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Genome instability & disease最新文献

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Correction: Ubiquitin carboxyl-terminal hydrolase 11 promotes autophagy by de-ubiquitinating and stabilizing Beclin-1 纠正:泛素羧基末端水解酶11通过去泛素化和稳定Beclin-1促进自噬
Genome instability & disease Pub Date : 2023-10-10 DOI: 10.1007/s42764-023-00107-3
Zheng Li, Shaohong Rao, Chunwei Song, Min Zhu, Hongchang Zhao, Shuping Yuan, Bin Peng, Xingzhi Xu
{"title":"Correction: Ubiquitin carboxyl-terminal hydrolase 11 promotes autophagy by de-ubiquitinating and stabilizing Beclin-1","authors":"Zheng Li, Shaohong Rao, Chunwei Song, Min Zhu, Hongchang Zhao, Shuping Yuan, Bin Peng, Xingzhi Xu","doi":"10.1007/s42764-023-00107-3","DOIUrl":"https://doi.org/10.1007/s42764-023-00107-3","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Silico design and characterization of RAD51 protein inhibitors targeting homologous recombination repair for cancer therapy 靶向肿瘤同源重组修复的RAD51蛋白抑制剂的设计与表征
Genome instability & disease Pub Date : 2023-09-20 DOI: 10.1007/s42764-023-00106-4
Harsimrat Kaur, Harsimran Kaur, Preeti Rajesh, Changanamkandath Rajesh
{"title":"In Silico design and characterization of RAD51 protein inhibitors targeting homologous recombination repair for cancer therapy","authors":"Harsimrat Kaur, Harsimran Kaur, Preeti Rajesh, Changanamkandath Rajesh","doi":"10.1007/s42764-023-00106-4","DOIUrl":"https://doi.org/10.1007/s42764-023-00106-4","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136313958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PRMT1 and PRMT5: on the road of homologous recombination and non-homologous end joining. PRMT1 和 PRMT5：同源重组和非同源末端连接之路。
Genome instability & disease Pub Date : 2023-08-01 Epub Date: 2022-12-07 DOI: 10.1007/s42764-022-00095-w
Shasha Yin, Liu Liu, Wenjian Gan
{"title":"PRMT1 and PRMT5: on the road of homologous recombination and non-homologous end joining.","authors":"Shasha Yin, Liu Liu, Wenjian Gan","doi":"10.1007/s42764-022-00095-w","DOIUrl":"10.1007/s42764-022-00095-w","url":null,"abstract":"<p><p>DNA double-strand breaks (DSBs) are widely accepted to be the most deleterious form of DNA lesions that pose a severe threat to genome integrity. Two predominant pathways are responsible for repair of DSBs, homologous recombination (HR) and non-homologous end-joining (NHEJ). HR relies on a template to faithfully repair breaks, while NHEJ is a template-independent and error-prone repair mechanism. Multiple layers of regulation have been documented to dictate the balance between HR and NHEJ, such as cell cycle and post-translational modifications (PTMs). Arginine methylation is one of the most common PTMs, which is catalyzed by protein arginine methyltransferases (PRMTs). PRMT1 and PRMT5 are the predominate PRMTs that promote asymmetric dimethylarginine and symmetric dimethylarginine, respectively. They have emerged to be crucial regulators of DNA damage repair. In this review, we summarize current understanding and unaddressed questions of PRMT1 and PRMT5 in regulation of HR and NHEJ, providing insights into their roles in DSB repair pathway choice and the potential of targeting them for cancer therapy.</p>","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10155247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mechanism and consequences of BRAF inhibitor resistance in melanoma 黑色素瘤中BRAF抑制剂耐药的机制和后果
Genome instability & disease Pub Date : 2023-07-31 DOI: 10.1007/s42764-023-00105-5
Ksenia Golub, Weiyu Bai, Zhimeng Zhang, Huilin Xiao, Rongyuan Sun, Junling Shen, Jianwei Sun
