Advances in Dental Research最新文献_第10页

Future innovation and research in dental restorative materials. 口腔修复材料的未来创新与研究。

Advances in Dental Research Pub Date : 2013-11-01 DOI: 10.1177/0022034513502205

E D Rekow, C H Fox, T Watson, P E Petersen

{"title":"Future innovation and research in dental restorative materials.","authors":"E D Rekow, C H Fox, T Watson, P E Petersen","doi":"10.1177/0022034513502205","DOIUrl":"https://doi.org/10.1177/0022034513502205","url":null,"abstract":"lifetime superiority over currently available Bis-GMA/TEGDMA-based systems (http://grants.nih.gov/grants/guide/rfa-files/ RFA-DE-13-001.html). Together, these challenges prompted the International Association for Dental Research (IADR), the World Health Organization (WHO), the United Nations Environmental Programme (UNEP), the FDI World Dental Federation (FDI), and King’s College London Dental Institute to sponsor a joint workshop in December 2012 to explore innovations in dental materials, with particular emphasis on direct restorative materials. It is recognized, however, that the availability and acceptance of new materials depend on factors far broader than their properties alone. Consequently, we engaged a dynamic group of experts to address the full scope of hurdles to design, produce, approve, and utilize any new but especially innovative materials. These experts were drawn from both dental and non-dental academic institutions, and industry, along with those from policy, research funding, and professional organizations. The presentations were thought provoking and the discussion lively. This issue of Advances in Dental Research offers highlights and summaries of the conversations in the following sessions:","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"25 1","pages":"2-7"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034513502205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31810420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Incorporating new materials and techniques into clinical practice. 将新材料和新技术应用于临床实践。

Advances in Dental Research Pub Date : 2013-11-01 DOI: 10.1177/0022034513502209

N B Pitts, J Drummond, R Guggenberger, P Ferrillo, S Johnston

{"title":"Incorporating new materials and techniques into clinical practice.","authors":"N B Pitts, J Drummond, R Guggenberger, P Ferrillo, S Johnston","doi":"10.1177/0022034513502209","DOIUrl":"https://doi.org/10.1177/0022034513502209","url":null,"abstract":"This article outlines the subjects presented and discussed at the December 2012 IADR Dental Materials Innovation Workshop held at King's College London. Incorporating new materials and techniques into clinical practice was considered from 4 perspectives: (1) Accelerating the \"research to regulatory approval\" process was presented with current developments in the United States, with the National Institutes of Health/Food and Drug Administration process as a working example; (2) intellectual property and regulatory requirements were discussed across the well-established US and EU frameworks, as well as the more recently developed procedures across Brazil, Russia, India, and China; (3) the challenges and opportunities of incorporating innovations into dental education were considered with reference to the future needs of both students and faculty; and (4) the key but difficult and unpredictable step of translating such innovations into routine dental practice was then explored. Constructive and far-ranging discussion among the broadly based Workshop participants (from dental research, education, practice, and industry, as well as environmental organizations and the World Health Organization) mapped out key issues for the future. The focus was on facilitating the more timely adoption of improvements in both materials and techniques to improve patient health and health systems, while minimizing environmental impact. ","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"25 1","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034513502209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31810424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Next-generation sequencing approaches to understanding the oral microbiome. 了解口腔微生物组的新一代测序方法。

Advances in Dental Research Pub Date : 2012-09-01 DOI: 10.1177/0022034512449466

E Zaura

{"title":"Next-generation sequencing approaches to understanding the oral microbiome.","authors":"E Zaura","doi":"10.1177/0022034512449466","DOIUrl":"https://doi.org/10.1177/0022034512449466","url":null,"abstract":"Until recently, the focus in dental research has been on studying a small fraction of the oral microbiome-so-called opportunistic pathogens. With the advent of next-generation sequencing (NGS) technologies, researchers now have the tools that allow for profiling of the microbiomes and metagenomes at unprecedented depths. The major advantages of NGS are the high throughput and the fact that specific taxa do not need to be targeted. The relatively low cost and the availability of sequencing facilities have contributed to nearly exponential growth of NGS datasets. The quality and interpretation of the NGS data could be undermined at numerous steps-from sample collection, storage, and DNA extraction to PCR bias, sequencing errors, choice of algorithms for data processing, and statistical analyses. Making sense out of this data deluge is and will be the major challenge. The community analyses based on systems ecology principles will bring us closer to an understanding of the underlying forces that facilitate the stability (or imbalance) of the microbiome. The next logical step will take us beyond the microbiome. The integration of bacterial, viral, fungal \"meta-omes\" such as the meta-transcriptome, meta-proteome, and meta-metabolome, together with the host as a major co-factor, should be the ultimate goal in unraveling the complexity of the oral interactome.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"24 2","pages":"81-5"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034512449466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30840790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 73

