Global journal of obesity, diabetes and metabolic syndrome最新文献

Low CD4+ T Cell count among HIV-seronegative Type 2 Diabetes Mellitus patients in Ilorin metropolis 伊洛林市艾滋病毒抗体阴性的 2 型糖尿病患者 CD4+ T 细胞计数偏低的情况

Global journal of obesity, diabetes and metabolic syndrome Pub Date : 2024-02-17 DOI: 10.17352/2455-8583.000064

Ilesanmi Ayodele O, Atanda Tiamiyu A, Ilesanmi Rose, Ogunniyi Tolulope J, Akinleye Waheed A

{"title":"Low CD4+ T Cell count among HIV-seronegative Type 2 Diabetes Mellitus patients in Ilorin metropolis","authors":"Ilesanmi Ayodele O, Atanda Tiamiyu A, Ilesanmi Rose, Ogunniyi Tolulope J, Akinleye Waheed A","doi":"10.17352/2455-8583.000064","DOIUrl":"https://doi.org/10.17352/2455-8583.000064","url":null,"abstract":"Background and aims: Diabetes Mellitus (DM) is a metabolic disorder that manifests as chronic hyperglycemia accompanied by a dysfunctional metabolism of carbohydrates, lipids, and proteins. Several studies have earlier pointed out several complications associated with the disease and in particular, the sufferer’s susceptibility to various infectious diseases. We therefore sought to investigate the adaptive immune status of the condition, as represented by the assessment of CD4+ T cell count among DM patients. Method: Seventy-six type 2 DM patients were recruited for the study. Thirty (30) age and sex-matched, non-diabetic individuals were enrolled as negative controls. Their fasting blood sugar (FBS), HbA1c, and CD4 count were assayed using standardized procedures. The demographic and clinical data of the studied group and controls were compared with respect to age, sex, BMI, FBS, HbA1c, and CD4+ T cell counts. Result: The mean concentration of glucose (7.82 ± 2.58) and the percentage concentration of HBA1c (8.21 ± 2.31) were significantly higher in DM individuals as against the control (3.67 ± 0.66) (p = 0.0001) and (5.20 ± 0.48) (p = 0.0001) respectively. The CD4+ cell count was also significantly lower in DM subjects (843.58 ± 297.6) when compared with the control (1067.9 ±195.4) (p = 0.035). Conclusion: A significant reduction in CD4+ T cell level was noted among diabetic patients in our study, which could be a contributing factor for aggravating some of the associated complications in DM, especially those that involve susceptibility to infectious diseases. We found out that having Hb-AA is associated with normal or elevated CD4+ T cells in DM patients; whereas having the Hb-AS variant increases the chance of a low CD4+ T cell count. Assessment of CD4+ T cell count should be included as part of periodic investigations in DM patients, especially for those with unresolved complications, in spite of treatment.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing insulin supply chain resilience: A critical importance for diabetes management 加强胰岛素供应链弹性:对糖尿病管理至关重要

Global journal of obesity, diabetes and metabolic syndrome Pub Date : 2023-10-25 DOI: 10.17352/2455-8583.000063

AA Haji Mona Hussain

{"title":"Enhancing insulin supply chain resilience: A critical importance for diabetes management","authors":"AA Haji Mona Hussain","doi":"10.17352/2455-8583.000063","DOIUrl":"https://doi.org/10.17352/2455-8583.000063","url":null,"abstract":"Diabetes, a chronic metabolic disorder affecting millions worldwide, relies heavily on a stable and efficient supply chain for insulin, a life-saving hormone. However, the insulin supply chain faces multifaceted challenges that can disrupt access to this essential medication. In the realm of diabetes management, a novel and devastating occurrence has emerged—a severe shortage of insulin. This case report revolves around a singular clinical encounter that showcases a series of remarkable and uncommon aspects, which can enrich the knowledge of healthcare professionals. The patient’s condition presented several unique features, providing a learning opportunity that transcends the typical clinical scenarios seen in diabetes management. The findings surrounding the unavailability of insulin, the dire consequences it has on patients, and the clinical course and prognosis of an individual patient closely related to previous challenges. The shortage of insulin, though not a new challenge, has now reached unparalleled levels, resulting in life-threatening situations for those dependent on this vital hormone. This case report delves into a unique scenario where an individual patient’s health dramatically deteriorated due to the insulin scarcity, highlighting the urgency for comprehensive solutions and international cooperation to ensure access to this life-saving medication. This case report manuscript reviews the importance of enhancing the resistance and resilience of the insulin supply chain to ensure uninterrupted access to insulin for people with diabetes. We discuss the current challenges, their impact on diabetes management, and propose strategies to mitigate these issues. Strengthening the insulin supply chain is essential for the well-being of those living with diabetes, highlighting its significance for healthcare systems globally.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135218120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare and challenging case of ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) syndrome 一例罕见且具有挑战性的ROHHAD(快速发作性肥胖伴低通气，下丘脑功能障碍，自主神经失调)综合征

