Endocrines最新文献_第4页

Thyroid and Heart: A Fatal Pathophysiological Attraction in a Controversial Clinical Liaison 甲状腺与心脏：有争议的临床联系中致命的病理生理学吸引力

Endocrines Pub Date : 2023-11-30 DOI: 10.3390/endocrines4040053

A. Pingitore, F. Mastorci, Maria Francesca Lodovica Lazzeri, C. Vassalle

引用次数: 0

Higher Adiponectin Levels in Children and Adolescents with T1D Probably Contribute to the Osteopenic Phenotype through the RANKL/OPG System Activation 儿童和青少年T1D患者较高的脂联素水平可能通过RANKL/OPG系统激活导致骨质减少表型

Endocrines Pub Date : 2023-11-03 DOI: 10.3390/endocrines4040051

Charalampos Tsentidis, Dimitrios Gourgiotis, Lydia Kossiva, Antonios Marmarinos, Artemis Doulgeraki, Kyriaki Karavanaki

{"title":"Higher Adiponectin Levels in Children and Adolescents with T1D Probably Contribute to the Osteopenic Phenotype through the RANKL/OPG System Activation","authors":"Charalampos Tsentidis, Dimitrios Gourgiotis, Lydia Kossiva, Antonios Marmarinos, Artemis Doulgeraki, Kyriaki Karavanaki","doi":"10.3390/endocrines4040051","DOIUrl":"https://doi.org/10.3390/endocrines4040051","url":null,"abstract":"Background: Diabetes mellitus is an increasing global health emergency, with serious complications (including osteoporosis). Leptin and adiponectin are among the least-investigated possible contributing factors of T1D low bone mass. Methods: In this case-control cross-sectional analysis, we evaluated 40 pairs of T1D children and adolescents and controls. We evaluated body diameters and skinfolds, leptin, adiponectin, lipids and lipoproteins, bone metabolic markers and DXA parameters of BMD and fat percentage. Results: Leptin levels were comparable between groups and correlated well with body mass parameters. Adiponectin levels were found to be higher in the patient group and correlated with higher levels of HbA1c, triglycerides and s-RANKL. Conclusions: In this study, leptin levels were no different, but adiponectin levels were found to be higher in children and adolescents with T1D and correlated with diabetic metabolic derangement indices and s-RANKL in the patient group. Adiponectin can be considered a surrogate marker of T1D in young patients’ metabolic status and probably contributes to the diabetic low bone mass phenotype via activation of the RANKL/OPG metabolic pathway.","PeriodicalId":72908,"journal":{"name":"Endocrines","volume":"8 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135818930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontal Lobe Functions and Quality of Life in Individuals with Obesity with and without Binge Eating Disorder 伴有或不伴有暴食症的肥胖患者的额叶功能和生活质量

Endocrines Pub Date : 2023-10-08 DOI: 10.3390/endocrines4040050

Fátima Gameiro, Beatriz Rosa, Miguel Faria

{"title":"Frontal Lobe Functions and Quality of Life in Individuals with Obesity with and without Binge Eating Disorder","authors":"Fátima Gameiro, Beatriz Rosa, Miguel Faria","doi":"10.3390/endocrines4040050","DOIUrl":"https://doi.org/10.3390/endocrines4040050","url":null,"abstract":"Frontal lobe functions (FLFs) play an important role in human behavioral regulation and can be a determinant of eating behavior. The aim of this study was to analyse FLFs in individuals with obesity, with and without binge eating disorder (BED), compared to individuals with normal weight (NW), and to analyse the effect of sex and binge disorder on quality of life, with age and BMI as covariates. A total of 114 participants, comprising three different groups (NW individuals, individuals with obesity but without BED, and individuals with obesity and BED), completed the Frontal Assessment Battery (FAB) and Impact of Weight on Quality of Life (IWQOL-lite) questionnaires. The results showed that individuals with obesity, with and without BED, have poorer frontal lobe functioning than the NW group. Individuals with obesity and BED have lower performance in terms of FLFs than individuals with obesity but without BED. Male participants have a higher perception of quality of life in all dimensions, with women showing lower values in self-esteem and sex life. Individuals with obesity and BED show greater weaknesses in physical function. These results suggest that low FLFs and worse quality of life characterize individuals with obesity, and this is more evident in these individuals with BED.","PeriodicalId":72908,"journal":{"name":"Endocrines","volume":"164 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135251449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin Resistance and Glucose Metabolism during Infection 感染期间胰岛素抵抗与葡萄糖代谢

