Discover mental health最新文献_第8页

Overview of the potential use of fluvoxamine for COVID-19 and long COVID. 氟伏沙明用于 COVID-19 和长 COVID 的可能性概述。

Discover mental health Pub Date : 2023-01-01 Epub Date: 2023-03-21 DOI: 10.1007/s44192-023-00036-3

Kenji Hashimoto

引用次数: 0

Interaction of the pre- and postnatal environment in the maternal immune activation model. 母体免疫激活模型中产前和产后环境的相互作用。

Discover mental health Pub Date : 2023-01-01 Epub Date: 2023-08-22 DOI: 10.1007/s44192-023-00042-5

Anna Gundacker, Laura Cuenca Rico, Peter Stoehrmann, Katharina E Tillmann, Ulrike Weber-Stadlbauer, Daniela D Pollak

{"title":"Interaction of the pre- and postnatal environment in the maternal immune activation model.","authors":"Anna Gundacker, Laura Cuenca Rico, Peter Stoehrmann, Katharina E Tillmann, Ulrike Weber-Stadlbauer, Daniela D Pollak","doi":"10.1007/s44192-023-00042-5","DOIUrl":"10.1007/s44192-023-00042-5","url":null,"abstract":"Adverse influences during pregnancy are associated with a range of unfavorable outcomes for the developing offspring. Maternal psychosocial stress, exposure to infections and nutritional imbalances are known risk factors for neurodevelopmental derangements and according psychiatric and neurological manifestations later in offspring life. In this context, the maternal immune activation (MIA) model has been extensively used in preclinical research to study how stimulation of the maternal immune system during gestation derails the tightly coordinated sequence of fetal neurodevelopment. The ensuing consequence of MIA for offspring brain structure and function are majorly manifested in behavioral and cognitive abnormalities, phenotypically presenting during the periods of adolescence and adulthood. These observations have been interpreted within the framework of the \"double-hit-hypothesis\" suggesting that an elevated risk for neurodevelopmental disorders results from an individual being subjected to two adverse environmental influences at distinct periods of life, jointly leading to the emergence of pathology. The early postnatal period, during which the caregiving parent is the major determinant of the newborn´s environment, constitutes a window of vulnerability to external stimuli. Considering that MIA not only affects the developing fetus, but also impinges on the mother´s brain, which is in a state of heightened malleability during pregnancy, the impact of MIA on maternal brain function and behavior postpartum may importantly contribute to the detrimental consequences for her progeny. Here we review current information on the interaction between the prenatal and postnatal maternal environments in the modulation of offspring development and their relevance for the pathophysiology of the MIA model.","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10444676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10127312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disease-specific differences in gene expression, mitochondrial function and mitochondria-endoplasmic reticulum interactions in iPSC-derived cerebral organoids and cortical neurons in schizophrenia and bipolar disorder. 精神分裂症和双相情感障碍患者ipsc衍生的脑类器官和皮质神经元中基因表达、线粒体功能和线粒体-内质网相互作用的疾病特异性差异

Discover mental health Pub Date : 2023-01-01 DOI: 10.1007/s44192-023-00031-8

Annie Kathuria, Kara Lopez-Lengowski, Donna McPhie, Bruce M Cohen, Rakesh Karmacharya

{"title":"Disease-specific differences in gene expression, mitochondrial function and mitochondria-endoplasmic reticulum interactions in iPSC-derived cerebral organoids and cortical neurons in schizophrenia and bipolar disorder.","authors":"Annie Kathuria, Kara Lopez-Lengowski, Donna McPhie, Bruce M Cohen, Rakesh Karmacharya","doi":"10.1007/s44192-023-00031-8","DOIUrl":"https://doi.org/10.1007/s44192-023-00031-8","url":null,"abstract":"We compared transcriptomic profiles of cerebral organoids differentiated from induced pluripotent stem cells of eight schizophrenia and eight bipolar disorder patients to identify genes that were differentially expressed in cerebral organoids between two disorders. Gene ontology analysis showed relative up-regulation in schizophrenia organoids of genes related to response to cytokines, antigen binding and clathrin-coated vesicles, while showing up-regulation in bipolar disorder of genes involved in calcium binding. Gene set enrichment analysis revealed enrichment in schizophrenia of genes involved in mitochondrial and oxidative phosphorylation while showing enrichment in bipolar disorder of genes involved in long term potentiation and neuro-transporters. We compared mitochondrial function in cerebral organoids from schizophrenia and bipolar disorder subjects and found that while schizophrenia organoids showed deficits in basal oxygen consumption rate and ATP production when compared to healthy control organoids, while bipolar disorder organoids did not show these deficits. Gene ontology analyses also revealed enrichment in bipolar disorder of genes in ion binding and regulation of transport. Experiments examining the interaction between mitochondria and endoplasmic reticulum in cortical neurons from bipolar disorder subjects showed a significantly lower number of contact sites between mitochondria and endoplasmic reticulum when compared to cortical neurons from schizophrenia patients. These results point to disease-specific deficits in mitochondrial respiration in schizophrenia and in mitochondrial-endoplasmic reticulum interactions in bipolar disorder.Supplementary information: The online version contains supplementary material available at 10.1007/s44192-023-00031-8.","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9113813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Whole Person Modeling: a transdisciplinary approach to mental health research. 全人建模：心理健康研究的跨学科方法。

