Hematology and cell therapy最新文献_第8页

Molecular pathophysiology of chronic myelogenous leukemia. 慢性骨髓性白血病的分子病理生理学。

Hematology and cell therapy Pub Date : 1998-10-01

A G Turhan, E Solary, W Vainchenker, I Dusanter-Fourt

引用次数: 0

Interferon-alpha: mechanisms of action in chronic myelogenous leukemia in chronic phase. 干扰素- α在慢性粒细胞白血病慢性期的作用机制。

Hematology and cell therapy Pub Date : 1998-10-01

F Guilhot, L Lacotte-Thierry

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Anti-phospholipid syndrome: from patient's bedside to experimental animal models and back to the patient's bedside. 抗磷脂综合征:从患者床边到实验动物模型，再回到患者床边。

Hematology and cell therapy Pub Date : 1998-10-01

L Ziporen, Y Shoenfeld

{"title":"Anti-phospholipid syndrome: from patient's bedside to experimental animal models and back to the patient's bedside.","authors":"L Ziporen, Y Shoenfeld","doi":"","DOIUrl":"","url":null,"abstract":"The availability of animal models of the APS has provided a lot of experimental data which might be considered in trying to unravel several questions concerning this complicated disease. The main clinical manifestations associated with this disorder are repeated pregnancy loss, thrombocytopenia and thrombotic events. Other manifestations have been reported in relation to APS. However, the association with anti-phospholipid antibodies (aPL) are still uncertain. In the APS murine models presented here, both the Lupus-prone mice and the naive mice with induced APS, fetal resorption (parallels to embryo loss) and reduced fecundity rate were prominent features strongly associated with pathogenic aCL antibodies, making these models appropriate for investigating the human disease. Utilizing these models for APS have enabled to show the pathogenicity of aPL in pregnancy loss, neurological and behavioral changes, renal involvement and thrombus formation. Antiphospholipid antibodies from patients with APS, as well as natural aCL antibodies exerted pathogenic effects in naive mice, and in an in vivo thrombosis model. Several therapeutic modalities were found promising for application in the clinics. These include the antithrombotic and anticoagulant treatments using aspirin or LMWH, IL-3, or immunomodulation by high dose IVIG, specific anti-idiotypic or anti-CD4 antibodies, cyprofloxacin or bromocriptin administration.","PeriodicalId":73231,"journal":{"name":"Hematology and cell therapy","volume":"40 5","pages":"175-82"},"PeriodicalIF":0.0,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20753160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Chronic myeloid leukemia: application of cellular and gene therapy to the clinic]. 慢性髓性白血病:细胞和基因治疗在临床中的应用。

Hematology and cell therapy Pub Date : 1998-10-01

J Reiffers

引用次数: 0

Clinical, morphological, cytogenetic and molecular aspects of a series of Ph-negative chronic myeloid leukemias. 一系列ph阴性慢性髓性白血病的临床、形态学、细胞遗传学和分子方面的研究。

Hematology and cell therapy Pub Date : 1998-08-01

J Aurich, E Duchayne, F Huguet-Rigal, F Bauduer, M Navarro, Y Perel, J Pris, M R Caballin, N Dastugue

{"title":"Clinical, morphological, cytogenetic and molecular aspects of a series of Ph-negative chronic myeloid leukemias.","authors":"J Aurich, E Duchayne, F Huguet-Rigal, F Bauduer, M Navarro, Y Perel, J Pris, M R Caballin, N Dastugue","doi":"","DOIUrl":"","url":null,"abstract":"Clinical, morphological, cytogenetic and molecular (fluorescence in situ hybridization and RT-PCR) data were analyzed in twelve Philadelphia negative chronic myeloid leukemias (Ph-negative CMLs). Four patients were classified as BCR-positive. A standard b2a2 or b3a2 transcript was found, and the BCR-ABL hybrid gene was located on the 22q11 band in three cases and on the 1p35 band in one case with a t(1;9)(p35;q34). All were classified as typical chronic granulocytic leukemia (CGL) according to the French-American-British (FAB) morphological guidelines. Responses to therapy were evaluated by FISH in the four patients, and proved to be poorer than in Ph-positive CMLs. Eight BCR-negative patients were identified. They could be characterized by an older age, a less proliferative form of disease than the BCR-positive patients, and a frequent (six out of eight) abnormal karyotype. The FAB classification identified four CGLs and four atypical CMLs (aCML). A normal karyotype was more frequent in the patients classified as CGL whereas all the aCMLs had a chromosomal abnormality. Three patients had chromatin clumping and this morphologic feature was associated with trisomy 8 in two. No correlation between the cytogenetic, morphologic and the clinical data were found. Five patients had poor tolerance to therapy with a frequent occurrence of bone marrow failure and hemorragic syndrome, whereas three patients responded to a standard treatment of CML. Our study reinforces previous data on Ph-negative BCR-positive CMLs and emphasizes the difficulty in correlating clinical, morphologic, cytogenetic data in Ph-negative BCR-negative CMLs. However, our data also argue in favor of the existence of true Ph-negative BCR-negative CMLs and suggest that some of them can respond to a standard treatment of CML.","PeriodicalId":73231,"journal":{"name":"Hematology and cell therapy","volume":"40 4","pages":"149-58"},"PeriodicalIF":0.0,"publicationDate":"1998-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20679954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hairy cell leukemia. What is new forty years after the first description? 毛细胞白血病。在第一次描述之后的四十年里，有什么新的东西?

