Roshan Reddy Upendra, Richard Simon, Suzanne M Shontz, Cristian A Linte
{"title":"Deformable Image Registration Using Vision Transformers for Cardiac Motion Estimation from Cine Cardiac MRI Images.","authors":"Roshan Reddy Upendra, Richard Simon, Suzanne M Shontz, Cristian A Linte","doi":"10.1007/978-3-031-35302-4_39","DOIUrl":"10.1007/978-3-031-35302-4_39","url":null,"abstract":"<p><p>Accurate cardiac motion estimation is a crucial step in assessing the kinematic and contractile properties of the cardiac chambers, thereby directly quantifying the regional cardiac function, which plays an important role in understanding myocardial diseases and planning their treatment. Since the cine cardiac magnetic resonance imaging (MRI) provides dynamic, high-resolution 3D images of the heart that depict cardiac motion throughout the cardiac cycle, cardiac motion can be estimated by finding the optical flow representation between the consecutive 3D volumes from a 4D cine cardiac MRI dataset, thereby formulating it as an image registration problem. Therefore, we propose a hybrid convolutional neural network (CNN) and Vision Transformer (ViT) architecture for deformable image registration of 3D cine cardiac MRI images for consistent cardiac motion estimation. We compare the image registration results of our proposed method with those of the VoxelMorph CNN model and conventional B-spline free form deformation (FFD) non-rigid image registration algorithm. We conduct all our experiments on the open-source Automated Cardiac Diagnosis Challenge (ACDC) dataset. Our experiments show that the deformable image registration results obtained using the proposed method outperform the CNN model and the traditional FFD image registration method.</p>","PeriodicalId":73120,"journal":{"name":"Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76723168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emilio A Mendiola, Eric Wang, Abby Leatherman, Qian Xiang, Sunder Neelakantan, Peter Vanderslice, Reza Avazmohammadi
{"title":"A Micro-anatomical Model of the Infarcted Left Ventricle Border Zone to Study the Influence of Collagen Undulation.","authors":"Emilio A Mendiola, Eric Wang, Abby Leatherman, Qian Xiang, Sunder Neelakantan, Peter Vanderslice, Reza Avazmohammadi","doi":"10.1007/978-3-031-35302-4_4","DOIUrl":"10.1007/978-3-031-35302-4_4","url":null,"abstract":"<p><p>Myocardial infarction (MI) results in cardiac myocyte death and often initiates the formation of a fibrotic scar in the myocardium surrounded by a border zone. Myocyte loss and collagen-rich scar tissue heavily influence the biomechanical behavior of the myocardium which could lead to various cardiac diseases such as systolic heart failure and arrhythmias. Knowledge of how myocyte and collagen micro-architecture changes affect the passive mechanical behavior of the border zone remains limited. Computational modeling provides us with an invaluable tool to identify and study the mechanisms driving the biomechanical remodeling of the myocardium post-MI. We utilized a rodent model of MI and an image-based approach to characterize the three-dimensional (3-D) myocyte and collagen micro-architecture at various timepoints post-MI. Left ventricular free wall (LVFW) samples were obtained from infarcted hearts at 1-week and 4-week post-MI (n = 1 each). Samples were labeled using immunoassays to identify the extracellular matrix (ECM) and myocytes. 3-D reconstructions of the infarct border zone were developed from confocal imaging and meshed to develop high-fidelity micro-anatomically accurate finite element models. We performed a parametric study using these models to investigate the influence of collagen undulation on the passive micromechanical behavior of the myocardium under a diastolic load. Our results suggest that although parametric increases in collagen undulation elevate the strain amount experienced by the ECM in both early- and late-stage MI, the sensitivity of myocytes to such increases is reduced from early to late-stage MI. Our 3-D micro-anatomical modeling holds promise in identifying mechanisms of border zone maladaptation post-MI.</p>","PeriodicalId":73120,"journal":{"name":"Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352642/pdf/nihms-1916028.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9903825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Usman, Emilio A Mendiola, Tanmay Mukherjee, Rana Raza Mehdi, Jacques Ohayon, Prasanna G Alluri, Sakthivel Sadayappan, Gaurav Choudhary, Reza Avazmohammadi
{"title":"On the possibility of estimating myocardial fiber architecture from cardiac strains.","authors":"Muhammad Usman, Emilio A Mendiola, Tanmay Mukherjee, Rana Raza Mehdi, Jacques Ohayon, Prasanna G Alluri, Sakthivel Sadayappan, Gaurav Choudhary, Reza Avazmohammadi","doi":"10.1007/978-3-031-35302-4_8","DOIUrl":"10.1007/978-3-031-35302-4_8","url":null,"abstract":"<p><p>The myocardium is composed of a complex network of contractile myofibers that are organized in such a way as to produce efficient contraction and relaxation of the heart. The myofiber architecture in the myocardium is a key determinant of cardiac motion and the global or organ-level function of the heart. Reports of architectural remodeling in cardiac diseases, such as pulmonary hypertension and myocardial infarction, potentially contributing to cardiac dysfunction call for the inclusion of an architectural marker for an improved assessment of cardiac function. However, the in-vivo quantification of three-dimensional myo-architecture has proven challenging. In this work, we examine the sensitivity of cardiac strains to varying myofiber orientation using a multiscale finite-element model of the LV. Additionally, we present an inverse modeling approach to predict the myocardium fiber structure from cardiac strains. Our results indicate a strong correlation between fiber orientation and LV kinematics, corroborating that the fiber structure is a principal determinant of LV contractile behavior. Our inverse model was capable of accurately predicting the myocardial fiber range and regional fiber angles from strain measures. A concrete understanding of the link between LV myofiber structure and motion, and the development of non-invasive and feasible means of characterizing the myocardium architecture is expected to lead to advanced LV functional metrics and improved prognostic assessment of structural heart disease.