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The UpSMART Accelerator: driving digital innovation to change the conduct of early phase cancer medicine trials UpSMART加速器:推动数字创新，改变早期癌症药物试验的实施
Digital medicine Pub Date : 2022-01-01 DOI: 10.4103/digm.digm_3_21
Butt Fouziah, Stephenson Laura, Agnelli Luca, Villalobos Xenia, Carter Louise, Chown Rachel, De Filippo, Damian Silvia, Dienstmann Rodrigo, Formica Elisabetta, Garralda Elena, M. Donna, Graley Andrew, Landers Dónal, O'Regan Paul, Patil Akshita, Regan Aoife, K. Jennifer, Stevenson Julie, Walker Alison, Dive Caroline, H. Andrew
{"title":"The UpSMART Accelerator: driving digital innovation to change the conduct of early phase cancer medicine trials","authors":"Butt Fouziah, Stephenson Laura, Agnelli Luca, Villalobos Xenia, Carter Louise, Chown Rachel, De Filippo, Damian Silvia, Dienstmann Rodrigo, Formica Elisabetta, Garralda Elena, M. Donna, Graley Andrew, Landers Dónal, O'Regan Paul, Patil Akshita, Regan Aoife, K. Jennifer, Stevenson Julie, Walker Alison, Dive Caroline, H. Andrew","doi":"10.4103/digm.digm_3_21","DOIUrl":"https://doi.org/10.4103/digm.digm_3_21","url":null,"abstract":"Digitalizing clinical trials provide an opportunity to address challenges faced in the Phase I trial settings, where near real-time data capture and data interpretation are prerequisites for iterative decision-making to rapidly adapt trial designs based on emerging insights. Although digital technologies have driven significant improvements in many businesses and organizations, the adoption of digital technologies in clinical trials has been slow. In recognition of this lag, the UpSMART consortium, a 5-year funded program (2020–2024), has been established in Europe between the UK, Spain, and Italy to embrace digital technologies and drive benefits to patients. The consortium, led by the Cancer Research UK Manchester Institute Cancer Biomarker Centre, aims to 'digitalize' Experimental Cancer Medicine Centres in the UK and Early Drug Development Units in Spain and Italy by open-sourcing and sharing digital healthcare products between participating centers across the consortium. The goal is to optimize data capture and interpretation thus accelerating Phase I clinical research to ultimately benefit patients by allowing faster access to tomorrow's medicines.","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"8 1","pages":"7 - 7"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70712559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application progress of three-dimensional printing technology in orthodontics 三维打印技术在口腔正畸中的应用进展
Digital medicine Pub Date : 2022-01-01 DOI: 10.4103/digm.digm_36_22
Xuepeng Chen, Qianming Chen, Tingwu Su, Hongqi Zhang, Ting Kang, Mengqi Zhou, Jie Han, Nan Ning, Hai Lin
{"title":"Application progress of three-dimensional printing technology in orthodontics","authors":"Xuepeng Chen, Qianming Chen, Tingwu Su, Hongqi Zhang, Ting Kang, Mengqi Zhou, Jie Han, Nan Ning, Hai Lin","doi":"10.4103/digm.digm_36_22","DOIUrl":"https://doi.org/10.4103/digm.digm_36_22","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70712839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Development of models for predicting the objective response of immune checkpoint inhibitor therapy in patients with nonsmall-cell lung cancer 非小细胞肺癌患者免疫检查点抑制剂治疗客观反应预测模型的建立
Digital medicine Pub Date : 2022-01-01 DOI: 10.4103/digm.digm_20_22
Jianguo Sun, Qiao Yang, Lin Cui, Yu Gao, Xiu Yang
{"title":"Development of models for predicting the objective response of immune checkpoint inhibitor therapy in patients with nonsmall-cell lung cancer","authors":"Jianguo Sun, Qiao Yang, Lin Cui, Yu Gao, Xiu Yang","doi":"10.4103/digm.digm_20_22","DOIUrl":"https://doi.org/10.4103/digm.digm_20_22","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70712475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive rehabilitation via head-mounted virtual reality technology in patients with Alzheimer's disease: A systematic review 通过头戴式虚拟现实技术在阿尔茨海默病患者中的认知康复:一项系统综述
Digital medicine Pub Date : 2022-01-01 DOI: 10.4103/digm.digm_42_21
Bin Liu, Jianqing Li, Yanfeng Zhao, Junxiao Yu, Jiamin Liu, Zhen Chen, Wentao Xiang, Songsheng Zhu, Yunzhi Qian, Rongkun Wang, Jinyang Mao, Zhaodan Feng
