A. V. Boreyko, M. G. Zadneprianetc, V. N. Chausov, T. S. Hramko, R. A. Kozhina, E. A. Kuzmina, S. I. Tiounchik, E. A. Krasavin
{"title":"Combined Action of DNA Synthesis Inhibitors and Accelerated Protons on Malignant Tumor Cells","authors":"A. V. Boreyko, M. G. Zadneprianetc, V. N. Chausov, T. S. Hramko, R. A. Kozhina, E. A. Kuzmina, S. I. Tiounchik, E. A. Krasavin","doi":"10.1134/S1547477123040131","DOIUrl":"10.1134/S1547477123040131","url":null,"abstract":"<p>The modifying effect of 1-β-D-arabinofuranosylcytosine (AraC) and hydroxyurea (HU) on the formation frequency of DNA double-strand breaks (DSB) in human U87 glioblastoma and murine B16 melanoma cells after accelerated proton and nitrogen ion (<sup>15</sup>N) exposure has been studied. The DNA comet assay and immunocytochemistry methods were used to determine the dependences of the frequency of DNA DSB formation and kinetics of their repair in tumor cells upon irradiation with particles of a wide linear energy transfer (LET) range under normal conditions and in the presence of modifiers. The combination of AraC and HU has the strongest modifying effect on the DSB yield. Under the influence of radiomodifiers, the dose change factor is ~2. Under normal conditions, DSB repair proceeds with exponential kinetics. In the presence of modifiers, a certain increase in the DNA DSB yield is observed after 6 h of post-irradiation incubation, followed by a decrease after 24 h of observation. The strongest modifying effect of AraC on the formation of radiation-induced foci (RIF) in glioblastoma cells is observed for proton exposure compared with nitrogen ions. In the presence of AraC, 24 hours after proton irradiation the RIF yield was 2.3 times higher than after exposure without it. For nitrogen ions with LET = 81 keV/μm and 180 keV/μm, the RIF yield in glioblastoma cells in the presence of AraC increases by 1.7 and 1.5 times 24 hours after irradiation, respectively, compared with the control samples. Possible mechanisms of tumor cell response to exposure to radiations with different LET in the presence of radiomodifiers are discussed.</p>","PeriodicalId":730,"journal":{"name":"Physics of Particles and Nuclei Letters","volume":"20 4","pages":"683 - 689"},"PeriodicalIF":0.5,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4328950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prompt Fission Neutron Spectra of 240Pu(n, F), 239Pu(n, F), and 238U(n, F)","authors":"V. M. Maslov","doi":"10.1134/S1547477123040490","DOIUrl":"10.1134/S1547477123040490","url":null,"abstract":"<p>Pre-fission neutron spectra are indicators of the distribution of fission reaction energy between the kinetic energy of fragments and prompt fission neutrons. Using the <sup>240</sup>Pu(<i>n</i>, <i>F</i>), <sup>239</sup>Pu(<i>n</i>, <i>F</i>), and <sup>238</sup>U(<i>n</i>, <i>F</i>) reactions as an example, it is shown how the shape of the observed prompt fission neutron spectra (PFNS) depends on the fissility (fission probability) of compound and residual nuclei. A correlation of this effect with the contributions of the (<i>n</i>, <i>xnf</i>) emission fission to the observed fission cross section and the competition of the (<i>n</i>, <i>n</i>γ) and (<i>n</i>, <i>xn</i>)<sup>1,<i>...x</i></sup> reactions is established. The exclusive spectra of the (<i>n</i>, <i>xnf</i>)<sup>1,...<i>x</i></sup> neutrons correspond to the consistent description of the observed cross sections for the <sup>240</sup>Pu(<i>n</i>, <i>F</i>), <sup>239</sup>Pu(<i>n</i>, <i>F</i>), <sup>238</sup>Pu(<i>n</i>, <i>F</i>), <sup>237</sup>Pu(<i>n</i>, <i>F</i>), and <sup>236</sup>Pu(<i>n</i>, <i>F</i>) fission reactions, as well as <sup>239</sup>Pu(<i>n</i>, <i>xn</i>) neutron emission spectra for neutrons with energies up to 20 MeV. The initial values of the model parameters for describing the <sup>240</sup>Pu(<i>n</i>, <i>F</i>) PFNS are fixed when describing the prompt neutron spectra of <sup>240</sup>Pu(<i>sf</i>) spontaneous fission. Taking into account the influence of the exclusive spectra of <sup>240</sup>Pu (<i>n</i>, <i>xnf</i>)<sup>1,...