Advances in Dental Research最新文献

Sex, Gender and Sexuality in Oral Health Research: Setting the Scene. 口腔健康研究中的性、性别和性行为：背景。

Advances in Dental Research Pub Date : 2026-01-01 Epub Date: 2025-12-19 DOI: 10.1177/00220345251392082

L Jamieson, G Soares, C Randall

引用次数: 0

Whose Knowledge Counts? Considering Gender, Sexuality, and Race in Description, Prediction, and Causal Inference in Oral Epidemiology. 谁的知识最重要？在口腔流行病学的描述、预测和因果推论中考虑性别、性向和种族。

Advances in Dental Research Pub Date : 2026-01-01 Epub Date: 2025-12-19 DOI: 10.1177/00220345251392147

D G Haag, J L Bastos, G H Soares, B Poirier, L Jamieson, H S Schuch

引用次数: 0

An “anaerobic invisible” genetically engineered bacterium for periodontitis treatment through temporal modulation on microenvironment 一种“厌氧隐形”基因工程细菌通过微环境的时间调节治疗牙周炎

Advances in Dental Research Pub Date : 2026-01-01 DOI: 10.1016/j.dtrs.2025.100002

Jiwei Sun, Junshuai Zhang, Haoqi Lei, Qingming Tang, Pingping Han, Yutian Xia, Ronghua Deng, Yifan Wang, Yunsong Shi, Junyuan Zhang, Yifan Zhang, Zhenshuo Han, Yingjia Huang, Yuzhou Wu, L. Chen

引用次数: 5

Analysing the Interaction of Sex and Laboratory Conditions in Animal Research. 分析动物研究中性别与实验室条件的相互作用。

Advances in Dental Research Pub Date : 2026-01-01 Epub Date: 2025-12-19 DOI: 10.1177/00220345251392141

L Schiebinger

{"title":"Analysing the Interaction of Sex and Laboratory Conditions in Animal Research.","authors":"L Schiebinger","doi":"10.1177/00220345251392141","DOIUrl":"10.1177/00220345251392141","url":null,"abstract":"The persistent underrepresentation of female animals in biomedical research, particularly in medical and dental sciences, has significant implications for research quality, translational validity and patient safety. In dental preclinical studies, the exclusion of female animals can obscure key biological differences in oral disease pathogenesis, progression and response to treatment, thus compromising the development of effective therapies for diverse populations. Evidence from biomedical research underlines the public health risks of such omission, and parallels in dental science highlight that ignoring sex as a biological variable can jeopardise efficacy and safety in novel oral health interventions. Addressing these gaps requires a systematic, sex-informed approach: from problem identification and research design, through data collection and sex-based disaggregation, to analysis and dissemination of results. Researchers must also assess extrinsic laboratory conditions, such as caging practices, environmental controls and researcher effects, since these may differentially influence male, female and hermaphroditic animal models. In the context of human research, interactions among sex, gender and broader social determinants (eg, age, socioeconomic status, geography, race and ethnicity) are crucial for experimental outcomes. Similarly, dental animal studies must consider how biological traits interact with laboratory environments to avoid misattributing outcomes to sex when they may be driven by external factors. However, many oral health researchers lack training in these advanced methodologies. Thus, dental schools need to integrate sex, gender and intersectional analysis into their curricula, equipping future researchers with the methodological rigour necessary to produce reproducible, equitable and innovative dental science for all populations.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"33 1","pages":"4-8"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Oral Health Workforce Equity in Gender and Sexual Orientation. 促进口腔卫生人力在性别和性取向方面的公平。

Advances in Dental Research Pub Date : 2026-01-01 Epub Date: 2025-12-19 DOI: 10.1177/00220345251392066

