Frontiers in clinical diabetes and healthcare最新文献

{"title":"Insulin deficiency is associated with early postpartum T2DM in Indian women with gestational diabetes.","authors":"Puja Chebrolu, Mallika Alexander, Shilpa Naik, Megh Prajapati, Priyanka Raichur, Samhita Bellamkonda, Sanjaykumar Tambe, Vandana Kulkarni, Aditi Kole, Sanghamitra Pati, Myung Hee Lee, Daniel W Fitzgerald, Todd T Brown, K M Venkat Narayan, Jyoti S Mathad","doi":"10.3389/fcdhc.2026.1788084","DOIUrl":"10.3389/fcdhc.2026.1788084","url":null,"abstract":"<p><strong>Introduction: </strong>Women with gestational diabetes mellitus (GDM) are at increased risk of type 2 diabetes mellitus (T2DM). Understanding the pathophysiology of postpartum T2DM is crucial for prevention. We conducted a prospective study to characterize insulin mechanics in postpartum T2DM among women with GDM.</p><p><strong>Materials and methods: </strong>GDM was diagnosed by oral glucose tolerance test (OGTT) or oral glucose challenge test. We administered an OGTT at 6 weeks and 3, 6, and 12 months postpartum. Postpartum T2DM was defined by the American Diabetes Association criteria at any time point. We assessed whether the insulinogenic index (a measure of early-phase insulin secretion) or the Matsuda index (a measure of insulin sensitivity) at 6 weeks postpartum was associated with T2DM at any time point.</p><p><strong>Results: </strong>Of 100 women [median age 28 years (IQR 25-32), BMI 27.6 kg/m² (IQR 23.8-30.6) at 6 weeks postpartum], 42% (39) developed T2DM by 1 year postpartum. Among those with T2DM, 67% (26) were diagnosed at 6 weeks postpartum. Age, height, and baseline weight were similar in women with and without T2DM. Baseline triglycerides were higher (127.6 vs. 93.1 mg/dL, p=0.02) among women with T2DM. In proportional hazards analysis, a higher insulinogenic index at 6 weeks postpartum was protective against T2DM [aHR 0.24, 95% CI (0.11, 0.51], independent of age, BMI, triglycerides, and insulin use. The Matsuda index was not associated with T2DM (p=0.53).</p><p><strong>Conclusions: </strong>Over 40% of women with GDM developed T2DM by 12 months postpartum, most within 6 weeks. Insulin secretion was more strongly associated with T2DM than insulin sensitivity. Earlier screening and further study of the role of beta-cell preservation may help reduce T2DM among young Indian women.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1788084"},"PeriodicalIF":3.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13162042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yoga interventions and randomized controlled trials: key issues and the centered impact on sedentary lifestyle-associated cardiometabolic disorders.","authors":"Rakhi Radhamani, Shyam Diwakar","doi":"10.3389/fcdhc.2026.1805160","DOIUrl":"10.3389/fcdhc.2026.1805160","url":null,"abstract":"<p><strong>Introduction: </strong>Yoga training has been shown to reduce health risks associated with a sedentary lifestyle. This meta-analytical approach systematically assesses the impact of Hatha yoga on non-communicable diseases (NCDs) and cardiometabolic disorders linked to sedentary lifestyles, including type II diabetes, hypertension, and cardiovascular diseases (CVDs)-the key contributors to morbidity and mortality in India.</p><p><strong>Methods: </strong>Eighteen randomized controlled trials (RCTs) were selected from database searches (PubMed, Cochrane Central, Google Scholar, and Scopus) and involved patients diagnosed with NCDs. The meta-analysis included 644 participants for studies on diastolic blood pressure (DBP), 592 for those on systolic blood pressure (SBP), 1,387 for fasting blood glucose (FBG), 1,243 for postprandial blood sugar (PPBS), 963 for total cholesterol (TC), and 772 for low-density lipoprotein (LDL) levels.</p><p><strong>Results: </strong>Statistical analysis of the RCTs indicated that yoga training improved stress-related physiological responses, reduced the risk of hypertension, was a complementary intervention for diabetes management, and regulated lipid biomarkers associated with CVDs compared to control conditions (usual care or physical exercise). The variability between the studies and the resultant heterogeneity across the outcome measures may influence the precision of the pooled estimates. The observed effects reported in this study were indicative trends of yoga interventions in managing cardiometabolic disease-associated risk factors.</p><p><strong>Discussion: </strong>Yoga as a potential alternative and complementary therapeutic approach in mitigating risks from sedentary lifestyle-driven NCDs, particularly T2DM, HTN, and CVDs. We also report that heterogeneity among studies must be addressed by delivering standardized yoga protocols and yoga training strategies uniformly across diverse populations in future studies focusing on cardiometabolic outcome measures and yoga practices.