Frontiers in bioscience (Scholar edition)最新文献_第9页

Multifarious targets beyond microtubules-role of eribulin in cancer therapy. 微管以外的多种靶点——伊瑞布林在癌症治疗中的作用。

Frontiers in bioscience (Scholar edition) Pub Date : 2021-12-03 DOI: 10.52586/S559

Priya Seshadri, Barnali Deb, Prashant Kumar

{"title":"Multifarious targets beyond microtubules-role of eribulin in cancer therapy.","authors":"Priya Seshadri, Barnali Deb, Prashant Kumar","doi":"10.52586/S559","DOIUrl":"https://doi.org/10.52586/S559","url":null,"abstract":"Eribulin, a synthetic marine based drug has received extensive attention recently due to its promising anticancer activities against a wide variety of cancer types as evidenced by preclinical and clinical data. Eribulin is predominantly shown to exhibit microtubule inhibitory activity, however recent reports indicate that it acts via multiple molecular mechanisms targeting both the cancer cells as well as the tumor microenvironment. In this review, a comprehensive account on various modes of action of eribulin on cancer cells is presented along with important clinical aspects in the management of cancer through a comprehensive literature review. We have also highlighted approaches including combination therapy to improve the efficacy of eribulin in cancer treatment. Currently, eribulin is used to treat heavily pretreated patients with metastatic breast cancer, for which it gained FDA approval a decade ago and more recently, it has been approved for treating anthracycline-pretreated patients with metastatic liposarcoma. Novel therapeutic strategies should aim at resolving the toxicity and resistance conferred due to eribulin treatment so that it could be integrated in the clinics as a first-line treatment approach.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"13 2","pages":"157-172"},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39704108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Metformin-associated lactic acidosis and acute kidney injury in the era of COVID-19. 新冠肺炎时代二甲双胍相关性乳酸酸中毒与急性肾损伤

Frontiers in bioscience (Scholar edition) Pub Date : 2021-12-03 DOI: 10.52586/S563

Aikaterini Vordoni, Panagiotis Theofilis, Georgios Vlachopanos, Maria Koukoulaki, Rigas G Kalaitzidis

引用次数: 1

A short review on the influence of magnetic fields on neurological diseases. 磁场对神经系统疾病影响的简要综述。

Frontiers in bioscience (Scholar edition) Pub Date : 2021-12-03 DOI: 10.52586/S561

Richard H W Funk, Manfred Fähnle

引用次数: 7

Modern approaches and innovations in the diagnosis and treatment of peripheral vascular diseases. 外周血管疾病诊断和治疗的现代方法和创新。

Frontiers in bioscience (Scholar edition) Pub Date : 2021-12-03 DOI: 10.52586/S560

Richard Shi, Sateesh Babu

引用次数: 3

Mitochondrial mechanisms by which gasotransmitters (H₂S, NO and CO) protect cardiovascular system against hypoxia. 气体递质(H2S, NO和CO)保护心血管系统免受缺氧的线粒体机制。

Frontiers in bioscience (Scholar edition) Pub Date : 2021-12-03 DOI: 10.52586/S556

Irina Shemarova, Vladimir Nesterov, Larisa Emelyanova, Sergey Korotkov

{"title":"Mitochondrial mechanisms by which gasotransmitters (H2S, NO and CO) protect cardiovascular system against hypoxia.","authors":"Irina Shemarova, Vladimir Nesterov, Larisa Emelyanova, Sergey Korotkov","doi":"10.52586/S556","DOIUrl":"https://doi.org/10.52586/S556","url":null,"abstract":"Over past few years, there has been a dramatic increase in studying physiological mechanisms of the activity of various signaling low-molecular molecules that directly or indirectly initiate adaptive changes in the cardiovascular system cells (CVSC) to hypoxia. These molecules include biologically active endogenous gases or gasotransmitters (H2S, NO and CO) that influence on many cellular processes, including mitochondrial biogenesis, oxidative phosphorylation, K+/Ca2+ exchange, contractility of cardiomyocytes (CM) and vascular smooth muscle cells (VSMC) under conditions of oxygen deficiency. The present review focuses on the mechanistic role of the gasotransmitters (NO, H2S, CO) in cardioprotection. The structural components of these mechanisms involve mitochondrial enzyme complexes and redox signal proteins, K+ and Ca2+ channels, and mitochondrial permeability transition pore (MPTP) that have been considered as the final molecular targets of mechanisms underlying antioxidant and mild mitochondrial uncoupling effects, preconditioning, vasodilatation and adaptation to hypoxia. In this article, we have reviewed recent findings on the gasotransmitters and proposed a unifying model of mitochondrial mechanisms of cardioprotection.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"13 2","pages":"105-130"},"PeriodicalIF":0.0,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39816093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Fortification methods of coenzyme Q10 in yogurt and its health functionality-a review. 酸奶中辅酶Q10的强化方法及其保健功能综述

