Epilepsy research and treatment最新文献_第3页

Highights in the history of epilepsy: the last 200 years. 癫痫史上的高峰：过去200年。

Epilepsy research and treatment Pub Date : 2014-01-01 Epub Date: 2014-08-24 DOI: 10.1155/2014/582039

Emmanouil Magiorkinis, Aristidis Diamantis, Kalliopi Sidiropoulou, Christos Panteliadis

引用次数: 0

Adaptive skills and somatization in children with epilepsy. 癫痫患儿的适应技能和躯体化。

Epilepsy research and treatment Pub Date : 2014-01-01 Epub Date: 2014-01-27 DOI: 10.1155/2014/856735

Nichole Wicker Villarreal, Cynthia A Riccio, Morris J Cohen, Yong Park

{"title":"Adaptive skills and somatization in children with epilepsy.","authors":"Nichole Wicker Villarreal, Cynthia A Riccio, Morris J Cohen, Yong Park","doi":"10.1155/2014/856735","DOIUrl":"https://doi.org/10.1155/2014/856735","url":null,"abstract":"Objective. Children with epilepsy are at risk for less than optimum long-term outcomes. The type and severity of their epilepsy may contribute to educational, psychological, and social outcomes. The objective of this study was to determine the relation between somatization and adaptive skills based on seizure type that could impact on those outcomes. Methods. This study examined adaptive functioning and somatization in 87 children with epilepsy using archival data from a tertiary care facility. Results. No significant differences in adaptive skills emerged between groups of children diagnosed with complex partial (CP) as compared to CP-secondary generalized (SG) seizures; however, deficits in adaptive behavior were found for both groups. The number of medications, possibly reflecting the severity of the epilepsy, was highly correlated to adaptive function. Conclusions. Identification of deficits in adaptive behavior may represent an opportunity for tailored prevention and intervention programming for children with epilepsy. Addressing functional deficits may lead to improved outcomes for these children. ","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":"2014 ","pages":"856735"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/856735","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32174772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy. 选择性杏仁海马体切除术与前颞叶切除术治疗内侧颞叶癫痫的神经认知和癫痫结果。

Epilepsy research and treatment Pub Date : 2014-01-01 Epub Date: 2014-10-01 DOI: 10.1155/2014/306382

Alireza Mansouri, Aria Fallah, Mary Pat McAndrews, Melanie Cohn, Diana Mayor, Danielle Andrade, Peter Carlen, Jose M Del Campo, Peter Tai, Richard A Wennberg, Taufik A Valiante

{"title":"Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy.","authors":"Alireza Mansouri, Aria Fallah, Mary Pat McAndrews, Melanie Cohn, Diana Mayor, Danielle Andrade, Peter Carlen, Jose M Del Campo, Peter Tai, Richard A Wennberg, Taufik A Valiante","doi":"10.1155/2014/306382","DOIUrl":"https://doi.org/10.1155/2014/306382","url":null,"abstract":"Objective. To report our institutional seizure and neuropsychological outcomes for a series of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH) between 2004 and 2011. Methods. A retrospective study of patients with mTLE was conducted. Seizure outcome was reported using time-to-event analysis. Cognitive outcome was reported using the change principal in component factor scores, one each, for intellectual abilities, visuospatial memory, and verbal memory. The Boston Naming Test was used for naming assessment. Language dominant and nondominant resections were compared separately. Student's t-test was used to assess statistical significance. Results. Ninety-six patients (75 ATL, 21 SelAH) were included; fifty-four had complete neuropsychological follow-up. Median follow-up was 40.5 months. There was no statistically significant difference in seizure freedom or any of the neuropsychological outcomes, although there was a trend toward greater postoperative decline in naming in the dominant hemisphere group following ATL. Conclusion. Seizure and neuropsychological outcomes did not differ for the two surgical approaches which is similar to most prior studies. Given the theoretical possibility of SelAH sparing language function in patients with epilepsy secondary to mesial temporal sclerosis and the limited high-quality evidence creating equipoise, a multicenter randomized clinical trial is warranted. ","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":"2014 ","pages":"306382"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/306382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32775248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

The syndrome of absence status epilepsy: review of the literature. 缺席状态癫痫综合征:文献综述。

Epilepsy research and treatment Pub Date : 2014-01-01 Epub Date: 2014-02-10 DOI: 10.1155/2014/624309