Discover mental health Pub Date : 2023-01-01 Epub Date: 2023-08-24 DOI: 10.1007/s44192-023-00041-6

Daniel Felsky, Alyssa Cannitelli, Jon Pipitone

{"title":"Whole Person Modeling: a transdisciplinary approach to mental health research.","authors":"Daniel Felsky, Alyssa Cannitelli, Jon Pipitone","doi":"10.1007/s44192-023-00041-6","DOIUrl":"10.1007/s44192-023-00041-6","url":null,"abstract":"The growing global burden of mental illness has prompted calls for innovative research strategies. Theoretical models of mental health include complex contributions of biological, psychosocial, experiential, and other environmental influences. Accordingly, neuropsychiatric research has self-organized into largely isolated disciplines working to decode each individual contribution. However, research directly modeling objective biological measurements in combination with cognitive, psychological, demographic, or other environmental measurements is only now beginning to proliferate. This review aims to (1) to describe the landscape of modern mental health research and current movement towards integrative study, (2) to provide a concrete framework for quantitative integrative research, which we call Whole Person Modeling, (3) to explore existing and emerging techniques and methods used in Whole Person Modeling, and (4) to discuss our observations about the scarcity, potential value, and untested aspects of highly transdisciplinary research in general. Whole Person Modeling studies have the potential to provide a better understanding of multilevel phenomena, deliver more accurate diagnostic and prognostic tests to aid in clinical decision making, and test long standing theoretical models of mental illness. Some current barriers to progress include challenges with interdisciplinary communication and collaboration, systemic cultural barriers to transdisciplinary career paths, technical challenges in model specification, bias, and data harmonization, and gaps in transdisciplinary educational programs. We hope to ease anxiety in the field surrounding the often mysterious and intimidating world of transdisciplinary, data-driven mental health research and provide a useful orientation for students or highly specialized researchers who are new to this area.","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10449734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10101773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A qualitative assessment of mental health literacy and help-seeking behaviors among male college students. 男大学生心理健康素养与求助行为的定性评价

Discover mental health Pub Date : 2022-12-29 DOI: 10.1007/s44192-022-00028-9

Rita DeBate, Amy Gatto, Gregor Rafal, Jennifer Bleck

引用次数: 0

A novel set of volatile urinary biomarkers for late-life major depressive and anxiety disorders upon the progression of frailty: a pilot study. 一套新的易挥发性尿液生物标志物对老年抑郁症和焦虑症的进展脆弱:一项试点研究

Discover mental health Pub Date : 2022-10-27 DOI: 10.1007/s44192-022-00023-0

Akiko Fujita, Kazushige Ihara, Hisashi Kawai, Shuichi Obuchi, Yutaka Watanabe, Hirohiko Hirano, Yoshinori Fujiwara, Yoichi Takeda, Masashi Tanaka, Keiko Kato