Clinical efficacy and effects of xylitol wipes on bacterial virulence. 木糖醇湿巾的临床疗效及对细菌毒力的影响。

Advances in Dental Research Pub Date : 2012-09-01 DOI: 10.1177/0022034512449835

L Zhan, J D B Featherstone, J Lo, C Krupansky, N Hoang, P DenBesten, T Huynh

{"title":"Clinical efficacy and effects of xylitol wipes on bacterial virulence.","authors":"L Zhan, J D B Featherstone, J Lo, C Krupansky, N Hoang, P DenBesten, T Huynh","doi":"10.1177/0022034512449835","DOIUrl":"https://doi.org/10.1177/0022034512449835","url":null,"abstract":"The aim of the study was to investigate whether xylitol-wipe use in young children prevented caries by affecting bacterial virulence. In a double-blinded randomized controlled clinical trial, 44 mother-child pairs were randomized to xylitol-wipe or placebo-wipe groups. Salivary mutans streptococci levels were enumerated at baseline, 6 months, and one year. Ten mutans streptococci colonies were isolated and genotyped from each saliva sample. Genotype-colonization stability, xylitol sensitivity, and biofilm formation of these isolates were studied. Despite a significant reduction in new caries at one year in the xylitol-wipe group, no significant differences were found between the two groups in levels of mutans streptococci. Children in the xylitol-wipe group had significantly fewer retained genotypes (p = 0.06) and more transient genotypes of mutans streptococci (p = 0.05) than those in the placebo-wipe group. At one year, there was no significant difference in the prevalence of xylitol-resistant genotypes or in biofilm formation ability of mutans streptococci isolates between the two groups. The mechanism of the caries-preventive effect of xylitol-wipe use may be related to the stability of mutans streptococci colonization. Further studies with genomic characterization methods are needed to determine specific gene(s) that account for the caries-preventive effect of xylitol.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"24 2","pages":"117-22"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034512449835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30839778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Remineralization agents - new and effective or just marketing hype? 矿化剂-新的和有效的或只是营销炒作?

Advances in Dental Research Pub Date : 2012-09-01 DOI: 10.1177/0022034512454295

R J M Lynch, S R Smith

{"title":"Remineralization agents - new and effective or just marketing hype?","authors":"R J M Lynch, S R Smith","doi":"10.1177/0022034512454295","DOIUrl":"https://doi.org/10.1177/0022034512454295","url":null,"abstract":"This is a review of the need for better remineralization and of the status of calcium-based remineralizing agents for use in anti-caries toothpastes. Use of fluoride toothpastes has markedly reduced caries. However, the decline may be over or in reverse. There is a limit to what fluoride alone can do; complementary agents are needed. Using plaque as a reservoir for calcium-based agents holds promise. Plaque fluid is already supersaturated with respect to relevant calcium phosphates at neutral pH; extra calcium may lead to surface-blocking and sub-optimal lesion consolidation. However, at cariogenic pH, lesions may be more porous to the ingress of mineral, leading to fuller consolidation, and controlled release of calcium should reduce undersaturation with respect to enamel and accelerate deposition of fluorhydroxyapatite. Clinical data to validate in vitro screening models are scarce. Direct progression to in situ models may often be appropriate. The spectrum of lesion types, from softening to relatively advanced subsurface, and lesion activity should be considered. Far from being 'marketing hype', progress with calcium-based remineralizing agents is both encouraging and scientifically sound. Clinical evidence exists for the efficacy of some agents, but further unequivocal clinical data are needed before these agents might be considered 'effective' when delivered from toothpaste.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"24 2","pages":"63-7"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034512454295","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30840786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 52

