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Acta chirurgica Scandinavica. Supplementum最新文献

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Mechanisms of postoperative pulmonary dysfunction. 术后肺功能障碍的机制。
Acta chirurgica Scandinavica. Supplementum Pub Date : 1989-01-01
G Hedenstierna
{"title":"Mechanisms of postoperative pulmonary dysfunction.","authors":"G Hedenstierna","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Postoperative pulmonary complications are not uncommon, and the factors that contribute to lung dysfunction are well documented. Postoperative pain, spasm, and paralysis are all known to reduce lung function, although relief of pain does not completely restore function. Rather, diaphragmatic dysfunction has been found to persist even with adequate pain relief. Functional residual capacity is reduced both by the supine position and anesthesia. During anesthesia, the reduced FRC can contribute to airway closure during expiration and to a compression atelectasis that in turn precipitates hypoxemia and infection. Muscle paralysis can also create or contribute to atelectasis. Microthromboembolism impedes perfusion distribution, adding to the other causes of a ventilation-perfusion mismatch. Different anesthetic techniques and intraoperative management may help prevent or reduce the incidence of postoperative lung complications.</p>","PeriodicalId":7309,"journal":{"name":"Acta chirurgica Scandinavica. Supplementum","volume":"550 ","pages":"152-8"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13795141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoclonal antibodies (MAb 17-1A) for the treatment of patients with metastatic colorectal carcinomas. 单克隆抗体(MAb 17-1A)用于治疗转移性结直肠癌患者。
Acta chirurgica Scandinavica. Supplementum Pub Date : 1989-01-01
H Mellstedt, J E Frödin, G Masucci, C Lindemalm, C Wedelin, B Christensson, J Shetye, P Biberfeld, A K Lefvert, P Pihlstedt
{"title":"Monoclonal antibodies (MAb 17-1A) for the treatment of patients with metastatic colorectal carcinomas.","authors":"H Mellstedt,&nbsp;J E Frödin,&nbsp;G Masucci,&nbsp;C Lindemalm,&nbsp;C Wedelin,&nbsp;B Christensson,&nbsp;J Shetye,&nbsp;P Biberfeld,&nbsp;A K Lefvert,&nbsp;P Pihlstedt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7309,"journal":{"name":"Acta chirurgica Scandinavica. Supplementum","volume":"549 ","pages":"63-70"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14064573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beneficial effects on intraoperative and postoperative blood loss in total hip replacement when performed under lumbar epidural anesthesia. An explanatory study. 腰椎硬膜外麻醉对全髋关节置换术中术后出血量的有益影响。解释性研究。
Acta chirurgica Scandinavica. Supplementum Pub Date : 1989-01-01
J Modig
{"title":"Beneficial effects on intraoperative and postoperative blood loss in total hip replacement when performed under lumbar epidural anesthesia. An explanatory study.","authors":"J Modig","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of continuous lumbar epidural anesthesia and two types of general anesthesia on blood loss and hemodynamics during and after total hip replacement were compared in three groups of patients. Fourteen patients received local anesthetics via continuous lumbar epidural administration; 10 patients received inhalational anesthetics and breathed spontaneously after endotracheal intubation; and 14 received artificial ventilation after intubation and intermittent intravenous (i.v.) injections of pancuronium and fentanyl. The results documented that both intraoperative and postoperative blood losses were significantly reduced in patients subjected to total hip replacement under lumbar epidural anesthesia as compared with the patients receiving the two general anesthetic techniques. Hemodynamic differences explained the differences in blood loss. The epidural anesthesia induced hypotension on the arterial and venous sides as compared with the two general anesthetic techniques. Inhalational anesthesia also induced hypotension on the arterial and venous sides intraoperatively as compared with general anesthesia with artificial ventilation. Postoperatively, the hemodynamics of the general anesthesia groups were similar, and no differences in blood loss occurred. Continuous' epidural anesthesia can be viewed as a tool to achieve hypotensive anesthesia--notably on the venous side--for the purpose of minimizing blood loss. The reduction in blood loss associated with lumbar epidural anesthesia is beneficial in decreasing the hazard and cost of blood transfusion.</p>","PeriodicalId":7309,"journal":{"name":"Acta chirurgica Scandinavica. Supplementum","volume":"550 ","pages":"95-100; discussion 100-3"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13852866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MHC status of primary human colorectal carcinoma: biological significance and implications for host immune recognition. 人类原发性结直肠癌的MHC状态:生物学意义及其对宿主免疫识别的影响
Acta chirurgica Scandinavica. Supplementum Pub Date : 1989-01-01
M Moore, A K Ghosh, D J Jones
{"title":"MHC status of primary human colorectal carcinoma: biological significance and implications for host immune recognition.","authors":"M Moore,&nbsp;A K Ghosh,&nbsp;D J Jones","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7309,"journal":{"name":"Acta chirurgica Scandinavica. Supplementum","volume":"549 ","pages":"17-25"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13790715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prophylactic methods against thromboembolism. 预防血栓栓塞的方法。
Acta chirurgica Scandinavica. Supplementum Pub Date : 1989-01-01
D T Reilly