{"title":"A novel set of volatile urinary biomarkers for late-life major depressive and anxiety disorders upon the progression of frailty: a pilot study.","authors":"Akiko Fujita, Kazushige Ihara, Hisashi Kawai, Shuichi Obuchi, Yutaka Watanabe, Hirohiko Hirano, Yoshinori Fujiwara, Yoichi Takeda, Masashi Tanaka, Keiko Kato","doi":"10.1007/s44192-022-00023-0","DOIUrl":"10.1007/s44192-022-00023-0","url":null,"abstract":"Mood and anxiety disorders are frequent in the elderly and increase the risk of frailty. This study aimed to identify novel biomarkers of major depressive disorder (MDD) and anxiety in the elderly. We examined 639 participants in the community-dwelling Otassha Study (518 individuals considered healthy control, 77 with depression, anxiety, etc.), mean age 75 years, 58.4% of female. After exclusion criteria, we analyzed VOCs from 18 individuals (9 healthy control, 9 of MDD/agoraphobia case). Urinary volatile and semi-volatile organic compounds (VOCs) were profiled using solid-phase microextraction and gas chromatography-mass spectrometry. Six urinary VOCs differed in the absolute area of the base peak between participants with MDD and/or agoraphobia and controls. High area under the receiver-operating characteristic curve (AUC) values were found for phenethyl isothiocyanate (AUC: 0.86, p = 0.009), hexanoic acid (AUC: 0.85, p = 0.012), texanol (AUC: 0.99, p = 0.0005), and texanol isomer (AUC: 0.89, p = 0.005). The combined indices of dimethyl sulfone, phenethyl isothiocyanate, and hexanoic acid, and texanol and texanol isomer showed AUCs of 0.91 (p = 0.003) and 0.99 (p = 0.0005) and correlated with the GRID-HAMD and the Kihon Checklist (CL score), respectively. These VOCs may be valuable biomarkers for evaluating MDD and/or agoraphobia in the elderly.","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46603149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of cannabidiol on weight and fasting blood sugar with chronic and subchronic haloperidol administration. 大麻二酚对慢性和亚慢性氟哌啶醇给药时体重和空腹血糖的影响

Discover mental health Pub Date : 2022-07-14 DOI: 10.1007/s44192-022-00021-2

Jaiyeola Abiola Kajero, Soraya Seedat, Jude U Ohaeri, Abidemi Akindele, Oluwagbemiga Aina

{"title":"Effects of cannabidiol on weight and fasting blood sugar with chronic and subchronic haloperidol administration.","authors":"Jaiyeola Abiola Kajero, Soraya Seedat, Jude U Ohaeri, Abidemi Akindele, Oluwagbemiga Aina","doi":"10.1007/s44192-022-00021-2","DOIUrl":"10.1007/s44192-022-00021-2","url":null,"abstract":"Objectives: The duration of administration (e.g., subchronic or chronic) of haloperidol may influence its adverse effects. We studied the effects of duration of administration of haloperidol on body weight and fasting blood sugar (FBS). In addition, we examined whether orally administered cannabidiol (CBD) had any putative mitigating influence on haloperidol-induced body weight changes and FBS elevation.Methods: Haloperidol (5 mg/kg/day) was administered for 21 days (subchronic administration), via the intraperitoneal (IP) route, or monthly (50 mg/kg monthly) for 3 months (chronic administration), via the intramuscular (IM) route, either alone or before CBD (5 mg/kg/day). Oral CBD (5 mg/kg/day) alone and distilled water alone were administered for 21 days. Weight and FBS were measured before administration of pharmacological agents (distilled water in the control group) and post-administration.Results: Group differences in average weight across time were significant. Pairwise comparisons showed that mean weight of the subchronic (IP) haloperidol alone group (Group A) and the chronic (IM) haloperidol before CBD group (Group F) increased significantly over time. Post medications, there was a significant increase in mean FBS in the subchronic (IP) haloperidol group compared to the subchronic (IP) haloperidol before CBD group. There was also a significant reduction in mean FBS from the baseline for the control group only.Conclusion: We demonstrated that the duration of administration of haloperidol influenced weight and FBS in rats, suggesting that metabolic side effects, may be influenced by duration of administration. CBD ameliorated the increase in weight and FBS observed in the subchronic (IP) haloperidol groups.","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48707913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Length of stay of hospitalized patients at tertiary psychiatry facilities in Uganda: the role of caregiver's presence. 乌干达三级精神病院住院病人的住院时间:护理人员在场的作用

Discover mental health Pub Date : 2022-07-04 DOI: 10.1007/s44192-022-00018-x

Mark Mohan Kaggwa, Maria Sarah Najjuka, Claire Kesande, Novatus Nyemara, Moses Kule, Mohammed A Mamum, Felix Bongomin, Scholastic Ashaba

