Discovery immunology最新文献

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NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression. NKG2D 信号调节小鼠体内产生 IL-17A 的 γδT 细胞，从而促进癌症进展。

Discovery immunology Pub Date : 2022-05-10 eCollection Date: 2022-01-01 DOI: 10.1093/discim/kyac002

Sophie Curio, Sarah C Edwards, Toshiyasu Suzuki, Jenny McGovern, Chiara Triulzi, Nagisa Yoshida, Gustav Jonsson, Teresa Glauner, Damiano Rami, Robert Wiesheu, Anna Kilbey, Rachel Violet Purcell, Seth B Coffelt, Nadia Guerra

{"title":"NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression.","authors":"Sophie Curio, Sarah C Edwards, Toshiyasu Suzuki, Jenny McGovern, Chiara Triulzi, Nagisa Yoshida, Gustav Jonsson, Teresa Glauner, Damiano Rami, Robert Wiesheu, Anna Kilbey, Rachel Violet Purcell, Seth B Coffelt, Nadia Guerra","doi":"10.1093/discim/kyac002","DOIUrl":"10.1093/discim/kyac002","url":null,"abstract":"γδT cells are unconventional T cells particularly abundant in mucosal tissues that play an important role in tissue surveillance, homeostasis, and cancer. γδT cells recognize stressed cells or cancer cells through the NKG2D receptor to kill these cells and maintain normality. Contrary to the well-established anti-tumor function of these NKG2D-expressing γδT cells, we show here that, in mice, NKG2D regulates a population of pro-tumor γδT cells capable of producing IL-17A. Germline deletion of Klrk1, the gene encoding NKG2D, reduced the frequency of γδT cells in the tumor microenvironment and delayed tumor progression. We further show that blocking NKG2D reduced the capability of γδT cells to produce IL-17A in the pre-metastatic lung and that co-culture of lung T cells with NKG2D ligand-expressing tumor cells specifically increased the frequency of γδT cells. Together, these data support the hypothesis that, in a tumor microenvironment where NKG2D ligands are constitutively expressed, γδT cells accumulate in an NKG2D-dependent manner and drive tumor progression by secreting pro-inflammatory cytokines, such as IL-17A.","PeriodicalId":72830,"journal":{"name":"Discovery immunology","volume":"1 1","pages":"kyac002"},"PeriodicalIF":0.0,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/df/kyac002.PMC9580227.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9729686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unconventional modes of peptide-HLA-I presentation change the rules of TCR engagement. 肽- hla - 1呈递的非常规模式改变了TCR参与的规则

Discovery immunology Pub Date : 2022-05-04 eCollection Date: 2022-01-01 DOI: 10.1093/discim/kyac001

Jade R Hopkins, Bruce J MacLachlan, Stephen Harper, Andrew K Sewell, David K Cole

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引用次数: 0

Discovery Immunology, a new Open Access journal from the British Society for Immunology 《发现免疫学》是英国免疫学学会的一份新的开放获取期刊

Discovery immunology Pub Date : 2022-01-01 DOI: 10.1093/discim/kyab002

S. Milling

引用次数: 0

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