Digestive medicine research最新文献

{"title":"Gastric adenocarcinoma peritoneal carcinomatosis: a narrative review.","authors":"Benjamin L Green,&nbsp;Jeremy L Davis","doi":"10.21037/dmr-21-94","DOIUrl":"https://doi.org/10.21037/dmr-21-94","url":null,"abstract":"<p><strong>Background and objective: </strong>To describe the diagnosis, workup, management, and areas of active research for peritoneal carcinomatosis (PC) arising from gastric adenocarcinoma (GA). The peritoneum is a common site of metastasis and recurrence for GA. Unlike other cancers of the peritoneal surface, there are no approved locoregional techniques to address peritoneal disease in GA. PC has a unique natural history, therapeutic response, and outlook that sets it apart from solid organ metastases.</p><p><strong>Methods: </strong>A search of PubMed and Google Scholar databases was performed for the terms \"Gastric Adenocarcinoma Peritoneal Carcinomatosis\" for English articles published between 2000 and October, 2021. A narrative review was undertaken to summarize literature pertaining to current diagnosis and management strategy of PC from GA. Future directions of diagnosis and treatment were discussed, including intraperitoneal chemotherapy and molecular diagnosis.</p><p><strong>Key content and findings: </strong>Incidence of carcinomatosis varies between Asia and Western populations, driving important differences in therapeutic algorithms and clinical trial eligibility. Determination of the extent of PC is a diagnostic challenge, with surgical staging as the most important modality. Systemic chemotherapy is the standard of care for patients with carcinomatosis. Intraperitoneal chemotherapy holds promise for patients with PC, but techniques are still considered experimental due to the paucity of data demonstrating improved survival.</p><p><strong>Conclusions: </strong>PC from gastric cancer represents both a significant clinical challenge and an area of great therapeutic potential.</p>","PeriodicalId":72814,"journal":{"name":"Digestive medicine research","volume":"5 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/4a/nihms-1818874.PMC9262327.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40492026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant peritoneal mesothelioma literature review: past, present, and future.","authors":"Stephanie N Gregory,&nbsp;A Leila Sarvestani,&nbsp;Andrew M Blakely","doi":"10.21037/dmr-22-19","DOIUrl":"https://doi.org/10.21037/dmr-22-19","url":null,"abstract":"<p><strong>Background and objective: </strong>Malignant peritoneal mesothelioma (MPM) is an insidious neoplasm that arises from the mesothelial lining of the abdominal cavity. Historically, outcomes of MPM were dismal, as MPM is relatively resistant to cytotoxic chemotherapy. However, with advances in technology and improved understanding of tumor pathophysiology, treatments for MPM have produced encouraging 5-year survival. The standard of care for patients with resectable disease remains cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). Patients with inoperable MPM can be offered several systemic treatments, including chemotherapy, immune checkpoint inhibitors, or investigational treatments. Our objective is to provide an overview of our current knowledge concerning MPM and latest advances in treatment.</p><p><strong>Methods: </strong>Narrative overview of the literature published in English from database origin until January 31, 2022 relating to MPM was searched in PubMed database, Google Scholar, and ClinicalTrials.gov.</p><p><strong>Key content and findings: </strong>CRS-HIPEC has offered improved survival for surgical candidates, however outcomes for inoperable MPM remains dismal. With advancements in technology and better understanding of underlying MPM biology, new treatment approaches are arising and imperative.</p><p><strong>Conclusions: </strong>MPM is a rare and lethal disease of the peritoneum. CRS-HIPEC remains the standard of care for resectable disease. In 2022, several clinical trials are available for patients with MPM offering future advances in therapy and further understanding of this rare disease process.</p>","PeriodicalId":72814,"journal":{"name":"Digestive medicine research","volume":"5 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/9d/nihms-1818868.PMC9436021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40349318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the chemokine system in liver fibrosis: a narrative review.","authors":"Kyle L Poulsen,&nbsp;Christina K Cajigas-Du Ross,&nbsp;Jarod K Chaney,&nbsp;Laura E Nagy","doi":"10.21037/dmr-21-87","DOIUrl":"https://doi.org/10.21037/dmr-21-87","url":null,"abstract":"<p><strong>Background and objective: </strong>Liver fibrosis is a disease with characteristics of an aberrant wound healing response. Fibrosis is commonly the end-stage for chronic liver diseases like alcohol-associated liver disease (ALD), metabolic-associated liver disease, viral hepatitis, and hepatic autoimmune disease. Innate immunity contributes to the progression of many diseases through multiple mechanisms including production of pro-inflammatory mediators, leukocyte infiltration and tissue injury. Chemokines and their receptors orchestrate accumulation and activation of immune cells in tissues and are associated with multiple liver diseases; however, much less is known about their potential roles in liver fibrosis. This is a narrative review of current knowledge of the relationship of chemokine biology to liver fibrosis with insights into potential future therapeutic opportunities that can be explored in the future.</p><p><strong>Methods: </strong>A comprehensive literature review was performed searching PubMed for relevant English studies and texts regarding chemokine biology, chronic liver disease and liver fibrosis published between 1993 and 2021. The review was written and constructed to detail the intriguing chemokine biology, the relation of chemokines to tissue injury and resolution, and identify areas of discovery for fibrosis treatment.