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Duodecim; laaketieteellinen aikakauskirja最新文献

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Health mind in a health brain. 健康的心灵寓于健康的大脑。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Jyrki Korkeila
{"title":"Health mind in a health brain.","authors":"Jyrki Korkeila","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The last few years have seen an increase in the research of psychic well-being and positive mental health. A positive point of view refers not only to pleasure but also to the ability to act in a constructive manner in challenging situations, and effectively regulate negative feelings and stress. Although a positive state of mind is often a passing experience, it can also be developed. Analogously, effective methods tested in a controlled manner have been established for the development of positive capabilities. It is furthermore possible to promote psychic well-being through exercise, healthy diet and practicing mindfulness.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 2","pages":"209-14"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35223671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High intensity focused ultrasound (HIFU) in tumor therapy. 高强度聚焦超声在肿瘤治疗中的应用。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Roberto Blanco Sequeiros, Kirsi Joronen, Gaber Komar, Seppo K Koskinen
{"title":"High intensity focused ultrasound (HIFU) in tumor therapy.","authors":"Roberto Blanco Sequeiros,&nbsp;Kirsi Joronen,&nbsp;Gaber Komar,&nbsp;Seppo K Koskinen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>HIFU (high intensity focused ultrasound) is a method in which high-frequency ultrasound is focused on a tissue in order to achieve a thermal effect and the subsequent percutaneously ablation, or tissue modulation. HIFU is non-invasive and results in an immediate tissue destruction effect corresponding to surgery, either percutaneously or through body cavities. HIFU can be utilized in the treatment of both benign and malignant tumors. In neurological diseases, focused HIFU can be used in the treatment of disorders of the basal ganglia.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 2","pages":"143-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35223663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric ocular disorders and visual handicap in Finland - what do the registers tell? 芬兰的儿童眼部疾病和视力障碍——注册表显示了什么?
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Mika Gissler, Matti Ojamo, Annukka Ritvanen, Hannu Uusitalo
{"title":"Pediatric ocular disorders and visual handicap in Finland - what do the registers tell?","authors":"Mika Gissler,&nbsp;Matti Ojamo,&nbsp;Annukka Ritvanen,&nbsp;Hannu Uusitalo","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>There is no published data from the last few years on the frequency of pediatric ocular disorders and visual handicap in Finland.</p><p><strong>Methods: </strong>We surveyed the registers of THL (National Institute for Health and Welfare) and statistics of Kela (The Social Insurance Institution of Finland).</p><p><strong>Results: </strong>The majority of visual defects are neurologic or congenital. Retinopathic lesions were reported in 11% of small premature infants. In the years from 1993 to 2011, significant abnormalities of the eye or its accessory organs were on the average registered annually in 94 liveborn infants, and the number of corresponding cancers was less than five.</p><p><strong>Conclusions: </strong>Ocular disorders in children are rare. They are significant because of the special attention required in everyday life.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 2","pages":"159-66"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35223665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinopathy of prematurity - from recognition of risk factors to treatment recommendations. 早产儿视网膜病变——从危险因素的认识到治疗建议。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Reija Fagerholm, Eija Vesti
{"title":"Retinopathy of prematurity - from recognition of risk factors to treatment recommendations.","authors":"Reija Fagerholm,&nbsp;Eija Vesti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Retinopathy of prematurity is a proliferative retinal disorder diagnosed exclusively in prematurely born infants. In retinopathy of prematurity, growth of the retinal vasculature is disturbed, leading to hypoxia-induced pathological changes typical of retinopathy of prematurity, in the worst case resulting in retinal detachment. The most typical risk factors predisposing to the disease include hyperoxemia, low levels of insulin-like growth factor 1 (IGF-I), and low birth weight in relation to weeks of pregnancy. Laser therapy of peripheral retina is the currently established form of treatment. Screening is applied in order to recognize the pathological changes in retinopathy of prematurity early enough.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 4","pages":"337-44"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35310770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute pericarditis. 急性心包炎。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Ville Kytö, Matti Matti Niemelä
{"title":"Acute pericarditis.","authors":"Ville Kytö,&nbsp;Matti Matti Niemelä","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Acute pericarditis is typically associated with a viral infection. Chest pain appearing in connection with or soon after the symptoms of infection is the characteristic symptom. Diagnosis is based on the recognition of two characteristic findings (pericardial chest pain, pericardial friction rub, new ECG changes or new pericardial effusion). Medication with an anti-inflammatory analgesic for 1 to 2 weeks is the first-line treatment. A longer course of colchicine is recommended for the prevention of recurrence of the disease. The use of glucocorticoids should be avoided due to the associated risk of recurrence. Exercise and physical activity are harmful during pericarditis.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 4","pages":"391-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35310775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
" Nature step" to prevent noncommunicable inflammatory disease. 预防非传染性炎性疾病的“自然步骤”。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Tari Haahtela, Ilkka Hanski, Leena von Hertzen, Pekka Jousilahti, Tiina Laatikainen, Mika Mäkelä, Pekka Puska, Kari Reijula, Kimmo Saarinen, Erkki Vartiainen, Tuula Vasankar, Suvi Virtanen
