Frontiers in clinical diabetes and healthcare最新文献

{"title":"The association between high fructose corn syrup and the development of type-2 diabetes.","authors":"Majid Almansouri","doi":"10.3389/fcdhc.2026.1785203","DOIUrl":"10.3389/fcdhc.2026.1785203","url":null,"abstract":"<p><p>Fructose and high-fructose corn syrup (HFCS) have become central to the debate on metabolic health and the rising prevalence of type 2 diabetes. Chemically, fructose is a monosaccharide found naturally in fruits and honey, whereas HFCS is an industrially produced sweetener composed of varying proportions of free fructose and glucose. While fructose has unique metabolic effects, its impact is comparable to other sugars when consumed in excess. HFCS is widely used in processed foods and sugar-sweetened beverages (SSBs) due to its high sweetness and low production cost. However, its metabolic effects remain a topic of scientific and public health concern. Animal and human studies suggest that excessive fructose consumption contributes to metabolic disturbances, including insulin resistance, impaired glucose tolerance, and increased fat accumulation in the liver through <i>de novo</i> lipogenesis (DNL). Unlike glucose, fructose bypasses key regulatory steps in glycolysis, leading to unregulated hepatic uptake and lipid synthesis. Epidemiological studies have reported a higher prevalence of type 2 diabetes in countries with greater HFCS availability, independent of obesity rates. Despite this, there remains controversy regarding whether HFCS is a direct contributor to diabetes or if overall energy intake plays a more significant role. This study aims to analyze the chemical composition of fructose and HFCS and their potential role in the development of type 2 diabetes. Additionally, it briefly discusses the global policy measures, such as sugar taxation and public health interventions, aimed at reducing sugar consumption and mitigating diabetes risk.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1785203"},"PeriodicalIF":3.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13035500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial support for adult-onset type 1 diabetes: the living with and adapting to type 1 diabetes programme - a cross-national feasibility study.","authors":"Mette Due-Christensen, Rhawann El Hakim, Daniel Piper, Ewa Romanczuk, Julie L Wad, Kirsty Winkley, Ingrid Willaing, Bryan Cleal, Angus Forbes","doi":"10.3389/fcdhc.2026.1749766","DOIUrl":"10.3389/fcdhc.2026.1749766","url":null,"abstract":"<p><strong>Background: </strong>Psychosocial challenges related to adult-onset type 1 diabetes are not systematically addressed in routine diabetes care. The Living with and Adapting to DiabetEs pRogramme (LADDER) was developed to support psychosocial adaptation to diabetes through two distinct interventions: 1) one-to-one consultations, and 2) group sessions. The LADDER interventions were tested in Denmark and the UK to evaluate the feasibility of 1) the research processes; 2) the delivery of the intervention; 3) collection of psychosocial and clinical outcomes and perceived benefits of participation; and to 4) identify key areas for improvement of the interventions.</p><p><strong>Methods: </strong>We aimed to examine the feasibility of the one-to-one consultations via a controlled design with either non-random (Denmark) or random allocation (UK) to intervention or usual care and the group sessions via a wait-list randomised trial (UK). Psychosocial outcomes were collected through questionnaires, and clinical outcomes were obtained from electronic records. A concurrent process evaluation was conducted through interviews with participants and healthcare professionals.</p><p><strong>Results: </strong>The recruitment target was reached in Denmark. Due to a lower-than-expected number of participants, randomisation was abandoned in the UK. Questionnaire response rates were low, and clinical data were difficult to obtain. Due to uncontrolled study designs, small sample sizes, and high questionnaire attrition, quantitative comparisons between intervention and control groups were not feasible. Qualitative findings suggested that the LADDER interventions may support psychosocial adaptation by facilitating reflection, articulation of concerns, and shared understanding within supportive clinical and peer contexts.