Leonilda Bilo, Sabina Pappatà, Roberto De Simone, Roberta Meo

引用次数: 16

The perception of family function by adolescents with epilepsy in a rural nigerian community. 尼日利亚农村地区青少年癫痫患者对家庭功能的认知。

Epilepsy research and treatment Pub Date : 2014-01-01 Epub Date: 2014-11-25 DOI: 10.1155/2014/959274

Edwin E Eseigbe, Folorunsho T Nuhu, Taiwo L Sheikh, Sam J Adama, Patricia Eseigbe, Okechukwu J Oguizu

{"title":"The perception of family function by adolescents with epilepsy in a rural nigerian community.","authors":"Edwin E Eseigbe, Folorunsho T Nuhu, Taiwo L Sheikh, Sam J Adama, Patricia Eseigbe, Okechukwu J Oguizu","doi":"10.1155/2014/959274","DOIUrl":"https://doi.org/10.1155/2014/959274","url":null,"abstract":"The family plays a significant role in epilepsy management in sub-Saharan Africa and how this role is perceived by persons with epilepsy could influence epilepsy outcomes. The objective of the study was to assess perception of family function by adolescents with epilepsy (AWE). The sociodemographic and epilepsy characteristics of AWE in a rural Nigerian community were assessed and the Family APGAR tool was used in assessing their perception of satisfaction with family functioning. Adolescents (n = 1708) constituted 26% of the community's population and 18 (10.5/1000) had epilepsy. The AWE age range was 11-19 years (mean 16.7 ± 2.6 years) with a male preponderance (15, 83.3%). The family was the only source of care. Family dysfunction (Family APGAR Score <7) was indicated by 15 (83.3%) of the AWE. The strongest perception of family function was in adaptability while the weakest was with growth. The indication of family dysfunction was significant (P<0.05) in the older (age 14-19 years) AWE when compared with the younger AWE (11-13 years) in the study. Most of the AWE indicated living in a dysfunctional family setting. The study highlights the need to address the role of the family in the provision of comprehensive epilepsy care. ","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":"2014 ","pages":"959274"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/959274","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32907093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy. 破伤风毒素与人类癫痫相关蛋白之间的肽网络。

Epilepsy research and treatment Pub Date : 2014-01-01 Epub Date: 2014-06-01 DOI: 10.1155/2014/236309

Guglielmo Lucchese, Jean Pierre Spinosa, Darja Kanduc

引用次数: 6

Caregiver burden in epilepsy: determinants and impact. 癫痫患者的照顾者负担:决定因素和影响。

Epilepsy research and treatment Pub Date : 2014-01-01 Epub Date: 2014-04-08 DOI: 10.1155/2014/808421

Ioannis Karakis, Andrew J Cole, Georgia D Montouris, Marta San Luciano, Kimford J Meador, Charitomeni Piperidou

{"title":"Caregiver burden in epilepsy: determinants and impact.","authors":"Ioannis Karakis, Andrew J Cole, Georgia D Montouris, Marta San Luciano, Kimford J Meador, Charitomeni Piperidou","doi":"10.1155/2014/808421","DOIUrl":"https://doi.org/10.1155/2014/808421","url":null,"abstract":"Aim. Caregiver burden (CB) in epilepsy constitutes an understudied area. Here we attempt to identify the magnitude of this burden, the factors associated with it, and its impact to caregiver quality of life (QOL). Methods. 48 persons with epilepsy (PWE) underwent video-EEG monitoring and their caregivers completed questionnaires providing demographic, disease-related, psychiatric, cognitive, sleep, QOL, and burden information. Results. On regression analysis, higher number of antiepileptic drugs, poorer patient neuropsychological performance, lower patient QOL score, and lower caregiver education level were associated with higher CB. Time allocated to patient care approximated but did not attain statistical significance. A moderate inverse correlation between CB and caregiver QOL physical component summary score and a stronger inverse correlation between CB and caregiver QOL mental component summary score were seen. Conclusion. In a selected cohort of PWE undergoing video-EEG monitoring, we identified modest degree of CB, comparable to that reported in the literature for other chronic neurological conditions. It is associated with specific patient and caregiver characteristics and has a negative effect on caregiver QOL. ","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":"2014 ","pages":"808421"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/808421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32323975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 90

Long-term survival and outcome in children admitted to kilifi district hospital with convulsive status epilepticus. 基利菲地区医院惊厥性癫痫持续状态患儿的长期生存率和转归。

Epilepsy research and treatment Pub Date : 2014-01-01 Epub Date: 2014-01-30 DOI: 10.1155/2014/643747

