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Nucleating amoeboid cancer cell motility with Diaphanous related formins. 用与Diaphanous相关的甲形蛋白核化变形虫癌细胞的运动性。
Cytoskeleton (Hoboken, N.J.) Pub Date : 2024-05-18 DOI: 10.1002/cm.21880
Neelakshi Kar, Jeremy S Logue
{"title":"Nucleating amoeboid cancer cell motility with Diaphanous related formins.","authors":"Neelakshi Kar, Jeremy S Logue","doi":"10.1002/cm.21880","DOIUrl":"10.1002/cm.21880","url":null,"abstract":"<p><p>The tissue invasive capacity of cancer cells is determined by their phenotypic plasticity. For instance, mesenchymal to amoeboid transition has been found to facilitate the passage of cancer cells through confined environments. This phenotypic transition is also heavily regulated by the architecture of the actin cytoskeleton, which may increase myosin contractility and the intracellular pressure that is known to drive bleb formation. In this review, we highlight several Diaphanous related formins (DRFs) that have been found to promote or suppress bleb formation in cancer cells, which is a hallmark of amoeboid migration. Based on the work discussed here, the role of the DRFs in cancer(s) is worthy of further scrutiny in animal models, as they may prove to be therapeutic targets.</p>","PeriodicalId":72766,"journal":{"name":"Cytoskeleton (Hoboken, N.J.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxoplasma replication is inhibited by MMV676477 without development of resistance. MMV676477 可抑制弓形虫的复制，但不会产生抗药性。
Cytoskeleton (Hoboken, N.J.) Pub Date : 2024-05-16 DOI: 10.1002/cm.21876
Izra Abbaali, Danny Truong, Dawn M Wetzel, Naomi S Morrissette
{"title":"Toxoplasma replication is inhibited by MMV676477 without development of resistance.","authors":"Izra Abbaali, Danny Truong, Dawn M Wetzel, Naomi S Morrissette","doi":"10.1002/cm.21876","DOIUrl":"10.1002/cm.21876","url":null,"abstract":"<p><p>Protozoan parasites cause life-threatening infections in both humans and animals, including agriculturally significant livestock. Available treatments are typically narrow spectrum and are complicated by drug toxicity and the development of resistant parasites. Protozoan tubulin is an attractive target for the development of broad-spectrum antimitotic agents. The Medicines for Malaria Pathogen Box compound MMV676477 was previously shown to inhibit replication of kinetoplastid parasites, such as Leishmania amazonensis and Trypanosoma brucei, and the apicomplexan parasite Plasmodium falciparum by selectively stabilizing protozoan microtubules. In this report, we show that MMV676477 inhibits intracellular growth of the human apicomplexan pathogen Toxoplasma gondii with an EC<sub>50</sub> value of ~50 nM. MMV676477 does not stabilize vertebrate microtubules or cause other toxic effects in human fibroblasts. The availability of tools for genetic studies makes Toxoplasma a useful model for studies of the cytoskeleton. We conducted a forward genetics screen for MMV676477 resistance, anticipating that missense mutations would delineate the binding site on protozoan tubulin. Unfortunately, we were unable to use genetics to dissect target interactions because no resistant parasites emerged. This outcome suggests that future drugs based on the MMV676477 scaffold would be less likely to be undermined by the emergence of drug resistance.</p>","PeriodicalId":72766,"journal":{"name":"Cytoskeleton (Hoboken, N.J.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An interview with Peter Gunning - School of Medical Sciences, UNSW Sydney, Australia. 采访彼得·甘宁-医学科学学院，新南威尔士大学悉尼，澳大利亚。
Cytoskeleton (Hoboken, N.J.) Pub Date : 2022-04-01 Epub Date: 2022-07-22 DOI: 10.1002/cm.21715
Paul Trevorrow, Peter Gunning
{"title":"An interview with Peter Gunning - School of Medical Sciences, UNSW Sydney, Australia.","authors":"Paul Trevorrow,&nbsp;Peter Gunning","doi":"10.1002/cm.21715","DOIUrl":"https://doi.org/10.1002/cm.21715","url":null,"abstract":"","PeriodicalId":72766,"journal":{"name":"Cytoskeleton (Hoboken, N.J.)","volume":"79 4-5","pages":"24-25"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40488764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Follow that cell: Leukocyte migration in L-plastin mutant zebrafish. 跟随细胞:l -活蛋白突变斑马鱼的白细胞迁移。
Cytoskeleton (Hoboken, N.J.) Pub Date : 2022-04-01 Epub Date: 2022-07-22 DOI: 10.1002/cm.21717
John B Linehan, Jose Lucas Zepeda, Taylor A Mitchell, Elizabeth E LeClair
{"title":"Follow that cell: Leukocyte migration in L-plastin mutant zebrafish.","authors":"John B Linehan,&nbsp;Jose Lucas Zepeda,&nbsp;Taylor A Mitchell,&nbsp;Elizabeth E LeClair","doi":"10.1002/cm.21717","DOIUrl":"https://doi.org/10.1002/cm.21717","url":null,"abstract":"Actin assemblies are important in motile cells such as leukocytes which form dynamic plasma membrane extensions or podia. L-plastin (LCP1) is a leukocyte-specific calcium-dependent actin-bundling protein that, in mammals, is known to affect immune cell migration. Previously, we generated CRISPR/Cas9 engineered zebrafish lacking L-plastin (lcp1-/-) and reported that they had reduced survival to adulthood, suggesting that lack of L-plastin might negatively affect the immune system. To test this hypothesis, we examined the distribution and migration of neutrophils