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1805160"},"PeriodicalIF":3.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemichorea associated with non-ketotic hyperglycemia: a case report and literature review.","authors":"Zhou Liu, Juan Chen, Chao Gui Zhang, Yi Ming Xiang, Ao Lin Zhuang, Yi Li, Jing Jin Man, Gui You Li, Min Jie Fan, Hui Li","doi":"10.3389/fcdhc.2026.1746146","DOIUrl":"10.3389/fcdhc.2026.1746146","url":null,"abstract":"<p><p>Hemichorea associated with non-ketotic hyperglycemia (HC-NH) is a rare neurological complication and is also considered a specific complication of diabetes. Its exact pathogenesis remains unclear. We report a case of a 79-year-old female patient with HC-NH. Her primary clinical presentation included involuntary movements in the right limbs that began 3 days prior to admission. These movements worsened during emotional agitation and could be accompanied by insomnia but resolved after falling asleep. Imaging studies revealed no significant intracranial lesions on CT. MRI showed hyperintensity on T1-weighted images (T1WI) in the left globus pallidus and putamen and slightly lower signal intensity on T2-weighted imaging (T2WI). Fingerstick glucose monitoring during hospitalization showed only mild elevation, and urine ketones showed negative results. Treatment included glucose control, tiapride, Trihexyphenidyl, and haloperidol for choreiform movements, along with lorazepam to alleviate anxiety and tension. The patient showed slight improvement, and choreiform movements markedly diminished 3 months after discharge. This case demonstrates that blood glucose levels may not be markedly elevated at the onset of HC-NH, potentially leading to delayed or misdiagnosis. Additionally, symptom control may not achieve optimal results in the short term. Therefore, early diagnosis and treatment are crucial for the prognosis of this condition.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1746146"},"PeriodicalIF":3.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13152719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-rich plasma combined with multimodal therapy for diabetic foot ulcer with tophi: a case report.","authors":"Xinjie Duan, Xinjuan Sun, Yang Liu, Maoyuan Chen, Li Dong","doi":"10.3389/fcdhc.2026.1795474","DOIUrl":"10.3389/fcdhc.2026.1795474","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the comprehensive therapeutic value of platelet-rich plasma (PRP) combined with antibiotic-loaded bone cement, systemic metabolic management, and topical herbal preparation for diabetic foot ulcer (DFU) with tophi.</p><p><strong>Methods: </strong>A 55-year-old male with tophaceous DFU received multimodal treatment, including debridement, antibiotic-impregnated bone cement implantation, local autologous PRP injections, topical Xiang Lei Tang Zu Ointment, and systemic control of glucose and uric acid. Efficacy was assessed via wound area, laboratory tests, and imaging.</p><p><strong>Results: </strong>After 4 months, the ulcers were nearly healed with significant reduction in wound area, healthy granulation tissue, and complete re-epithelialization. Serum uric acid decreased from 564 μmol/L to normal range, alongside reduced inflammatory markers.</p><p><strong>Conclusion: </strong>This multimodal strategy integrating local anti-infection, bioactive repair, topical agents, and systemic regulation effectively controlled infection, promoted tissue regeneration, and improved the metabolic microenvironment, offering a promising integrative model for refractory tophaceous DFU.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1795474"},"PeriodicalIF":3.5,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of integrative therapies on glycemic control in type 1 diabetes: a systematic review and global research landscape.","authors":"Acharya Balkrishna, Jaya Upreti, Muskan Chauhan, Mayur Chauhan, Prashant Katiyar, Anurag Dabas, Vedpriya Arya","doi":"10.3389/fcdhc.2026.1739023","DOIUrl":"10.3389/fcdhc.2026.1739023","url":null,"abstract":"<p><strong>Background: </strong>Type 1 diabetes mellitus (T1DM) requires lifelong insulin therapy due to autoimmune destruction of pancreatic β-cells, the difficulty of achieving ideal glycemic control despite advancements in conventional care has led to a rise interest in alternative and integrative medicine (CIM) practices like naturopathy, yoga, and Ayurveda.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aimed to evaluate the effects of integrative therapies on glycemic control in individuals with T1DM and to map the global research landscape through bibliometric analysis.