Endocrines Pub Date : 2023-10-07 DOI: 10.3390/endocrines4040049

Borros Arneth

{"title":"Insulin Resistance and Glucose Metabolism during Infection","authors":"Borros Arneth","doi":"10.3390/endocrines4040049","DOIUrl":"https://doi.org/10.3390/endocrines4040049","url":null,"abstract":"Specific critical functions of endocrine and immune cells ensure that an individual remains healthy and free from infection. This study aimed to explore immune–endocrine associations involved in disease. Methods: The PsycINFO, PubMed, Web of Science, and CINAHL databases were searched for relevant articles using the following search terms and phrases: “hormones”, “hormonal responses”, “immune system”, “endocrine system”, “infection”, “immune cells”, “endocrine cells”, “infection”, “immune”, “endocrine”, and “interactions”. The search was limited to articles published between 2009 and 2023. Results: A review of ninety-three studies showed that metabolic activity levels in the body as well as energy consumption patterns are affected by feedback loops that connect the endocrine and immune systems. The associations between endocrine cells and immune cells are complex and involve a wide range of hormones, molecules, and receptors related to antipathogen responses and metabolic regulation. Conclusions: During infection, endocrine cells and immune cells interact via feedback loops to ensure optimal energy utilization and a timely response to pathogens. Therefore, the endocrine system helps to regulate systemic metabolism while controlling the outcomes of regulatory elements of the immune system.","PeriodicalId":72908,"journal":{"name":"Endocrines","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135301087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Update on Experimental Therapeutic Strategies for Thin Endometrium 薄子宫内膜实验治疗策略研究进展

Endocrines Pub Date : 2023-10-04 DOI: 10.3390/endocrines4040048

Yiqun Tang, Caroline Frisendahl, Parameswaran Grace Lalitkumar, Kristina Gemzell-Danielsson

{"title":"An Update on Experimental Therapeutic Strategies for Thin Endometrium","authors":"Yiqun Tang, Caroline Frisendahl, Parameswaran Grace Lalitkumar, Kristina Gemzell-Danielsson","doi":"10.3390/endocrines4040048","DOIUrl":"https://doi.org/10.3390/endocrines4040048","url":null,"abstract":"Infertility caused by a thin endometrium remains a significant challenge in assisted reproduction and is often associated with a low success rate after treatment with assisted reproductive technology. There is a lack of consensus in the field concerning both its diagnostic criteria and clinical management. The currently available treatment options are few with limited efficacy. Recent advances in cell therapy and bioengineering have, however, shown promising results for the treatment of a thin endometrium. Notably, these novel interventions have demonstrated the ability to increase endometrial thickness, restore endometrial function, and improve reproductive outcomes. In this comprehensive review, we focus on a critical evaluation of these emerging therapeutic strategies for a thin endometrium including platelet-rich plasma, exosomes derived from stem cells, and bioengineering-based techniques. By synthesizing the findings from available clinical trials, we highlight the promising outcomes achieved so far and underscore the importance of robust clinical trials in assessing the safety and efficacy of these interventions in the future. Continued research efforts to unravel the intricate mechanisms involved in endometrial repair and regeneration will also be essential to enhance our understanding of this multifactorial condition and to identify novel treatment targets for future therapeutic interventions.","PeriodicalId":72908,"journal":{"name":"Endocrines","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135590410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated Third Cranial Nerve Palsy Associated with Sudden Worsening of Hypotonic Hyponatremia Secondary to Ischemic Pituitary Apoplexy 孤立性第三脑神经麻痹与缺血性垂体卒中继发低渗性低钠血症突然恶化相关

