Frontiers in bioscience (Scholar edition)最新文献_第10页

Gut dysbiosis, insulin resistance and Alzheimer's disease: review of a novel approach to neurodegeneration. 肠道生态失调、胰岛素抵抗和阿尔茨海默病:一种治疗神经变性的新方法综述。

Frontiers in bioscience (Scholar edition) Pub Date : 2021-06-30 DOI: 10.52586/S550

Evelyn Lazar, Ayesha Sherzai, Jennifer Adeghate, Dean Sherzai

{"title":"Gut dysbiosis, insulin resistance and Alzheimer's disease: review of a novel approach to neurodegeneration.","authors":"Evelyn Lazar, Ayesha Sherzai, Jennifer Adeghate, Dean Sherzai","doi":"10.52586/S550","DOIUrl":"https://doi.org/10.52586/S550","url":null,"abstract":"Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) share many common features including inflammation, oxidative stress and neuronal degeneration. Insulin resistance (IR) appears to be a common path in these pathological processes. IR is an early pathogenic event in AD, which leads to augmentation of hyperphosphorylated tau and Amyloid beta (Aβ). The reviewed studies related to AD have revealed a positive association between T2DM and AD. This association was maintained in peripheral hyperinsulinemia cases without the presence of T2DM, which might be due to decreased insulin transport to the brain or the inadequate cerebral insulin production. Gut dysbiosis induces inflammation and consequently provokes both peripheral and cerebral IR and can amplify processes promoting AD. Additionally, the risk of increased progression of AD was revealed due to pre-diabetes, T2DM and gut dysbiosis. The pro-inflammatory changes might affect progression of AD pathology by inhibition of the autophago-lysosomal pathway and cerebral insulin signaling pathway. This review elaborates the role that cerebral IR might play in the underlying pathological events in AD.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"13 1","pages":"17-29"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39179960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Review article on COVID-19 and Guillain-Barré syndrome. 关于COVID-19和格林-巴罗综合征的综述文章。

Frontiers in bioscience (Scholar edition) Pub Date : 2021-06-30 DOI: 10.52586/S555

U Juhi Patnaik

{"title":"Review article on COVID-19 and Guillain-Barré syndrome.","authors":"U Juhi Patnaik","doi":"10.52586/S555","DOIUrl":"https://doi.org/10.52586/S555","url":null,"abstract":"The tale COVID infection pandemic or as far as we might be concerned better, COVID-19, has assaulted society on a worldwide scale. For the unenlightened, the sickness is brought about by the specific infection Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It is only from time to time that we have a pandemic seething on that has carried with itself a particularly humongous size of harm and on each and every front of the human culture, be it clinical, practical, social or pretty much anything. Theemerging coronavirus disease 2019 (COVID-19) has neurological symptoms comparable to that of the Extreme Acute Respiratory Syndrome Coronavirus (SARS-CoV) and MERS-CoV. Medical symptoms such as pain in head, vomiting, nausea, dizziness, muscle pain, anosmia, ageusia, and disorder of consciousness are present in COVID-19 affected people. These signs confirm that the COVID-19 infection affects the nervous system. But nerve affecting manifestations of COVID-19 infection are underreported. Guillain-Barré Syndrome (GBS) is a condition that often arises in various forms. According to the evaluation case reports so far from the start of COVID-19 infection, GBS could be associated with COVID-19 infection. There was a systematic review and published cases that suggested that a broad age range with male predominance was affected. There were respiratory and/or systemic symptoms in most patients and they developed GBS manifestations after COVID-19. However, asymptomatic cases of COVID-19 have also been identified. The distribution of clinical variants and electrophysiological subtypes is close to that of classical GBS, with a higher prevalence of classical sensorimotor form and acute inflammatory demyelinating polyneuropathy. It seems like it is important to pay attention to the neurological effects of COVID-19.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"13 1","pages":"97-104"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39180407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Volatile oil of Teucrium alopecurus sensitizes colon cancer cells to TRAIL-induced cell death. 白头草挥发油使结肠癌细胞对trail诱导的细胞死亡敏感。