{"title":"\" Nature step\" to prevent noncommunicable inflammatory disease.","authors":"Tari Haahtela,&nbsp;Ilkka Hanski,&nbsp;Leena von Hertzen,&nbsp;Pekka Jousilahti,&nbsp;Tiina Laatikainen,&nbsp;Mika Mäkelä,&nbsp;Pekka Puska,&nbsp;Kari Reijula,&nbsp;Kimmo Saarinen,&nbsp;Erkki Vartiainen,&nbsp;Tuula Vasankar,&nbsp;Suvi Virtanen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The prevention of many diseases has significantly improved by intervening in known risk factors. However, the causes of the increase in allergy and type 1 diabetes are unknown. These diseases are often associated with a low-grade inflammation and immunological imbalance. The lifestyle and environment of urbanized populations have changed causing imbalance in the human normal flora and affecting immune regulation. We discuss everyday factors affecting immune regulation, using allergy as an example. Health may be promoted through the \"nature step\", by supporting the connection between humans and nature.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 1","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35611513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Physicians' working conditions, health and working capacity]. [医生的工作条件、健康和工作能力]。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Marko Elovainio, Marianna Virtanen, Tuula Oksanen
{"title":"[Physicians' working conditions, health and working capacity].","authors":"Marko Elovainio,&nbsp;Marianna Virtanen,&nbsp;Tuula Oksanen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Changes in the working environment will also influence the work of physicians. The greatest of these changes on the Finnish scale, the SOTE reform (the reform in social welfare and public health services), still lies ahead. Labor shortage, on-call duties and patient record systems providing little support to work add to the burden. In surveys related to psychosocial working conditions, physicians' greatest work load factors have been rush, forced working pace and poor communication despite the fact that, on average, they consider their working conditions to be good, frequently better than those of other professional groups, and are committed to carry on with their work until retirement age. Although psychic symptoms and sleep disturbances are common among physicians, there are fewer disability pensions due to e.g. depression among physicians than in other professional groups. Among the municipal professions, physicians have nearly the lowest rate of job absenteeism due to sickness. Challenges brought about by the changes in physician's work can be met with fair management, development of the social capital of the work community, organization of tasks and flexibility of working hours.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 7","pages":"647-52"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35658681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New study designs in clinical drug development. 临床药物开发中的新研究设计。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Olli Tenhunen, Miia Turpeinen, Pekka Kurki
{"title":"New study designs in clinical drug development.","authors":"Olli Tenhunen,&nbsp;Miia Turpeinen,&nbsp;Pekka Kurki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clinical development of a novel drug has traditionally been seen as a series of four phases, each having its own objectives in establishing the efficacy and safety of the drug. Increasingly individualized medicine and the changing mechanisms of drug action are also changing the designs of clinical drug testing. The borders of development phases become blurred and the traditional large, controlled multicenter studies may in part be replaced by individual and risk-based approaches. The indications for drugs are more precisely targeted from biological starting points, and a target-oriented development may guide the designs of clinical testing at all stages of development. Utilization of data from registries along with modeling will become more common in clinical drug testing.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 6","pages":"599-605"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35659282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Who would benefit from exome sequencing? 谁会从外显子组测序中受益?
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Janna Saarela, Kaisa Kettunen
{"title":"Who would benefit from exome sequencing?","authors":"Janna Saarela,&nbsp;Kaisa Kettunen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Next-generation sequencing methods have revolutionized the possibilities for analyzing the human genome. Sequencing the exome, the protein-encoding portion of the genome, is used, in clinical medicine, especially in the diagnosis of rare hereditary diseases, congenital developmental disorders and cancer. Using exome sequencing as a diagnostic test is justified when the results could lead to an accurate diagnosis, significantly influence the treatment and genetic counseling. It is a reliable method for detecting single base mutations as minor deletions and insertions. However, with current methods the reliable analysis of larger changes in the number of copies, the length or repeats and areas present in multiple copies in the genome is challenging. Every human has many mutations in their exome, and distinguishing between insignificant and pathogenic mutations is thus a key challenge when interpreting the results of exome sequencing.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 5","pages":"481-8"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35221045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy and delivery after a cesarean section. 剖宫产后怀孕和分娩。
Duodecim; laaketieteellinen aikakauskirja Pub Date : 2017-01-01
Marja Vääräsmäki, Tytti Raudaskoski
{"title":"Pregnancy and delivery after a cesarean section.","authors":"Marja Vääräsmäki,&nbsp;Tytti Raudaskoski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>One out of seven of all parturients and one out of five primigravid women deliver by caesarean section. Of four women having undergone caesarean section, three will give birth vaginally, provided that the indication for surgery has been temporary by nature. Spontaneous beginning of labor and a previous vaginal delivery improve the chances of succesful of vaginal delivery. Rupture of the uterus in subsequent pregnancies is the most feared sequel to a caesarean section, with an occurrence of 0.2 to 1.5%. Delivery by caesarean is indicated in case of previous rupture of the uterus, hysterotomy through vertical incision, and more than two previous caesarean sections.</p>","PeriodicalId":72850,"journal":{"name":"Duodecim; laaketieteellinen aikakauskirja","volume":"133 4","pages":"345-52"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35310773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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