</p><p><strong>Conclusion: </strong>Conducting an evaluation of the LADDER interventions through a controlled study was not feasible, likely due to small study populations at each site, combined with changes in clinical working following COVID-19. We suggest using a realist evaluation approach for a future larger study to explore what aspects of LADDER works, for whom and in which contexts.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1749766"},"PeriodicalIF":3.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13035499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary associations between pet ownership and mental health in youth with diabetes.","authors":"Noa R Mills, Erin K King, Megan K Mueller","doi":"10.3389/fcdhc.2026.1760110","DOIUrl":"10.3389/fcdhc.2026.1760110","url":null,"abstract":"<p><strong>Introduction: </strong>Youth with diabetes are at a higher risk for mental health challenges. Despite this awareness, there is much to learn how factors of a child's environment, such as pet ownership, may promote better diabetes-related health outcomes. This study assessed if pet ownership in diabetic youth was associated with anxiety/depression, parental stress, and A1C, as well as if geographic prevalence of diabetes differed by pet ownership status.</p><p><strong>Methods: </strong>Data were obtained from the Adolescent Brain Cognitive Development (ABCD) Study, including participants with pet ownership data (<i>n</i> = 9,802). Primary analyses were conducted with a subsample of youth with diabetes (<i>n</i> = 80).</p><p><strong>Results: </strong>There were no statistically significant relationships between pet ownership and anxiety/depression or parental stress. A1C levels among pet owners and non pet owners were explored (<i>n</i> = 10). In the full sample (<i>n</i> = 9,802), there was a significant difference between pet owners and non-pet owners on geographical diabetes prevalence where pet owners were more likely to live in communities with lower rates of diabetes.</p><p><strong>Conclusions: </strong>Pet ownership was not associated with mental health in families with diabetes. Preliminary analyses indicated the potential for an association between A1C and pet ownership as well as geographic prevalence of diabetes and living with a pet.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1760110"},"PeriodicalIF":3.5,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous glucose monitoring, diabetes distress, and well-being in adults with type 1 diabetes: findings from a National Survey in Lithuania.","authors":"Jurga Šuminienė, Rimantas Stukas, Virginija Gaigalaite, Dovilė Kriaučiūnienė, Natalja Istomina","doi":"10.3389/fcdhc.2026.1708124","DOIUrl":"10.3389/fcdhc.2026.1708124","url":null,"abstract":"<p><strong>Background: </strong>Continuous glucose monitoring (CGM) has transformed glycemic management in type 1 diabetes (T1D), yet its associations with general well-being remain heterogeneous.</p><p><strong>Objective: </strong>To examine associations between glucose monitoring modality and general well-being among adults with T1D in Lithuania and to explore relationships between diabetes distress, hypoglycemia confidence, and well-being, including within predefined higher-risk subgroups.</p><p><strong>Methods: </strong>A cross-sectional national online survey was conducted between December 2023 and May 2024 among 368 adults with T1D (171 using flash glucose monitoring [FGM] and 197 using continuous glucose monitoring [CGM]). Participants completed the WHO-5 Well-Being Index, Diabetes Distress Scale (DDS-17), and Hypoglycemia Confidence Scale. Multivariable logistic regression models were used to identify predictors of good well-being (WHO-5 ≥50) and high hypoglycemia confidence (≥3), adjusting for sociodemographic and clinical factors. Median duration of CGM use was 24 months (IQR 12-36).</p><p><strong>Results: </strong>Compared with FGM users, CGM users reported lower diabetes distress, higher hypoglycemia confidence, and higher median WHO-5 scores. After adjustment, CGM use was independently associated with high hypoglycemia confidence but not with good general well-being. Better glycemic stability (time in range >70%) and absence of recent acute events were independently associated with higher odds of good well-being. In selected higher-risk subgroups (unemployment, frequent non-severe hypoglycemia, and time in range <70%), CGM users more frequently reported good well-being; these findings represent cross-sectional associations.