Acta Odontologica Scandinavica最新文献

{"title":"Unequal smiles: consequences of untreated dental caries in citizens living in vulnerable circumstances in the Netherlands: an exploratory pilot study.","authors":"Sterre J Gitz, Geert J M G Van der Heijden, Catherine M C Volgenant","doi":"10.2340/aos.v83.42028","DOIUrl":"10.2340/aos.v83.42028","url":null,"abstract":"<p><p>The often poor oral health status of socioeconomically vulnerable adults is widely recognised. Nevertheless, research on it is scarce. To address this gap, this exploratory pilot study aimed to report on the prevalence of untreated caries and its clinical odontogenic consequences, as well as the associated Oral Health Related Quality of Life (OHRQoL) in a marginalised adult Dutch population. The Dutch department of Médecins du Monde (Doctors of the World) included socioeconomically vulnerable (low socioeconomic position [SEP]) adults in the Netherlands through community organisations. The validated Deprivation in Primary Care Questionnaire (DiPCare-Q) was translated in Dutch and used to characterise the SEP of the population. To document untreated caries and severe odontogenic consequences, the DMFT (Decayed, Missing, Filled Permanent Teeth) and PUFA (Pulpal, Fistula, Ulceration, Abscess) index were used. The validated Dutch Oral Health Impact Profile questionnaire (OHIP-14) was used to document the impact of these issues on OHRQoL. Data analysis was conducted in SPSS® (Statistical Package for the Social Sciences) statistics (Kruskal-Wallis, Mann-Whitney-U-test) and STATA software. Data from 59 adult participants were analysed. The prevalence of untreated caries (DT ≥ 1) was 65.5%, 57.9% of which experienced severe odontogenic consequences (DT+PUFA). The prevalence of severe odontogenic consequences (PUFA ≥ 1) was 45.5%. The mean OHIP-14 score of 17.7 ± 13.4 (25th-75th percentile: 6-26) illustrated that untreated caries may have impact on OHRQoL. Individuals who experienced any severe odontogenic consequences from untreated caries reported significantly higher OHIP-14 scores (mean ± s.d.: 21.8 ± 14.8 vs.11.1 ± 7.2). The untreated caries and severe odontogenic consequences seen in a large number of the socioeconomically vulnerable adult participants seemed to have an impact on OHRQoL. These findings emphasise the urgency of including these adults in the professional oral health system for treatment and prevention, and may emphasise the necessity of improving the socioeconomic circumstances of this population. Further exploration of the exact barriers and facilitators to oral healthcare access for socioeconomically vulnerable adults is necessary.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"574-581"},"PeriodicalIF":1.4,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health of Dutch primary school children in relation to social and health aspects.","authors":"Brenda G Grift, Denise Duijster, Geert J M G van der Heijden, Josef J J M Bruers, Katarina Jerković-Ćosić","doi":"10.2340/aos.v83.42053","DOIUrl":"10.2340/aos.v83.42053","url":null,"abstract":"<p><strong>Objective: </strong>This research investigated the oral health status of Dutch primary school children aged 10-12 years in Utrecht and its association with demographic characteristics, lifestyle factors, general psychosocial health, and dental treatment, to guide targeted interventions to improve children's oral and overall well-being.</p><p><strong>Materials and methods: </strong>A cross-sectional survey was conducted at 49 primary schools in Utrecht in 2017 and 42 schools in 2019. The questionnaire covered background characteristics (7 questions), psychosocial health (14 questions), nutrition and exercise (20 questions), school and leisure time (26 questions), home situation (23 questions), and oral health (4 questions). Associations were analyzed using multivariate logistic regression.</p><p><strong>Results: </strong>Data from 5,426 children were analyzed. Prior to the survey, 11% did not visit a dentist, 23% had a toothache, 22% had a cavity filled, and 8% had a tooth extracted. Independent predictors for increased odds of oral health problems were migration background, poor general health, drinking more than two glasses of soft drinks per day, having ever drunk alcohol, having fear of failure, experiencing problems at home and/or coming from average or low socioeconomic position group. Factors associated with increased odds of dental treatment, such as cavity filled and tooth extracted, were migration background, fear of failure and home problems.</p><p><strong>Conclusions: </strong>These findings emphasize the need for targeted prevention to improve the oral health of children with a migration background, average or low socioeconomic position and/or with poorer general and psychosocial health, unhealthy diets and problems in the home situation, within a community-based and transdisciplinary approach.