Frontiers in bioscience (Landmark edition)最新文献_第4页

Persister Intestinal Bacteria, Epigenetics and Major Depression. 持久性肠道细菌，表观遗传学和重度抑郁症。

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Frontiers in bioscience (Landmark edition) Pub Date : 2025-03-31 DOI: 10.31083/FBL26837

Luis Vitetta, Matthew Bambling, Esben Strodl

引用次数: 0

Angiopoietin-Like Protein Family-Mediated Functions in Modulating Triglyceride Metabolism and Related Metabolic Diseases. 血管生成素样蛋白家族介导的调节甘油三酯代谢和相关代谢疾病的功能

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Frontiers in bioscience (Landmark edition) Pub Date : 2025-03-31 DOI: 10.31083/FBL25862

Sen Yang, Xin Su, Min Lai, Xiaoxi Liu, Ye Cheng

引用次数: 0

Elucidating the Role of Nrf2 Signaling Pathway in Mycoplasma Infections. 阐明Nrf2信号通路在支原体感染中的作用。

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Frontiers in bioscience (Landmark edition) Pub Date : 2025-03-28 DOI: 10.31083/FBL28286

Sarmistha Saha, Nadezhda Sachivkina, Olga Kuznetsova, Ekaterina Neborak, Natallia Zhabo

{"title":"Elucidating the Role of Nrf2 Signaling Pathway in Mycoplasma Infections.","authors":"Sarmistha Saha, Nadezhda Sachivkina, Olga Kuznetsova, Ekaterina Neborak, Natallia Zhabo","doi":"10.31083/FBL28286","DOIUrl":"https://doi.org/10.31083/FBL28286","url":null,"abstract":"Mycoplasmas are the smallest cell-wall-less self-replicating prokaryotes. Mycoplasma species can be found within and outside cells as \"silent parasites\" that live intracellularly and as membrane surface parasites. The pathogen's impact on respiratory health seems primarily caused by its capacity to alter immune responses, cause airway inflammation, and damage epithelial barriers. Much progress has been made in understanding Mycoplasma-induced inflammation and oxidative stress. However, there are still issues in therapeutic management, such as the development of strains that are resistant to antibiotics, the shortcomings of the available diagnostic techniques, and possible long-term respiratory consequences. On the other hand, to combat oxidative stress, inflammation, and metabolic abnormalities, activation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is becoming a more appealing therapeutic strategy. Nrf2 activation coordinates a thorough defense through its transcriptional targets, enabling adaptability and survival under a variety of cellular stressors. Nrf2 is regarded as a therapeutic target, and pharmacological Nrf2 activators have demonstrated protective effects in multiple pathological consequences and advantages in clinical trials. In this review, we discussed the rationale for targeting Nrf2 in a series of inflammatory responses caused by Mycoplasma species.","PeriodicalId":73069,"journal":{"name":"Frontiers in bioscience (Landmark edition)","volume":"30 4","pages":"28286"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linker Histones Maintain Genome Stability and Drive the Process of Cellular Ageing. 连接体组蛋白维持基因组稳定并驱动细胞衰老过程。

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Frontiers in bioscience (Landmark edition) Pub Date : 2025-03-28 DOI: 10.31083/FBL26823

George Miloshev, Penyo Ivanov, Bela Vasileva, Milena Georgieva

{"title":"Linker Histones Maintain Genome Stability and Drive the Process of Cellular Ageing.","authors":"George Miloshev, Penyo Ivanov, Bela Vasileva, Milena Georgieva","doi":"10.31083/FBL26823","DOIUrl":"https://doi.org/10.31083/FBL26823","url":null,"abstract":"Ageing comprises a cascade of processes that are inherent in all living creatures. There are fourteen general hallmarks of cellular ageing, the majority of which occur at a molecular level. A significant disturbance in the regulation of genome activity is commonly observed during cellular ageing. Overall confusion and disruption in the proper functioning of the genome are also well-known prerogatives of cancerous cells, and it is believed that this genomic instability provides a direct link between aging and cancer. The spatial organization of nuclear DNA in chromatin is the foundation of the fine-tuning and refined regulation of gene activity, and it changes during ageing. Therefore, chromatin is the platform on which genes and the environment meet and interplay. Different protein factors, small molecules and metabolites affect this chromatin organization and, through it, drive cellular deterioration and, finally, ageing. Hence, studying chromatin structural organization and dynamics is crucial for understanding life, presumably the ageing process. The complex interplay among DNA and histone proteins folds, organizes, and adapts chromatin structure. Among histone proteins, the role of the family of linker histones comes to light. Recent data point out that linker histones play a unique role in higher-order chromatin organization, which, in turn, impacts ageing to a prominent degree. Here, we discuss emerging evidence that suggests linker histones have functions that extend beyond their traditional roles in chromatin architecture, highlighting their critical involvement in genome stability, cellular ageing, and cancer development, thereby establishing them as promising targets for therapeutic interventions.","PeriodicalId":73069,"journal":{"name":"Frontiers in bioscience (Landmark edition)","volume":"30 4","pages":"26823"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yolkin Ameliorates Effects of the Psychic Stress on the Contact Sensitivity, Cell Proliferation, and Cytokine Production in Mice. 蛋黄素改善心理应激对小鼠接触敏感性、细胞增殖和细胞因子产生的影响。