</p><p><strong>Conclusion: </strong>CGM use was associated with improved diabetes-specific emotional outcomes, particularly hypoglycemia confidence. Associations with general well-being appear to operate indirectly through glycemic stability and hypoglycemia-related factors. These findings support integrating CGM into comprehensive, patient-centered diabetes care models, particularly for individuals with elevated psychosocial vulnerability.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1708124"},"PeriodicalIF":3.5,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13021413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative burden of diabetes-related complications and health-related quality of life in primary care: a cross-sectional study from Mexico.","authors":"Ruben Silva-Tinoco, Lilia Castillo-Martínez, Ana Galindez-Fuentes, Alejandro Avalos-Bracho, Edward W Gregg, Teresa Cuatecontzi-Xochitiotzi, Christian Hinojosa-Segura, María Fernanda Bernal-Ceballos","doi":"10.3389/fcdhc.2026.1773692","DOIUrl":"10.3389/fcdhc.2026.1773692","url":null,"abstract":"<p><strong>Background: </strong>Understanding the coexistence of diabetes-related complications and their impact on quality of life can help guide healthcare strategies.</p><p><strong>Aim: </strong>The purpose of this study was to assess the prevalence and coexistence of diabetes-related complications and their association with health-related quality of life (HRQoL) in patients with type 2 diabetes (T2D).</p><p><strong>Methods: </strong>We conducted a cross-sectional study of 1,703 patients with T2D receiving standard care in primary healthcare units in Mexico. Diabetes-related complications assessed included peripheral neuropathy, retinopathy, chronic kidney disease, cardiovascular disease, and amputation history. HRQoL was measured using the EuroQol 5-Dimension 5-Level questionnaire. Multivariable regression analyses were used to adjust for confounders and assess associations with HRQoL.</p><p><strong>Results: </strong>Complications were present in 70.5% of patients, predominantly peripheral neuropathy. The most affected HRQoL dimensions were pain/discomfort (53.8%) and anxiety/depression (53.4%), followed by mobility (34.2%), self-care (34%), and usual activities (24.2%). Multivariable analysis showed female sex was independently associated with a higher likelihoodof reporting problems across all dimensions. Having at least one complication was also associated with impairment, except for anxiety/depression, where risk increased with two or more complications. Hypertension and use of insulin were associated with a higher risk of problems in mobility, selfcare, and usual activities. Longer diabetes duration and use of insulin were risk factors for pain/discomfort, while higher body mass index was associated with anxiety/depression.</p><p><strong>Conclusion: </strong>Diabetes-related complications are highly prevalent and affect HRQoL domains in primary care, with a greater burden as complications accumulate.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1773692"},"PeriodicalIF":3.5,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediabetes in acute coronary syndrome: an overlooked predictor of adverse outcomes.","authors":"Daniel Hakim, Louay Taha, Mohammad Karmi, Eyal Ben-Zvi, Asher Schnur, Rafael Hitter, Noam Fink, Pierre Sabouret, Mamas A Mamas, Ranim Aouda, Akiva Brin, Ari Naimark, Amjad Abu-Salaman, Michael Glikson, Elad Asher","doi":"10.3389/fcdhc.2026.1745724","DOIUrl":"10.3389/fcdhc.2026.1745724","url":null,"abstract":"<p><strong>Background: </strong>Hemoglobin A1c (HbA1c) is a well-established marker for long-term glycemic control and a diagnostic tool for diabetes mellitus (DM). The relationship between HbA1c levels and prognosis among acute coronary syndrome (ACS) patients is not well described. The aim of the current study was to assess HbA1c levels as an independent predictor of mortality in patients with ACS admitted to contemporary intensive cardiovascular care unit (ICCU).</p><p><strong>Methods: </strong>A retrospective single center study included all patients admitted to the ICCU between July 2019 and December 2024 with ACS. Patients were categorized by HbA1c levels into three groups: non-DM (<5.7%), pre-DM (5.7-6.4%), and DM (≥6.5%). Demographics, clinical characteristics, in-hospital complications, and long-term (up to 60 months) mortality were analyzed.