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"564-573"},"PeriodicalIF":1.4,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of immediate loading compared to conventional loading in implant-supported removable prostheses: a systematic review and meta-analysis.","authors":"Zhongke Wang, Sihui Li, Hongmei Chen, Ling Guo","doi":"10.2340/aos.v83.42027","DOIUrl":"10.2340/aos.v83.42027","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review and meta-analysis aimed to evaluate the efficacy of two different loading methods in implant-supported removable prostheses (partial dentures and full-maxillary dentures).</p><p><strong>Methods: </strong>As of August 2023, three electronic databases and nine oral implant-related journals had been searched. Only randomised controlled trials (RCTs) that compare immediate loading with conventional loading in implant-supported removable prostheses were included. The primary outcome was the implant survival rate. At the same time, a meta-analysis of bone-level changes was performed. Cochrane risk-of-bias tool for randomised trials (RoB 2) was used to evaluate the risk of bias in the included trials.</p><p><strong>Results: </strong>A total of 16 RCTs were included, including 543 participants with 1595 implants. The included trials compared immediate loading and conventional loading in implant-supported removable prostheses. Regarding implants as the statistical unit, the immediate loading group had a statistically significant lower survival rate (RR = 0.950; 95% confidence interval [CI], (0.926, 0.974); P = 0.027; I² = 47%). When patients were regarded as statistical units, a statistically significant lower survival rate was also observed in the immediate loading group (RR = 0.929; 95% CI, (0.897, 0.961); P = 0.590; I² = 0%). When we analysed the bone level changes, a statistically significant decrease was observed in bone level in the immediate loading group compared with the conventional loading group (weighted mean difference [WMD] = -0.127; 95% CI, (-0.195, -0.059); P < 0.00001).</p><p><strong>Conclusion: </strong>Lower implant survival rates and a decrease in marginal bone level was observed compared to immediate loading with conventional loading.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"553-563"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of citric acid on mineralisation and vascular endothelial growth factor secretion from apical papilla stem cells.","authors":"Krasimir Hristov, Nikolay Ishkitiev, Marina Miteva, Violeta Dimitrova, Ralitsa Gigova, Nataliya Gateva, Liliya Angelova","doi":"10.2340/aos.v83.42026","DOIUrl":"10.2340/aos.v83.42026","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the influence of citric acid on the osteogenic and angiogenic potential of stem cells from apical papillae (SCAPs).</p><p><strong>Materials and methods: </strong>Stem cells from apical papillae were isolated from freshly extracted third permanent molars. These cells were treated with 20 and 100 μM citric acid. Alizarin red staining was used to evaluate mineral deposition. The secreted levels of vascular endothelial growth factor (VEGF) were assessed by ELISA on days 18, 24 and 28. Immunofluorescence analysis was performed to assess the expression of surface markers after exposure to 20 and 100 μM citric acid.</p><p><strong>Results: </strong>Different mineralisation patterns were observed. Supplemented with citric acid, media showed more diffuse and less dense crystals. On day 18, most VEGF was secreted from the cells with no added citric acid. On day 24, there was a significant increase (p < 0.05) in the levels of VEGF secreted from cells treated with 20 μM citric acid. On day 28, cells from the control group did not secrete VEGF. There was a reduction in the levels of VEGF secreted by cells treated with 20 μM citric acid and a significant increase in the cells exposed to 100 μM citric acid (p < 0.05).</p><p><strong>Conclusion: </strong>Citric acid can promote the differentiation of SCAPs and angiogenesis.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"546-552"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical use of cone-beam computed tomography in Western Norway: a referral-based retrospective study.","authors":"Marianne L Vollan, Linda Cecilie Kleppe Hasselgren, Xie-Qi Shi, Malin V Jonsson","doi":"10.2340/aos.v83.41943","DOIUrl":"https://doi.org/10.2340/aos.v83.41943","url":null,"abstract":"<p><strong>Objective: </strong>To elucidate cone-beam computed tomography (CBCT) referral profiles in Western Norway.</p><p><strong>Materials and methods: </strong>In all, 3,031 referrals to oral- and maxillofacial radiologist were reviewed. Patient data were retrieved retrospectively from electronic charts. The patient's age, gender, and perceived clinical indication were noted, as well as relevant medical and dental history and whether the referring clinician was a general dentist or held a clinical dental specialty.