Modifying Effect of 1-β-D-arabinofuranosylcytosine on the Growth of the Solid Tumor Ehrlich Carcinoma in Mice under In Vivo and Ex Vivo Proton Irradiation of Cells
T. A. Belyakova, O. M. Rozanova, E. N. Smirnova, N. S. Strelnikova, E. A. Krasavin, A. V. Boreyko
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引用次数: 0
Abstract
In this work, we study the modifying effect of the 1-β-D-arabinofuranosylcytosine (AraC) on tumor induction and growth in mice under the proton irradiation of Ehrlich ascites carcinoma (EAC) cells in vivo and ex vivo. A decrease in tumor growth rate after proton irradiation in the presence of AraC, both in vivo and ex vivo, has been shown. The most expressed antitumor effects of AraC in combination with proton irradiation have been revealed during the ex vivo irradiation of ascites cells. This may indicate a difference in the effect of AraC on cells irradiated in vivo and ex vivo, both at the stage of primary oncogenesis and during the development of an established neoplasm. The impact of incubation conditions, irradiation, and AraC concentration on the magnitude of radiosensitizing effect of AraC is discussed.
本实验研究了1-β- d -阿拉伯糖醛酸胞嘧啶（AraC）在质子照射下对小鼠埃利希腹水癌（EAC）细胞诱导和生长的调节作用。在体内和体外均显示，在AraC存在的情况下，质子照射后肿瘤生长速度降低。在腹水细胞的离体照射中发现了AraC联合质子照射的抗肿瘤效果。这可能表明AraC对体内和体外照射细胞的影响不同，无论是在原发性肿瘤发生阶段还是在已确定的肿瘤发展过程中。讨论了培养条件、辐照和AraC浓度对AraC放射增敏效应大小的影响。
期刊介绍：
The journal Physics of Particles and Nuclei Letters, brief name Particles and Nuclei Letters, publishes the articles with results of the original theoretical, experimental, scientific-technical, methodological and applied research. Subject matter of articles covers: theoretical physics, elementary particle physics, relativistic nuclear physics, nuclear physics and related problems in other branches of physics, neutron physics, condensed matter physics, physics and engineering at low temperatures, physics and engineering of accelerators, physical experimental instruments and methods, physical computation experiments, applied research in these branches of physics and radiology, ecology and nuclear medicine.
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