E Ioannidou, M W B Araujo, M Bacino, C Randall

{"title":"Advancing Oral Health Workforce Equity in Gender and Sexual Orientation.","authors":"E Ioannidou, M W B Araujo, M Bacino, C Randall","doi":"10.1177/00220345251392066","DOIUrl":"10.1177/00220345251392066","url":null,"abstract":"Sex, gender, and sexual orientation are multidimensional constructs that influence representation, inclusion, and outcomes in the oral health workforce. Despite demographic shifts in dental education, persistent inequities related to these identities remain underexamined in academic, research, and clinical settings. Our goal was to evaluate how sex, gender, and sexual orientation affect equity in the oral health workforce and to propose evidence-based strategies for advancing inclusivity in education and policy. We conducted a narrative synthesis using US-based data sources and peer-reviewed literature to assess demographic trends, historical structures, and institutional barriers. Particular attention was given to leadership disparities, economic inequities, and discrimination faced by women and LGBTQIA+ professionals (Lesbian, Gay, Bisexual, Transgender, Queer, Intersex, Asexual +). Best practices and policy strategies were also reviewed. Although women now constitute >50% of dental school enrollees, they remain underrepresented in leadership and surgical specialties and experience persistent wage gaps. LGBTQIA+ professionals face limited visibility, compounded bias, and a lack of structural protections. These disparities are amplified by intersecting identities, such as race and caregiving roles. Institutional gaps in inclusive curricula, faculty mentorship, and data collection further constrain equity. However, there have been some national initiatives that demonstrate promise for addressing these challenges. A more inclusive oral health workforce requires systemic reforms in academic policies, leadership development, cultural competency training, and federal financial support. Data collection on gender identity and sexual orientation, bias mitigation, and mentorship programs are critical levers for transformation. Aligning workforce policy with contemporary family structures and demographic realities can help ensure an equitable, representative, and resilient profession.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"33 1","pages":"31-34"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12717279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Demographics: Sex, Gender, and Sexuality in Oral Health Research. 超越人口统计：口腔健康研究中的性、性别和性行为。

Advances in Dental Research Pub Date : 2026-01-01 Epub Date: 2025-12-19 DOI: 10.1177/00220345251392073

A Jessani

{"title":"Beyond Demographics: Sex, Gender, and Sexuality in Oral Health Research.","authors":"A Jessani","doi":"10.1177/00220345251392073","DOIUrl":"10.1177/00220345251392073","url":null,"abstract":"Sex, gender, and sexuality are crucial and interrelated factors influencing oral health outcomes, yet they are often overlooked and inadequately addressed in human studies on oral health. Biological sex influences oral disease susceptibility through hormonal, immunological, and microbiome-related mechanisms. Concomitantly, gender as a social construct modulates health through psychosocial stress, health care access, and societal norms. Sexuality intersects with oral health through behavioral risks, stigma, and discrimination, especially among lesbian, gay, bisexual, transgender, and queer or questioning populations. Despite their importance, oral health research often treats sex as a binary demographic variable, excluding sexual and gender minority individuals. There is a lack of meaningful integration of these variables across all phases of research, from proposal development and data collection to analysis and knowledge creation. This results in limited generalizability, perpetuates health inequities, and impedes the development of inclusive, evidence-based, and person-centered interventions. Furthermore, dental education and research training programs often lack comprehensive content on sex, gender, and sexuality, contributing to research approaches and training that reinforce binary-centered investigations. Substantial gaps in mentorship, representation, and inclusive curricula largely contribute to the underrepresentation of gender-diverse scholars and leaders in oral health. To address these gaps, a multipronged action plan is necessary, including an inclusive research design, robust data collection tools, curriculum reform that integrates person-centered frameworks, community engagement and service-learning, policy change, and accountability mechanisms. The integration of intersectionality, pertinent sex, gender, sexuality, and social determinants of health in oral health research and education is essential for achieving scientific rigor, health equity, and culturally responsive care for all populations.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"33 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12717285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-dimensional FeCu-metal-organic-framework boosts peroxidase activity for antibacterial application 二维fecu金属有机框架提高过氧化物酶活性，用于抗菌应用

Advances in Dental Research Pub Date : 2026-01-01 DOI: 10.1016/j.dtrs.2025.100008

Lu YiXuan, Yaru Guo, Xiaohua Guo, Shihan Zhang, F. Liu, Shuai Ding, Dandan Wang, Yanpei Wang, Kongliang Li, Yuchen Wang, Youxing Liu, Xuliang Deng

