Exposome最新文献_第3页

The exposome at NIEHS: from workshops to manuscripts. NIEHS的暴露:从工作坊到手稿。

Exposome Pub Date : 2023-11-30 eCollection Date: 2023-01-01 DOI: 10.1093/exposome/osad011

Gary W Miller

引用次数: 0

The Exposome and Nutritional Pharmacology and Toxicology: A New Application for Metabolomics 暴露体与营养药理学和毒理学：代谢组学的新应用

Exposome Pub Date : 2023-11-23 DOI: 10.1093/exposome/osad008

Blake R Rushing, A. Thessen, Ghada A Soliman, A. Ramesh, Susan J. Sumner

引用次数: 0

Community-level exposomics: A population-centered approach to address public health concerns 社区层面的暴露研究：以人口为中心解决公共卫生问题的方法

Exposome Pub Date : 2023-11-16 DOI: 10.1093/exposome/osad009

Jeanette A Stingone, Andrew M Geller, D. Hood, Konstantinos C Makris, Charles P Mouton, J. C. States, Susan J. Sumner, K. L. Wu, Arcot K Rajasekar

{"title":"Community-level exposomics: A population-centered approach to address public health concerns","authors":"Jeanette A Stingone, Andrew M Geller, D. Hood, Konstantinos C Makris, Charles P Mouton, J. C. States, Susan J. Sumner, K. L. Wu, Arcot K Rajasekar","doi":"10.1093/exposome/osad009","DOIUrl":"https://doi.org/10.1093/exposome/osad009","url":null,"abstract":"Environmental factors affecting health and vulnerability far outweigh genetics in accounting for disparities in health status and longevity in US communities. The concept of the exposome, the totality of exposure from conception onwards, provides a paradigm for researchers to investigate the complex role of the environment on the health of individuals. We propose a complementary framework, community-level exposomics, for population-level exposome assessment. The goal is to bring the exposome paradigm to research and practice on the health of populations, defined by various axes including geographic, social, and occupational. This framework includes the integration of community-level measures of the built, natural and social environments, environmental pollution-derived from conventional and community science approaches, internal markers of exposure that can be measured at the population-level and early responses associated with health status that can be tracked using population-based monitoring. Primary challenges to the implementation of the proposed framework include needed advancements in population-level measurement, lack of existing models with the capability to produce interpretable and actionable evidence and the ethical considerations of labeling geographically-bound populations by exposomic profiles. To address these challenges, we propose a set of recommendations that begin with greater engagement with and empowerment of affected communities and targeted investment in community-based solutions. Applications to urban settings and disaster epidemiology are discussed as examples for implementation.","PeriodicalId":73005,"journal":{"name":"Exposome","volume":"258 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139269232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A roadmap to advance exposomics through federation of data 通过数据联合推进暴露组学的路线图

Exposome Pub Date : 2023-11-14 DOI: 10.1093/exposome/osad010

Charles P Schmitt, Jeanette A Stingone, Arcot Rajasekar, Yuxia Cui, Xiuxia Du, Chris Duncan, Michelle Heacock, Hui Hu, Juan R Gonzalez, Paul D Juarez, Alex I Smirnov

{"title":"A roadmap to advance exposomics through federation of data","authors":"Charles P Schmitt, Jeanette A Stingone, Arcot Rajasekar, Yuxia Cui, Xiuxia Du, Chris Duncan, Michelle Heacock, Hui Hu, Juan R Gonzalez, Paul D Juarez, Alex I Smirnov","doi":"10.1093/exposome/osad010","DOIUrl":"https://doi.org/10.1093/exposome/osad010","url":null,"abstract":"Abstract The scale of the human exposome, which covers all environmental exposures encountered from conception to death, presents major challenges in managing, sharing, and integrating a myriad of relevant data types and available data sets for the benefit of exposomics research and public health. By addressing these challenges, the exposomics research community will be able to greatly expand on its ability to aggregate study data for new discoveries, construct and update novel exposomics data sets for building artificial intelligence and machine learning-based models, rapidly survey emerging issues, and advance the application of data-driven science. The diversity of the field, which spans multiple subfields of science disciplines and different environmental contexts, necessitates adopting data federation approaches to bridge between numerous geographically and administratively separated data resources that have varying usage, privacy, access, analysis, and discoverability capabilities and constraints. This paper presents use cases, challenges, opportunities, and recommendations for the exposomics community to establish and mature a federated exposomics data ecosystem.","PeriodicalId":73005,"journal":{"name":"Exposome","volume":"114 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Historical Exposomics: A Manifesto 历史揭秘学:一份宣言

