Frontiers in neuroengineering最新文献_第6页

Argus II Retinal Prosthesis System for peripheral retinal degeneration Argus II视网膜假体系统用于周围视网膜变性

Frontiers in neuroengineering Pub Date : 2014-01-01 DOI: 10.3389/CONF.FNENG.2014.11.00008

Arsiero Maura

引用次数: 3

Biocompatibility and electrochemical assessment of boron doped nanocrystalline diamond electrodes for neural stimulation 神经刺激用掺硼纳米晶金刚石电极的生物相容性及电化学评价

Frontiers in neuroengineering Pub Date : 2014-01-01 DOI: 10.3389/CONF.FNENG.2014.11.00005

C. Pennisi, M. Alcaide, Stavros Papaioannou, S. Meijs, A. Taylor, M. Nesladek, V. Zachar

引用次数: 2

Myoelectric control of upper limb prosthesis: current status, challenges and recent advances 上肢假体肌电控制的现状、挑战及最新进展

Frontiers in neuroengineering Pub Date : 2014-01-01 DOI: 10.3389/CONF.FNENG.2014.11.00004

Jiang Ning, F. Dario

引用次数: 22

A possible mechanism for PTSD symptoms in patients with traumatic brain injury: central autonomic network disruption. 创伤性脑损伤患者PTSD症状的可能机制:中枢自主神经网络中断。

Frontiers in neuroengineering Pub Date : 2013-12-19 DOI: 10.3389/fneng.2013.00013

John B Williamson, Kenneth M Heilman, Eric C Porges, Damon G Lamb, Stephen W Porges

{"title":"A possible mechanism for PTSD symptoms in patients with traumatic brain injury: central autonomic network disruption.","authors":"John B Williamson, Kenneth M Heilman, Eric C Porges, Damon G Lamb, Stephen W Porges","doi":"10.3389/fneng.2013.00013","DOIUrl":"https://doi.org/10.3389/fneng.2013.00013","url":null,"abstract":"Patients with traumatic brain injuries (TBI) often develop post traumatic stress disorder (PTSD). This syndrome, defined and diagnosed by psychological and behavioral features, is associated with symptoms such as anxiety and anger with an increase of arousal and vigilance, as well as flashbacks and nightmares. Many of these features and symptoms observed in PTSD may be in part the result of altered autonomic nervous system (ANS) activity in response to psychological and physical challenges. Brain imaging has documented that TBI often induces white matter damage to pathways associated with the anterior limb of the internal capsule and uncinate fasciculus. Since these white matter structures link neocortical networks with subcortical and limbic structures that regulate autonomic control centers, injury to these pathways may induce a loss of inhibitory control of the ANS. In this review, the autonomic features associated with PTSD are discussed in the context of traumatic brain injury. We posit that TBI induced damage to networks that regulate the ANS increase vulnerability to PTSD. The means by which the vulnerability can be measured and tested are also discussed. ","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"6 ","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2013-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2013.00013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32000911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

A hardware model of the auditory periphery to transduce acoustic signals into neural activity. 听觉外围的硬件模型，将声音信号转化为神经活动。

Frontiers in neuroengineering Pub Date : 2013-11-26 eCollection Date: 2013-01-01 DOI: 10.3389/fneng.2013.00012

Takashi Tateno, Jun Nishikawa, Nobuyoshi Tsuchioka, Hirofumi Shintaku, Satoyuki Kawano

