Advances in biochemical psychopharmacology最新文献

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GABAA-receptor subunits: functional expression and gene localisation. gabaa受体亚基:功能表达和基因定位。
H Mohler, P Malherbe, A Draguhn, E Sigel, J M Sequier, E Persohn, J G Richards
{"title":"GABAA-receptor subunits: functional expression and gene localisation.","authors":"H Mohler, P Malherbe, A Draguhn, E Sigel, J M Sequier, E Persohn, J G Richards","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13122010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New trends in mapping benzodiazepine receptors. 苯二氮卓类受体定位的新趋势。
J G Richards, R Glinz, P Schoch, H Möhler
{"title":"New trends in mapping benzodiazepine receptors.","authors":"J G Richards, R Glinz, P Schoch, H Möhler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13983779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional and structural correlates of GABA receptor modulation. GABA受体调节的功能和结构相关性。
T T Gibbs, D Mierlak, M Gyenes, J J Celentano, D H Farb
{"title":"Functional and structural correlates of GABA receptor modulation.","authors":"T T Gibbs, D Mierlak, M Gyenes, J J Celentano, D H Farb","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13983781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benzodiazepine, barbiturate, ethanol and hypnotic steroid hormone modulation of GABA-mediated chloride ion transport in rat brain synaptoneurosomes. 苯二氮卓、巴比妥酸盐、乙醇和催眠类固醇激素调节gaba介导的大鼠脑突触体氯离子转运。
A L Morrow, P D Suzdak, S M Paul
{"title":"Benzodiazepine, barbiturate, ethanol and hypnotic steroid hormone modulation of GABA-mediated chloride ion transport in rat brain synaptoneurosomes.","authors":"A L Morrow, P D Suzdak, S M Paul","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14038683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-uniformity of tolerance to the actions of benzodiazepine agonists. 对苯二氮卓类激动剂作用的耐受性不均匀。
H C Rosenberg, J M Duggan, E I Tietz, T H Chiu
{"title":"Non-uniformity of tolerance to the actions of benzodiazepine agonists.","authors":"H C Rosenberg, J M Duggan, E I Tietz, T H Chiu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14038685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased sensitivity to inverse agonists and decreased GABA-stimulated chloride influx induced by chronic treatment with FG 7142. 用FG 7142慢性治疗可增加对逆激动剂的敏感性,减少gaba刺激的氯化物内流。
M G Corda, O Giorgi, B Longoni, A Fernandez, G Biggio
{"title":"Increased sensitivity to inverse agonists and decreased GABA-stimulated chloride influx induced by chronic treatment with FG 7142.","authors":"M G Corda, O Giorgi, B Longoni, A Fernandez, G Biggio","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13605398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Desensitization of GABA-stimulated 36Cl-influx in cerebellar granule cells. gaba刺激的小脑颗粒细胞36cl内流脱敏。
J Kardos, A Guidotti
{"title":"Desensitization of GABA-stimulated 36Cl-influx in cerebellar granule cells.","authors":"J Kardos, A Guidotti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13605501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suppression of human and mouse lymphocyte proliferation by cocaine. 可卡因对人和小鼠淋巴细胞增殖的抑制作用。
T W Klein, C A Newton, H Friedman
{"title":"Suppression of human and mouse lymphocyte proliferation by cocaine.","authors":"T W Klein, C A Newton, H Friedman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14524234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drugs of abuse and virus susceptibility. 药物滥用和病毒易感性。
H Friedman, T Klein, S Specter, S Pross, C Newton, D K Blanchard, R Widen
{"title":"Drugs of abuse and virus susceptibility.","authors":"H Friedman,&nbsp;T Klein,&nbsp;S Specter,&nbsp;S Pross,&nbsp;C Newton,&nbsp;D K Blanchard,&nbsp;R Widen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is widely recognized that various microorganisms including viruses have immunomodulatory effects and, under appropriate circumstances, may markedly suppress the immune response mechanisms. Cannabinoids present in marijuana also have immunomodulatory effects. In the present studies THC as well as its metabolic product 11-OH THC were studied in regard to their effects in vivo and in vitro on selected parameters of the immune response system known to be important in antiviral resistance, including immunity to retroviruses. Cannabinoids markedly suppressed the ability of murine macrophages to spread on glass (an important functional marker of macrophages) as well as to phagocytize yeast particles. Splenic macrophage cultures treated with the cannabinoids also were deficient in their ability to produce interleukin 1 on appropriate stimulation with bacterial LPS. Spleen cells capable of producing antibody to sheep erythrocytes when stimulated with this antigen in vitro were markedly affected when treated with graded doses of THC or 11-OH THC. Furthermore, the blastogenic responsiveness of normal mouse splenocytes to the T-cell mitogens Con A and PHA as well as the B-cell mitogen E. coli LPS was markedly suppressed by graded concentrations of the cannabinoids in doses that did not affect the viability of the cells. Natural killer cell activity of normal mouse spleen cells was also markedly inhibited by THC and 11-OH THC. Similarly, these cannabinoids suppressed the blastogenic responsiveness and NK activity of human peripheral blood leukocytes from normal individuals. The ability of mouse spleen cells to produce interferon on in vitro stimulation was also suppressed by THC. In addition, injection of THC into mice suppressed blastogenic responsiveness of spleen cells, NK activity, and the production of interferon by lymphoid cells. Thus, it was apparent that these cannabinoids had immunomodulatory effects, both in vivo and in vitro, at noncytotoxic small doses and impaired the ability of the lymphoid cells to express immune function necessary for antiviral resistance.</p>","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13978819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethanol-associated immunosuppression. Ethanol-associated免疫抑制。
T R Jerrells, C A Marietta, G Bone, F F Weight, M J Eckardt
{"title":"Ethanol-associated immunosuppression.","authors":"T R Jerrells,&nbsp;C A Marietta,&nbsp;G Bone,&nbsp;F F Weight,&nbsp;M J Eckardt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14174278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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