium","volume":"2016 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/ULTSYM.2016.7728578","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34796153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Acoustic Nonlinearity as a Mechanism for Liquid Drop Explosions in Drop-chain Fountains Generated by a Focused Ultrasound Beam. 聚焦超声束引起滴链喷泉中液滴爆炸的声非线性机制。

IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium Pub Date : 2016-09-01 Epub Date: 2016-11-03 DOI: 10.1109/ultsym.2016.7728535

Elena A Annenkova, Oleg A Sapozhnikov, Wayne Kreider, Julianna C Simon

引用次数: 1