Global journal of obesity, diabetes and metabolic syndrome Pub Date : 2023-04-08 DOI: 10.17352/2455-8583.000062

Correia Cláudia, Cascais Inês, G. Rita, Mansilha Helena Ferreira, Morais Lurdes, Rios Marta, Afonso Alberto Caldas

{"title":"A rare and challenging case of ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) syndrome","authors":"Correia Cláudia, Cascais Inês, G. Rita, Mansilha Helena Ferreira, Morais Lurdes, Rios Marta, Afonso Alberto Caldas","doi":"10.17352/2455-8583.000062","DOIUrl":"https://doi.org/10.17352/2455-8583.000062","url":null,"abstract":"Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction and Autonomic Dysregulation is a rare and complex pediatric syndrome with unknown etiology. The disease hallmark is sudden and severe obesity in early childhood, with a later onset of central hypoventilation, responsible for high mortality. We present the case of a 2.5-year-old boy with sudden weight gain starting after 12 months of age (18 kg in a year) and hypoventilation in the setting of acute nasopharyngitis, requiring Non-Invasive Ventilation (NIV) initiation. Additionally, he presented symptoms and signs of autonomic disturbance, neurodevelopmental delay and behavior disorders. High prolactin, leptin and insulin were also present. Despite periodic adjustment of settings and adherence to NIV and great efforts to control food intake, he remained morbidly obese and died during an infectious intercurrence at 6 years of age. This case illustrates the challenging diagnosis and treatment/management of this rare syndrome, which can have a variable and not always complete presentation and has no specific diagnostic test available. Identifying hypoventilation and NIV treatment is essential to decrease morbimortality. However, most patients do not live past ten years old.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90606054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benefits of omega-3 polyunsaturated fatty acids to patients with oral and metabolic diseases omega-3多不饱和脂肪酸对口腔和代谢疾病患者的益处

Global journal of obesity, diabetes and metabolic syndrome Pub Date : 2023-02-21 DOI: 10.17352/2455-8583.000061

Da-Ming Liao, Chen Chieh

引用次数: 0

The period of manifestation of type 1 diabetes mellitus in children and adolescents living on the territory of ZATO (Closed administrative-territorial entity) 居住在ZATO(行政-领土封闭实体)境内的儿童和青少年1型糖尿病的表现期

Global journal of obesity, diabetes and metabolic syndrome Pub Date : 2022-12-31 DOI: 10.17352/2455-8583.000060

Proskurina Мargarita V, Taranushenko Tatiana E, Kiseleva Natalia G

{"title":"The period of manifestation of type 1 diabetes mellitus in children and adolescents living on the territory of ZATO (Closed administrative-territorial entity)","authors":"Proskurina Мargarita V, Taranushenko Tatiana E, Kiseleva Natalia G","doi":"10.17352/2455-8583.000060","DOIUrl":"https://doi.org/10.17352/2455-8583.000060","url":null,"abstract":"Type 1 diabetes mellitus (T1DM) in children and adolescents remains one of the urgent problems of pediatric endocrinology. There is a constant increase in disease rates, both worldwide and Russia. The occurrence of pathology in childhood leads to a decrease in the quality of life of patients and their parents, the early development of chronic complications and disability, which makes type 1 diabetes a social problem in society. Despite numerous scientific works devoted to the study of the factors of manifestation of the disease, the causes of the occurrence are still unclear and ambiguous. The purpose of the study: is to identify and study possible clinical and laboratory features of the onset of type 1 diabetes in children and adolescents permanently residing in the territory of closed administrative-territorial entities (ZATO). Materials and methods: a continuous cohort retrospective study of children with type 1 DM was conducted for the period from 2009-2019, permanently residing in the ZATO territory to obtain data related to the period of manifestation of the disease. The study group included 55 children from 0 - 18 years of age suffering from type 1 diabetes. Results: Data on the anamnesis of life and disease, and indicators of clinical and laboratory studies (fasting glycemia, postprandial glycemia, average daily glycemia, average amplitude of glycemia fluctuations and glycated hemoglobin) at the time of disease manifestation are presented. A comparative analysis was carried out with the indicators of the Krasnoyarsk Territory, Russia, the obtained features were described.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86065458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of primary aldosteronism 原发性醛固酮增多症1例

Global journal of obesity, diabetes and metabolic syndrome Pub Date : 2022-08-13 DOI: 10.17352/2455-8583.000059

Z. Stephanie, Paracha Nawar, Rafii Daniel

引用次数: 0

Clinically Both Effects of Weight and Glucose Variability by Oral Semaglutide (Rybelsus) for Younger Female Patient with Type 2 Diabetes (T2D) 口服西马鲁肽对年轻女性2型糖尿病(T2D)患者体重和血糖变异性的影响

Global journal of obesity, diabetes and metabolic syndrome Pub Date : 2022-06-22 DOI: 10.33805/2638-812x.126