</p>","PeriodicalId":73120,"journal":{"name":"Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478796/pdf/nihms-1922738.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10170205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prototype of a Cardiac MRI Simulator for the Training of Supervised Neural Networks","authors":"M. Varela, A. Bharath","doi":"10.1007/978-3-031-35302-4_38","DOIUrl":"https://doi.org/10.1007/978-3-031-35302-4_38","url":null,"abstract":"","PeriodicalId":73120,"journal":{"name":"Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78481985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Han Ling, Nathan Painchaud, P. Courand, Pierre-Marc Jodoin, Damien Garcia, O. Bernard
{"title":"Extraction of volumetric indices from echocardiography: which deep learning solution for clinical use?","authors":"Han Ling, Nathan Painchaud, P. Courand, Pierre-Marc Jodoin, Damien Garcia, O. Bernard","doi":"10.1007/978-3-031-35302-4_25","DOIUrl":"https://doi.org/10.1007/978-3-031-35302-4_25","url":null,"abstract":"","PeriodicalId":73120,"journal":{"name":"Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75693020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. On, K. Vimalesvaran, C. Galazis, S. Zaman, J. Howard, N. Linton, N. Peters, G. Cole, A. Bharath, M. Varela
{"title":"Automatic Aortic Valve Pathology Detection from 3-Chamber Cine MRI with Spatio-Temporal Attention Maps","authors":"Y. On, K. Vimalesvaran, C. Galazis, S. Zaman, J. Howard, N. Linton, N. Peters, G. Cole, A. Bharath, M. Varela","doi":"10.1007/978-3-031-35302-4_66","DOIUrl":"https://doi.org/10.1007/978-3-031-35302-4_66","url":null,"abstract":"","PeriodicalId":73120,"journal":{"name":"Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81784139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dieuwertje Alblas, Marie‐Claude Hofman, C. Brune, K. Yeung, J. Wolterink
{"title":"Implicit Neural Representations for Modeling of Abdominal Aortic Aneurysm Progression","authors":"Dieuwertje Alblas, Marie‐Claude Hofman, C. Brune, K. Yeung, J. Wolterink","doi":"10.48550/arXiv.2303.01069","DOIUrl":"https://doi.org/10.48550/arXiv.2303.01069","url":null,"abstract":"Abdominal aortic aneurysms (AAAs) are progressive dilatations of the abdominal aorta that, if left untreated, can rupture with lethal consequences. Imaging-based patient monitoring is required to select patients eligible for surgical repair. In this work, we present a model based on implicit neural representations (INRs) to model AAA progression. We represent the AAA wall over time as the zero-level set of a signed distance function (SDF), estimated by a multilayer perception that operates on space and time. We optimize this INR using automatically extracted segmentation masks in longitudinal CT data. This network is conditioned on spatiotemporal coordinates and represents the AAA surface at any desired resolution at any moment in time. Using regularization on spatial and temporal gradients of the SDF, we ensure proper interpolation of the AAA shape. We demonstrate the network's ability to produce AAA interpolations with average surface distances ranging between 0.72 and 2.52 mm from images acquired at highly irregular intervals. The results indicate that our model can accurately interpolate AAA shapes over time, with potential clinical value for a more personalised assessment of AAA progression.","PeriodicalId":73120,"journal":{"name":"Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74981496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SE(3) symmetry lets graph neural networks learn arterial velocity estimation from small datasets","authors":"J. Suk, C. Brune, J. Wolterink","doi":"10.1007/978-3-031-35302-4_46","DOIUrl":"https://doi.org/10.1007/978-3-031-35302-4_46","url":null,"abstract":"","PeriodicalId":73120,"journal":{"name":"Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79650567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hugo Barbaroux, M. Loecher, Karl P. Kunze, R. Neji, Daniel B. Ennis, S. Nielles-Vallespin, A. Scott, A. Young
{"title":"Generating Short-Axis DENSE Images from 4D XCAT Phantoms: A Proof-of-Concept Study","authors":"Hugo Barbaroux, M. Loecher, Karl P. Kunze, R. Neji, Daniel B. Ennis, S. Nielles-Vallespin, A. Scott, A. Young","doi":"10.1007/978-3-031-35302-4_43","DOIUrl":"https://doi.org/10.1007/978-3-031-35302-4_43","url":null,"abstract":"","PeriodicalId":73120,"journal":{"name":"Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75820556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Hasaballa, D. Zhao, V. Wang, T. B. Gamage, S. Creamer, G. Quill, P. Ruygrok, S. Arri, R. Doughty, M. Legget, A. Young, M. Nash
{"title":"Automated Estimation of Left Ventricular Diastolic Chamber Stiffness: Application to Patients with Heart Failure and Aortic Regurgitation","authors":"A. Hasaballa, D. Zhao, V. Wang, T. B. Gamage, S. Creamer, G. Quill, P. Ruygrok, S. Arri, R. Doughty, M. Legget, A. Young, M. Nash","doi":"10.1007/978-3-031-35302-4_64","DOIUrl":"https://doi.org/10.1007/978-3-031-35302-4_64","url":null,"abstract":"","PeriodicalId":73120,"journal":{"name":"Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80399678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}