Frontiers in bioscience (Scholar edition)最新文献_第10页

In vitro strategies to enhance oocyte developmental competence. 提高卵母细胞发育能力的体外策略。

Frontiers in bioscience (Scholar edition) Pub Date : 2020-03-01 DOI: 10.2741/S543

Vikash Chandra, Gutulla Taru Sharma

{"title":"In vitro strategies to enhance oocyte developmental competence.","authors":"Vikash Chandra, Gutulla Taru Sharma","doi":"10.2741/S543","DOIUrl":"https://doi.org/10.2741/S543","url":null,"abstract":"Oocyte quality influences early embryonic survival, establishment and maintenance of pregnancy, fetal development and adult diseases. The developmental competence of oocytes is acquired gradually and increases with follicular development. The ability of an oocyte to develop into an embryo depends on, having enough specific information in the form of mRNA or proteins. If this information is insufficient, defects in nuclear or cytoplasmic maturation, or in both processes, may arise and thus affect the in vitro development of fertilized oocytes. The greater developmental competence of oocytes aspirated from larger follicles is reported as compared with smaller follicles. Oocyte developmental competence is greatly correlated with the morphology of the cumulus oocyte complexes (COCs). Apart from morphological or biochemical markers, molecular markers have also been investigated. Until now, no specific markers of oocyte developmental competence could be described for the oocyte developmental competence. To, utilize female germplasm to its maximum, there is a need to enhance developmental competence of lesser competent oocytes derived from the follicles which are not fully grown. The oocyte pre-maturation and maturation conditions affect gene expression not only in the oocyte but till the blastocyst stages too. Strategies have been discussed in this review would be useful to enhance the developmental competence of oocytes.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"12 1","pages":"116-136"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37691235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Beneficial effect of ivabradine against cardiovascular diseases. 伊伐布雷定对心血管疾病的有益作用。

Frontiers in bioscience (Scholar edition) Pub Date : 2020-03-01 DOI: 10.2741/S545

Maria Alessandra Gammone, Graziano Riccioni, Francesco Massari, Nicolantonio D'Orazio

{"title":"Beneficial effect of ivabradine against cardiovascular diseases.","authors":"Maria Alessandra Gammone, Graziano Riccioni, Francesco Massari, Nicolantonio D'Orazio","doi":"10.2741/S545","DOIUrl":"https://doi.org/10.2741/S545","url":null,"abstract":"Coronary artery disease (CAD) and heart failure (HF) are major worldwide threat to health and well-being. Important progress in the treatment of CAD and HF have contributed to a decline in mortality around the world. A considerable number of epidemiological studies reported a strong independent association between elevated heart rate and major cardiovascular risk factors including atherosclerosis, ventricular arrhythmias, and left ventricular dysfunction. Ivabradine (IVA) is a pure heart rate-lowering agent with well-documented anti-anginal and anti-ischemic properties comparable to well-established anti-anginal agents, such as beta-blockers and calcium channel blockers. The heart rate reduction with IVA is beneficial in patients with CAD, chronic stable angina pectoris, and chronic HF, with an acceptable tolerance and safety profile. The pharmacodynamic and pharmacokinetic properties of this drug make it an important agent in the management of patients with CAD and HF. The aim of this short review is to explore recent results with IVA, a new medication that lowers heart rate by selectively inhibiting the If current, and to describe others future potential applications.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"12 1","pages":"161-172"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37691236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Non-genetic rats models for atherosclerosis research: from past to present. 动脉粥样硬化研究的非遗传大鼠模型:从过去到现在。

Frontiers in bioscience (Scholar edition) Pub Date : 2019-06-01 DOI: 10.2741/S535

Francislaine Aparecida Dos Reis Livero, Arquimedes Gasparotto Junior

{"title":"Non-genetic rats models for atherosclerosis research: from past to present.","authors":"Francislaine Aparecida Dos Reis Livero, Arquimedes Gasparotto Junior","doi":"10.2741/S535","DOIUrl":"https://doi.org/10.2741/S535","url":null,"abstract":"Atherosclerosis is an inflammatory, progressive, and chronic illness that involves several molecular and epigenetic factors. Despite treatment limitations, clinical and therapeutic approaches have undeniably changed radically in recent decades through better knowledge of the pathophysiological basis of the disease, which has considerably improved patients' survival and quality of life. Some of these advances are attributable to basic biomedical research that provides insights into a better understanding and identification of new molecular and cellular targets for atherosclerosis treatment. Although rodent models have contributed substantially to a better understanding of the development of atherosclerosis, the accuracy of these models remains controversial. Research that utilizes genetic rodent models is well established, but the use of specific diets that are associated with other risk factors (e.g., hypertension, hormone deprivation, and pharmacological tools) is still debatable. The present review provides an update on non-genetic rat models of atherosclerosis and an overview of the main methodologies that are currently available.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"11 2","pages":"203-213"},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37281842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Detection to treatment and global impacts of algal toxins. 藻类毒素的检测、治疗和全球影响。

Frontiers in bioscience (Scholar edition) Pub Date : 2019-06-01 DOI: 10.2741/S536

Ali Parsaeimehr, Giovanni Antonio Lutzu, Mahzufur Rahman Shah, Roberto Parra Saldivar

引用次数: 3

Anticancer potential of natural products: a review focusing on Sri Lankan plants. 天然产物的抗癌潜力:以斯里兰卡植物为重点。

Frontiers in bioscience (Scholar edition) Pub Date : 2019-03-01 DOI: 10.2741/S532