<i>x</i></sup> prefission neutrons, the prompt fission neutron spectra, the total kinetic energy (TKE) of fragments and fission products, and the average number of <sup>240</sup>Pu(<i>n</i>, <i>F</i>) prompt fission neutrons are predicted.</p>","PeriodicalId":730,"journal":{"name":"Physics of Particles and Nuclei Letters","volume":"20 4","pages":"565 - 576"},"PeriodicalIF":0.5,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4330862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"State-of-the-Art Nuclear Physics Research in Medicine","authors":"A. P. Chernyaev, E. N. Lykova","doi":"10.1134/S1547477123040209","DOIUrl":"10.1134/S1547477123040209","url":null,"abstract":"<p>This work is a review of scientific research on the development of nuclear physics methods and technologies for medicine.<sup>1</sup> The most relevant results, many of which are already used in the practical treatment of patients, are considered. New methods for improving the quality (quality assurance) of radiation therapy during irradiation with bremsstrahlung photon and proton beams are proposed. Methods for improving the accuracy of magnetic resonance imaging (MRI) tomography of pathological foci in the planning of radiation therapy are described. In nuclear medicine, methods for producing radionuclides on electron accelerators for immune positron emission tomography (PET) diagnostics and targeted radiotherapy are proposed. New results in biomedical applications of radiation technologies (for food processing and sterilization of bioimplants) are presented.</p>","PeriodicalId":730,"journal":{"name":"Physics of Particles and Nuclei Letters","volume":"20 4","pages":"729 - 744"},"PeriodicalIF":0.5,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4326420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. A. Emanov, K. V. Astrelina, V. V. Balakin, O. V. Belikov, D. E. Berkaev, Yu. M. Boimelshtain, D. Yu. Bolkhovityanov, A. R. Frolov, G. V. Karpov, A. S. Kasaev, A. A. Kondakov, G. Ya. Kurkin, R. M. Lapik, N. N. Lebedev, A. E. Levichev, Yu. I. Maltseva, A. A. Murasev, S. L. Samoylov, S. V. Vasiliev, A. Yu. Martinovsky, C. V. Motygin, A. M. Pilan, A. G. Tribendis, A. V. Pavlenko, E. S. Kotov, M. V. Arsentyeva
{"title":"VEPP-5 Injection Complex","authors":"F. A. Emanov, K. V. Astrelina, V. V. Balakin, O. V. Belikov, D. E. Berkaev, Yu. M. Boimelshtain, D. Yu. Bolkhovityanov, A. R. Frolov, G. V. Karpov, A. S. Kasaev, A. A. Kondakov, G. Ya. Kurkin, R. M. Lapik, N. N. Lebedev, A. E. Levichev, Yu. I. Maltseva, A. A. Murasev, S. L. Samoylov, S. V. Vasiliev, A. Yu. Martinovsky, C. V. Motygin, A. M. Pilan, A. G. Tribendis, A. V. Pavlenko, E. S. Kotov, M. V. Arsentyeva","doi":"10.1134/S1547477123040258","DOIUrl":"10.1134/S1547477123040258","url":null,"abstract":"<p>The VEPP-5 injection complex is a source of intense electron and positron beams that supplies the VEPP-4M and VEPP-2000 accelerator complexes through the K-500 transport channel. At present, the injection complex is in regular operation. Work is being carried out to improve the performance and stability of the facility, and possible ways of working with perspective beam users are being considered. This article presents a description of the injection complex and the experience of its operation, as well as the latest improvements being considered.</p>","PeriodicalId":730,"journal":{"name":"Physics of Particles and Nuclei Letters","volume":"20 4","pages":"754 - 756"},"PeriodicalIF":0.5,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4328947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu. K. Osina, O. V Ananyeva, A. V. Galchuck, I. V. Gorbunov, S. V. Grigorenko, V. G. Mudrolyubov, K. E. Smirnov, Yu. I. Stogov