</p><p><strong>Methods: </strong>Following PRISMA, a thorough literature search was carried out in PubMed, Scopus, Embase, and Google Scholar. Included were studies evaluating CIM interventions for T1DM, such as yoga, naturopathy, and Ayurvedic treatments. Both qualitative and quantitative methods were used to synthesise the data, and bibliometric studies were conducted to evaluate country-level output, temporal trends, institutional contributions, and keyword network analysis.</p><p><strong>Results: </strong>Out 612 screened records, 12 studies met inclusion criteria for qualitative and quantitative analysis. Integrative therapies showed adjunctive benefits to insulin therapy, including improved glycemic control, insulin sensitivity, stress reduction and quality of life. After 2023, bibliometric study showed a growing research trend, In the context of citation impact, Italy and Vietnam are leading, whereas India leads in publications. Keyword network analysis revealed strong associations between integrative practices, particularly yoga and lifestyle modification and glycemic outcomes.</p><p><strong>Conclusion: </strong>Integrative therapies appear to be promising alternative in the management of T1DM, supporting glycemic control and holistic well-being. However, larger multicenter clinical trials are required to strengthen the evidence base and support their integration into standard diabetes care frameworks. Broader clinical integration, rigorous multicentric trials, and greater alignment with national AYUSH policies are recommended to optimize T1DM management in India and potentially enhance outcomes globally.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1739023"},"PeriodicalIF":3.5,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between sleep duration, insomnia and sleep patterns with metabolic syndrome: an integrative review.","authors":"Bekalu Bewket, Adriano Marçal Pimenta","doi":"10.3389/fcdhc.2026.1794920","DOIUrl":"10.3389/fcdhc.2026.1794920","url":null,"abstract":"<p><strong>Introduction: </strong>Due to the use of various methods across different studies, the association between sleep duration, insomnia and sleep pattern with metabolic syndrome (MetS) remains inconsistent. Integrative reviews that thoroughly synthesize data from various study types are therefore required in order to clarify the relationships between particular aspects of sleep and MetS. Therefore, this integrative review aimed to assess and summarize the most recent data regarding the relationship between sleep duration, sleep patterns and insomnia with MetS.</p><p><strong>Design: </strong>Integrative review.</p><p><strong>Methods: </strong>Problem identification, literature search, data evaluation, data analysis, and presentation five stage methodology developed by Whitmore and Knaff's (2005) guided this review. Four databases including; PubMed, Embase, Scopus and Web of Science were utilized. The quality of included studies were assessed by the Mixed Methods Appraisal Tool (2018). Conventional quantitative content analysis method was used to analyze extracted date and the preferred reporting items for systematic reviews and meta analyses checklist guided the reports of this review.</p><p><strong>Result: </strong>Initially a total of 25,472 articles were retrieved, 12 cross-sectional, 5 cohorts, 1 case-control studies were finally included. This study revealed sleep duration, insomnia and specific sleep characteristics such as; long daytime napping > 90 minutes, irregular sleep, social jetlag and early wake-up linked with increased risk of MetS.</p><p><strong>Conclusion: </strong>MetS is a complex problem and could be affected by the interaction of multiple sleep characteristics. Short sleep duration consistently was associated with MetS. However, the association between long sleep duration and insomnia with MetS remained inconsistent.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1794920"},"PeriodicalIF":3.5,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of the Roy Adaptation Model in clinical nursing care of an adolescent diagnosed with type 1 diabetes (case report).","authors":"Ecem Oksal Güneş, Senay Cetinkaya","doi":"10.3389/fcdhc.2026.1721420","DOIUrl":"10.3389/fcdhc.2026.1721420","url":null,"abstract":"<p><p>Adolescence is considered one of the most difficult periods in life due to the physical, cognitive, emotional and social changes that occur. With the developmental characteristics of adolescence and the existence of a chronic disease such as type 1 diabetes (T1D), adolescents may face problems such as a decrease in self-esteem, feeling different from their peers, and not being