The role of matrix metalloproteinases in dental erosion. 基质金属蛋白酶在牙侵蚀中的作用。

Advances in Dental Research Pub Date : 2012-09-01 DOI: 10.1177/0022034512455029

M A R Buzalaf, M T Kato, A R Hannas

{"title":"The role of matrix metalloproteinases in dental erosion.","authors":"M A R Buzalaf, M T Kato, A R Hannas","doi":"10.1177/0022034512455029","DOIUrl":"https://doi.org/10.1177/0022034512455029","url":null,"abstract":"This review discusses the role of matrix metalloproteinases (MMPs) in the development of dentin erosion and the protective effects of MMP inhibitors, based on recent evidence from in vitro and in situ studies. MMPs are present in both dentin and saliva and play an important role in dentin erosion progression. Enzymatic removal of the organic matrix by MMPs increases the demineralization process, since the demineralized organic matrix has been shown to hamper ionic diffusion after an acidic challenge. Recent evidence from in vitro and in situ studies has shown a protective role of MMP inhibitors against dentin erosion and erosion plus abrasion. The inhibitors tested were green tea and its active epigallocatechin-gallate (EGCG), ferrous sulfate, and chlorhexidine. They have been tested in dentifrices, solutions, and gels. The latter led to a more pronounced protective effect against dentin erosion and erosion plus abrasion. The protection was long-lasting and could be observed after up to 10 days of severe erosive and erosive-plus-abrasive challenges in situ. Thus, the use of MMP inhibitors has emerged as an important preventive tool against dentin erosion. Clinical studies should be conducted to confirm the results obtained and to give support to the establishment of clinical protocols of use.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"24 2","pages":"72-6"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034512455029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30840788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 81

Probiotics for caries prevention and control. 预防和控制龋齿的益生菌。

Advances in Dental Research Pub Date : 2012-09-01 DOI: 10.1177/0022034512449465

S Twetman, M K Keller

{"title":"Probiotics for caries prevention and control.","authors":"S Twetman, M K Keller","doi":"10.1177/0022034512449465","DOIUrl":"https://doi.org/10.1177/0022034512449465","url":null,"abstract":"Modulation of the microbiota for restoring and maintaining health is a growing issue in medical science. A search for relevant clinical trials on the use of probiotic bacteria as a potential and clinically applicable anti-caries measure was performed. According to predetermined criteria, papers were selected and key data on study design, sample size, intervention, duration, and results were extracted. Two animal and 19 human studies were retrieved. Most studies were short-term and restricted to microbiological endpoints, and only 3 human studies reported a caries endpoint. A high degree of heterogeneity among the included investigations hampered the analysis. Significant reductions of mutans streptococci in saliva or plaque following daily intake of probiotic lactobacilli or bifidobacteria were reported in 12 out of 19 papers, whereas 3 reported an increase of lactobacilli. Three caries trials in preschool children and the elderly demonstrated prevented fractions of between 21% and 75% following regular intakes of milk supplemented with L. rhamnosus. No adverse effects or potential risks were reported. The currently available literature does not exclude the possibility that probiotic bacteria can interfere with the oral biofilm, but any clinical recommendation would be premature. Large-scale clinical studies with orally derived specific anti-caries candidates are still lacking.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"24 2","pages":"98-102"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034512449465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30840793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 103

Caries clinical trial methods for the assessment of oral care products in the 21st century. 21世纪口腔护理产品龋病临床试验评价方法。