{"title":"Prophylactic methods against thromboembolism.","authors":"D T Reilly","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Deep vein thrombosis and pulmonary embolism are significant hazards of surgery, especially in orthopedic procedures. However, the true incidence of these complications is unknown. Many surgeons are now using prophylactic methods to prevent the postoperative occurrence of thromboembolic disease. Pneumatic compression devices are recommended in some instances, especially in cases where increased bleeding could be devastating. Several pharmacologic agents are also used, alone or in combination with pneumatic devices. These include subcutaneous heparin, warfarin, dextran, and aspirin. Each agent has advantages and disadvantages. The US National Institutes of Health (NIH) and numerous ongoing clinical trials are attempting to establish recommendations and guidelines for the use of prophylaxis against postoperative deep vein thrombosis and pulmonary embolism.</p>","PeriodicalId":7309,"journal":{"name":"Acta chirurgica Scandinavica. Supplementum","volume":"550 ","pages":"115-8"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13795137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of regional anesthesia, local anesthetics, and sympathicomimetics on the pathophysiology of deep vein thrombosis. 区域麻醉、局麻药和交感麻醉药对深静脉血栓形成病理生理的影响。
Acta chirurgica Scandinavica. Supplementum Pub Date : 1989-01-01
J Modig
{"title":"Influence of regional anesthesia, local anesthetics, and sympathicomimetics on the pathophysiology of deep vein thrombosis.","authors":"J Modig","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Studies have shown that lumbar epidural and spinal anesthesia seem to offer two distinct clinical advantages over general anesthesia, particularly in total hip replacement patients. These major regional blocks reduce the frequency of deep vein thrombosis and pulmonary embolism and reduce intraoperative and postoperative blood losses. The beneficial effects on thromboembolism are probably explained by several factors, such as hyperkinetic blood flow in the lower legs, reduced tendency to coagulation, and improved fibrinolytic function. The effects of local anesthetics on leukocytes, platelets, erythrocytes, and plasma proteins and on the interactions among various blood cells and endothelial cells are other factors in the protection against thromboembolism. Sympathicomimetic agents (i.e., epinephrine in the local anesthetic solution together with ephedrine given prophylactically to maintain a stable blood pressure) probably also play a significant role, notably on fibrinolytic function. The reduction in blood loss and thus in transfusion requirements may also be important.</p>","PeriodicalId":7309,"journal":{"name":"Acta chirurgica Scandinavica. Supplementum","volume":"550 ","pages":"119-24; discussion 124-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13795138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of anesthetic methods on mental function. 麻醉方法对心理功能的影响。
Acta chirurgica Scandinavica. Supplementum Pub Date : 1989-01-01
M J Jones
{"title":"The influence of anesthetic methods on mental function.","authors":"M J Jones","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of anesthetic methods on mental function has been the subject of much discussion and debate over many years. Although it is commonly recognized that sedative, narcotic, and anesthetic agents have observable effects on cerebral function at the time of administration, more subtle and less easily detectable effects may persist into the postoperative period. Identifying and describing the effects of these drugs requires reliable and reproducible methods of measurement. The tests used for evaluating the effect of anesthetic methods on mental function are reviewed. The roles played by intraoperative and postoperative factors and their possible involvement in detectable decrement in mental function are described. Early postoperative effects of anesthetic methods on cognitive function are discussed, and the evidence for prolonged changes in mental function following anesthesia (particularly in the elderly) is reviewed.</p>","PeriodicalId":7309,"journal":{"name":"Acta chirurgica Scandinavica. Supplementum","volume":"550 ","pages":"169-75; discussion 175-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13795143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-2 and lymphokine-activated killer cell therapy for gastrointestinal cancer. 白细胞介素-2和淋巴因子激活的杀伤细胞治疗胃肠道肿瘤。
Acta chirurgica Scandinavica. Supplementum Pub Date : 1989-01-01
P Guillou
{"title":"Interleukin-2 and lymphokine-activated killer cell therapy for gastrointestinal cancer.","authors":"P Guillou","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7309,"journal":{"name":"Acta chirurgica Scandinavica. Supplementum","volume":"549 ","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13924420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumour growth factors. 肿瘤生长因子。
Acta chirurgica Scandinavica. Supplementum Pub Date : 1989-01-01
I T Ernberg
{"title":"Tumour growth factors.","authors":"I T Ernberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7309,"journal":{"name":"Acta chirurgica Scandinavica. Supplementum","volume":"549 ","pages":"11-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13683097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Host defense mechanisms in surgical patients: effect of surgery and trauma. 手术患者的宿主防御机制:手术和创伤的影响。
Acta chirurgica Scandinavica. Supplementum Pub Date : 1989-01-01
J L Meakins
{"title":"Host defense mechanisms in surgical patients: effect of surgery and trauma.","authors":"J L Meakins","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Numerous experimental and clinical studies have documented that trauma-including surgery-alters the immune response, and that the response is a function of the magnitude of the injury or operation. The abnormalities seen after surgical operations on humans or animals include decreased antibody response, decreased neutrophil chemotaxis, decreased delayed-type hypersensitivity reaction, abnormal neutrophil adherence, serum immunosuppressive factors, decreased fibronectin levels, reduced serum opsonic activity, and reduced efficacy of interleukin-2. These abnormalities involve all aspects of the host defense mechanisms, both the cellular and humoral mediators and the specific and nonspecific immune responses. The capacity to control these responses in surgical patients may have important clinical applications.</p>","PeriodicalId":7309,"journal":{"name":"Acta chirurgica Scandinavica. Supplementum","volume":"550 ","pages":"43-51; discussion 51-3"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13793284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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