{"title":"Cognitive rehabilitation via head-mounted virtual reality technology in patients with Alzheimer's disease: A systematic review","authors":"Bin Liu, Jianqing Li, Yanfeng Zhao, Junxiao Yu, Jiamin Liu, Zhen Chen, Wentao Xiang, Songsheng Zhu, Yunzhi Qian, Rongkun Wang, Jinyang Mao, Zhaodan Feng","doi":"10.4103/digm.digm_42_21","DOIUrl":"https://doi.org/10.4103/digm.digm_42_21","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70713072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The efficacy and safety of trifluridine/tipiracil plus bevacizumab compared with trifluridine/tipiracil monotherapy for metastatic colorectal cancer: A meta-analysis trifluridine/tipiracil联合贝伐单抗与trifluridine/tipiracil单药治疗转移性结直肠癌的疗效和安全性:一项荟萃分析
Digital medicine Pub Date : 2022-01-01 DOI: 10.4103/digm.digm_44_21
D. Gu, Xiaowei Wei, Yutong Ge
{"title":"The efficacy and safety of trifluridine/tipiracil plus bevacizumab compared with trifluridine/tipiracil monotherapy for metastatic colorectal cancer: A meta-analysis","authors":"D. Gu, Xiaowei Wei, Yutong Ge","doi":"10.4103/digm.digm_44_21","DOIUrl":"https://doi.org/10.4103/digm.digm_44_21","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70713173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The comparison of properties of Ti-6Aluminum-4Vanadium porous scaffolds fabricated through low-power selective laser Melting and electron beam melting 低功率选择性激光熔化和电子束熔化制备ti -6铝-4钒多孔支架的性能比较
Digital medicine Pub Date : 2022-01-01 DOI: 10.4103/digm.digm_46_21
Q. Yao, Pengfei Zheng, Jun Hu, Yiwei Wang, Minjie Fan
{"title":"The comparison of properties of Ti-6Aluminum-4Vanadium porous scaffolds fabricated through low-power selective laser Melting and electron beam melting","authors":"Q. Yao, Pengfei Zheng, Jun Hu, Yiwei Wang, Minjie Fan","doi":"10.4103/digm.digm_46_21","DOIUrl":"https://doi.org/10.4103/digm.digm_46_21","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70713677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A rehabilitation comparison of thoracoscopic and robotic lobectomy 胸腔镜与机器人肺叶切除术的康复比较
Digital medicine Pub Date : 2022-01-01 DOI: 10.4103/digm.digm_9_22
Lei Shen, X. Mo, Min Wang, Jiahao Yang
{"title":"A rehabilitation comparison of thoracoscopic and robotic lobectomy","authors":"Lei Shen, X. Mo, Min Wang, Jiahao Yang","doi":"10.4103/digm.digm_9_22","DOIUrl":"https://doi.org/10.4103/digm.digm_9_22","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70714446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new approach to Maslach Burnout Inventory: Measuring burnout syndrome in health-care staff with fuzzy conjoint analysis Maslach职业倦怠量表的新方法:用模糊联合分析法测量医务人员的职业倦怠综合征
Digital medicine Pub Date : 2022-01-01 DOI: 10.4103/digm.digm_2_22
Guney Gursel, Ömer Turunç
{"title":"A new approach to Maslach Burnout Inventory: Measuring burnout syndrome in health-care staff with fuzzy conjoint analysis","authors":"Guney Gursel, Ömer Turunç","doi":"10.4103/digm.digm_2_22","DOIUrl":"https://doi.org/10.4103/digm.digm_2_22","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70712461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telepresence robots to support telehealth during pandemics 在大流行期间支持远程保健的远程呈现机器人
Digital medicine Pub Date : 2022-01-01 DOI: 10.4103/digm.digm_15_22
Mingzhong Wang, Chongdan Pan, P. Ray
{"title":"Telepresence robots to support telehealth during pandemics","authors":"Mingzhong Wang, Chongdan Pan, P. Ray","doi":"10.4103/digm.digm_15_22","DOIUrl":"https://doi.org/10.4103/digm.digm_15_22","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70712115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic performance of reduced field-of-view diffusion-weighted imaging-targeted biopsy in suspected prostate cancer patients: A comparison with systematic biopsy 缩小视场扩散加权成像靶向活检在疑似前列腺癌患者中的诊断价值:与系统活检的比较
Digital medicine Pub Date : 2022-01-01 DOI: 10.4103/digm.digm_3_22
Tingyue Qi, Haiyan Cao, Hongguang Sun, Fang Du, Hao Feng, Xin Rong, Qibing Fan, Lei Wang
{"title":"Diagnostic performance of reduced field-of-view diffusion-weighted imaging-targeted biopsy in suspected prostate cancer patients: A comparison with systematic biopsy","authors":"Tingyue Qi, Haiyan Cao, Hongguang Sun, Fang Du, Hao Feng, Xin Rong, Qibing Fan, Lei Wang","doi":"10.4103/digm.digm_3_22","DOIUrl":"https://doi.org/10.4103/digm.digm_3_22","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70712677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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