{"title":"A hardware model of the auditory periphery to transduce acoustic signals into neural activity.","authors":"Takashi Tateno, Jun Nishikawa, Nobuyoshi Tsuchioka, Hirofumi Shintaku, Satoyuki Kawano","doi":"10.3389/fneng.2013.00012","DOIUrl":"https://doi.org/10.3389/fneng.2013.00012","url":null,"abstract":"To improve the performance of cochlear implants, we have integrated a microdevice into a model of the auditory periphery with the goal of creating a microprocessor. We constructed an artificial peripheral auditory system using a hybrid model in which polyvinylidene difluoride was used as a piezoelectric sensor to convert mechanical stimuli into electric signals. To produce frequency selectivity, the slit on a stainless steel base plate was designed such that the local resonance frequency of the membrane over the slit reflected the transfer function. In the acoustic sensor, electric signals were generated based on the piezoelectric effect from local stress in the membrane. The electrodes on the resonating plate produced relatively large electric output signals. The signals were fed into a computer model that mimicked some functions of inner hair cells, inner hair cell-auditory nerve synapses, and auditory nerve fibers. In general, the responses of the model to pure-tone burst and complex stimuli accurately represented the discharge rates of high-spontaneous-rate auditory nerve fibers across a range of frequencies greater than 1 kHz and middle to high sound pressure levels. Thus, the model provides a tool to understand information processing in the peripheral auditory system and a basic design for connecting artificial acoustic sensors to the peripheral auditory nervous system. Finally, we discuss the need for stimulus control with an appropriate model of the auditory periphery based on auditory brainstem responses that were electrically evoked by different temporal pulse patterns with the same pulse number. ","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"6 ","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2013-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2013.00012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31942507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Effects of antiepileptic drugs on hippocampal neurons coupled to micro-electrode arrays. 抗癫痫药物对偶联微电极阵列海马神经元的影响。

Frontiers in neuroengineering Pub Date : 2013-11-19 eCollection Date: 2013-01-01 DOI: 10.3389/fneng.2013.00010

Ilaria Colombi, Sameehan Mahajani, Monica Frega, Laura Gasparini, Michela Chiappalone

{"title":"Effects of antiepileptic drugs on hippocampal neurons coupled to micro-electrode arrays.","authors":"Ilaria Colombi, Sameehan Mahajani, Monica Frega, Laura Gasparini, Michela Chiappalone","doi":"10.3389/fneng.2013.00010","DOIUrl":"https://doi.org/10.3389/fneng.2013.00010","url":null,"abstract":"Hippocampal networks exhibit spontaneous electrophysiological activity that can be modulated by pharmacological manipulation and can be monitored over time using Micro-Electrode Arrays (MEAs), devices composed by a glass substrate and metal electrodes. The typical mode of activity of these dissociated cultures is the network-wide bursting pattern, which, if properly chemically modulated, can recall the ictal events of the epileptic phenotypes and is well-suited to study the effects of antiepileptic compounds. In this paper, we analyzed the changes induced by Carbamazepine (CBZ) and Valproate (VPA) on mature networks of hippocampal neurons in \"control\" condition (i.e., in the culturing medium) and upon treatment with the pro-convulsant bicuculline (BIC). We found that, in both control and BIC-treated networks, high doses (100 μM-1 mM) of CBZ almost completely suppressed the spiking and bursting activity of hippocampal neurons. On the contrary, VPA never completely abolish the electrophysiological activity in both experimental designs. Interestingly, VPA cultures pre-treated with BIC showed dual effects. In fact, in some cultures, at low VPA concentrations (100 nM-1 μM), we observed decreased firing/bursting levels, which returned to values comparable to BIC-evoked activity at high VPA concentrations (100 μM-1 mM). In other cultures, VPA reduced BIC-evoked activity in a concentration-independent manner. In conclusion, our study demonstrates that MEA-coupled hippocampal networks are responsive to chemical manipulations and, upon proper pharmacological modulation, might provide model systems to detect acute pharmacological effects of antiepileptic drugs. ","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"6 ","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2013-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2013.00010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31932274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58

Identification of a self-paced hitting task in freely moving rats based on adaptive spike detection from multi-unit M1 cortical signals. 基于多单元M1皮质信号自适应尖峰检测的自由运动大鼠自定节奏击打任务识别。

Frontiers in neuroengineering Pub Date : 2013-11-15 eCollection Date: 2013-01-01 DOI: 10.3389/fneng.2013.00011