Frontiers in bioscience (Scholar edition) Pub Date : 2021-06-30 DOI: 10.52586/S548

Fatma Guesmi, Sahdeo Prasad, Wiem Tahri, Imen Dridi, Manel Ben Ali, Amor Hedfi, Ismail A Ismail, Ahmed Landoulsi

{"title":"Volatile oil of Teucrium alopecurus sensitizes colon cancer cells to TRAIL-induced cell death.","authors":"Fatma Guesmi, Sahdeo Prasad, Wiem Tahri, Imen Dridi, Manel Ben Ali, Amor Hedfi, Ismail A Ismail, Ahmed Landoulsi","doi":"10.52586/S548","DOIUrl":"https://doi.org/10.52586/S548","url":null,"abstract":"TNF-related apoptosis-inducing ligand (TRAIL/Apo2L), a member of cytokine family, is known to selectively induce apoptosis in cancer cells. However, developing resistance to TRAIL is a major obstacle in cancer therapy. In this study, the in vitro effect of Teucrium alopecurus (TA) essential oil on inhibition of cancer cell growth and enhancing TRAIL-induced apoptosis were investigated in colon cancer cells. Untreated tumor cell lines are used as controls. TA induced cell death and increased the anticancer effects of TRAIL as observed by cell toxicity, live/dead assay, cleavage of caspases and PARP. Furthermore, the mechanism of anticancer potentiating effect of TA was found to be linked with the upregulation of death receptors (DRs) and reduced expression of TRAIL decoy receptors (DcRs). TA also down-regulated antiapoptotic proteins and induced p53 in colon cancer cells. In addition, we observed upregulation of MAPK signalling pathway (p38 kinase, JNK, ERK) and increased expression of C/EBP homologous transcription factor (CHOP) and specificity protein 1 (SP1) by TA. These findings demonstrate the potent anticancer effect of bioactive constituents of Teucrium alopecurus essential oil.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"13 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39179958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Is synaesthesia a predisposing factor to post-traumatic stress disorder? 联觉是创伤后应激障碍的诱发因素吗?

Frontiers in bioscience (Scholar edition) Pub Date : 2021-06-30 DOI: 10.52586/S549

Jamie Ward

引用次数: 1

Aberrant cardiac metabolism leads to cardiac arrhythmia. 心脏代谢异常导致心律失常。

Frontiers in bioscience (Scholar edition) Pub Date : 2020-06-01 DOI: 10.2741/S547

Martin Ezeani

引用次数: 1

Neural correlates of meditation: a review of structural and functional MRI studies. 冥想的神经关联:结构和功能MRI研究综述。

Frontiers in bioscience (Scholar edition) Pub Date : 2020-03-01 DOI: 10.2741/S542

Rui Ferreira Afonso, Inessa Kraft, Maria Adelia Aratanha, Elisa Harumi Kozasa

引用次数: 30

Epigenetic regulation as a promising tool for treatment of atherosclerosis. 表观遗传调控作为一种治疗动脉粥样硬化的有前途的工具。

Frontiers in bioscience (Scholar edition) Pub Date : 2020-03-01 DOI: 10.2741/S546

Daria Alexandrovna Skuratovskaia, Maria Alexandrovna Vulf, Aleksandra Komar, Elena Kirienkova, Larisa Sergeevna Litvinova

引用次数: 3

Role of natural compounds in preventing and treating breast cancer. 天然化合物在预防和治疗乳腺癌中的作用。

Frontiers in bioscience (Scholar edition) Pub Date : 2020-03-01 DOI: 10.2741/S544