Exposome Pub Date : 2023-08-18 DOI: 10.1093/exposome/osad007

Dagny Aurich, Aida Horaniet Ibañez, C. Hissler, Simon Kreipl, L. Pfister, Emma L. Schymanski, A. Fickers

{"title":"Historical Exposomics: A Manifesto","authors":"Dagny Aurich, Aida Horaniet Ibañez, C. Hissler, Simon Kreipl, L. Pfister, Emma L. Schymanski, A. Fickers","doi":"10.1093/exposome/osad007","DOIUrl":"https://doi.org/10.1093/exposome/osad007","url":null,"abstract":"\u0000 The exposome complements information captured in the genome by covering all external influences and internal (biological) responses of a human being from conception onwards. Such a paradigm goes beyond a single scientific discipline and instead requires a truly interdisciplinary approach. The concept of “historical exposomics” could help bridge the gap between “nature” and “nurture” using both natural and social archives to capture the influence of humans on earth (the Anthropocene) in an interdisciplinary manner. The LuxTIME project served as a test bed for an interdisciplinary exploration of the historical exposome, focusing on the Belval area located in the Minett region in southern Luxembourg. This area evolved from a source of mineral water to steel production through to the current campus for research and development. This article explores the various possibilities of natural and social archives that were considered in creating the historical exposome of Belval and reflects upon possibilities and limitations of the current approaches in assessing the exposome using purely a natural science approach. Issues surrounding significance, visualization, and availability of material suitable to form natural archives are discussed in a critical manner. The “Minett Stories” are presented as a way of creating new historical narratives to support exposome research. New research perspectives on the history of the Anthropocene were opened by investigating the causal relationships between factual evidence and narrative evidence stemming from historical sources. The concept of historical exposome presented here may thus offer a useful conceptual framework for studying the Anthropocene in a truly interdisciplinary fashion.","PeriodicalId":73005,"journal":{"name":"Exposome","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60831270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The contribution to policies of an exposome-based approach to childhood obesity. 以暴露为基础的儿童肥胖方法对政策的贡献。

Exposome Pub Date : 2023-05-26 DOI: 10.1093/exposome/osad006

Paolo Vineis, Evangelos Handakas, Rossella Alfano, Christopher Millett, Daniela Fecht, Leda Chatzi, Michelle Plusquin, Tim Nawrot, Lorenzo Richiardi, Henrique Barros, Martine Vrijheid, Franco Sassi, Oliver Robinson

{"title":"The contribution to policies of an exposome-based approach to childhood obesity.","authors":"Paolo Vineis, Evangelos Handakas, Rossella Alfano, Christopher Millett, Daniela Fecht, Leda Chatzi, Michelle Plusquin, Tim Nawrot, Lorenzo Richiardi, Henrique Barros, Martine Vrijheid, Franco Sassi, Oliver Robinson","doi":"10.1093/exposome/osad006","DOIUrl":"10.1093/exposome/osad006","url":null,"abstract":"Childhood obesity is an increasingly severe public health problem, with a prospective impact on health. We propose an exposome approach to identify actionable risk factors for this condition. Our assumption is that relationships between external exposures and outcomes such as rapid growth, overweight, or obesity in children can be better understood through a \"meet-in-the-middle\" model. This is based on a combination of external and internal exposome-based approaches, that is, the study of multiple exposures (in our case, dietary patterns) and molecular pathways (metabolomics and epigenetics). This may strengthen causal reasoning by identifying intermediate markers that are associated with both exposures and outcomes. Our biomarker-based studies in the STOP consortium suggest (in several ways, including mediation analysis) that branched-chain amino acids (BCAAs) could be mediators of the effect of dietary risk factors on childhood overweight/obesity. This is consistent with intervention and animal studies showing that higher intake of BCAAs has a positive impact on body composition, glycemia, and satiety. Concerning food, of particular concern is the trend of increasing intake of ultra-processed food (UPF), including among children. Several mechanisms have been proposed to explain the impact of UPF on obesity and overweight, including nutrient intake (particularly proteins), changes in appetite, or the role of additives. Research from the Avon Longitudinal Study of Parents and Children cohort has shown a relationship between UPF intake and trajectories in childhood adiposity, while UPF was related to lower blood levels of BCAAs. We suggest that an exposome-based approach can help strengthening causal reasoning and support policies. Intake of UPF in children should be restricted to prevent obesity.","PeriodicalId":73005,"journal":{"name":"Exposome","volume":"3 1","pages":"osad006"},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41222064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ethical aspects of exposome research: a systematic review. 暴露体研究的伦理方面：系统综述。