Sofyan H H Hammad, Dario Farina, Ernest N Kamavuako, Winnie Jensen

{"title":"Identification of a self-paced hitting task in freely moving rats based on adaptive spike detection from multi-unit M1 cortical signals.","authors":"Sofyan H H Hammad, Dario Farina, Ernest N Kamavuako, Winnie Jensen","doi":"10.3389/fneng.2013.00011","DOIUrl":"https://doi.org/10.3389/fneng.2013.00011","url":null,"abstract":"Invasive brain-computer interfaces (BCIs) may prove to be a useful rehabilitation tool for severely disabled patients. Although some systems have shown to work well in restricted laboratory settings, their usefulness must be tested in less controlled environments. Our objective was to investigate if a specific motor task could reliably be detected from multi-unit intra-cortical signals from freely moving animals. Four rats were trained to hit a retractable paddle (defined as a \"hit\"). Intra-cortical signals were obtained from electrodes placed in the primary motor cortex. First, the signal-to-noise ratio was increased by wavelet denoising. Action potentials were then detected using an adaptive threshold, counted in three consecutive time intervals and were used as features to classify either a \"hit\" or a \"no-hit\" (defined as an interval between two \"hits\"). We found that a \"hit\" could be detected with an accuracy of 75 ± 6% when wavelet denoising was applied whereas the accuracy dropped to 62 ± 5% without prior denoising. We compared our approach with the common daily practice in BCI that consists of using a fixed, manually selected threshold for spike detection without denoising. The results showed the feasibility of detecting a motor task in a less restricted environment than commonly applied within invasive BCI research. ","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"6 ","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2013-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2013.00011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31920418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Characterization of affective states by pupillary dynamics and autonomic correlates. 瞳孔动力学和自主神经相关性对情感状态的表征。

Frontiers in neuroengineering Pub Date : 2013-11-06 eCollection Date: 2013-01-01 DOI: 10.3389/fneng.2013.00009

Francesco Onorati, Riccardo Barbieri, Maurizio Mauri, Vincenzo Russo, Luca Mainardi

{"title":"Characterization of affective states by pupillary dynamics and autonomic correlates.","authors":"Francesco Onorati, Riccardo Barbieri, Maurizio Mauri, Vincenzo Russo, Luca Mainardi","doi":"10.3389/fneng.2013.00009","DOIUrl":"10.3389/fneng.2013.00009","url":null,"abstract":"With the recent advent of new recording devices and an easier access to signal processing tools, researchers are increasingly exploring and studying the Pupil Dilation (PD) signal. Recently, numerous studies pointed out the relations between PD dynamics and psychophysiological states. Although it is well known that PD is controlled by the Autonomic Nervous System (ANS), and ANS responses are related to emotional events/stimuli, the relationship between emotional states and PD is still an open issue. The aim of this study is to define the statistical properties of the PD signal, to understand its relation with ANS correlates such as Heart Rate Variability (HRV) and respiration (RESP), and to explore if PD could provide information for the evaluation of the psychophysiological response of ANS to affective triggering events. ECG, RESP, and PD data from 13 normal subjects were recorded during a memory recall paradigm, and processed with spectral and cross-spectral analysis. Our results demonstrate that variability indices extracted from fast PD oscillations, not observable through standard cardiorespiratory identification in the frequency domain, would be able to discern psychophysiological responses elicited by basic emotional stimuli. A strong linear coupling was found between the variables, due to the influence of RESP on both PD and HRV within the High Frequency (HF) band, from 0.15 to 0.45 Hz. Most importantly, our results point at PD features as possible candidates for characterizing basic emotional stimuli. ","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"6 ","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2013-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31857734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A long-lasting wireless stimulator for small mammals. 小型哺乳动物的长效无线刺激器。

Frontiers in neuroengineering Pub Date : 2013-10-11 eCollection Date: 2013-01-01 DOI: 10.3389/fneng.2013.00008