{"title":"Modeling of Magnetic Field and Dynamics of H–, H+ Ions for the Cyclotron C-250","authors":"Yu. K. Osina, O. V Ananyeva, A. V. Galchuck, I. V. Gorbunov, S. V. Grigorenko, V. G. Mudrolyubov, K. E. Smirnov, Yu. I. Stogov","doi":"10.1134/S1547477123040532","DOIUrl":"10.1134/S1547477123040532","url":null,"abstract":"<p>In this work the features of cyclotron C-250 magnetic field for proton energies 30–250 MeV are considered. To implement the design parameters, a non-standard technical solution was adopted. In the energy range of 30–125 MeV to use negative hydrogen ions as accelerated particles, and in the range of 125–250 MeV—protons. A set of trim coils has been developed to provide isochronous proton acceleration in the indicated energy range. The focusing properties of the magnetic field were studied by using trajectory analysis.</p>","PeriodicalId":730,"journal":{"name":"Physics of Particles and Nuclei Letters","volume":"20 4","pages":"846 - 849"},"PeriodicalIF":0.5,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4331125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ya. V. Getmanov, V. M. Borin, N. A. Vinokurov, X. Ma, Yu. I. Maltseva, O. I. Meshkov, O. A. Shevchenko
{"title":"Experiments on the Short X-Ray Pulse Generation at the NovoFEL Facility","authors":"Ya. V. Getmanov, V. M. Borin, N. A. Vinokurov, X. Ma, Yu. I. Maltseva, O. I. Meshkov, O. A. Shevchenko","doi":"10.1134/S1547477123040301","DOIUrl":"10.1134/S1547477123040301","url":null,"abstract":"<p>The energy recovery linear accelerator of the Novosibirsk Free Electron Laser facility can be used as a source of short X-ray pulses. Bremsstrahlung is produced by the electron current of the accelerator passing through a thin foil with a bunch repetition frequency of several megahertz and a picosecond duration of an individual bunch. This article discusses the possibilities of creating such a source and the results of the first experiments.</p>","PeriodicalId":730,"journal":{"name":"Physics of Particles and Nuclei Letters","volume":"20 4","pages":"772 - 775"},"PeriodicalIF":0.5,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4331471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New Perspective in the Use of Power Index Formula for Level Energies","authors":"Rajesh Kumar, S. Sharma","doi":"10.1134/S154747712304043X","DOIUrl":"10.1134/S154747712304043X","url":null,"abstract":"<p>The power index formula is an alternative method in the form of single term energy expression i.e. <span>({{E}_{{left( I right)}}} = a{{I}^{{b~}}})</span> to calculate the energy spectrum of even-even nuclei. In the earlier studies the validity of power index formula for <i>g-,</i> β<i>-</i> and γ-bands in various mass regions of nuclear chart were discussed well. In this paper, we illustrate the new perspective in the use of power index formula for <i>g-,</i> β<i>-</i> and γ<i>-</i>bands of even <i>Z</i>, even <i>N</i> nuclei i.e. sub-shell change in semi magic nuclei, the validity of formula for β-band energies and kinetic moment of inertia (kinetic MoI) of γ-band for some <sup>142–148</sup>Ba, <sup>144–152</sup>Ce and <sup>146–156</sup>Nd nuclei. We also compared the energy values calculated by power index formula with the experimental values and Interacting Boson Model-1(IBM-1) values.</p>","PeriodicalId":730,"journal":{"name":"Physics of Particles and Nuclei Letters","volume":"20 4","pages":"583 - 588"},"PeriodicalIF":0.5,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4331490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. V. Belikov, Yu. S. Aktershev, G. B. Baranov, D. S. Vinnik, K. M. Gorchakov, S. M. Gurov, S. E. Karnaev, A. A. Krylov, A. A. Morsin, P. A. Piminov, D. N. Pureskin, D. V. Senkov, Sh. R. Singatulin, S. V. Sinyatkin, A. D. Chernyakin