Brianna Noel, Santosh Kumar Singh, James W Lillard, Rajesh Singh

{"title":"Role of natural compounds in preventing and treating breast cancer.","authors":"Brianna Noel, Santosh Kumar Singh, James W Lillard, Rajesh Singh","doi":"10.2741/S544","DOIUrl":"https://doi.org/10.2741/S544","url":null,"abstract":"Breast cancer (BrCa) is the most commonly diagnosed cancer and the second leading cause of cancer-related death in women. Alarming increases in the cases quests for more effective treatment of BrCa. As most chemotherapeutic drugs are associated with drug resistance, cancer relapse, and side effects, scientists are turning to agents with more efficacy, such as natural compounds for treatment and prevention of BrCa. Selected natural compounds, substances derived from living organisms, promote apoptosis and inhibit metastasis, preventing cancer growth. As a result, these compounds have the potential to suppress BrCa progression, thus increasing patient survival rates and decreasing the number of BrCa-related deaths. In this review, we summarize natural compounds that have displayed, anti-cancer effects on BrCa cells in various studies. These natural compounds inhibit the development of BrCa, suppress the growth of cancer cells, and promote cell death. We conclude that natural compounds are efficient, effective and promising agents for treating BrCa other than therapeutic methods.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"12 1","pages":"137-160"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326582/pdf/nihms-1598641.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37691131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

In vitro strategies to enhance oocyte developmental competence. 提高卵母细胞发育能力的体外策略。

Frontiers in bioscience (Scholar edition) Pub Date : 2020-03-01 DOI: 10.2741/S543

Vikash Chandra, Gutulla Taru Sharma

{"title":"In vitro strategies to enhance oocyte developmental competence.","authors":"Vikash Chandra, Gutulla Taru Sharma","doi":"10.2741/S543","DOIUrl":"https://doi.org/10.2741/S543","url":null,"abstract":"Oocyte quality influences early embryonic survival, establishment and maintenance of pregnancy, fetal development and adult diseases. The developmental competence of oocytes is acquired gradually and increases with follicular development. The ability of an oocyte to develop into an embryo depends on, having enough specific information in the form of mRNA or proteins. If this information is insufficient, defects in nuclear or cytoplasmic maturation, or in both processes, may arise and thus affect the in vitro development of fertilized oocytes. The greater developmental competence of oocytes aspirated from larger follicles is reported as compared with smaller follicles. Oocyte developmental competence is greatly correlated with the morphology of the cumulus oocyte complexes (COCs). Apart from morphological or biochemical markers, molecular markers have also been investigated. Until now, no specific markers of oocyte developmental competence could be described for the oocyte developmental competence. To, utilize female germplasm to its maximum, there is a need to enhance developmental competence of lesser competent oocytes derived from the follicles which are not fully grown. The oocyte pre-maturation and maturation conditions affect gene expression not only in the oocyte but till the blastocyst stages too. Strategies have been discussed in this review would be useful to enhance the developmental competence of oocytes.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"12 1","pages":"116-136"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37691235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Beneficial effect of ivabradine against cardiovascular diseases. 伊伐布雷定对心血管疾病的有益作用。

Frontiers in bioscience (Scholar edition) Pub Date : 2020-03-01 DOI: 10.2741/S545

Maria Alessandra Gammone, Graziano Riccioni, Francesco Massari, Nicolantonio D'Orazio

{"title":"Beneficial effect of ivabradine against cardiovascular diseases.","authors":"Maria Alessandra Gammone, Graziano Riccioni, Francesco Massari, Nicolantonio D'Orazio","doi":"10.2741/S545","DOIUrl":"https://doi.org/10.2741/S545","url":null,"abstract":"Coronary artery disease (CAD) and heart failure (HF) are major worldwide threat to health and well-being. Important progress in the treatment of CAD and HF have contributed to a decline in mortality around the world. A considerable number of epidemiological studies reported a strong independent association between elevated heart rate and major cardiovascular risk factors including atherosclerosis, ventricular arrhythmias, and left ventricular dysfunction. Ivabradine (IVA) is a pure heart rate-lowering agent with well-documented anti-anginal and anti-ischemic properties comparable to well-established anti-anginal agents, such as beta-blockers and calcium channel blockers. The heart rate reduction with IVA is beneficial in patients with CAD, chronic stable angina pectoris, and chronic HF, with an acceptable tolerance and safety profile. The pharmacodynamic and pharmacokinetic properties of this drug make it an important agent in the management of patients with CAD and HF. The aim of this short review is to explore recent results with IVA, a new medication that lowers heart rate by selectively inhibiting the If current, and to describe others future potential applications.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"12 1","pages":"161-172"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37691236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10