and macrophages in the transparent tail of early zebrafish larvae using cell-specific markers and an established wound-migration assay. Knockout larvae were similar to their heterozygous siblings in having equal body sizes and comparable numbers of neutrophils in caudal hematopoietic tissue at two days post-fertilization, indicating no gross defect in neutrophil production or developmental migration. When stimulated by a tail wound, all genotypes of neutrophils were equally migratory in a two-hour window. However for macrophages we observed both migration defects and morphological differences. L-plastin knockout macrophages still homed to wounds but were slower, less directional and had a star-like morphology with many leading and trailing projections. In contrast, wild type macrophages were faster, more directional, and had a more streamlined, slug-like morphology. Overall, these findings show that in larval zebrafish L-plastin knockout primarily affects the macrophage response with possible consequences for organismal immunity. Consistent with our observations, we propose a model in which cytoplasmic L-plastin negatively regulates macrophage integrin adhesion by holding these transmembrane heterodimers in a ‘clasped’, inactive form and is a necessary part of establishing macrophage polarity during chemokine-induced motility.","PeriodicalId":72766,"journal":{"name":"Cytoskeleton (Hoboken, N.J.)","volume":"79 4-5","pages":"26-37"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40488845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Meet the editorial staff: Interview series. 与编辑人员见面：访谈系列。
Cytoskeleton (Hoboken, N.J.) Pub Date : 2022-04-01 Epub Date: 2022-07-13 DOI: 10.1002/cm.21714
Paul Trevorrow
{"title":"Meet the editorial staff: Interview series.","authors":"Paul Trevorrow","doi":"10.1002/cm.21714","DOIUrl":"10.1002/cm.21714","url":null,"abstract":"","PeriodicalId":72766,"journal":{"name":"Cytoskeleton (Hoboken, N.J.)","volume":"79 4-5","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40578145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytoskeleton: Methods and Protocols 细胞骨架:方法和方案
Cytoskeleton (Hoboken, N.J.) Pub Date : 2022-01-01 DOI: 10.1007/978-1-0716-1661-1
Marina Daecher
{"title":"Cytoskeleton: Methods and Protocols","authors":"Marina Daecher","doi":"10.1007/978-1-0716-1661-1","DOIUrl":"https://doi.org/10.1007/978-1-0716-1661-1","url":null,"abstract":"","PeriodicalId":72766,"journal":{"name":"Cytoskeleton (Hoboken, N.J.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51711105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Chosun Policies Regarding to the Dynasty's Relationship with the Japanese, in the King Sukjong's Reign 肃宗年间朝鲜对日政策
Cytoskeleton (Hoboken, N.J.) Pub Date : 2021-04-30 DOI: 10.19120/CY.2021.04.48.205
Tae-Hoon Kim
{"title":"The Chosun Policies Regarding to the Dynasty's Relationship with the Japanese, in the King Sukjong's Reign","authors":"Tae-Hoon Kim","doi":"10.19120/CY.2021.04.48.205","DOIUrl":"https://doi.org/10.19120/CY.2021.04.48.205","url":null,"abstract":"","PeriodicalId":72766,"journal":{"name":"Cytoskeleton (Hoboken, N.J.)","volume":"48 1","pages":"205-239"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42554905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Study of Choryanghwajib:Comparison between Different Versions of Choryanghwajib and the Reproduced Choryanghwajib Choryanghwajib的研究：Choryangwa jib不同版本与复制Choryangwajib的比较
Cytoskeleton (Hoboken, N.J.) Pub Date : 2021-04-30 DOI: 10.19120/CY.2021.04.48.241
Heung-Sook Yang, Sung-il Chung, Dong-Chul Kim
{"title":"A Study of Choryanghwajib:Comparison between Different Versions of Choryanghwajib and the Reproduced Choryanghwajib","authors":"Heung-Sook Yang, Sung-il Chung, Dong-Chul Kim","doi":"10.19120/CY.2021.04.48.241","DOIUrl":"https://doi.org/10.19120/CY.2021.04.48.241","url":null,"abstract":"","PeriodicalId":72766,"journal":{"name":"Cytoskeleton (Hoboken, N.J.)","volume":"48 1","pages":"241-280"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48446150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ancient Yangsan and Byeonjin Jeopdoguk 古代阳山和Byeonjin Jeopdoguk
Cytoskeleton (Hoboken, N.J.) Pub Date : 2021-04-30 DOI: 10.19120/CY.2021.04.48.5
Seok-yeol Seon
{"title":"Ancient Yangsan and Byeonjin Jeopdoguk","authors":"Seok-yeol Seon","doi":"10.19120/CY.2021.04.48.5","DOIUrl":"https://doi.org/10.19120/CY.2021.04.48.5","url":null,"abstract":"","PeriodicalId":72766,"journal":{"name":"Cytoskeleton (Hoboken, N.J.)","volume":"48 1","pages":"5-34"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49346870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gaya Buddhism and Pasa Stone Stūpa 伽耶佛教和巴沙石Stūpa
Cytoskeleton (Hoboken, N.J.) Pub Date : 2021-04-30 DOI: 10.19120/CY.2021.04.48.35
One-Young Jo
{"title":"Gaya Buddhism and Pasa Stone Stūpa","authors":"One-Young Jo","doi":"10.19120/CY.2021.04.48.35","DOIUrl":"https://doi.org/10.19120/CY.2021.04.48.35","url":null,"abstract":"","PeriodicalId":72766,"journal":{"name":"Cytoskeleton (Hoboken, N.J.)","volume":"48 1","pages":"35-72"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46935945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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