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Drug discovery today. Disease mechanisms最新文献

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Novel mechanisms underlie the initiation and progression of colorectal cancer 结直肠癌发生和发展的新机制
Drug discovery today. Disease mechanisms Pub Date : 2011-12-01 Epub Date: 2012-03-30 DOI: 10.1016/j.ddmec.2012.03.001
Jarod A. Zepp , Xiaoxia Li
{"title":"Novel mechanisms underlie the initiation and progression of colorectal cancer","authors":"Jarod A. Zepp , Xiaoxia Li","doi":"10.1016/j.ddmec.2012.03.001","DOIUrl":"10.1016/j.ddmec.2012.03.001","url":null,"abstract":"","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"8 3","pages":"Pages e53-e55"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2012.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76402004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) 过氧化物酶体增殖物激活受体-β/δ (PPARβ/δ)对胃肠道炎症和结直肠肿瘤发生的调节
Drug discovery today. Disease mechanisms Pub Date : 2011-12-01 Epub Date: 2011-11-29 DOI: 10.1016/j.ddmec.2011.11.002
Jeffrey M. Peters , Jose L. Morales , Frank J. Gonzalez
{"title":"Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)","authors":"Jeffrey M. Peters ,&nbsp;Jose L. Morales ,&nbsp;Frank J. Gonzalez","doi":"10.1016/j.ddmec.2011.11.002","DOIUrl":"10.1016/j.ddmec.2011.11.002","url":null,"abstract":"<div><p><span><span>Critical physiological roles of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) include the regulation glucose and lipid homeostasis<span>, cellular differentiation and modulation of inflammation. The potential for targeting PPARβ/δ for the prevention and treatment of </span></span>metabolic diseases<span> or cancer, is compromised because of major inconsistencies in the literature. This is due primarily to uncertainty regarding the effect of PPARβ/δ and its activation on cell proliferation<span>, apoptosis and cell survival. This review summarizes both the confirmed and conflicting mechanisms that have been described for PPARβ/δ and the potential for targeting this nuclear receptor for the prevention and treatment of </span></span></span>colon cancer.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"8 3","pages":"Pages e85-e93"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2011.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30632521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Inflammasomes and intestinal tumorigenesis 炎性小体与肠道肿瘤发生
Drug discovery today. Disease mechanisms Pub Date : 2011-12-01 Epub Date: 2011-12-15 DOI: 10.1016/j.ddmec.2011.11.003
Md. Hasan Zaki , Mohamed Lamkanfi , Thirumala-Devi Kanneganti
{"title":"Inflammasomes and intestinal tumorigenesis","authors":"Md. Hasan Zaki ,&nbsp;Mohamed Lamkanfi ,&nbsp;Thirumala-Devi Kanneganti","doi":"10.1016/j.ddmec.2011.11.003","DOIUrl":"10.1016/j.ddmec.2011.11.003","url":null,"abstract":"<div><p><span>Colorectal cancer<span><span> is a major health problem in developed countries. Chronic intestinal inflammation<span> predisposes individuals to the development of colorectal cancer. The intracellular NOD-like receptors (NLRs) have emerged as crucial regulators of intestinal inflammation and colorectal tumorigenesis. Activation of several NLRs leads to the formation of a protein complex called the </span></span>inflammasome<span>, which then triggers the activation of the cysteine protease caspase-1 and the downstream maturation and secretion of the </span></span></span>inflammatory cytokines<span> interleukin (IL)-1β and -18. Defective inflammasome signaling in the gut contributes to colitis and colorectal tumorigenesis by increasing the permeability of the epithelial barrier, dysregulating the proliferation of epithelial cells, and inducing oncogenic mediators. In this review, we discuss our current knowledge on how the inflammasome protects against colorectal tumorigenesis.</span></p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"8 3","pages":"Pages e71-e78"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2011.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30742436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
MicroRNAs and gastroenterological cancers 微小核糖核酸与胃肠道癌症。
Drug discovery today. Disease mechanisms Pub Date : 2011-12-01 Epub Date: 2011-12-12 DOI: 10.1016/j.ddmec.2011.11.005
Anuradha Budhu, Xin W. Wang