Hematology and cell therapy Pub Date : 1998-08-01

X Troussard, F Maloisel, G Flandrin

引用次数: 0

Epidemiological data in polycythaemia vera: a study of 842 cases. 真性红细胞增多症的流行病学资料:842例的研究。

Hematology and cell therapy Pub Date : 1998-08-01

Y Najean, J D Rain, C Billotey

{"title":"Epidemiological data in polycythaemia vera: a study of 842 cases.","authors":"Y Najean, J D Rain, C Billotey","doi":"","DOIUrl":"","url":null,"abstract":"An epidemiological study of 842 polycythaemic patients (entered between 1980 and 1997 in the French investigational prospective protocols) is presented. The global incidence is approximately 0.8-1.5/100,000/year in the reference area (Ile-de-France and surrounding areas). It increases linearly with age until 80, which suggests that several mutational somatic events are necessary. There was a slight male excess (sex-ratio 1.2, after correction for the percentage of male and female French people still living at risk). We did observe a slight excess of PV in the population of Jewish ancestry. A surprising excess of former blood donors (20.7% of the PV cases, compared to 8% estimated in the reference population) was observed. Only a few cases of familial myeloproliferative diseases and occurence of leukemia in the family of our patients have been observed; even if slight, this excess is statistically significant. In contrast, no excess of carcinomas was observed either in the family or in the patients' antecedents. We did not find any excess of radiation exposure in our cases. When analysing the previous occupation of our patients a possible excess of physicians and of patients previously working in occupations using solvents and glues was found, but this finding needs confirmation.","PeriodicalId":73231,"journal":{"name":"Hematology and cell therapy","volume":"40 4","pages":"159-65"},"PeriodicalIF":0.0,"publicationDate":"1998-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20679955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic and diagnostic value of endogenous erythroid colony formation in essential thrombocythemia. 内源性红系集落形成对原发性血小板增多症的预后和诊断价值。

Hematology and cell therapy Pub Date : 1998-08-01

M Ciaudo, J M Hadjez, I Teyssandier, E Coly, R Zittoun, J P Marie

引用次数: 0

Severe infection caused by Stomatococcus mucilaginosus in a neutropenic patient: case report and review of the literature. 中性粒细胞减少患者严重感染粘液口球菌1例报告及文献复习。

Hematology and cell therapy Pub Date : 1998-08-01

D Gruson, G Hilbert, A Pigneux, F Vargas, O Guisset, J Texier, J M Boiron, J Reiffers, G Gbikpi-Benissan, J P Cardinaud

引用次数: 0

Antiphospholipid antibodies: lupus anticoagulants, anticardiolipin and antiphospholipid isotypes in patients with sickle cell disease. 抗磷脂抗体:狼疮抗凝剂、抗心磷脂和镰状细胞病患者的抗磷脂同型。

Hematology and cell therapy Pub Date : 1998-06-01

B Nsiri, E Ghazouani, N Gritli, C Mazigh, F Bayoudh, T Messaoud, S Fattoum, S Machghoul

{"title":"Antiphospholipid antibodies: lupus anticoagulants, anticardiolipin and antiphospholipid isotypes in patients with sickle cell disease.","authors":"B Nsiri, E Ghazouani, N Gritli, C Mazigh, F Bayoudh, T Messaoud, S Fattoum, S Machghoul","doi":"","DOIUrl":"","url":null,"abstract":"Antiphospholipid antibodies were investigated in 37 individuals with sickle cell disease and compared to a control group of 30 healthy subjects. Sickle cell patients included 18 homozygous sickle cell patients, 8 S/beta thalassemic patients and 11 sickle cell trait subjects. In all individuals, antiphospholipid antibodies were explored by lupus anticoagulant (LA) detection and the quantification of IgG and IgM anticardiolipin (aCL) isotypes, total antiphospholipid antibodies (APA) and IgM, IgG and IgA antiphospholipid classes. In homozygous sickle cell patients, mean level of IgG aCL and total APA were significantly increased (17.02 +/- 8.88 GPL/ml, p < 0.05 and 10.64 +/- 10.58 UPL/ml, p < 0.05 respectively). The IgG aCL, total APA and LA frequencies were 22.2%, 44.4% and 62.2%, respectively. APA isotypes were mostly IgG or IgG and IgA. In S/beta thalassemic patients, mean levels of APA were significantly increased (10.81 +/- 7.82 UPL/ml, p< 0.05). Their frequency was 71.4% and they were mostly IgG or IgG and IgA. In patients with sickle cell trait, mean levels of APA were significantly increased (10.84 +/- 5.84 UPL/ml, p < 0.01). Their frequency was 72.7% and mostly of IgG isotype. Our study showed a close association between high APA levels and sickle cell syndrome, however there was no relationship between high levels of antiphospholipid antibodies and the major complications of sickle cell disease.","PeriodicalId":73231,"journal":{"name":"Hematology and cell therapy","volume":"40 3","pages":"107-12"},"PeriodicalIF":0.0,"publicationDate":"1998-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20614691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0