</p><p><strong>Results: </strong>A total of 2,772 patients were admitted with a diagnosis of ACS and had HbA1c levels recorded at admission. Among them, 41.4% were non-diabetic, 29.1% had pre-diabetes, and 29.5% had diabetes. In-hospital mortality showed a gradual increase across these groups: 2.0% in non-diabetics, 1.6% in pre-diabetics, and 2.9% in diabetics (p = 0.294). Long-term mortality rose significantly with higher HbA1c categories, reaching 11.4%, 14.7%, and 18.1%, respectively (p<0.001). Multivariate analysis confirmed DM as an independent predictor of mortality (HR 1.635, 95% CI: 1.280-2.08, p<0.001).</p><p><strong>Conclusions: </strong>Over half of patients admitted with an ACS have evidence of dysglycemia. Both pre-DM and DM groups were associated with increased long-term mortality in ACS patients. The findings highlight the need for greater recognition and management, especially of pre-DM ACS patients in acute cardiovascular care.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1745724"},"PeriodicalIF":3.5,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant shortening of leukocyte telomeres one year after childbirth in women with type 1 diabetes mellitus: a prospective cohort study.","authors":"Mislav Herman, Marina Ivanisevic, Josip Djelmis","doi":"10.3389/fcdhc.2026.1776531","DOIUrl":"10.3389/fcdhc.2026.1776531","url":null,"abstract":"<p><strong>Background: </strong>Telomere shortening is influenced by biological and environmental factors, which are especially pronounced during and after pregnancy in women with type 1 diabetes mellitus (T1DM). This study investigates the dynamics of maternal leukocyte telomere length (LTL) during pregnancy and the postpartum period in women with T1DM.</p><p><strong>Methods: </strong>A prospective cohort of 74 pregnant women with T1DM was enrolled from February 2019 to January 2021 in Zagreb, Croatia. Leukocyte telomere length (LTL), measured as T/S ratio by quantitative PCR, was assessed at delivery (n=74) and one year postpartum (n=46).</p><p><strong>Result: </strong>At delivery, median LTL was 2.64 (IQR: 1.87-4.59). One year postpartum, median LTL decreased significantly to 1.87 (IQR: 1.23-2.46), representing a 29% relative reduction (P < 0.001, Wilcoxon signed-rank test, r = 0.72). Neither HbA1c levels nor BMI significantly influenced LTL at delivery. No significant difference in LTL was observed between term and preterm deliveries.</p><p><strong>Conclusions: </strong>Women with T1DM experience significant telomere shortening within the first year postpartum. While HbA1c and BMI showed no significant effects in this cohort, they remain potential modifiers of telomere dynamics and merit further investigation. These findings highlight the need for targeted postpartum care strategies in this high-risk population.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1776531"},"PeriodicalIF":3.5,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and outcomes of diabetes emergencies in nonagenarians admitted to ICU: a binational retrospective cohort study.","authors":"Kyle Williams, Je Min Suh, Nattaya Raykateeraroj, Elif I Ekinci, David Pilcher, Dong-Kyu Lee, Laurence Weinberg","doi":"10.3389/fcdhc.2026.1769848","DOIUrl":"10.3389/fcdhc.2026.1769848","url":null,"abstract":"<p><strong>Introduction: </strong>Nonagenarian patients admitted to Intensive Care Units (ICU) are expected to rise with an ageing population. However, diagnosis-specific data is lacking in this cohort to guide clinical decisions. This includes diabetic emergencies, namely hyperosmolar hyperglycemic state (HHS) and diabetic ketoacidosis (DKA), which carry substantial morbidity and mortality. We sought to determine the incidence, clinical characteristics, and outcomes of nonagenarians admitted to ICUs across Australia and New Zealand (ANZ) with DKA and HHS to provide foundations for evidence-based prognostication and resource allocation.</p><p><strong>Methods: </strong>We conducted a binational multi-center retrospective analysis of nonagenarian patients admitted to ANZ ICUs with DKA or HHS between 2018-2024. Data was sourced from the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation. Our primary outcome was to determine the incidence of nonagenarians ICU admissions for diabetic emergencies. Baseline characteristics, physiological and biochemical data, length-of-stay (LOS) and mortality were compared between groups. Multivariable regression models were used to explore associations between diagnosis, complications, interventions, and ICU and hospital LOS. Cox proportional hazards models assessed effects of diagnosis on ICU and hospital LOS, and mortality.