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Frontiers in bioscience (Landmark edition) Pub Date : 2025-03-28 DOI: 10.31083/FBL27949

Michał Zimecki, Jolanta Artym, Maja Kocięba, Ewa Zaczyńska, Katarzyna Kaleta-Kuratewicz, Jan P Madej, Piotr Kuropka, Aleksandra Zambrowicz, Łukasz Bobak

{"title":"Yolkin Ameliorates Effects of the Psychic Stress on the Contact Sensitivity, Cell Proliferation, and Cytokine Production in Mice.","authors":"Michał Zimecki, Jolanta Artym, Maja Kocięba, Ewa Zaczyńska, Katarzyna Kaleta-Kuratewicz, Jan P Madej, Piotr Kuropka, Aleksandra Zambrowicz, Łukasz Bobak","doi":"10.31083/FBL27949","DOIUrl":"https://doi.org/10.31083/FBL27949","url":null,"abstract":"Background: Prolonged psychic stress leads to immune suppression, which preferentially affects the cellular immune response. Yolkin is an egg-derived protein with firmly established immunoregulatory activities in rodent models.Objective: The aim of this work was to evaluate the effects of oral administration of yolkin, when mice experience prolonged exposure to immobilization stress, on in vivo and in vitro parameters of contact sensitivity (CS) to oxazolone (OXA).Materials and methods: BALB/c mice were exposed to 5-day immobilization stress, followed by immunization with OXA. Yolkin was applied in drinking water during stress. Ear thickness and auricle histology, concanavalin A (Con A)- and lipopolysaccharide (LPS)-stimulated production of interferon-gamma (IFN γ) and interleukin 6 (IL-6) in splenocyte cultures, Con A-induced splenocyte proliferation, as well as serum corticosterone levels and thymocyte number were analyzed.Results: We showed that the treatment with stress alone led to a lower thymocyte number and a decreased thickness of the auricle skin. Control mice that were stressed also exhibited an increase in the number and area of pustules in the epidermis. The treatment of stressed mice with yolkin resulted in a partial normalization of several parameters that were lowered in stressed mice, such as auricle thickness, thymus cell content, Con A-induced splenocyte proliferation, production of IFN γ and IL-6. The serum levels of corticosterone were correlated with several histological parameters.Conclusion: Oral administration of yolkin normalizes the antigen-specific and nonspecific parameters of the immune system altered by chronic psychic stress in mice.","PeriodicalId":73069,"journal":{"name":"Frontiers in bioscience (Landmark edition)","volume":"30 4","pages":"27949"},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Plasma Biomarkers for Alzheimer's Disease: Insights from Organotypic Brain Slice and Microcontact Printing Techniques. 阿尔茨海默病的新型血浆生物标志物：来自器官型脑切片和微接触打印技术的见解。

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Frontiers in bioscience (Landmark edition) Pub Date : 2025-03-24 DOI: 10.31083/FBL36257

Sakir Necat Yilmaz, Katharina Steiner, Josef Marksteiner, Klaus Faserl, Bettina Sarg, Christian Humpel