able to be included in peer groups. In this case report, nursing approaches to improve the physical, psychological, and psychosocial adaptation of an adolescent diagnosed with T1D were implemented based on the Roy Adaptation nursing model. In line with data obtained (with permission) from a 14 -year-old patient with T1D, pain, nutritional insufficiency, hyperglycemia, fatigue, decreased social interaction, lack of knowledge, anxiety, inadequacy in individual coping, ineffective role performance and impairment in social interaction were diagnosed and appropriate nursing interventions were implemented. In this context, the patient was given counseling and nursing care on the complications of diabetes, insulin administration training, and diet training, ensuring the organization of her self-concept, roles, and responsibilities, eliminating the lack of information regarding the diagnosis of diabetes, and ensuring compliance with the diagnosis of diabetes. At the end of the nursing interventions, the patient's pain was relieved. Since nausea is the cause of the patient's \"nutrition less than the body requirement\" problem, interventions to relieve nausea have yielded positive results. Fatigue decreased and the patient was more willing to perform activities. The patient's lack of information about her ilnesses was addressed. Despite all nursing interventions about the patient's role function and mutual interaction areas, she still expresses the changes caused by her illness in her school life with negative evaluations. In this case report, it was seen that the use of the Roy Adaptation Model was appropriate and beneficial, considering that the most common problems among adolescents hospitalized for T1D are physical, psychological, and psychosocial adaptation to the illness.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1721420"},"PeriodicalIF":3.5,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of infection in amputations in patients with diabetic foot ulcer: a retrospective study.","authors":"Kaitlyn Depinet, Bryce Hockman, Rodica Muraru, David A Ajayi, Zachary Carr, Beth Altenburger, Jaimee Haan, Gregory Westin, Emma Holler, Christopher A Harle, Mithun Sinha","doi":"10.3389/fcdhc.2026.1746688","DOIUrl":"10.3389/fcdhc.2026.1746688","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prevalence of infection in diabetic foot ulcers (DFUs) and its association with lower limb major and minor amputations, examining demographic and socioeconomic factors influencing DFU outcomes.</p><p><strong>Research design and methods: </strong>This retrospective study analyzed data from the Indiana Network for Patient Care (INPC) from January 2019 to May 2024. A total of 27,078 patients with DFUs were included, aged 9 to 103 years. Data included demographics, clinical encounters, ICD-10, CPT codes, laboratory values, and microbiological assessments. Analyses included Pearson correlation, logistic regression, and one-sample proportion tests.</p><p><strong>Results: </strong>Patients were predominately male (64.3%) and female (35.7%) with a mean age of 63.8 years. DFU prevalence showed significant inverse correlation with median income (r=0.2108, p=0.0016); lower-income areas (median income < $64,200) had DFU rates > 5.0 per 1,000 population. Of cultured specimens, 33.79% showed infections, primarily <i>Staphylococcus</i> spp. (22.52%) and <i>Streptococcus</i> spp. (11.27%). In major and minor amputation cases with microbial data available, <i>Staphylococcus</i> spp. (22.75%), <i>Enterococcus</i> spp. (11.86%) and <i>Streptococcus</i> spp. (10.42%) genera were most common. Osteomyelitis increased amputation odds by 7.83 times (p<0.001).</p><p><strong>Conclusions: </strong>Bacterial infections, particularly <i>Staphylococcus</i>, <i>Enterococcus</i> and <i>Streptococcus</i> genera were strongly associated with amputation risk. These findings have important clinical implications: early identification of these specific bacterial pathogens could guide targeted antibiotic therapy and inform risk stratification for amputation prevention. Improved bacterial identification could enhance DFU management and reduce complications such as amputation.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1746688"},"PeriodicalIF":3.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective observational cohort of algorithm-guided reassessment in diabetic foot: real-world outcomes and prognostic associations.","authors":"João Antônio Correa, Gabriela Tessaro Cremoneis, Paula Stefany Santos Caetano, Isabela Yones Nogara, Sidnei José Galego, Rafael Vilhena de Carvalho Furst, João Paulo Tardivo, Rodrigo Daminello Raimundo","doi":"10.3389/fcdhc.2026.1799455","DOIUrl":"10.3389/fcdhc.2026.1799455","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot is among the most frequent complications of diabetes mellitus (DM), with potentially dramatic consequences ranging from chronic wounds to major lower-limb amputations. The Tardivo Algorithm is a simple prognostic scoring system designed to support risk stratification and structured longitudinal reassessment in routine clinical care.