{"title":"MicroRNAs and gastroenterological cancers","authors":"Anuradha Budhu,&nbsp;Xin W. Wang","doi":"10.1016/j.ddmec.2011.11.005","DOIUrl":"10.1016/j.ddmec.2011.11.005","url":null,"abstract":"<div><p><span>MicroRNAs are small noncoding </span>RNAs<span><span> that control gene expression. In doing so, they functionally contribute to the maintenance of </span>cellular processes<span> as well as several important features related to cancer development and progression such as cell growth control, differentiation and apoptosis. In fact, recent studies have shown that microRNAs are suitable and effective cancer-related biomarkers because they display altered expression profiles in cancers versus normal tissue. In addition, microRNAs have been associated with cancer progression and outcome. In this review, the current state of knowledge of microRNA expression and function in relation to gastroenterological cancers will be addressed. Moreover, the mechanisms to alter their expression and the potential application of microRNAs in clinical settings will also be highlighted. Finally, the challenges involved in translating microRNA research to the clinic will be discussed.</span></span></p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"8 3","pages":"Pages e95-e102"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2011.11.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30615283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
IL-17 and intestinal tumorigenesis IL-17与肠道肿瘤发生
Drug discovery today. Disease mechanisms Pub Date : 2011-12-01 Epub Date: 2011-11-26 DOI: 10.1016/j.ddmec.2011.11.001
Wook-Jin Chae, Alfred L.M. Bothwell
{"title":"IL-17 and intestinal tumorigenesis","authors":"Wook-Jin Chae,&nbsp;Alfred L.M. Bothwell","doi":"10.1016/j.ddmec.2011.11.001","DOIUrl":"10.1016/j.ddmec.2011.11.001","url":null,"abstract":"<div><p>IL-17 is an important proinflammatory cytokine<span> in autoimmune diseases. The constant presence of IL-17 in the intestinal tract raises the possibility that it may be a critical enhancer of intestinal tumorigenesis. Yet the role of IL-17 in cancer development is controversial. Animal studies and clinical studies suggest that the role of IL-17 may be differential depending on type of cancer and tumor microenvironment. The role of IL-17 in intestinal tumorigenesis is largely proinflammatory and likely affects Treg function. Thus, targeting IL-17 in intestinal tumorigenesis may be an effective approach for treating cancer.</span></p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"8 3","pages":"Pages e79-e83"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2011.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84564367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
TLR signaling: a link between gut microflora, colorectal inflammation and tumorigenesis TLR信号:肠道菌群、结直肠炎症和肿瘤发生之间的联系
Drug discovery today. Disease mechanisms Pub Date : 2011-12-01 Epub Date: 2012-03-27 DOI: 10.1016/j.ddmec.2012.02.002
Rebeca Santaolalla , Daniel A. Sussman , Maria T. Abreu
{"title":"TLR signaling: a link between gut microflora, colorectal inflammation and tumorigenesis","authors":"Rebeca Santaolalla ,&nbsp;Daniel A. Sussman ,&nbsp;Maria T. Abreu","doi":"10.1016/j.ddmec.2012.02.002","DOIUrl":"10.1016/j.ddmec.2012.02.002","url":null,"abstract":"<div><p><span><span>A growing body of evidence supports the role of toll-like receptor (TLR) signaling in the intestinal mucosa<span> and its role in inflammation and tumorigenesis. Patients with chronic intestinal inflammation<span>, as is the case with inflammatory bowel disease (IBD), and a subset of patients with inflammatory and sporadic </span></span></span>colorectal neoplasia<span>, have increased expression of TLRs, especially TLR4<span>, on colonic epithelial cells. Mouse models of colitis and cancer are useful to understand the role of TLRs and bacteria in the development of </span></span></span>colon cancer<span><span>. Clear differences in bacterial colonization patterns are noted between normal and dysplastic </span>colonic mucosa. TLRs offer a potential prognostic and therapeutic target, serving as the link between bacterial ligands and epithelial inflammation.</span></p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"8 3","pages":"Pages e57-e62"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2012.02.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87596757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
SIGIRR, a negative regulator of colon tumorigenesis SIGIRR，结肠肿瘤发生的负调节因子
Drug discovery today. Disease mechanisms Pub Date : 2011-12-01 Epub Date: 2012-03-15 DOI: 10.1016/j.ddmec.2012.02.003
Junjie Zhao , Jarod Zepp , Katarzyna Bulek , Xiaoxia Li