Advances in Dental Research Pub Date : 2012-09-01 DOI: 10.1177/0022034512449464

R P Ellwood, J Gomez, J Goma, I A Pretty

{"title":"Caries clinical trial methods for the assessment of oral care products in the 21st century.","authors":"R P Ellwood, J Gomez, J Goma, I A Pretty","doi":"10.1177/0022034512449464","DOIUrl":"10.1177/0022034512449464","url":null,"abstract":"Traditionally, caries clinical trials of oral care products have focused on the prevention of caries in children and adolescents at the \"cavitation\" level. Because of a general reduction in caries incidence and the use of positive control comparators, studies have grown both in size and duration to improve statistical power. Currently, they tend to be of 2 to 3 years' duration, with up to 2,000 high-risk individuals per group. During the past decade, there has been a shift in emphasis from a restorative approach to the treatment of dental caries to a therapeutic approach focused on the remineralization of early caries lesions. However, caries clinical trials of oral care products have not often reflected this paradigm change. This manuscript reviews alternative caries clinical trial methods for oral care products. It is concluded that methods focused on the detection and monitoring of enamel caries and root caries, by visual approaches such as ICDAS and instrumental methods such as QLF, Diagnodent, and Electrical Caries Monitors, provide viable alternatives to traditional methods. In particular, such approaches more accurately reflect the modes of action of many therapeutic agents and formulations and may reduce the cost and duration of product innovation.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"24 2","pages":"32-5"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30839901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light therapy: complementary antibacterial treatment of oral biofilm. 光疗:口腔生物膜的辅助抗菌治疗。

Advances in Dental Research Pub Date : 2012-09-01 DOI: 10.1177/0022034512449469

O Feuerstein

{"title":"Light therapy: complementary antibacterial treatment of oral biofilm.","authors":"O Feuerstein","doi":"10.1177/0022034512449469","DOIUrl":"https://doi.org/10.1177/0022034512449469","url":null,"abstract":"Conventional antibacterial treatment fails to eradicate biofilms associated with common infections of the oral cavity. Unlike chemical agents, which are less effective than anticipated, owing to diffusion limitations in biofilms, light is more effective on bacteria in biofilm than in suspension. Effectiveness depends also on the type and parameters of the light. We tested the phototoxic effects of non-coherent blue light (wavelengths, 400-500 nm) and CO(2) laser (wavelength, 10.6 μm), which have different mechanisms of action on the oral bacterium Streptoccocus mutans, in biofilm and on tooth enamel. Exposure of S. mutans in biofilm to blue light had a delayed effect on bacterial viability throughout the biofilm and a sustained antibacterial effect on biofilm newly formed by previously irradiated bacteria. A synergistic antibacterial effect between blue light and H(2)O(2) may enhance the phototoxic effect, which involves a photochemical mechanism mediated by reactive oxygen species (ROS) formation. The effect of CO(2) laser irradiation on the viability of S. mutans in biofilm on enamel samples appeared to be higher in the deep layers, due to heating of the enamel surface by the absorbed energy. Biofilms do not interfere with the chemical changes resulting from irradiation, which may increase the enamel's resistance to acid attack.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"24 2","pages":"103-7"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034512449469","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30839775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Delivery of active agents from chewing gum for improved remineralization. 从口香糖中输送活性剂以改善再矿化。

Advances in Dental Research Pub Date : 2012-09-01 DOI: 10.1177/0022034512452886

M W J Dodds, D Chidichimo, M S Haas

{"title":"Delivery of active agents from chewing gum for improved remineralization.","authors":"M W J Dodds, D Chidichimo, M S Haas","doi":"10.1177/0022034512452886","DOIUrl":"https://doi.org/10.1177/0022034512452886","url":null,"abstract":"Most surrogate measures of caries were developed to test products containing fluoride, typically at relatively high and closely controlled oral concentrations. However, since the primary mechanism for the remineralization of early enamel caries lesions by chewing gum is through stimulation of saliva, delivering Ca and Pi to the demineralized enamel lesion, established methods may lack the sensitivity to detect the additional benefit of an active agent without the strong remineralizing potential of fluoride. Issues related to the release of active agents from the gum matrix, dilution in the saliva, and limited oral retention time, along with taste, safety, regulatory, and cost concerns, impose further limitations. This paper reviews the efficacy of some active agents used in chewing gum for improved remineralization and includes results from in situ testing of calcium-containing gums, including calcium lactate, tetracalcium phosphate/dicalcium phosphate anhydrous, calcium citrate/encapsulated phosphate, and a calcium lactate/sodium phosphate blend. Despite promising in vitro data from these agents, they did not provide consistently superior results from in situ testing. There is a need to develop better predictive in vitro models for chewing gum, as well as improved sensitivity of in situ models to discriminate relatively small amounts of remineralization against a background of high biological variability.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"24 2","pages":"58-62"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034512452886","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30839906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30