{"title":"Two-dimensional FeCu-metal-organic-framework boosts peroxidase activity for antibacterial application","authors":"Lu YiXuan, Yaru Guo, Xiaohua Guo, Shihan Zhang, F. Liu, Shuai Ding, Dandan Wang, Yanpei Wang, Kongliang Li, Yuchen Wang, Youxing Liu, Xuliang Deng","doi":"10.1016/j.dtrs.2025.100008","DOIUrl":"https://doi.org/10.1016/j.dtrs.2025.100008","url":null,"abstract":"The overuse of antibiotics has led to the emergence of drug-resistant bacteria, posing a serious threat to human health and increasing the medical burden. Metal–organic frameworks (MOFs) have shown great potential as enzyme mimics for antibacterial applications; however, their performance is often limited by the low density and poor accessibility of active sites. Herein, we report an innovative surface-active agent intercalation–assisted confinement growth strategy for constructing two-dimensional (2D) NH₂-BDC-Cu, Fe nanosheets (NSs) with highly exposed active site to enhance reactive oxygen species (ROS) generation, thereby improving the antibacterial efficiency against drug-resistant bacteria. We demonstrate that the synthesized 2D NH₂-BDC-Cu, Fe NSs exhibit 6.6-fold higher ROS production compared to NH₂-BDC-Cu, Fe nanopowders (NPs). Consequently, NH₂-BDC-Cu, Fe NSs achieve 100 % antibacterial activity against both Staphylococcus aureus and Escherichia coli within 1 h, markedly outperforming NH₂-BDC-Cu, Fe NPs and previously reported biomaterials. Moreover, in vivo experiments confirm that NH₂-BDC-Cu, Fe NSs accelerate wound healing, achieving a 100 % healing rate within 10 days, which is substantially higher than that of NH₂-BDC-Cu, Fe NPs. Overall, this work introduces a novel and efficient strategy for fabricating 2D MOF nanoenzymes with high active-site exposure, offering great promise for the development of advanced biomaterial-based antibacterial therapies.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"1 1","pages":"100008-100008"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147907396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Sex, Gender, and Sexuality in Oral Health Research: Future Directions. 口腔健康研究中的性、性别和性行为：未来方向。

Advances in Dental Research Pub Date : 2026-01-01 Epub Date: 2025-12-19 DOI: 10.1177/00220345251392114

C L Randall, G H Soares, L M Jamieson

引用次数: 0

Gender, Sexual Orientation, and Intersectionality in Oral Health Care. 口腔卫生保健中的性别、性取向和交叉性。

Advances in Dental Research Pub Date : 2026-01-01 Epub Date: 2025-12-19 DOI: 10.1177/00220345251392145

G H Soares, C L Randall, D Haag, B Poirier, G G Nascimento, L Jamieson

引用次数: 0

Conceptualisations of Sex and Gender in Oral Health Research. 口腔健康研究中的性与社会性别概念。

Advances in Dental Research Pub Date : 2026-01-01 Epub Date: 2025-12-19 DOI: 10.1177/00220345251392130

P Neville, V Muirhead

{"title":"Conceptualisations of Sex and Gender in Oral Health Research.","authors":"P Neville, V Muirhead","doi":"10.1177/00220345251392130","DOIUrl":"10.1177/00220345251392130","url":null,"abstract":"Sex and gender are widely recognised as determinants of health, influencing general and oral health outcomes. In this conceptual article, we argue that the potential of sex- and gender-based oral health research to deliver transformative insights into oral health inequalities has been limited by 3 key factors: 1) a lack of theoretical understanding of the difference between sex and gender, 2) the continued conflation of sex with gender in research and 3) the hegemony of a biomedical paradigm in oral health research and its depoliticised view of health and its determinants. Drawing on the precedent set by medicine espousing its 'gender medicine' movement, this article calls for a similar movement within dentistry and oral health research, acknowledging and calling out decades of gender blindness and gender bias. Such a paradigm shift will contribute to the emergence of 'gender-conscious' dentistry. We describe gender-conscious dentistry as a discipline where gender is foregrounded in its theoretical, methodological and empirical work. The article concludes by highlighting ways that oral health research can achieve this goal. Overall, this article is an invitation for further discussion and debate on the role and place of sex and gender in oral health research.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"33 1","pages":"13-16"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0