{"title":"Magnet Power Supply System for the Storage Ring of the SKIF Common Use Center","authors":"O. V. Belikov, Yu. S. Aktershev, G. B. Baranov, D. S. Vinnik, K. M. Gorchakov, S. M. Gurov, S. E. Karnaev, A. A. Krylov, A. A. Morsin, P. A. Piminov, D. N. Pureskin, D. V. Senkov, Sh. R. Singatulin, S. V. Sinyatkin, A. D. Chernyakin","doi":"10.1134/S1547477123040064","DOIUrl":"10.1134/S1547477123040064","url":null,"abstract":"<p>The power supply system for the electromagnets of the electron storage ring of the SKIF common use center (CUC) includes five types of stabilized current sources totaling 2259. The maximum output current of the power supplies is from 3 to 800 A, the output power is from 70 to 300 kW, and the permissible instability of the output current is from 10 to 100 ppm. For reliable operation of the light source, it is necessary to ensure the stability of the parameters of the current sources, high reliability of operation, and the fast replacing failed power supply source within the same type.</p>","PeriodicalId":730,"journal":{"name":"Physics of Particles and Nuclei Letters","volume":"20 4","pages":"704 - 707"},"PeriodicalIF":0.5,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4330852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. M. Bulgacheva, Ya. V. Shashkov, A. A. Gorchakov, M. A. Gusarova, M. V. Lalayan
{"title":"Development of the Power Coupler for H-Type Resonators","authors":"M. M. Bulgacheva, Ya. V. Shashkov, A. A. Gorchakov, M. A. Gusarova, M. V. Lalayan","doi":"10.1134/S1547477123040179","DOIUrl":"10.1134/S1547477123040179","url":null,"abstract":"<p>The article discusses the design of power coupling device for IH-type resonators for a new linear ion accelerator under development at the National Research Nuclear University MEPhI. The influence of mesh partitioning parameters on the accuracy of calculating the electric field intensity on the coupling loop surface is studied. The effect of the radius of curvature of the loop ends on the electric field intensity is also investigated. The electric field intensity values on the coupling loop surface are determined at the operating power level.</p>","PeriodicalId":730,"journal":{"name":"Physics of Particles and Nuclei Letters","volume":"20 4","pages":"720 - 723"},"PeriodicalIF":0.5,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4330860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving Experiment Control in the Sonix+ Software Package","authors":"A. S. Kirilov, L. A. Truntova","doi":"10.1134/S1547477123040362","DOIUrl":"10.1134/S1547477123040362","url":null,"abstract":"<p>This study is aimed at improving the Sonix+ software package on the measuring setups of the IBR‑2 reactor to minimize the measurement time losses when mathematical operations (summation of matrices, construction of spectral intensity distributions on the basis of data from a list of events, etc.) are incorporated immediately into the procedure of experiment in Python (script). For this purpose, the execution of all similar operations was separated from the main script into one or several background scripts. To provide the execution of background scripts, a special class of devices was added to the package structure. In addition, the mechanism of checkpoints applied earlier to connect the user interface with the script was replaced by a new one based on Python decorators and context managers. This significantly simplified the script, increased its reliability, and reduced the time of its development or modification. The new package version was tested in October 2021 on the NERA spectrometer. In the nearest future, it is planned to prepare similar versions for all the other instruments. This study was carried out at the Frank Laboratory of Neutron Physics of the Joint Institute for Nuclear Research.</p>","PeriodicalId":730,"journal":{"name":"Physics of Particles and Nuclei Letters","volume":"20 4","pages":"668 - 674"},"PeriodicalIF":0.5,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4331132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}