{"title":"The mechanism and consequences of BRAF inhibitor resistance in melanoma","authors":"Ksenia Golub, Weiyu Bai, Zhimeng Zhang, Huilin Xiao, Rongyuan Sun, Junling Shen, Jianwei Sun","doi":"10.1007/s42764-023-00105-5","DOIUrl":"https://doi.org/10.1007/s42764-023-00105-5","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78711459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal evolution in leukemia: preleukemia, evolutionary models, and clinical implications 白血病的克隆进化：白血病前期、进化模型和临床意义
Genome instability & disease Pub Date : 2023-07-20 DOI: 10.1007/s42764-023-00104-6
Xu-Dong He, Meng-Fang Xia, Ji-Yuan Teng, Bin Zhou, Qian-Fei Wang
{"title":"Clonal evolution in leukemia: preleukemia, evolutionary models, and clinical implications","authors":"Xu-Dong He, Meng-Fang Xia, Ji-Yuan Teng, Bin Zhou, Qian-Fei Wang","doi":"10.1007/s42764-023-00104-6","DOIUrl":"https://doi.org/10.1007/s42764-023-00104-6","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44269250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Major genomic mutations driving hepatocellular carcinoma 驱动肝细胞癌的主要基因组突变
Genome instability & disease Pub Date : 2023-07-12 DOI: 10.1007/s42764-023-00103-7
Ran Chen, Moubin Lin, Daming Gao
{"title":"Major genomic mutations driving hepatocellular carcinoma","authors":"Ran Chen, Moubin Lin, Daming Gao","doi":"10.1007/s42764-023-00103-7","DOIUrl":"https://doi.org/10.1007/s42764-023-00103-7","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44566716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a novel inflammation-related gene signature for predicting inflammatory breast cancer survival 一种预测炎性乳腺癌生存的新型炎症相关基因标记的鉴定
Genome instability & disease Pub Date : 2023-06-01 DOI: 10.1007/s42764-023-00102-8
Weiyu Bai, Q. Hao, Zhimeng Zhang, Bingxing Han, Huilin Xiao, D. Chang, Yun Zhu, Junling Shen, Jianwei Sun
{"title":"Identification of a novel inflammation-related gene signature for predicting inflammatory breast cancer survival","authors":"Weiyu Bai, Q. Hao, Zhimeng Zhang, Bingxing Han, Huilin Xiao, D. Chang, Yun Zhu, Junling Shen, Jianwei Sun","doi":"10.1007/s42764-023-00102-8","DOIUrl":"https://doi.org/10.1007/s42764-023-00102-8","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42479141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Common hotspots of cancer chemotherapy 癌症化疗的常见热点
Genome instability & disease Pub Date : 2023-06-01 DOI: 10.1007/s42764-023-00101-9
Adekunle Ademikanra, Olutayo Oyewole, Azeemat Olayiwola
{"title":"Common hotspots of cancer chemotherapy","authors":"Adekunle Ademikanra, Olutayo Oyewole, Azeemat Olayiwola","doi":"10.1007/s42764-023-00101-9","DOIUrl":"https://doi.org/10.1007/s42764-023-00101-9","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48124303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PARP molecular functions and applications of PARP inhibitors in cancer treatment PARP分子功能及PARP抑制剂在癌症治疗中的应用
Genome instability & disease Pub Date : 2023-05-09 DOI: 10.1007/s42764-023-00100-w
Yuhan Guo, Boyang Fan, Mo Li
{"title":"PARP molecular functions and applications of PARP inhibitors in cancer treatment","authors":"Yuhan Guo, Boyang Fan, Mo Li","doi":"10.1007/s42764-023-00100-w","DOIUrl":"https://doi.org/10.1007/s42764-023-00100-w","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48225425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Proximity RNA labeling reveals functions of lncRNA in DNA damage response 近距离RNA标记揭示lncRNA在DNA损伤应答中的功能
Genome instability & disease Pub Date : 2023-05-08 DOI: 10.1007/s42764-023-00099-0
Weili Li, Zhongxia Li, Zhiwen Deng, J. Zhai, Shuzhen Han, Xiangyu Liu
{"title":"Proximity RNA labeling reveals functions of lncRNA in DNA damage response","authors":"Weili Li, Zhongxia Li, Zhiwen Deng, J. Zhai, Shuzhen Han, Xiangyu Liu","doi":"10.1007/s42764-023-00099-0","DOIUrl":"https://doi.org/10.1007/s42764-023-00099-0","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47996885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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