{"title":"Length of stay of hospitalized patients at tertiary psychiatry facilities in Uganda: the role of caregiver's presence.","authors":"Mark Mohan Kaggwa, Maria Sarah Najjuka, Claire Kesande, Novatus Nyemara, Moses Kule, Mohammed A Mamum, Felix Bongomin, Scholastic Ashaba","doi":"10.1007/s44192-022-00018-x","DOIUrl":"10.1007/s44192-022-00018-x","url":null,"abstract":"Background: Whether the presence of caregivers during the hospital stay of patients with mental illness affects the length of hospital stay (LoS) remains inconclusive.Aims: (1) To determine the average LoS and the associated factors, and (2) to determine the role of caregivers' presences during inpatient stay on LoS.Methods: We conducted a cross-sectional study in two hospitals in Uganda; one with caregivers and the other without caregivers between July to November 2020. Mann-Whitney U test was used to compare LoS in the two selected hospitals and linear regression was used to determine factors associated with LoS.Results: A total of 222 participants were enrolled, the majority were males (62.4%). Mean age was 36.3 (standard deviation (SD) = 13.1) years. The average LoS was 18.3 (SD = 22.3) days, with patients in a hospital without caregivers having a longer median LoS (i.e., (30 (interquartile range (IQR) = 30) vs. 7 (7) days; χ2 = 68.95, p < 0.001). The factors significantly associated a longer LoS among our study participants included; being admitted in a hospital without caregivers (adjusted coefficient [aCoef]: 14.88, 95% CI 7.98-21.79, p < 0.001), a diagnosis of schizophrenia (aCoef: 10.68, 95 %CI 5.53-15.83, p < 0.001), being separated or divorced (aCoef: 7.68, 95% CI 1.09-14.27, p = 0.023), and increase in money spent during the admission (aCoef: 0.14, 95% CI 0.09-0.18, p < 0.001).Conclusion: Patients with mental illness in southwestern Uganda have a short LoS (below 28 days), and the stay was much shorter for patients with fulltime caregivers. We recommend caregivers presence during patient's hospital stay to reduce the LoS and minimize healthcare expenditure.","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41738916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Child, adolescent, and parent mental health in general population during a year of COVID-19 pandemic in belgium: a cross-sectional study. 比利时2019冠状病毒病大流行期间普通人群的儿童、青少年和父母心理健康:一项横断面研究

Discover mental health Pub Date : 2022-07-04 DOI: 10.1007/s44192-022-00019-w

Amélyne Wauters, Julien Tiete, Joana Reis, Isabelle Lambotte, Simone Marchini, Véronique Delvenne

{"title":"Child, adolescent, and parent mental health in general population during a year of COVID-19 pandemic in belgium: a cross-sectional study.","authors":"Amélyne Wauters, Julien Tiete, Joana Reis, Isabelle Lambotte, Simone Marchini, Véronique Delvenne","doi":"10.1007/s44192-022-00019-w","DOIUrl":"10.1007/s44192-022-00019-w","url":null,"abstract":"Background: This study aims to evaluate the mental health status of children, adolescents and their parents during the first year of COVID-19 pandemic in Belgium.Method: Analysis compared results before and during the second national lockdown, which started on November 2nd 2020. A cross-sectional online survey was conducted between May 2020 and April 2021.Results: Two hundred and eighteen adults and 273 children fully completed the survey. Almost one in five children (17.9%) presented moderate-to-severe scores of depression. Adolescents presented a higher level of depression than children (p = 0.007). The rate of moderate-to-severe depression scores (10.8% to 21%, p = 0.007) and internalized symptoms increased during the second lockdown (p < 0.001). Parents' depression (p < 0.001) and anxiety (p = 0.027) levels also increased during the second lockdown. Logistic regression showed that the use of psychotropic medication in parents and parents' depression scores were risk factors for children to have worse depression scores.Conclusion: The second lockdown appears to worsen the effects of the pandemic on children's and parents' mental health. There is a need to implement specific interventions targeting both children/adolescents and their parents to support them during lockdown periods and improve mental health outcomes.","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41264096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Narratives and mental health in the Covid-19 Pandemic Covid-19大流行中的叙事与心理健康

Discover mental health Pub Date : 2022-04-19 DOI: 10.1007/s44192-022-00013-2

M. Mendes

引用次数: 1