</p><p><strong>Results: </strong>A total of 2,680 referrals fulfilled the inclusion criteria (UiB n = 1,471, and TkVestland, n = 1,209). The female:male ratio was 1,427:1,253. Mean age was 33 years - 35 years for females compared to 31 years for males (p < 0.001). The most common clinical indications were related to impacted teeth (29%), endodontic issues (17%), cleft lip palate (12%), and resorptions (10%). Less common were bone lesions, implant planning, trauma to the teeth or jaws, atypical orofacial pain, and temporo-mandibular joint (TMJ). The patient age-profiles mirrored differences in indications within the cohort. Most referrals were from specialist dentists such as orthodontists, oral surgeons, and endodontists. Interestingly, 543/2,680 (20%) referrals were from general dentists.  Conclusions: Specialist dentists such as orthodontists, oral surgeons, and endodontists refer most patients for clinical indications such as impacted teeth, endodontic issues, and resorptions.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"537-545"},"PeriodicalIF":1.4,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of self-perceived oral health and socio-economic factors on oral health-related behavior in Estonian adults.","authors":"Marjo Sinijärv, Jana Olak, Rein Murakas, Riina Runnel","doi":"10.2340/aos.v83.41902","DOIUrl":"https://doi.org/10.2340/aos.v83.41902","url":null,"abstract":"<p><strong>Objective: </strong>To identify which socioeconomic factors are affecting oral health-related behavior and to provide suggestions for improving the population's oral health.  Materials and methods: The survey includes population groups from age 35 and older from all 15 Estonian counties and major cities (n = 2,376). The study is based on data from a nationwide Estonian Adult Oral Health Survey questionnaire. In addition to analyzing eight aspects of oral health-related behavior and self-perceived oral health variables, the survey also includes participants' socio-economic and demographic characteristics. The study utilizes frequency tables (including cumulative distributions), means, correlations, and regression analysis as its methods.</p><p><strong>Results: </strong>The mean number of beneficial behaviors reported by the participant was 4.2 (SD 1.6). The value of the oral health-related behavior index (OHBI, the number of reported behaviors from the eight) is initially determined by the optimal timing between meals, abstinence from smoking, and the choice of drinking water or refraining from any intake between meals. Participants with higher OHBI tended to rate their self-perceived oral health better. Adherence to beneficial dental health-related behavior in Estonian adults is primarily influenced by gender, educational level, type of settlement, and household income level.</p><p><strong>Conclusions: </strong>In order to significantly improve oral health and related behaviors, it is imperative to integrate dental services into universal health coverage and deliver ongoing oral health education for adults.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"522-530"},"PeriodicalIF":1.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary chronic osteomyelitis of the jaw - a descriptive study of the condition and its occurrence in Sweden between 2012 and 2018.","authors":"Caroline Robertsson, Carina Cardemil","doi":"10.2340/aos.v83.41989","DOIUrl":"10.2340/aos.v83.41989","url":null,"abstract":"<p><strong>Purpose: </strong>Primary chronic osteomyelitis (PCO) of the jaw is a non-infectious, inflammatory state of the jawbone of unknown etiology.  This study aimed to investigate the occurrence of PCO in Sweden between the years 2012 and 2018, the characteristics of the condition, treatment methods, and outcomes.  Material and methods: The search for patients with PCO in Sweden 2012-2018 was performed at 24 oral and maxillofacial surgery units in Sweden.</p><p><strong>Results: </strong>During this 6-year period, 17 patients were identified as diagnosed with PCO in Sweden. The mean age was 10.6 years at diagnosis, and the female:male ratio was 4:1.</p><p><strong>Conclusion: </strong>We conclude that PCO is a very rare disease in Sweden, and that standardized, well-defined criteria are necessary to calculate incidence rates but also to increase knowledge about etiology, clinical characteristics, and treatment outcomes in rare conditions such as PCO.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"531-536"},"PeriodicalIF":1.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between cycle threshold values and oral manifestations in COVID-19: a comprehensive overview.","authors":"Dalit Porat Ben Amy, Hanan Rohana, Maya Azrad, Michael V Joachim, Ori Bar, Imad Abu El-Naaj, Avi Peretz","doi":"10.2340/aos.v83.41390","DOIUrl":"10.2340/aos.v83.41390","url":null,"abstract":"<p><strong>Objective: </strong>This cross-sectional study aimed to compare oral manifestations between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-positive and SARS-CoV-2-negative patients and to examine associations between oral symptoms, Ct values of E and N SARS-CoV-2 viral genes, and the implications of low Ct values indicating a high viral load, which is a predictive factor for the outcome of COVID-19.</p><p><strong>Methods: </strong>A total of 353 participating patients were aged ≥18 years with clinical manifestations of COVID-19 infection and tested for SARS-CoV-2 carriage at the medical center, by reverse transcriptase polymerase chain reaction (RT-PCR). All patients filled out an anonymous digital questionnaire regarding oral and general symptoms and overall medical health.  