Anchala Kuruppu, Priyani Paranagama, Ranil De Silva

{"title":"Anticancer potential of natural products: a review focusing on Sri Lankan plants.","authors":"Anchala Kuruppu, Priyani Paranagama, Ranil De Silva","doi":"10.2741/S532","DOIUrl":"https://doi.org/10.2741/S532","url":null,"abstract":"In the pharmaceutical industry, the expected surge in production of new therapeutic entities promised by technological advances, such as high-throughput screening, synthetic libraries and advances in molecular biology and genomics, has not materialized. The unique structural diversity of natural products continues to provide opportunities to discover novel compounds. Secondary metabolites, active components of natural products such as marine organisms, microbial organisms and terrestrial plants, are particularly exciting untapped resources for exploration as medicines. Sri Lanka is home to around 3700 plant species, half of which are considered as medicinal plants. Seventy per cent of the Sri Lankan population relies on this plant-based traditional medicine system for treating various illnesses such as tumors. As such these medicinal plant sources should be used to conquer terminal diseases and for prevention of diseases. Sri Lankan researchers have found several plant species that possess cytotoxic activity. This review summarizes the current information regarding the Sri Lankan plant materials that possess anticancer properties.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"11 1","pages":"161-177"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37034198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

----Delivery of siRNA therapeutics: PLGA nanoparticles approach. ---- siRNA疗法的递送:PLGA纳米颗粒方法。

Frontiers in bioscience (Scholar edition) Pub Date : 2019-03-01 DOI: 10.2741/S526

Jihane Matta, Rita Maalouf

引用次数: 5

Zebrafish embryo extract counteracts human stem cell senescence. 斑马鱼胚胎提取物对抗人类干细胞衰老。

Frontiers in bioscience (Scholar edition) Pub Date : 2019-03-01 DOI: 10.2741/S528

Federica Facchin, Silvia Canaider, Eva Bianconi, Margherita Maioli, Umberto Santoro, Sara Santaniello, Valentina Basoli, Pier Mario Biava, Carlo Ventura

{"title":"Zebrafish embryo extract counteracts human stem cell senescence.","authors":"Federica Facchin, Silvia Canaider, Eva Bianconi, Margherita Maioli, Umberto Santoro, Sara Santaniello, Valentina Basoli, Pier Mario Biava, Carlo Ventura","doi":"10.2741/S528","DOIUrl":"https://doi.org/10.2741/S528","url":null,"abstract":"Human adult stem cells hold promise for regenerative medicine. They are usually expanded for multiple passages in vitro to increase cell yield prior to transplantation. Unfortunately, prolonged culture leads to cell senescence, a major drawback from successful outcomes in cell therapy approaches. Here, we show that an extract from early Zebrafish embryo (ZF1) counteracted senescence progression in human adipose-derived stem cells (hASCs) along multiple culture passages (from the 5th to the 20th). Exposure to ZF1 strongly reduced the expression of senescence marker beta-galactosidase. Both stemness (NANOG, OCT4, and MYC) and anti-senescence (BMI1, and telomerase reverse transcriptase - TERT) related genes were overexpressed at specific experimental points, without recruitment of the cyclin-dependent kinase Inhibitor 2A (CDKN2A, ali-as p16). Increased telomerase activity was associatt-ed with TERT overexpression. Both osteogenic and adipogenic abilities were enhanced. In conclusion, hASCs exposure to ZF1 is a feasible tool to counteract and reverse human stem cell senescence in long-term culturing conditions.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"11 1","pages":"89-104"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37034194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Targeting risk factors for reducing the racially disparate burden in breast cancer. 针对危险因素减少乳腺癌的种族差异负担。

Frontiers in bioscience (Scholar edition) Pub Date : 2019-03-01 DOI: 10.2741/S531

Nikita Wright, Tomi Akinyemiju, Preeti Subhedar, Padmashree Rida, Ritu Aneja

{"title":"Targeting risk factors for reducing the racially disparate burden in breast cancer.","authors":"Nikita Wright, Tomi Akinyemiju, Preeti Subhedar, Padmashree Rida, Ritu Aneja","doi":"10.2741/S531","DOIUrl":"https://doi.org/10.2741/S531","url":null,"abstract":"African-American (AA) women are more likely to die from breast cancer (BC), at any age, compared to European-American women. Although breakthroughs in pre-clinical studies have resulted in potentially actionable targets in AA BC, drugs that were rationally designed for these targets have performed poorly in clinical trials. Challenges with interpatient and intratumoral heterogeneity, lack of drug sensitivity and specificity, suboptimal biomarker cut-offs, lack of drug response predictive biomarkers, drug side effects, high costs of drug development, and under-representation of AAs in clinical trials complicate the development of targeted therapies for AA BC patients. Accumulating evidence suggests that racial disparities exist in non-genetic risk factors that can alter genetic and epigenetic programs to promote breast tumorigenesis. Herein, we present a \"roadmap\" that addresses non-genetic risk factors that are suspected to contribute to the racial disparity in BC mortality. Increased targeting of these non-genetic risk factors may proffer a safer and more economical route to alleviating the racially disparate burden in BC.","PeriodicalId":73070,"journal":{"name":"Frontiers in bioscience (Scholar edition)","volume":"11 1","pages":"136-160"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37034197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Role of NO and other vascular mediators in the etiopathogenesis of necrotizing enterocolitis. 一氧化氮和其他血管介质在坏死性小肠结肠炎发病中的作用。

Frontiers in bioscience (Scholar edition) Pub Date : 2019-03-01 DOI: 10.2741/S524

Jayasree Nair, Satyan Lakshminrusimha

引用次数: 19

Time will tell: Circadian clock dysregulation in triple negative breast cancer. 时间会证明:三阴性乳腺癌的生物钟失调。

Frontiers in bioscience (Scholar edition) Pub Date : 2019-03-01 DOI: 10.2741/S533

Padmashree Rida, Mishal Imaan Syed, Ritu Aneja

引用次数: 9