Hematology and cell therapy最新文献_第7页

Comparison of the cytotoxic effects of corticoids on the neoplastic B cells. 皮质激素对肿瘤B细胞的细胞毒作用比较。

Hematology and cell therapy Pub Date : 1998-12-01

V Genty, R Genevrier, S Brahimi, G Dine

{"title":"Comparison of the cytotoxic effects of corticoids on the neoplastic B cells.","authors":"V Genty, R Genevrier, S Brahimi, G Dine","doi":"","DOIUrl":"","url":null,"abstract":"Many clinical trials have been engaged to prove the benefits of new drugs in the treatment of hematological tumours. However, no real progress have occurred in diseases such as multiple myeloma, the association of melphalan and prednisone is still the mainstay of the treatment. During all these years, the family of glucocorticoids have not been totally studied. Their efficiency in the cure of lymphoid malignancies has been early recognised, but still to be based on their anti-inflammatory potency for the dosages. Only few works reported the comparison between members of this family. We demonstrate in this work, in vitro, with a cell line of medium sensibility and a B cell of tumoral origin grew up in our laboratory, that exists some differences in the anti-neoplastic potency of the more commonly used corticoids. If the order in which we can class these drugs is not surprising and empirically known, the importance of the differences observed need a special attention. We also found that these drugs might have stimulatory effects, at various degree in function of their concentrations, on the proliferation of the B cell lines. Theses side effects coupled to the efficiency variations of each corticoid present the need of paying more attention to the choice of the molecule implied in the chemotherapy.","PeriodicalId":73231,"journal":{"name":"Hematology and cell therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20830866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leukemic pleural effusion in B-cell prolymphocytic leukemia. b细胞前淋巴细胞白血病的白血病性胸腔积液。

Hematology and cell therapy Pub Date : 1998-12-01

V Andrieu, R Encaoua, C Carbon, A Couvelard, M J Grange

引用次数: 0

Early infectious complications after bone marrow transplantation requiring medical ICU admission. 骨髓移植术后早期感染并发症需要ICU住院。

Hematology and cell therapy Pub Date : 1998-12-01

D Gruson, G Hilbert, C Bébéar, A Allery, J M Boiron, A Pigneux, F Vargas, C Bébéar, J Reiffers, G Gbikpi-Benissan, J P Cardinaud

{"title":"Early infectious complications after bone marrow transplantation requiring medical ICU admission.","authors":"D Gruson, G Hilbert, C Bébéar, A Allery, J M Boiron, A Pigneux, F Vargas, C Bébéar, J Reiffers, G Gbikpi-Benissan, J P Cardinaud","doi":"","DOIUrl":"","url":null,"abstract":"The objective of this study was to define the type, the incidence and the outcome of early infectious complications (mean interval between day 1 post-BMT and the onset of fever was 9+/-3 days) occurring in granulocytopenic bone marrow transplant recipients, requiring medical intensive care unit admission. Over a five-years period, forty-one patients with microbiologically confirmed infection were enrolled, with a statistically significant higher frequency of allogeneic marrow transplant recipients (51%, p < 0.02). Infectious pneumonia occurred in 24 patients (59%), septicemia with septic shock in ten patients (24%), catheter-related infection in 5 patients (12%) and meningitis in 2 patients (5%) (p < 0.001). Twenty-six patients died (63%). Among the patients with confirmed infectious pneumonitis, which occurred most frequently in allogeneic marrow recipients (p < 0.02), 16 died (67%). This poor outcome was related to the requirement of mechanical ventilation. Eight patients (80%) with septicemia and septic shock and the two patients with meningitis died. Bacteria (Pseudomonas aeruginosa and Staphylococcal species) were the most common isolated in bronchoalveolar lavage fluid and blood cultures. We found a lower incidence of fungal or viral infections compared to previous studies. Empiric antimicrobial therapy in the cases of patients admitted in ICU may be included antibiotics anti-Pseudomonas and anti-Staphylococcus, as the ecology of hematology unit. The requirement of mechanical ventilation is the main adverse prognostic factor in transplanted patients. At ICU admission, patients with hepatic failure combined with respiratory failure represented a subgroup with a dismal prognosis.","PeriodicalId":73231,"journal":{"name":"Hematology and cell therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20830868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

G-CSF: a very efficient therapy in chronic autoimmune neutropenia. A brief review of the literature. G-CSF:一种治疗慢性自身免疫性中性粒细胞减少症的有效方法。简要回顾一下相关文献。