Current molecular biology reports最新文献_第3页

Cellular Senescence in Idiopathic Pulmonary Fibrosis. 特发性肺纤维化中的细胞衰老

Current molecular biology reports Pub Date : 2021-01-01 Epub Date: 2021-08-12 DOI: 10.1007/s40610-021-00145-4

D L Kellogg, D L Kellogg, N Musi, A M Nambiar

{"title":"Cellular Senescence in Idiopathic Pulmonary Fibrosis.","authors":"D L Kellogg, D L Kellogg, N Musi, A M Nambiar","doi":"10.1007/s40610-021-00145-4","DOIUrl":"10.1007/s40610-021-00145-4","url":null,"abstract":"Cellular senescence (CS) is increasingly implicated in the etiology of age-related diseases. While CS can facilitate physiological processes such as tissue repair and wound healing, senescent cells also contribute to pathophysiological processes involving macromolecular damage and metabolic dysregulation that characterize multiple morbid and prevalent diseases, including Alzheimer's disease, osteoarthritis, atherosclerotic vascular disease, diabetes mellitus, and idiopathic pulmonary fibrosis (IPF). Preclinical studies targeting senescent cells and the senescence-associated secretory phenotype (SASP) with \"senotherapeutics\" have demonstrated improvement in age-related morbidity associated with these disease states. Despite promising results from these preclinical trials, few human clinical trials have been conducted. A first-in-human, open-label, pilot study of the senolytic combination of dasatinib and quercetin (DQ) in patients with IPF showed improved physical function and mobility. In this review, we will discuss our current understanding of cellular senescence, its role in age-associated diseases, with a specific focus on IPF, and potential for senotherapeutics in the treatment of fibrotic lung diseases.","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"7 3","pages":"31-40"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39318061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Senescent Mesenchymal Stem Cells: Disease Mechanism and Treatment Strategy. 衰老间充质干细胞：疾病机理与治疗策略

Current molecular biology reports Pub Date : 2020-12-01 Epub Date: 2020-10-28 DOI: 10.1007/s40610-020-00141-0

Yajun Liu, Qian Chen

{"title":"Senescent Mesenchymal Stem Cells: Disease Mechanism and Treatment Strategy.","authors":"Yajun Liu, Qian Chen","doi":"10.1007/s40610-020-00141-0","DOIUrl":"10.1007/s40610-020-00141-0","url":null,"abstract":"Purpose of review: Mesenchymal stem cells (MSCs) have been extensively studied for therapeutic application in tissue engineering and regenerative medicine. Despite their promise, recent findings suggest that MSC replication during repair process may lead to replicative senescence and stem cell exhaustion. Here, we review the basic mechanisms of MSC senescence, how it leads to degenerative diseases, and potential treatments for such diseases.Recent findings: Emerging evidence has shown a link between senescent MSCs and degenerative diseases, especially age-related diseases such as osteoarthritis and idiopathic pulmonary fibrosis. During these disease processes, MSCs undergo cell senescence and mediate Senescence Associated Secretory Phenotypes (SASP) to affect the surrounding microenvironment. Thus, senescent MSCs can accelerate tissue aging by increasing the number of senescent cells and spreading inflammation to neighboring cells.Summary: Senescent MSCs not only hamper tissue repair through cell senescence associated stem cell exhaustion, but also mediate tissue degeneration by initiating and spreading senescence-associated inflammation. It suggests new strategies of MSC-based cell therapy to remove, rejuvenate, or replace (3Rs) the senescent MSCs.","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"6 4","pages":"173-182"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011589/pdf/nihms-1642077.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25558646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Senolytics: targeting senescent cells for age-associated diseases. 衰老药物:针对衰老细胞治疗与年龄相关的疾病。

Current molecular biology reports Pub Date : 2020-12-01 Epub Date: 2020-10-24 DOI: 10.1007/s40610-020-00140-1

Iman M A Al-Naggar, George A Kuchel, Ming Xu

引用次数: 4

The Causal Association Between Occupational, Environmental, and Lifestyle Factors and Reproductive Cancer Risk 职业、环境和生活方式因素与生殖癌症风险之间的因果关系

Current molecular biology reports Pub Date : 2020-08-18 DOI: 10.1007/s40610-020-00139-8

H. Shankar, Shukla Saluja, Monica Rawat, Gyanendra Singh, M. Tarique, N. Mohammad, H. Naz

引用次数: 2

Calcium-/Calmodulin-Dependent Protein Kinase IV (CAMKIV): A Multifunctional Enzyme and Its Role in Various Cancer: An Update 钙/钙调素依赖性蛋白激酶IV（CAMKIV）：一种多功能酶及其在各种癌症中的作用

Current molecular biology reports Pub Date : 2020-07-15 DOI: 10.1007/s40610-020-00138-9

H. Naz, M. Tarique, M. Suhail, H. Shankar, Naoshad Muhammad, Darksha Usmani, M. Ashraf, T. Zughaibi

引用次数: 4

Oncogenic Mutations in Tumorigenesis and Targeted Therapy in Breast Cancer 癌症肿瘤发生中的肿瘤突变及靶向治疗

Current molecular biology reports Pub Date : 2020-07-10 DOI: 10.1007/s40610-020-00136-x

B. Kumar, Vaibhav Chand, Anupama Ram, Darksha Usmani, Naoshad Muhammad

引用次数: 15

When to Die Is the Question: Need and Manipulation of Cell Death by Mycobacterium 何时死亡是个问题：分枝杆菌对细胞死亡的需要和操作

Current molecular biology reports Pub Date : 2020-06-17 DOI: 10.1007/s40610-020-00137-w

Ekansh Mittal, S. Deore, Mahendra Kumar, M. Krishnasastry

引用次数: 0

Developmental Correlations of Head and Heart Musculature: Importance for Understanding Human Syndromes 头部和心脏肌肉的发育相关性：理解人类综合征的重要性

Current molecular biology reports Pub Date : 2020-06-01 DOI: 10.1007/s40610-020-00132-1

J. Ziermann

引用次数: 0

Quasi-religious Belief in Darwin and Darwinism: “Straw-Men” Scientist Believers Everywhere 达尔文与达尔文主义的准宗教信仰：“稻草人”科学家无处不在

Current molecular biology reports Pub Date : 2020-06-01 DOI: 10.1007/s40610-020-00127-y

R. Diogo

引用次数: 6

The Pivotal Role of Senescence in Cell Death and Aging: Where Do We Stand? 衰老在细胞死亡和衰老中的关键作用：我们的立场是什么？

Current molecular biology reports Pub Date : 2020-05-23 DOI: 10.1007/s40610-020-00129-w

Sadaf, Mohammad Z Najm, V. Shingatgeri, M. Uddin, M. Izhari, M. Akhtar, A. Kathait, S. Kar, Ishita Jain, Pulkit Datt, K. Komal, Anoushka Sharma

引用次数: 0