Frontiers in bioscience (Scholar edition) Pub Date : 2021-12-03 DOI: 10.52586/S557

Shaswati Sarma, Shiny Derose, Nagamaniammai Govindarajan, Musthafa Mohamed Essa, M Walid Qoronfleh, Saravana Babu Chidambaram, Buthaina Al-Bulushi

引用次数: 2

Approaches for network based drug discovery. 基于网络的药物发现方法。

Frontiers in bioscience (Scholar edition) Pub Date : 2021-06-30 DOI: 10.52586/S551

Priyanka Jayachandran, Suganya Ilango, Biswaranjan Paital, Shravani Bhanja, Ramalingam Nirmaladevi

引用次数: 0

Role of non-coding RNAs in Dengue virus-host interaction. 非编码rna在登革热病毒与宿主相互作用中的作用。

Frontiers in bioscience (Scholar edition) Pub Date : 2021-06-30 DOI: 10.52586/S552

Deeksha Madhry, Kush Kumar Pandey, Jaskaran Kaur, Yogita Rawat, Leena Sapra, Ravi Kumar Y S, Rupesh K Srivastava, Sankar Bhattacharyya, Bhupendra Verma

{"title":"Role of non-coding RNAs in Dengue virus-host interaction.","authors":"Deeksha Madhry, Kush Kumar Pandey, Jaskaran Kaur, Yogita Rawat, Leena Sapra, Ravi Kumar Y S, Rupesh K Srivastava, Sankar Bhattacharyya, Bhupendra Verma","doi":"10.52586/S552","DOIUrl":"https://doi.org/10.52586/S552","url":null,"abstract":"Dengue is potentially a life-threatening arthropod-borne viral infection for which there are no known therapeutic agents till date. Early stage diagnosis of dengue infection is still lacking. Diagnosis is only made after severe manifestations and later stages of infection. Timely prognosis can prevent dengue related mortalities. The nucleic acid-based therapy has potential to emerge as a promising approach for early diagnosis and treatment of this viral infection. Many studies have been carried out suggested the regulatory role of ncRNAs thereby revealing the importance of protein-RNA and RNA-RNA interactions during infection. Various regulatory RNAs are either expressed by mammalian cells or generated by viral RNA have reported to play important roles in viral life cycle including dengue virus. Thus exploring host-virus interaction will pave the novel path for understanding the pathophysiology of febrile infection in dengue. Rapid advances in sequencing techniques along with significant developments in the field of RNA studies has made RNA therapeutics as one of the promising approaches as antiviral targets. The idea of RNA based therapies has been greatly backed by a Hepatitis C virus drug, Miravirsen which has successfully completed phase II clinical trial. In the present review, we will discuss the implications of different non-coding RNAs in dengue infection. Differential expression of small ncRNA may serve as a reliable biomarker of disease severity during different stages of infection and can also play regulatory roles in disease progression.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"13 1","pages":"44-55"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39179962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Yoga in major depressive disorder: molecular mechanisms and clinical utility. 瑜伽在重度抑郁症中的作用:分子机制和临床应用。

Frontiers in bioscience (Scholar edition) Pub Date : 2021-06-30 DOI: 10.52586/S553

Madhuri Rajaneesh Tolahunase, Surabhi Gautam, Rajesh Sagar, Manoj Kumar, Rima Dada

引用次数: 3

Empty names, hallucinations, and semantics. 空名字、幻觉和语义。

Frontiers in bioscience (Scholar edition) Pub Date : 2021-06-30 DOI: 10.52586/S554

Fred Adams, Andrew Jackson

引用次数: 0