{"title":"Novel Plasma Biomarkers for Alzheimer's Disease: Insights from Organotypic Brain Slice and Microcontact Printing Techniques.","authors":"Sakir Necat Yilmaz, Katharina Steiner, Josef Marksteiner, Klaus Faserl, Bettina Sarg, Christian Humpel","doi":"10.31083/FBL36257","DOIUrl":"10.31083/FBL36257","url":null,"abstract":"Background: Alzheimer's disease (AD) is a severe neurodegenerative disorder characterized by beta-amyloid plaques and tau neurofibrillary tangles. The diagnosis of AD is complex, with the analysis of beta-amyloid and tau in cerebrospinal fluid being a well-established diagnostic approach. However, currently no blood biomarkers have been identified or validated for clinical use. In the present study, we will identify novel plasma biomarkers for AD using our well-established organotypic mouse brain slice model connected to microcontact prints. We hypothesize that AD plasma contains factors that affect endothelial cell migration and new vessel formation.Methods: In the present study, plasma from human patients is microcontact printed and connected to mouse brain slices. After 4 weeks in culture, laminin+ and lectin+ endothelial cells (ECs) and vessels are analyzed by immunostaining techniques. The most promising samples were processed by differential mass spectrometry.Results: Our data show that AD plasma significantly increased the migration length of laminin+ and lectin+ ECs along the microcontact prints. Using differential mass spectrometry, we could identify three potential biomarkers: C-reactive protein, basigin, and trem-like transcript 1 protein.Conclusion: Here we show that brain slices connected to human plasma prints allow the identification of novel human AD biomarkers with subsequent mass spectrometry. This technique represents a novel and innovative approach to translate research findings from mouse models to human applications.","PeriodicalId":73069,"journal":{"name":"Frontiers in bioscience (Landmark edition)","volume":"30 3","pages":"36257"},"PeriodicalIF":3.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction: Zhu et al. Resveratrol reverts Streptozotocin-induced diabetic nephropathy. Frontiers in Bioscience (Landmark Edition). 2020; 25: 699-709. 撤稿：Zhu等。白藜芦醇可逆转链脲佐菌素引起的糖尿病肾病。生物科学前沿（里程碑版）。2020年;25日:699 - 709。

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Frontiers in bioscience (Landmark edition) Pub Date : 2025-03-24 DOI: 10.31083/FBL39230

引用次数: 0

Effect of HepG2-Derived Exosome with PDGF-D Knockdown on Transformation of Normal Fibroblasts into Tumor-Associated Fibroblasts in Liver Cancer. 敲除 PDGF-D 的 HepG2 外泌体对肝癌中正常成纤维细胞向肿瘤相关成纤维细胞转化的影响

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Frontiers in bioscience (Landmark edition) Pub Date : 2025-03-21 DOI: 10.31083/FBL26045

Yan-Yan Wu, Liu-Shen-Yan Yu, Han-Yu Zhou, Jun-Chao Xue

{"title":"Effect of HepG2-Derived Exosome with PDGF-D Knockdown on Transformation of Normal Fibroblasts into Tumor-Associated Fibroblasts in Liver Cancer.","authors":"Yan-Yan Wu, Liu-Shen-Yan Yu, Han-Yu Zhou, Jun-Chao Xue","doi":"10.31083/FBL26045","DOIUrl":"10.31083/FBL26045","url":null,"abstract":"Background: It is known that the transformation of liver cancer-mediated fibroblasts into cancer-related fibroblasts (CAFs) is beneficial to the development of liver cancer. However, the specific mechanism is still unclear.Methods: Human hepatocarcinoma (HepG2) cells were treated with short hairpin RNA (shRNA) of platelet-derived growth factor-D (shPDGF-D) vector, and the exosomes secreted by the cells were separated using ultracentrifugation and identified by using nanoparticle tracking analysis, transmission electron microscope, and western blot analysis. Exosomes were co-cultured with mouse primary fibroblasts, and then the activity, proliferation, cell cycle, migration, epithelial-mesenchymal transition- (EMT-) and CAF marker-related protein expression levels of fibroblasts were determined by cell counting kit-8 (CCK-8), immunofluorescence, flow cytometry, wound healing, real-time reverse transcription-PCR, and western blotting assays, respectively. Co-cultured fibroblasts were mixed with HepG2 cells and injected subcutaneously into mice to construct animal models. The size and weight of xenograft tumor and the expression of epithelial-mesenchymal transition- (EMT-), angiogenesis- and CAFs marker-related proteins were detected.Results: The exosomes inhibited the proliferation, migration, EMT, and induced cell cycle arrest, as well as decreased the expression of α-SMA, FAP, MMP-9, and VEGF in fibroblasts. In vivo, sh-PDGF-D inhibited tumor growth, reduced the expressions of CD31, vimentin, α-SMA, FAP, MMP9, and VEGF, and promoted the expression of E-cadherin.Conclusions: Exosomes derived from HepG2 cells transfected with shPDGF-D prevent normal fibroblasts from transforming into CAFs, thus inhibiting angiogenesis and EMT of liver cancer.","PeriodicalId":73069,"journal":{"name":"Frontiers in bioscience (Landmark edition)","volume":"30 3","pages":"26045"},"PeriodicalIF":3.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD44 and Its Role in Solid Cancers - A Review: From Tumor Progression to Prognosis and Targeted Therapy. CD44及其在实体癌中的作用——综述：从肿瘤进展到预后和靶向治疗。