</p><p><strong>Results: </strong>19,078 nonagenarian patients were admitted to an ANZ ICU during the study period, and 86 (0.45%) were admitted with DKA (55 (64.0%)) or HHS (31 (36.0%)). Pre-admission diabetes related complications were more prevalent in HHS compared to DKA (100% vs 80%, P = 0.004), with no other significant differences in demographic, clinical and biochemical measures. DKA patients had significantly lower odds of developing AKI compared to HHS (adjusted OR 0.29, 95% CI 0.08 to 0.98; P = 0.046). ICU and hospital LOS did not differ significantly between groups. ICU mortality occurred in 1 (1.8%) DKA patient and 3 (9.7%) HHS patients, and in-hospital mortality in 7 (12.7%) and 6 (19.4%) patients, respectively. Survival over 48-months did not differ between groups (log-rank P = 0.790).</p><p><strong>Conclusion: </strong>Our findings suggest favourable outcomes can be achieved in suitable nonagenarians with reversible endocrine emergencies through ICU admission. We provide the first detailed description of this cohort, where future functional outcomes and quality of life assessment post-ICU admission could further inform triage decision-making.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1769848"},"PeriodicalIF":3.5,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Community and clinical pharmacy services in type 2 diabetes care, volume II.","authors":"Muhammad Shahzad Aslam","doi":"10.3389/fcdhc.2026.1812553","DOIUrl":"10.3389/fcdhc.2026.1812553","url":null,"abstract":"","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1812553"},"PeriodicalIF":3.5,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and outcomes of diabetes mellitus amongst hospital admissions with <i>de novo</i> heart failure; a retrospective cohort study from a nationwide registry.","authors":"Ammar Chapra, Rasha Kaddoura, Ashfaq Patel, Tina Francis, Sharin Varghese, Mohamed Izham Mohamed Ibrahim, Jassim Shah, Haisam Alsadi, Abdelfatah Elasfar, Amr Badr, Rajvir Singh, Abdulrahman Arabi","doi":"10.3389/fcdhc.2026.1719223","DOIUrl":"10.3389/fcdhc.2026.1719223","url":null,"abstract":"<p><strong>Background: </strong>Diabetes Mellitus (DM) is a recognized risk factor for the development of acute and chronic heart failure (HF). <i>De Novo</i> HF (DNHF), defined as acute HF occurring in patients with no prior history of HF, is a distinct type which is usually seen in patients with established cardiovascular risk factors such as DM. However, in some cases, DNHF may be the initial manifestation of DM and lead to a new diagnosis of DM during admission for HF symptoms. The incidence of this occurrence is under-recognized in the setting of DNHF. Our study aimed to determine the incidence of newly diagnosed DM in patients presenting with DNHF and to determine any differences in clinical characteristics or short-term outcomes across the spectrum of DM.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted at the largest advanced HF center in Qatar. All patients admitted with DNHF were grouped as: 1) newly diagnosed DM, 2) pre-existing DM, 3) prediabetes, and 4) no DM. Clinical characteristics and in-hospital/post-discharge outcomes were described. Continuous variables were reported as mean with standard deviation or IQR and categorical variables as frequency distribution with percentage.</p><p><strong>Results: </strong>Among 260 patients with DNHF, 173 (66.5%) had DM, and 52 (20%) were prediabetic. Newly diagnosed DM was identified in 26 (10%), 147 (56.5%) were known diabetics. Compared with known DM, newly diagnosed patients were predominantly male (92.3% <i>vs</i>. 74.1%), had fewer comorbidities such as hypertension (84.6% <i>vs</i>. 90.5%), coronary artery disease (57.7% <i>vs</i> 79.6%), chronic kidney disease (11.5% <i>vs</i>. 29.9%), had a greater non-ischemic etiology of HF (30.4% <i>vs</i>. 23.2%), and higher prevalence of HFrEF (92.3% <i>vs</i> 70.3%). In-hospital mortality and readmissions were similar across all groups.</p><p><strong>Conclusion: </strong>Our findings indicate the high burden of dysglycemia (DM and prediabetes) that is present in DNHF patients. Furthermore, DNHF served as the initial clinical presentation of DM or prediabetes in approximately one-third of our patients. This underscores the need for routine metabolic screening in patients presenting with DNHF, as early identification and management of DM is crucial in this population to improve outcomes.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1719223"},"PeriodicalIF":3.5,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}