</p><p><strong>Objective: </strong>To describe the real-world implementation and feasibility of dynamic risk reassessment using the Tardivo Algorithm in a prospective observational cohort of patients with diabetic foot managed in a vascular surgery outpatient setting, and to explore associations between baseline risk stratification and clinical outcomes.</p><p><strong>Methods: </strong>This prospective observational cohort study was conducted in a routine outpatient clinic for complex wounds. Adult patients with diabetic foot were classified according to the Tardivo Algorithm at baseline and underwent structured serial reassessments at each follow-up visit as part of usual multidisciplinary care. No comparator group was included. Patients were followed for 6-18 months, and outcomes were descriptively recorded as minor amputation, major amputation, wound in process of healing, or complete healing.</p><p><strong>Results: </strong>A total of 42 patients were followed for up to 18 months. Mean initial Tardivo score was 7.6 ± 4.8, with 19% classified as high risk (≥12 points). Limb preservation was observed in 94.3% of participants, and complete healing occurred in 57%, with a mean healing time of 5.05 ± 1.95 months. Higher baseline Tardivo scores were positively associated with peripheral arterial disease (r = 0.740; p < 0.001), while healing time correlated with both PAD (r = 0.547; p = 0.006) and prior amputations (r = 0.523; p = 0.009). These correlations were not independent in multivariable models. Findings reflect associations observed in a real-world, structured outpatient care model.</p><p><strong>Conclusion: </strong>In this prospective real-world cohort, structured application of the Tardivo Algorithm was feasible and allowed dynamic clinical monitoring. Clinical outcomes observed during follow-up are described within the context of this non-controlled design and should be interpreted as observational associations rather than indicators of therapeutic effect. Controlled studies are required to determine the independent impact of algorithm-guided reassessment and adjunctive therapies.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1799455"},"PeriodicalIF":3.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of patients with diabetic peripheral neuropathy: a retrospective descriptive study.","authors":"Dana Rashwan, Bashair M Mussa, Amena Sadiya, Rawoof Khan, Salah Abusnana","doi":"10.3389/fcdhc.2026.1792894","DOIUrl":"10.3389/fcdhc.2026.1792894","url":null,"abstract":"<p><strong>Background: </strong>Diabetic Peripheral Neuropathy (DPN) is a common complication of diabetes, particularly in regions with high disease prevalence, such as the United Arab Emirates (UAE). This study aims to describe the clinical characteristics of patients with DPN and compare differences in patient profiles according to the status of protective foot sensation.</p><p><strong>Methods: </strong>This retrospective cross-sectional study included 387 patients with Type 2 diabetes diagnosed with DPN at University Hospital Sharjah (UHS) between 2019 and 2024. Data were extracted from medical records. Patients were grouped by protective sensation status and compared using t-tests, chi-square tests, and logistic regression.</p><p><strong>Results: </strong>Among the cohort, 45% had Loss of Protective sensation(LOPS) and 55% had reduced protective sensation (RPS). Significant differences were observed in smoking status, active ulcers, amputation, Chronic Kidney Disease severity, lipid profile, and HbA1c levels. Multivariable regression analysis identified smoking (OR = 38.91), ulcer history (OR = 3.35), amputation (OR = 3.46), and severe CKD (OR = 6.04) as predictors of LOPS (all p<0.01).</p><p><strong>Conclusion: </strong>This study confirms prior findings on DPN and highlights new associations related to loss of protective sensation. Patients with LOPS had higher rates of smoking, renal dysfunction, dyslipidemia, foot complications, and osteomyelitis. Smoking, ulcer or amputation history, and advanced CKD were significantly associated with LOPS. These findings emphasize the need for early detection and targeted interventions to prevent DPN progression.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1792894"},"PeriodicalIF":3.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}