{"title":"SIGIRR, a negative regulator of colon tumorigenesis","authors":"Junjie Zhao ,&nbsp;Jarod Zepp ,&nbsp;Katarzyna Bulek ,&nbsp;Xiaoxia Li","doi":"10.1016/j.ddmec.2012.02.003","DOIUrl":"10.1016/j.ddmec.2012.02.003","url":null,"abstract":"<div><p><span>Inappropriate activation of the Toll-IL-1R (TLR-IL-1R) signaling by commensal bacteria contributes to the pathogenesis of inflammatory bowel diseases and colitis-associated cancer. Recent studies have identified Single Immunoglobulin IL-1 Receptor Related molecule (SIGIRR) as a negative regulator of TLR-IL-1R signaling. It dampens </span>intestinal inflammation<span> and tumorigenesis in the colon. In this review, we will discuss the role of SIGIRR in different cell types and the mechanisms underlying its tumor suppressor function.</span></p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"8 3","pages":"Pages e63-e69"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2012.02.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40180446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Blood in a dish: in vitro synthesis of red blood cells 培养皿中的血液:红细胞的体外合成
Drug discovery today. Disease mechanisms Pub Date : 2011-06-01 Epub Date: 2011-11-15 DOI: 10.1016/j.ddmec.2011.10.002
Anna Rita Migliaccio , James Palis
{"title":"Blood in a dish: in vitro synthesis of red blood cells","authors":"Anna Rita Migliaccio ,&nbsp;James Palis","doi":"10.1016/j.ddmec.2011.10.002","DOIUrl":"10.1016/j.ddmec.2011.10.002","url":null,"abstract":"<div><p><span>Red blood cells, currently obtained from donors, represent the most common form of cell-based therapy. A better understanding of normal erythropoiesis is leading to improved multi-step protocols for the </span><em>in vitro</em> generation of fully mature red cells. The extensive <em>in vitro</em> expansion of embryonic erythroblasts and development of erythroid precursors as a potential transfusion product may help to deal with issues of scale and eventually find a place in the treatment of patients with acute and chronic anemias.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"8 1","pages":"Pages e3-e8"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2011.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32804720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Exciting times for life without a nucleus: broad roles for platelets in vascular inflammation 无核生命的激动时刻:血小板在血管炎症中的广泛作用
Drug discovery today. Disease mechanisms Pub Date : 2011-06-01 Epub Date: 2011-12-15 DOI: 10.1016/j.ddmec.2011.12.001
Craig N. Morrell
{"title":"Exciting times for life without a nucleus: broad roles for platelets in vascular inflammation","authors":"Craig N. Morrell","doi":"10.1016/j.ddmec.2011.12.001","DOIUrl":"10.1016/j.ddmec.2011.12.001","url":null,"abstract":"","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"8 1","pages":"Pages e1-e2"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2011.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73213034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer-associated thrombosis: an update 癌症相关血栓:最新进展
Drug discovery today. Disease mechanisms Pub Date : 2011-06-01 Epub Date: 2012-03-14 DOI: 10.1016/j.ddmec.2012.02.001
Abhay R. Shelke, Alok A. Khorana
{"title":"Cancer-associated thrombosis: an update","authors":"Abhay R. Shelke,&nbsp;Alok A. Khorana","doi":"10.1016/j.ddmec.2012.02.001","DOIUrl":"10.1016/j.ddmec.2012.02.001","url":null,"abstract":"<div><p><span>Cancer-associated thrombosis is a common complication seen in oncology patients, and its incidence is rising. Thromboembolism<span> is the second most common cause of death in cancer patients. Cancer-associated venous thromboembolism (VTE) is associated with high rate of recurrence, increased risk of bleeding, and a requirement for long-term </span></span>anticoagulation<span>. The hypercoagulable state in cancer involves several complex interdependent mechanisms including emerging roles for tumor-derived tissue factor and platelets. Identifying patients at risk for VTE and utilizing available anticoagulant agents for primary or secondary prophylaxis is crucial to reduce morbidity, enhance quality of life, and improve survival.</span></p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"8 1","pages":"Pages e39-e45"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2012.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84669619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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