Digestive medicine research最新文献

Histone acylations as a mechanism for regulation of intestinal epithelial cells. 组蛋白酰化是调节肠上皮细胞的一种机制。

Digestive medicine research Pub Date : 2024-03-30 Epub Date: 2023-06-05 DOI: 10.21037/dmr-23-3

Mariane Font Fernandes, Marco Aurélio Ramirez Vinolo

{"title":"Histone acylations as a mechanism for regulation of intestinal epithelial cells.","authors":"Mariane Font Fernandes, Marco Aurélio Ramirez Vinolo","doi":"10.21037/dmr-23-3","DOIUrl":"https://doi.org/10.21037/dmr-23-3","url":null,"abstract":"<p><p>Histone post-translational modifications are reversible epigenetic mechanisms that regulate chromatin structure and gene transcription. In recent years, in addition to the well-characterized histone acetylation, new acylations such as propionylation, crotonylation, butyrylation and beta-hydroxybutyrylation have been described and explored in different cell types at contexts of health and disease. Understanding how histone acylations contribute to gene expression regulation is especially important in intestinal epithelial cells (IECs) because they receive many different signals from other cells and the external environment and must adapt to maintain essential functions such as nutrient and water absorption, maintenance of tolerance and protection against pathogens. In this review, we describe how cells regulate these modifications, how they are recognized by other proteins and impact gene expression. We summarize recent studies that explored the role of these distinct epigenetic marks in the regulation of IECs and discuss their biological importance for the intestinal epithelium's adaptations to changes in metabolism and to respond to environmental signals provided, for example, by the diet, components of the intestinal microbiota and pathogens. Finally, we discuss how the histone acylations are affected by inflammatory signals and how this knowledge may provide new targets for treatment of pathologies such as the inflammatory bowel diseases.</p>","PeriodicalId":72814,"journal":{"name":"Digestive medicine research","volume":"7 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}