Exposome Pub Date : 2023-04-12 DOI: 10.1093/exposome/osad004

Caspar W Safarlou, Karin R Jongsma, Roel Vermeulen, Annelien L Bredenoord

{"title":"The ethical aspects of exposome research: a systematic review.","authors":"Caspar W Safarlou, Karin R Jongsma, Roel Vermeulen, Annelien L Bredenoord","doi":"10.1093/exposome/osad004","DOIUrl":"10.1093/exposome/osad004","url":null,"abstract":"In recent years, exposome research has been put forward as the next frontier for the study of human health and disease. Exposome research entails the analysis of the totality of environmental exposures and their corresponding biological responses within the human body. Increasingly, this is operationalized by big-data approaches to map the effects of internal as well as external exposures using smart sensors and multiomics technologies. However, the ethical implications of exposome research are still only rarely discussed in the literature. Therefore, we conducted a systematic review of the academic literature regarding both the exposome and underlying research fields and approaches, to map the ethical aspects that are relevant to exposome research. We identify five ethical themes that are prominent in ethics discussions: the goals of exposome research, its standards, its tools, how it relates to study participants, and the consequences of its products. Furthermore, we provide a number of general principles for how future ethics research can best make use of our comprehensive overview of the ethical aspects of exposome research. Lastly, we highlight three aspects of exposome research that are most in need of ethical reflection: the actionability of its findings, the epidemiological or clinical norms applicable to exposome research, and the meaning and action-implications of bias.","PeriodicalId":73005,"journal":{"name":"Exposome","volume":"3 1","pages":"osad004"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41160583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A spatial and contextual exposome-wide association study and polyexposomic score of COVID-19 hospitalization. 全暴露体的空间和环境关联研究以及 COVID-19 住院治疗的多暴露体得分。

Exposome Pub Date : 2023-04-11 eCollection Date: 2023-05-01 DOI: 10.1093/exposome/osad005

Hui Hu, Francine Laden, Jaime Hart, Peter James, Jennifer Fishe, William Hogan, Elizabeth Shenkman, Jiang Bian

{"title":"A spatial and contextual exposome-wide association study and polyexposomic score of COVID-19 hospitalization.","authors":"Hui Hu, Francine Laden, Jaime Hart, Peter James, Jennifer Fishe, William Hogan, Elizabeth Shenkman, Jiang Bian","doi":"10.1093/exposome/osad005","DOIUrl":"10.1093/exposome/osad005","url":null,"abstract":"Environmental exposures have been linked to COVID-19 severity. Previous studies examined very few environmental factors, and often only separately without considering the totality of the environment, or the exposome. In addition, existing risk prediction models of severe COVID-19 predominantly rely on demographic and clinical factors. To address these gaps, we conducted a spatial and contextual exposome-wide association study (ExWAS) and developed polyexposomic scores (PES) of COVID-19 hospitalization leveraging rich information from individuals' spatial and contextual exposome. Individual-level electronic health records of 50 368 patients aged 18 years and older with a positive SARS-CoV-2 PCR/Antigen lab test or a COVID-19 diagnosis between March 2020 and October 2021 were obtained from the OneFlorida+ Clinical Research Network. A total of 194 spatial and contextual exposome factors from 10 data sources were spatiotemporally linked to each patient based on geocoded residential histories. We used a standard two-phase procedure in the ExWAS and developed and validated PES using gradient boosting decision trees models. Four exposome measures significantly associated with COVID-19 hospitalization were identified, including 2-chloroacetophenone, low food access, neighborhood deprivation, and reduced access to fitness centers. The initial prediction model in all patients without considering exposome factors had a testing-area under the curve (AUC) of 0.778. Incorporation of exposome data increased the testing-AUC to 0.787. Similar findings were observed in subgroup analyses focusing on populations without comorbidities and aged 18-24 years old. This spatial and contextual exposome study of COVID-19 hospitalization confirmed previously reported risk factor but also generated novel predictors that warrant more focused evaluation.","PeriodicalId":73005,"journal":{"name":"Exposome","volume":"3 1","pages":"osad005"},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/10/79/osad005.PMC10118922.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10170829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposomics as a tool to investigate differences in health and disease by sex and gender. 将 Exposomics 作为研究不同性别健康和疾病差异的工具。