Results: A significant association was found between SARS-CoV-2 carriage and dry mouth, unpleasant taste and changes in taste (p < 0.001); for example, 37.4% of the 147 SARS-CoV-2- positive participants had a dry mouth, compared to 18.9% of the 206 SARS-CoV-2- negative participants. Oral blisters were experienced by patients with an E gene Ct value of 10-20 (50%) or 21-30 (50%) (p = 0.041). Bad breath, dry mouth, unpleasant taste and changes in taste were mostly present in participants whose Ct values of both E and N genes were between 21 and 30.  Conclusions: This study found significant associations between low Ct values of E and N SARS-CoV-2 viral genes and high viral load, indicating that Ct values can serve as predictive factors for COVID-19 outcomes. The findings suggest that while oral symptoms are present, the Ct values and associated high viral loads are more critical indicators of disease severity and prognosis.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"516-521"},"PeriodicalIF":1.4,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedation of Adults with Orally Administered Midazolam in Dentistry - A Retrospective Study.","authors":"Marika Storskrubb, Pia Gabre","doi":"10.2340/aos.v83.41403","DOIUrl":"10.2340/aos.v83.41403","url":null,"abstract":"<p><strong>Objective: </strong>The use of midazolam (MZ) has increased in dentistry, but the effect in adults is sparsely studied. The aim of this study was to investigate doses, effects, and side effects of orally administered MZ as a sedative for adults in a dental care organization.</p><p><strong>Material and methods: </strong>A retrospective record review was performed including all adult patients in the dental care organization ≥20 years receiving MZ, identified through a logbook for addictive drugs, during 2020. From patients' records, the following data were extracted: age, gender, medical history, reason for sedation, performed treatments, doses, effects, and side effects of MZ.  Results: In total, 265 patients on 418 occasions had been sedated, which constituted 2.3 sedations per 1,000 visits and 3.3 sedations per 1,000 treated patients. Mean age was 40.8 years and 67.7% were females. The most common reason for sedation was anxiety. Mean dose in primary dental clinics was 7.9 mg and in specialist clinics, 6.8 mg (p < 0.001). Older patients (>70 years) had lower doses than younger (p < 0.001), while no difference was found between ages 55-70 years and those who were younger. Dental treatment was completed in 91.9% of occasions, and side effects were registered in 2.2%. Successful dental treatment was related to type of treatment performed.</p><p><strong>Conclusions: </strong>Sedation is rarely used, particularly in primary dental care, and the use varies widely between clinics. MZ administered by dentists seems to be safe and effective. A sedation record should be used to make patient data such as weight and medical conditions available.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"83 ","pages":"507-515"},"PeriodicalIF":1.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11425061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chewing Side Preference, Facial Asymmetry and Related Factors in the Northern Finland Birth Cohort 1986.","authors":"Elina V Heikkinen,Ville Vuollo,Tuomo Heikkinen,Virpi Harila","doi":"10.2340/aos.v83.41392","DOIUrl":"https://doi.org/10.2340/aos.v83.41392","url":null,"abstract":"OBJECTIVEThe aim of this study was to find out how the preferred chewing side (PCS) affects facial asymmetry, what kind of factors affect PCS, and whether there are differences in facial asymmetry between symmetrical and asymmetrical masticators.MATERIAL AND METHODSThe study included 748 subjects (females n=452, males n=296) born in 1985-1986 in Northern Finland (Northern Finland Birth Cohort 1986, NFBC 1986). Subjects' faces were captured in facial 3D images with stereophotogrammetry technology, and they filled in a questionnaire concerning oral health. A comprehensive dental examination was done by a dentist. Subject´s chewing side preference was studied by chewing a piece of paraffin, cotton roll or parafilm. Asymmetry was measured from 3D images with different asymmetry measurements and facial landmarks.RESULTSReduced number of teeth on contralateral side affects PCS (OR = 2.44 in the case of one tooth is missing). Being female increased the whole face and lower face symmetry (p values <0.001-0.824). Self-reported TMD pain has an effect on the sidedness of the chin; there is more pain in the larger side of the chin (OR = 9.45). Different chewing materials had no significant effect on the proportion of chewing sides.CONCLUSIONSFemales have a more symmetrical face compared to males. PCS does not have a statistically significant effect on facial asymmetry, but the variable affecting PCS itself is extracted teeth.","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":"49 1","pages":"500-506"},"PeriodicalIF":2.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}