Agnes Prins, Eddie Chengo, Victor Mung'ala Odera, Manish Sadarangani, Claire Seaton, Penny Holding, Greg Fegan, Charles R Newton

{"title":"Long-term survival and outcome in children admitted to kilifi district hospital with convulsive status epilepticus.","authors":"Agnes Prins, Eddie Chengo, Victor Mung'ala Odera, Manish Sadarangani, Claire Seaton, Penny Holding, Greg Fegan, Charles R Newton","doi":"10.1155/2014/643747","DOIUrl":"10.1155/2014/643747","url":null,"abstract":"Objectives. The incidence of convulsive status epilepticus (CSE) is high in Africa but the long-term outcome is unknown. We examined the neurocognitive outcome and survival of children treated for CSE in a Kenyan hospital 3 to 4 years after discharge. Methods. The frequency and nature of neurological deficits among this group of children were determined and compared to a control group. The children were screened with the Ten Questions Questionnaire for neurodevelopmental impairment if alive and those that screened positive were invited for further assessment to determine the pattern and extent of their impairment. A verbal autopsy was performed to determine the cause of death in those that died. Results. In the 119 cases followed-up, 9 (8%) died after discharge, with the majority having seizures during their fatal illness. The 110 survivors (median age 5 years) had significantly more neurological impairments on the screening compared to 282 controls (34/110 (30.9%) versus 11/282 (3.9%), OR = 11.0, 95% CI 5.3-22.8). Fifteen percent of the cases had active epilepsy. Conclusions. This study demonstrates the considerable burden of CSE in African children. Strategies to manage children with CSE that are acceptable to the community need to be explored to improve the longer-term outcome. ","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":"2014 ","pages":"643747"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32176414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The modified atkins diet in refractory epilepsy. 改良阿特金斯饮食法治疗难治性癫痫。

Epilepsy research and treatment Pub Date : 2014-01-01 Epub Date: 2014-01-30 DOI: 10.1155/2014/404202

Suvasini Sharma, Puneet Jain

引用次数: 25

Temporal lobe resective surgery for medically intractable epilepsy: a review of complications and side effects. 颞叶切除手术治疗难治性癫痫:并发症和副作用的回顾。

Epilepsy research and treatment Pub Date : 2013-01-01 Epub Date: 2013-10-31 DOI: 10.1155/2013/752195

Iordanis Georgiadis, Effie Z Kapsalaki, Kostas N Fountas

{"title":"Temporal lobe resective surgery for medically intractable epilepsy: a review of complications and side effects.","authors":"Iordanis Georgiadis, Effie Z Kapsalaki, Kostas N Fountas","doi":"10.1155/2013/752195","DOIUrl":"https://doi.org/10.1155/2013/752195","url":null,"abstract":"Object. It is widely accepted that temporal resective surgery represents an efficacious treatment option for patients with epilepsy of temporal origin. The meticulous knowledge of the potential complications, associated with temporal resective procedures, is of paramount importance. In our current study, we attempt to review the pertinent literature for summating the complications of temporal resective procedures for epilepsy. Method. A PubMed search was performed with the following terms: \"behavioral,\" \"cognitive,\" \"complication,\" \"deficit,\" \"disorder,\" \"epilepsy,\" \"hemianopia,\" \"hemianopsia,\" \"hemorrhage,\" \"lobectomy,\" \"medial,\" \"memory,\" \"mesial,\" \"neurobehavioral,\" \"neurocognitive,\" \"neuropsychological,\" \"psychological,\" \"psychiatric,\" \"quadranopia,\" \"quadranopsia,\" \"resective,\" \"side effect,\" \"surgery,\" \"temporal,\" \"temporal lobe,\" and \"visual field.\" Results. There were six pediatric, three mixed-population, and eleven adult surgical series examining the incidence rates of procedure-related complications. The reported mortality rates varied between 0% and 3.5%, although the vast majority of the published series reported no mortality. The cumulative morbidity rates ranged between 3.2% and 88%. Conclusions. Temporal resective surgery for epilepsy is a safe treatment modality. The reported morbidity rates demonstrate a wide variation. Accurate detection and frank reporting of any surgical, neurological, cognitive, and/or psychological complications are of paramount importance for maximizing the safety and improving the patients' overall outcome. ","PeriodicalId":72948,"journal":{"name":"Epilepsy research and treatment","volume":"2013 ","pages":"752195"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/752195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31913732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 79