Exposome Pub Date : 2023-03-21 eCollection Date: 2023-01-01 DOI: 10.1093/exposome/osad003

Meghan L Bucher, Faith L Anderson, Yunjia Lai, Jocelyn Dicent, Gary W Miller, Ami R Zota

{"title":"Exposomics as a tool to investigate differences in health and disease by sex and gender.","authors":"Meghan L Bucher, Faith L Anderson, Yunjia Lai, Jocelyn Dicent, Gary W Miller, Ami R Zota","doi":"10.1093/exposome/osad003","DOIUrl":"10.1093/exposome/osad003","url":null,"abstract":"The health and disease of an individual is mediated by their genetics, a lifetime of environmental exposures, and interactions between the two. Genetic or biological sex, including chromosome composition and hormone expression, may influence both the types and frequency of environmental exposures an individual experiences, as well as the biological responses an individual has to those exposures. Gender identity, which can be associated with social behaviors such as expressions of self, may also mediate the types and frequency of exposures an individual experiences. Recent advances in exposome-level analysis have progressed our understanding of how environmental factors affect health outcomes; however, the relationship between environmental exposures and sex- and gender-specific health remains underexplored. The comprehensive, non-targeted, and unbiased nature of exposomic research provides a unique opportunity to systematically evaluate how environmental exposures interact with biological sex and gender identity to influence health. In this forward-looking narrative review, we provide examples of how biological sex and gender identity influence environmental exposures, discuss how environmental factors may interact with biological processes, and highlight how an intersectional approach to exposomics can provide critical insights for sex- and gender-specific health sciences.","PeriodicalId":73005,"journal":{"name":"Exposome","volume":"3 1","pages":"osad003"},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d1/cf/osad003.PMC10125831.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9404751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect-directed analysis and beyond: how to find causal environmental toxicants 以效果为导向的分析及其后:如何发现因果环境毒物

Exposome Pub Date : 2023-02-07 DOI: 10.1093/exposome/osad002

Z. Tian, Madison H McMinn, Mingliang Fang

{"title":"Effect-directed analysis and beyond: how to find causal environmental toxicants","authors":"Z. Tian, Madison H McMinn, Mingliang Fang","doi":"10.1093/exposome/osad002","DOIUrl":"https://doi.org/10.1093/exposome/osad002","url":null,"abstract":"\u0000 Humans and wildlife are exposed to complex environmental mixtures. Identifying causal toxic pollutants in environmental samples remains challenging because of the high complexity of sample mixtures and the unknown nature of the potential toxicants. In the field of environmental chemistry and toxicology, this pursuit of causal toxicants leads us to the method of effect-directed analysis (EDA), an integrated method comprised of three iterative modules: (1) bioassays to guide component prioritization; (2) fractionation to reduce the mixture complexity; and (3) chemical analysis to identify the toxicants. In this commentary review, we try to provide a concise guideline for EDA beginners by summarizing good practices from successful EDA studies, categorized by sample-toxicity pair selection, efficient separation, and chemical analysis. We also discussed the practical challenges faced with current EDA practices. Based on these above, we try to provide suggestions and perspectives for future EDA studies. Specifically, we discussed the potential of applying EDA on human biological examples to identify the environmental causes of human diseases. We proposed future collaboration between environmental chemists and toxicologists, environmental health scientists, epidemiologists, physicians, and social scientists.","PeriodicalId":73005,"journal":{"name":"Exposome","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46621615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0