Endocrines Pub Date : 2023-09-11 DOI: 10.3390/endocrines4030047

Emanuele Varaldo, Alessandro Maria Berton, Mauro Maccario, Valentina Gasco

{"title":"Isolated Third Cranial Nerve Palsy Associated with Sudden Worsening of Hypotonic Hyponatremia Secondary to Ischemic Pituitary Apoplexy","authors":"Emanuele Varaldo, Alessandro Maria Berton, Mauro Maccario, Valentina Gasco","doi":"10.3390/endocrines4030047","DOIUrl":"https://doi.org/10.3390/endocrines4030047","url":null,"abstract":"Pituitary apoplexy (PA) is a rare medical emergency. The sudden pressure increase in the sella turcica may determine compression on the surrounding structures determining the classical symptomatology associated, especially visual field impairment and/or ocular palsies and hypopituitarism; hypotonic hyponatremia may occur too, even if it is not common. Although already described in the literature, cases of isolated III cranial nerve palsies are extremely rare events. We report the case of a mid-60-year-old man with a known pituitary adenoma accessing the Emergency Department (ED) for worsening headaches unresponsive to analgesics, with a morphological picture consistent with ischemic PA, despite no dimensional increase of the pituitary lesion; upon ED access, a mild paucisymptomatic hyponatremia was also observed. Dexamethasone and mannitol were empirically introduced upon neurosurgical indication and tramadol and ketorolac were promptly administered as well, but without benefit. In the next days, a severe hypotonic hyponatremia was evidenced and a clear left III cranial nerve palsy developed, but no clear signs of cerebral bleeding or ischemia, nor a significant compression on the homolateral cavernous sinus, were observed. Upon ruling out other possible causes, a likely diagnosis of syndrome of inappropriate antidiuresis (SIAD) was made, confirmed by the quick response to fluid restriction. Overall, the sudden fall in tonicity plasma levels seemed to contribute to the exacerbation of the neurological deficit since the normalization of sodium levels was associated with a rapid and complete reversion of the III cranial nerve palsy.","PeriodicalId":72908,"journal":{"name":"Endocrines","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gynecomastia and Leydigioma: An Unexpected Case Report Outcome 妇科和间质瘤：一例意外病例报告结果

Endocrines Pub Date : 2023-09-08 DOI: 10.3390/endocrines4030046

Giuseppe Seminara, Paola Chiarello, Rodolfo Iuliano, Emanuele Tinelli, Umberto Sabatini, S. Iuliano, Antonio Aversa

{"title":"Gynecomastia and Leydigioma: An Unexpected Case Report Outcome","authors":"Giuseppe Seminara, Paola Chiarello, Rodolfo Iuliano, Emanuele Tinelli, Umberto Sabatini, S. Iuliano, Antonio Aversa","doi":"10.3390/endocrines4030046","DOIUrl":"https://doi.org/10.3390/endocrines4030046","url":null,"abstract":"We report a case of a 19-year-old male referred to the Endocrine Unit because of gynecomastia. Initial investigation revealed elevated levels of estradiol (E2) along with secondary hypogonadism (hypotestosteronemia and severe oligoasthenoteratozoospermia (OAT)) despite normal testicular volume (12 mL) and secondary sexual characteristics. Surprisingly, an ultrasound examination revealed a small hypoechoic mass (1.1 cm) with intense intralesional vascularization within the right testicle, even though tumor markers were normal. Surgical removal of testicular mass led to the identification of Leydigioma, and the patient showed regression of gynecomastia during the nine-month follow-up. Unexpectedly, hypergonadotropinemia manifested along with normal testosterone (T) levels and significant improvement in OAT. Magnetic resonance imaging (MRI) showed pituitary hyperplasia (PH). Gynecomastia represents an atypical manifestation of Leydig cell tumors and typically resolves after surgical removal. However, unilateral orchiectomy may determine compensatory PH. Currently, it is uncertain whether the shift from hypogonadotropic to permanent hypergonadotropinemia was the only factor responsible for the high sperm count occurring in our patient. Further research is needed to elucidate the underlying mechanisms.","PeriodicalId":72908,"journal":{"name":"Endocrines","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45031198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring SGLT-2 Inhibitors: Benefits beyond the Glucose-Lowering Effect—What Is New in 2023? 探索SGLT-2抑制剂:降糖效果之外的益处- 2023年有什么新发现?

Endocrines Pub Date : 2023-09-04 DOI: 10.3390/endocrines4030045

Clipper F. Young, Neeka Farnoudi, Jenny Chen, Jay H. Shubrook

引用次数: 0

Anti-Dyslipidemic and Anti-Diabetic Properties of Corosolic Acid: A Narrative Review 科罗索酸的抗血脂和抗糖尿病特性：叙述性综述

Endocrines Pub Date : 2023-09-01 DOI: 10.3390/endocrines4030044

R. Cannarella, Vincenzo Garofalo, A. Calogero

引用次数: 0

Regulation of Phosphate Transporters and Novel Regulator of Phosphate Metabolism 磷酸转运蛋白的调控和磷酸代谢的新调节剂

Endocrines Pub Date : 2023-08-21 DOI: 10.3390/endocrines4030043

Megumi Koike, Minori Uga, Yuji Shiozaki, K. Miyamoto, H. Segawa

引用次数: 0