Ian D Hentall

{"title":"A long-lasting wireless stimulator for small mammals.","authors":"Ian D Hentall","doi":"10.3389/fneng.2013.00008","DOIUrl":"https://doi.org/10.3389/fneng.2013.00008","url":null,"abstract":"The chronic effects of electrical stimulation in unrestrained awake rodents are best studied with a wireless neural stimulator that can operate unsupervised for several weeks or more. A robust, inexpensive, easily built, cranially implantable stimulator was developed to explore the restorative effects of brainstem stimulation after neurotrauma. Its connectorless electrodes directly protrude from a cuboid epoxy capsule containing all circuitry and power sources. This physical arrangement prevents fluid leaks or wire breakage and also simplifies and speeds implantation. Constant-current pulses of high compliance (34 volts) are delivered from a step-up voltage regulator under microprocessor control. A slowly pulsed magnetic field controls activation state and stimulation parameters. Program status is signaled to a remote reader by interval-modulated infrared pulses. Capsule size is limited by the two batteries. Silver oxide batteries rated at 8 mA-h were used routinely in 8 mm wide, 15 mm long and 4 mm high capsules. Devices of smaller contact area (5 by 12 mm) but taller (6 mm) were created for mice. Microstimulation of the rat's raphe nuclei with intermittent 5-min (50% duty cycle) trains of 30 μA, 1 ms pulses at 8 or 24 Hz frequency during 12 daylight hours lasted 21.1 days ±0.8 (mean ± standard error, Kaplan-Meir censored estimate, n = 128). Extended lifetimes (>6 weeks, no failures, n = 16) were achieved with larger batteries (44 mA-h) in longer (18 mm), taller (6 mm) capsules. The circuit and electrode design are versatile; simple modifications allowed durable constant-voltage stimulation of the rat's sciatic nerve through a cylindrical cathode from a subcutaneous pelvic capsule. Devices with these general features can address in small mammals many of the biological and technical questions arising neurosurgically with prolonged peripheral or deep brain stimulation. ","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"6 ","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2013-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fneng.2013.00008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31811311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

The blood-brain barrier: an engineering perspective. 血脑屏障：工程学视角。

Frontiers in neuroengineering Pub Date : 2013-08-30 DOI: 10.3389/fneng.2013.00007

Andrew D Wong, Mao Ye, Amanda F Levy, Jeffrey D Rothstein, Dwight E Bergles, Peter C Searson

{"title":"The blood-brain barrier: an engineering perspective.","authors":"Andrew D Wong, Mao Ye, Amanda F Levy, Jeffrey D Rothstein, Dwight E Bergles, Peter C Searson","doi":"10.3389/fneng.2013.00007","DOIUrl":"10.3389/fneng.2013.00007","url":null,"abstract":"It has been more than 100 years since Paul Ehrlich reported that various water-soluble dyes injected into the circulation did not enter the brain. Since Ehrlich's first experiments, only a small number of molecules, such as alcohol and caffeine have been found to cross the blood-brain barrier, and this selective permeability remains the major roadblock to treatment of many central nervous system diseases. At the same time, many central nervous system diseases are associated with disruption of the blood-brain barrier that can lead to changes in permeability, modulation of immune cell transport, and trafficking of pathogens into the brain. Therefore, advances in our understanding of the structure and function of the blood-brain barrier are key to developing effective treatments for a wide range of central nervous system diseases. Over the past 10 years it has become recognized that the blood-brain barrier is a complex, dynamic system that involves biomechanical and biochemical signaling between the vascular system and the brain. Here we reconstruct the structure, function, and transport properties of the blood-brain barrier from an engineering perspective. New insight into the physics of the blood-brain barrier could ultimately lead to clinical advances in the treatment of central nervous system diseases. ","PeriodicalId":73093,"journal":{"name":"Frontiers in neuroengineering","volume":"6 ","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2013-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31711976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0