Acta Pharmaceutica Sinica B

Controlling tumor progression and recurrence in mice through combined treatment with a PD-L1 inhibitor and a designer Salmonella strain that delivers GM-CSF

Pub Date : 2024-07-01 DOI: 10.1016/j.apsb.2024.07.011 H. Jeon, Daejin Lim, EunA. So, Solbi Kim, J. Jeong, Miryoung Song, Hyojin Lee

Discovery of a novel exceptionally potent and orally active Nur77 ligand NB1 with a distinct binding mode for cancer therapy

Pub Date : 2024-07-01 DOI: 10.1016/j.apsb.2024.07.012 Jun Chen, Taige Zhao, Wenbin Hong, Hongsheng Li, Mingtao Ao, Yijing Zhong, Xiaoya Chen, Yingkun Qiu, Xiumin Wang, Zhen Wu, Tianwei Lin, Baicun Li, Xueqin Chen, M. Fang

Natural product mediated mesenchymal–epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA

Pub Date : 2024-07-01 DOI: 10.1016/j.apsb.2024.07.013 Tianyang Chen, Guangju Liu, Sisi Chen, Fengyuan Zhang, Shuoqian Ma, Yongping Bai, Quan Zhang, Yahui Ding