B. Hiroshi, Yamashita Hisako, Kato Yoshinobu, Ogura Katsunori, Kato Yoshikane, Kanazawa Setsuko

引用次数: 0

Hemoglobin and Red Blood Cells Count in Pregnant Sudanese Women 苏丹孕妇血红蛋白和红细胞计数

Global journal of obesity, diabetes and metabolic syndrome Pub Date : 2022-06-21 DOI: 10.33805/2638-812x.125

Manal Hamed Awad Elmadih, A. Khalid, Ibrahim Abdelrhim Ali, Adam Hussein, Omer Abd elaziz Musa

{"title":"Hemoglobin and Red Blood Cells Count in Pregnant Sudanese Women","authors":"Manal Hamed Awad Elmadih, A. Khalid, Ibrahim Abdelrhim Ali, Adam Hussein, Omer Abd elaziz Musa","doi":"10.33805/2638-812x.125","DOIUrl":"https://doi.org/10.33805/2638-812x.125","url":null,"abstract":"The study discussed the physiological changes of pregnancy in Sudanese pregnant women the study aimed to assess the effect of pregnancy in Red blood cell, Packed Cell Volume (PCV) and hemoglobin among Sudanese pregnant women, and to correlate the PCV as an indicator of hemodilution in different trimesters among Sudanese women using or not using iron and folic acid supplement. The researcher used across sectional study which applied on 300 pregnant women presented to Port-Sudan obstetrical Hospital for antenatal care from 2019 to 2020. The samples were collected with Chemically clean and sterile disposable needles, syringes and swab were used for all blood samples, 4.5 mL of blood was collected from each participant into a tube containing the anticoagulant Ethylene Diamine Tetraacetic Acid (EDTA), gently mixed the tube five to six times A full blood count was performed using Hematological analyzer (Sysmex XP 300). The study found out that 90 women in each trimester of pregnancy (first, second and third) the mean value of Hemoglobin (Hb) in pregnant women was 11.3±1.4 g/dl, 11.4 ±1.4 g/dl and 10.3±1.2 g/dl in 1st, 2nd and 3rd trimester respectively. The study also found out that the mean value of PCV was 33.35%. Moreover, Hb was lower during 3rd trimester compared with 1st (hemodilution). The cut off level for anemia in Sudanese non pregnant females could be even lower than 11g/dl as the normal level was found to be lower than the international one. Due to hemodilution anemia in pregnancy is considered if Hb less than 9g/dl. The study recommends that diagnosis of anemia should be revised during pregnancy as this study has shown Hb level less than 9g/dl (66%) can be the cut off level.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83746465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Psychopathology in Bariatric Surgical Candidates with Type 2 Diabetes Mellitus: Systematic Review 2型糖尿病减肥手术患者的精神病理患病率:系统综述

Global journal of obesity, diabetes and metabolic syndrome Pub Date : 2022-06-21 DOI: 10.17352/2455-8583.000058

C. Pekin, M. Mchale, G. Byrne

引用次数: 0

Cases Study on the Management of Diminished Ovarian Reserve (DOR) and Premature Ovarian Insufficiency (POI) with Traditional Chinese Medicine (TCM) 卵巢储备功能减退(DOR)和卵巢功能不全(POI)的中医治疗案例研究

Global journal of obesity, diabetes and metabolic syndrome Pub Date : 2022-04-24 DOI: 10.33805/2638-812x.124

D. Jiang, F. Meng

{"title":"Cases Study on the Management of Diminished Ovarian Reserve (DOR) and Premature Ovarian Insufficiency (POI) with Traditional Chinese Medicine (TCM)","authors":"D. Jiang, F. Meng","doi":"10.33805/2638-812x.124","DOIUrl":"https://doi.org/10.33805/2638-812x.124","url":null,"abstract":"Diminished Ovarian Reserve (DOR) is one of the main causes of female infertility and is common in women under of 40s. The definition and diagnosis are pragmatic and the treatment in mainstream medicine is not promising as many of the sufferers have to choose IVF as the last resort. DOR could be the reduced ability of producing quality egg or the poor quality of eggs produced. Premature Ovarian Insufficiency (POI) belongs to its aggravate stage. Traditional Chinese medicine has long been employed in treating female infertility, and a large proportion of the cases in the records now could be classified as DOR or POI. Some clinical reports have demonstrated great potential in treating DOR & POI. The authors have treated many cases of DOR and POI, and great achievements have been recorded. The protocol used in the treatment is a whole system approach which combines acupuncture, Chinese herbal medicine and lifestyle advice into an organic composition to maximize the effects. The cases reported here are of good details and could demonstrate the application of the TCM diagnosis of syndrome pattern which logically leads to the whole-system treatment implementation.","PeriodicalId":73168,"journal":{"name":"Global journal of obesity, diabetes and metabolic syndrome","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83401790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0