</p><p><strong>Key content and findings: </strong>Chemokines are implicated in many chronic liver diseases, regardless of etiology. Most of these diseases will progress to fibrosis without appropriate treatment. The contributions of chemokines to liver disease and fibrosis are diverse and include canonical roles of modulating hepatic inflammation as well as directly contributing to fibrosis via activation of hepatic stellate cells (HSCs). Limited clinical evidence suggests that targeting chemokines in certain liver diseases might provide a therapeutic benefit to patients with hepatic fibrosis.</p><p><strong>Conclusions: </strong>The chemokine system of ligands and receptors is a complex network of inflammatory signals in nearly all diseases. The specific sources of chemokines and cellular targets lend unique pathophysiological consequences to chronic liver diseases and established fibrosis. Although most chemokines are pro-inflammatory and contribute to tissue injury, others likely aid in the resolution of established fibrosis. To date, very few targeted therapies exist for the chemokine system and liver disease and/or fibrosis, and further study could identify viable treatment options to improve outcomes in patients with end-stage liver disease.</p>","PeriodicalId":72814,"journal":{"name":"Digestive medicine research","volume":"5 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4a/6c/nihms-1818871.PMC9632683.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40684745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“The pathogenesis of hepatic fibrosis: basic facts and clinical challenges”—assessment of liver fibrosis: a narrative review","authors":"M. Brol, U. Drebber, J. Luetkens, M. Odenthal, J. Trebicka","doi":"10.21037/dmr-22-9","DOIUrl":"https://doi.org/10.21037/dmr-22-9","url":null,"abstract":"","PeriodicalId":72814,"journal":{"name":"Digestive medicine research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47194716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interview with Dr. Leigh Kelliher: perioperative care and cancer surgery","authors":"L. Kelliher, Annabel Liao, Lucine M. Gao","doi":"10.21037/dmr-22-75","DOIUrl":"https://doi.org/10.21037/dmr-22-75","url":null,"abstract":"","PeriodicalId":72814,"journal":{"name":"Digestive medicine research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49353073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial vs. total fundoplication for gastroesophageal reflux disease (GERD): has the debate really settled in a tie?","authors":"R. Petrov, C. Bakhos, Abbas E. Abbas","doi":"10.21037/dmr-22-76","DOIUrl":"https://doi.org/10.21037/dmr-22-76","url":null,"abstract":"","PeriodicalId":72814,"journal":{"name":"Digestive medicine research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42636615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adalimumab for Crohn disease: does more mean better?","authors":"A. Hudson, E. Wine","doi":"10.21037/dmr-22-58","DOIUrl":"https://doi.org/10.21037/dmr-22-58","url":null,"abstract":"","PeriodicalId":72814,"journal":{"name":"Digestive medicine research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47702853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of immunotherapy with chemotherapy as standard first-line treatment against advanced gastric cancer","authors":"K. Taira, Akie Kimura, Akinobu Nakata, F. Tanaka, Y. Nagami, Y. Fujiwara","doi":"10.21037/dmr-22-64","DOIUrl":"https://doi.org/10.21037/dmr-22-64","url":null,"abstract":"","PeriodicalId":72814,"journal":{"name":"Digestive medicine research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46381170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous polyarteritis nodosa associated with IgG deficiency & inflammatory bowel disease case report","authors":"S. Philip, Simple Modi, Rose George, Arkhar Htoo, Ruben A. Peredo-Wende","doi":"10.21037/dmr-22-31","DOIUrl":"https://doi.org/10.21037/dmr-22-31","url":null,"abstract":"","PeriodicalId":72814,"journal":{"name":"Digestive medicine research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42778141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor regression grade (TRG) for gastric cancer and radiological methods on predicting response to perioperative chemotherapy: a narrative review","authors":"G. Garbarino, F. Mainardi, E. Berardi, Marta Zerunian, M. Polici, M. Campanelli, G. Lisi, G. Laracca, A. Pecoraro, G. Costa, D. Caruso, A. Laghi, F. Mazzuca, E. Pilozzi, P. Mercantini","doi":"10.21037/dmr-22-34","DOIUrl":"https://doi.org/10.21037/dmr-22-34","url":null,"abstract":"Mainardi, study Mainardi, Campanelli; Collection and data: Garbarino, Mainardi, Polici; Data Background and Objective: Perioperative chemotherapy has been increasingly practiced on gastric cancer (GC) in Western Countries where two third of the patients have locally advanced disease at diagnosis. The histological and radiological evaluation of the tumor response to chemotherapy are both cornerstones of this multimodal therapy to predict the oncological outcomes. This article aims to review the current tumor regression grade (TRG) classification systems available and give an overview regarding radiological methods on predicting response to therapy. Methods: A literature search was performed in MEDLINE (PubMed) and Scopus. The terms tumor regression grade, pathologic response, gastric cancer, gastric adenocarcinoma, RECIST 1.1, radiological prediction of response, perioperative, preoperative and neoadjuvant chemotherapy were included. English papers published until December 2021 were reviewed. Key Content and Findings: Several TRG systems (Dworak, Mandard, Ryan, Becker, and Japanese Gastric Cancer Association-TRG) are available in literature, but none has been widely accepted and indicated by the international guidelines for GC. The response evaluation criteria in solid tumors (RECIST) 1.1 are still the most widely used radiological criteria in clinical trials despite their limitations regarding GC. In fact, the stomach is not a solid organ and its lesions are often not measurables. In order to discriminate responders from non-responders patients to perioperative chemotherapy for GC, all imaging techniques have been evaluated in terms of prediction of tumor response to chemotherapy. there is still no clear evidence of superiority of one imaging the Conclusions: An effective histopathological evaluation method of TRG with an independent for GC in practice.","PeriodicalId":72814,"journal":{"name":"Digestive medicine research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44054173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}