IF 3.3

Frontiers in bioscience (Landmark edition) Pub Date : 2025-03-21 DOI: 10.31083/FBL24821

João Martins Gama, Rui Caetano Oliveira

{"title":"CD44 and Its Role in Solid Cancers - A Review: From Tumor Progression to Prognosis and Targeted Therapy.","authors":"João Martins Gama, Rui Caetano Oliveira","doi":"10.31083/FBL24821","DOIUrl":"10.31083/FBL24821","url":null,"abstract":"Cluster of differentiation 44 (CD44) is a transmembrane protein expressed in normal cells but overexpressed in several types of cancer. CD44 plays a major role in tumor progression, both locally and systemically, by direct interaction with the extracellular matrix, inducing tissue remodeling, activation of different cellular pathways, such as Akt or mechanistic target of rapamycin (mTOR), and stimulation of angiogenesis. As a prognostic marker, CD44 has been identified as a major player in cancer stem cells (CSCs). CSCs with a CD44 phenotype are associated with chemoresistance, alone or in combination with other CSC markers, such as CD24 or aldehyde dehydrogenase 1 (ALDH1), and may be used for patient stratification. In the therapy setting, CD44 has been explored as a viable target, directly or indirectly. It has revealed promising potential, paving the way for its future use in the clinical setting. Immunohistochemistry effectively detects CD44 overexpression, enabling patients to be accurately selected for surgery and targeted anti-CD44 therapies. In this review, we highlight the properties of CD44, its expression in normal and tumoral tissues through immunohistochemistry and potential treatment options. We also discuss the clinical significance of this marker and its added value in therapeutic decision-making.","PeriodicalId":73069,"journal":{"name":"Frontiers in bioscience (Landmark edition)","volume":"30 3","pages":"24821"},"PeriodicalIF":3.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NOL6 Promotes Tumor Progression by Facilitating Cancer Cell-Induced Platelet Aggregation and Angiogenesis in Breast Cancer. 在乳腺癌中，NOL6通过促进癌细胞诱导的血小板聚集和血管生成促进肿瘤进展。

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Frontiers in bioscience (Landmark edition) Pub Date : 2025-03-21 DOI: 10.31083/FBL25361

Tingting Zhang, Cheng Lu, Mingming Lv, Shengwang Du, Xinjun Wu

{"title":"NOL6 Promotes Tumor Progression by Facilitating Cancer Cell-Induced Platelet Aggregation and Angiogenesis in Breast Cancer.","authors":"Tingting Zhang, Cheng Lu, Mingming Lv, Shengwang Du, Xinjun Wu","doi":"10.31083/FBL25361","DOIUrl":"10.31083/FBL25361","url":null,"abstract":"Background: Breast cancer (BC) is a prevalent malignancy among women, and numerous investigations have reported that platelet aggregation may play a role in BC progression. Thus, identifying new targets for BC is essential. In this regard, we focused on nucleolar protein 6 (NOL6), located on chromosome 9p13, which is implicated in tumor development.Objective: To investigate NOL6 expression in BC, examine its role in platelet aggregation and angiogenesis, and elucidate the underlying mechanisms.Methods: Bioinformatic analyses, immunoblotting, and quantitative real-time polymerase chain reaction (qPCR) were performed to assess NOL6 expression in BC. Cell counting kit-8 (CCK-8) and 5-ethynyl-2'-deoxyuridine (EdU) assays were conducted to determine the impact of NOL6 on BC cell proliferation. Immunostaining, enzyme-linked immunosorbent assay (ELISA), and flow cytometry (FCM) assays were utilized to analyze the effects of NOL6 on platelet aggregation. Tube formation and transwell assays were performed to examine angiogenesis and invasion, immunoblot assays were used to confirm the underlying mechanisms, and tumor growth assays in mice were conducted to validate the findings in vivo.Results: NOL6 was found to be highly expressed in BC and was associated with patient prognosis, platelet aggregation, and angiogenesis. Its knockdown inhibited BC cell proliferation and reduced platelet aggregation induced by BC cells. Additionally, NOL6 depletion impaired angiogenesis and migration of BC cells. In vivo studies confirmed that NOL6 promotes tumor growth. Mechanistically, NOL6 enhances the Twisted spiral transcription factor 1 (Twist1)/galectin-3 axis, contributing to BC progression.Conclusions: NOL6 can promote tumor progression by facilitating platelet aggregation and angiogenesis in BC cells through the Twist1/galectin-3 axis.","PeriodicalId":73069,"journal":{"name":"Frontiers in bioscience (Landmark edition)","volume":"30 3","pages":"25361"},"PeriodicalIF":3.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0