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Acta Pharmaceutica Sinica B最新文献

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Counteracting Alzheimer’s disease via normalizing neurovascular unit with a self-regulated multi-functional nano-modulator 通过自调节多功能纳米调节器使神经血管正常化来对抗阿尔茨海默病
Acta Pharmaceutica Sinica B Pub Date : 2024-05-01 DOI: 10.1016/j.apsb.2024.05.017
Xue Xia, Ya Wei, Qianqian Huang, Yang Zhou, Xiaorong Wang, Yulong Shi, Xiaotong Yang, Wenqin Yang, Yiwei Zhang, Ting Lei, Yuan Huang, Hanmei Li, Meng Qin, Huile Gao
{"title":"Counteracting Alzheimer’s disease via normalizing neurovascular unit with a self-regulated multi-functional nano-modulator","authors":"Xue Xia, Ya Wei, Qianqian Huang, Yang Zhou, Xiaorong Wang, Yulong Shi, Xiaotong Yang, Wenqin Yang, Yiwei Zhang, Ting Lei, Yuan Huang, Hanmei Li, Meng Qin, Huile Gao","doi":"10.1016/j.apsb.2024.05.017","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.05.017","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141131798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling 通过靶向ERα信号传导促进人骨髓间充质干细胞的成骨分化，从而逆转骨质疏松症
Acta Pharmaceutica Sinica B Pub Date : 2024-02-01 DOI: 10.1016/j.apsb.2024.02.005
Qing Zhao, Junjie Feng, Fubin Liu, Qianxin Liang, Manlin Xie, Jiaming Dong, Yanfang Zou, J. Ye, Guilong Liu, Yue Cao, Zhaodi Guo, Hongzhi Qiao, Lei Zheng, Kewei Zhao
{"title":"Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling","authors":"Qing Zhao, Junjie Feng, Fubin Liu, Qianxin Liang, Manlin Xie, Jiaming Dong, Yanfang Zou, J. Ye, Guilong Liu, Yue Cao, Zhaodi Guo, Hongzhi Qiao, Lei Zheng, Kewei Zhao","doi":"10.1016/j.apsb.2024.02.005","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.005","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":"29 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139823607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2-BECN1 interaction 与ALS相关的C9orf72二肽重复序列通过调节BCL2-BECN1的相互作用抑制饥饿诱导的自噬作用
Acta Pharmaceutica Sinica B Pub Date : 2024-02-01 DOI: 10.1016/j.apsb.2024.02.004
Shiqiang Xu, Qilian Ma, Junwen Shen, Ningning Li, Shan Sun, Na-na Wang, Yang Chen, Chunsheng Dong, Kin Yip Tam, Jochen H.M. Prehn, Hongfeng Wang, Zheng Ying
{"title":"ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2-BECN1 interaction","authors":"Shiqiang Xu, Qilian Ma, Junwen Shen, Ningning Li, Shan Sun, Na-na Wang, Yang Chen, Chunsheng Dong, Kin Yip Tam, Jochen H.M. Prehn, Hongfeng Wang, Zheng Ying","doi":"10.1016/j.apsb.2024.02.004","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.004","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139893152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges 直接以 BAX 为靶点进行药物研发：治疗机遇与挑战
Acta Pharmaceutica Sinica B Pub Date : 2024-02-01 DOI: 10.1016/j.apsb.2024.02.010
Zhenwei Zhang, Linghui Hou, Dan Liu, Shenglin Luan, Min Huang, Linxiang Zhao
{"title":"Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges","authors":"Zhenwei Zhang, Linghui Hou, Dan Liu, Shenglin Luan, Min Huang, Linxiang Zhao","doi":"10.1016/j.apsb.2024.02.010","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.010","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139814359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma 受circCPNE1/miR-330-3p途径启发的基于顺铂的miRNA递送策略治疗口腔鳞状细胞癌
Acta Pharmaceutica Sinica B Pub Date : 2024-02-01 DOI: 10.1016/j.apsb.2024.02.009
Hua-yang Fan, Ming-da Zhao, Hong-jie Jiang, Zhen-wei Yu, Yu-jiang Fan, Xin-hua Liang, Ya-Ling Tang, Yong Sun
{"title":"Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma","authors":"Hua-yang Fan, Ming-da Zhao, Hong-jie Jiang, Zhen-wei Yu, Yu-jiang Fan, Xin-hua Liang, Ya-Ling Tang, Yong Sun","doi":"10.1016/j.apsb.2024.02.009","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.009","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":"62 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139821082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits 气体推进纳米马达通过调节肠道免疫环境-血液循环-微生物群回路缓解结肠炎
Acta Pharmaceutica Sinica B Pub Date : 2024-02-01 DOI: 10.1016/j.apsb.2024.02.008
Bo Xiao, Yuqi Liang, Ga Liu, Lingshuang Wang, Zhan Zhang, Libin Qiu, Haiting Xu, Sean Carr, Xiaoxiao Shi, Rui L Reis, Subhas C. Kundu, Zhenghua Zhu
{"title":"Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits","authors":"Bo Xiao, Yuqi Liang, Ga Liu, Lingshuang Wang, Zhan Zhang, Libin Qiu, Haiting Xu, Sean Carr, Xiaoxiao Shi, Rui L Reis, Subhas C. Kundu, Zhenghua Zhu","doi":"10.1016/j.apsb.2024.02.008","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.008","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":"19 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139815948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular characterization and structure basis of a malonyltransferase with both substrate promiscuity and catalytic regiospecificity from Cistanche tubulosa 具有底物杂合性和催化区域特异性的肉苁蓉丙二酰转移酶的分子特征和结构基础
Acta Pharmaceutica Sinica B Pub Date : 2024-02-01 DOI: 10.1016/j.apsb.2024.02.007
Xiao Liu, Yuyu Liu, Xiping Xu, Wenqian Huang, Yaru Yan, Ying-Xian Wang, Weisheng Tian, Ting Mo, Xiaoxue Cui, Jun Li, Shepo Shi, Pengfei Tu
{"title":"Molecular characterization and structure basis of a malonyltransferase with both substrate promiscuity and catalytic regiospecificity from Cistanche tubulosa","authors":"Xiao Liu, Yuyu Liu, Xiping Xu, Wenqian Huang, Yaru Yan, Ying-Xian Wang, Weisheng Tian, Ting Mo, Xiaoxue Cui, Jun Li, Shepo Shi, Pengfei Tu","doi":"10.1016/j.apsb.2024.02.007","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.007","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":"14 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139876768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bile acids and coronavirus disease 2019 胆汁酸与冠状病毒疾病 2019
Acta Pharmaceutica Sinica B Pub Date : 2024-02-01 DOI: 10.1016/j.apsb.2024.02.011
Xiaoru Huang, Xuening Liu, Zijian Li
{"title":"Bile acids and coronavirus disease 2019","authors":"Xiaoru Huang, Xuening Liu, Zijian Li","doi":"10.1016/j.apsb.2024.02.011","DOIUrl":"https://doi.org/10.1016/j.apsb.2024.02.011","url":null,"abstract":"","PeriodicalId":7314,"journal":{"name":"Acta Pharmaceutica Sinica B","volume":"87 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139878676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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