Current medicine research and practice最新文献_第9页

Cold agglutinin autoimmune haemolytic anaemia as an initial presentation of diffuse large B cell lymphoma: A case study 冷凝集素自身免疫性溶血性贫血作为弥漫性大B细胞淋巴瘤的初始表现:一个病例研究

Current medicine research and practice Pub Date : 2022-07-01 DOI: 10.4103/cmrp.cmrp_115_21

V. Ranjan, Gaurav Dhingra, N. Gupta, K. Khillan, R. Rana

引用次数: 0

Has the corporatisation of our health sector in India helped us? 印度卫生部门的公司化对我们有帮助吗?

Current medicine research and practice Pub Date : 2022-07-01 DOI: 10.4103/cmrp.cmrp_53_22

J. Peer, S. Nundy

引用次数: 0

Pre-operative evaluation in geriatric patients: Are we over-investigating? 老年患者术前评估:我们是否调查过度?

Current medicine research and practice Pub Date : 2022-07-01 DOI: 10.4103/cmrp.cmrp_44_22

B. Sharma, C. Sahai, J. Sood

引用次数: 2

Redo hepaticojejunostomy in the management of bilioenteric anastomotic strictures 肝肠吻合术在胆肠吻合口狭窄治疗中的应用

Current medicine research and practice Pub Date : 2022-07-01 DOI: 10.4103/cmrp.cmrp_43_22

B. Bhat, S. Ray, S. Lalwani, V. Mangla, N. Mehta, A. Yadav, S. Nundy

{"title":"Redo hepaticojejunostomy in the management of bilioenteric anastomotic strictures","authors":"B. Bhat, S. Ray, S. Lalwani, V. Mangla, N. Mehta, A. Yadav, S. Nundy","doi":"10.4103/cmrp.cmrp_43_22","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_43_22","url":null,"abstract":"Background: The Roux-en-Y hepaticojejunostomy (RYHJ) is the commonly done drainage procedure for strictures which occasionally follow operations on the gallbladder and bile ducts. However, 8%–40% of these anastomoses become narrowed again and the redo operation is technically challenging. There are only a few reports which have examined the results of these revision procedures and we therefore decided to analyse our experience of this unusual operation. Aim: To study the role of redo-hepaticojejunostomy in the management of bilio-enteric anastomotic strictures. Materials and Methods: Between January 2010 and January 2016, we performed 23 redo-hepaticojejunostomies for the strictures following an initial hepaticojejunostomy which was done for benign indications in our department and followed them for a minimum of 2 years with clinical, biochemical and radiological tests. Results: There were 7 males and 16 were females who had a median age of 37 years (range 15–63 years). The median interval between the index operation and the stricture recurrence was 10 months. Thirteen (57%) patients underwent initial surgical revision and 10 had the procedure following unsuccessful percutaneous intervention. The median length of hospital stay was 10 days and 21 (91%) only had minor complications. There was no operative mortality. On follow-up of all 23 patients after 2–8 years, six (26%) patients developed stricture recurrence, of whom three were managed with percutaneous dilatation and three required a second revisional surgery. Seventeen patients are symptom-free. Conclusion: Redo RYHJ is a feasible option for strictures following an initial biliary enteric anastomosis with no surgical mortality and three-quarters of the patients being rendered symptom-free.","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85275577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anal cytological abnormalities in human immunodeficiency virus-infected men and prevalence of high-risk human papillomavirus co-infection 人类免疫缺陷病毒感染男性肛门细胞学异常与高危人乳头瘤病毒合并感染的流行

Current medicine research and practice Pub Date : 2022-07-01 DOI: 10.4103/cmrp.cmrp_114_21

A. Kakar, P. Bakshi, S. Tripathi:, A. Gogia

{"title":"Anal cytological abnormalities in human immunodeficiency virus-infected men and prevalence of high-risk human papillomavirus co-infection","authors":"A. Kakar, P. Bakshi, S. Tripathi:, A. Gogia","doi":"10.4103/cmrp.cmrp_114_21","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_114_21","url":null,"abstract":"Background: Human immunodeficiency virus (HIV) infects cells of the immune system, leading to a compromised and depleted immune system. Progressive failure of the immune system predisposes an individual to many life-threatening opportunistic infections and malignancies. As compared to the general population, the incidence of anal squamous cell carcinoma (ASCC) is substantially higher in HIV-infected individuals. Majority of ASCC are related to infections caused by high-risk strains of human papillomavirus (HPV). Aims: We conducted an observational study on HIV-positive men who had a history of homosexual contact. The aim of this study was to assess the spectrum of cytological abnormalities on anal smear cytology in individuals with HIV infection, and also estimate the prevalence of anal infection with high-risk HPV strains. Materials and Methods: We enrolled 56 individuals for this pilot study. This study involved the collection of specimens from the anal canal of the patients by using cytobrush in liquid-based cytology (LBC) vial. The sample was simultaneously tested for cytological abnormalities by LBC (Sure Path, BD) and for 13 high-risk strains by Hybrid Capture II technique (Qiagen) based on antibody capture and chemiluminescent signal detection. Anal smear cytology was reported as per guidelines of The Bethesda System of reporting anal cytology, 2014. Results: The prevalence of high-risk HPV infection was seen in 41.07% of individuals and low-grade squamous intraepithelial lesion and atypical squamous cells of undetermined significance were seen in 12.5% and 16.07% individuals, respectively. Cytology was useful in 7% of cases to diagnose opportunistic infections. The latter is a field yet to be tapped. Conclusion: We would recommend LBC in HIV-positive patients, for screening of cytological abnormalities and HPV status. This would also give an opportunity to screen for opportunistic infections, which have otherwise not been diagnosed.","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85085407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Musings on medicine, myth, and history; India's legacy 对医学、神话和历史的思考;印度的遗产

Current medicine research and practice Pub Date : 2022-07-01 DOI: 10.4103/cmrp.cmrp_75_22

Palak Agarwal

引用次数: 0

Formulation design of oral lamotrigine suspension for the treatment of epilepsy 口服拉莫三嗪混悬液治疗癫痫的配方设计

Current medicine research and practice Pub Date : 2022-07-01 DOI: 10.4103/cmrp.cmrp_45_22

S. Neerumalla, Ishrat S. Chhowala, Mehul Patel

{"title":"Formulation design of oral lamotrigine suspension for the treatment of epilepsy","authors":"S. Neerumalla, Ishrat S. Chhowala, Mehul Patel","doi":"10.4103/cmrp.cmrp_45_22","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_45_22","url":null,"abstract":"Aim: Lamotrigine is a broad-spectrum anticonvulsant drug widely used as mono- or adjunct therapy in adults and children. The aim of this study was to develop a liquid formulation of lamotrigine to fulfil the unmet needs of children and geriatric epileptic patients. Materials and Methods: Suspension formulation was prepared using Carbopol 974P as a suspending agent. It was evaluated for its sedimentation and re-dispersibility, solubility, morphology, particle-size distribution, rheological properties, pH measurement, uniformity of dosage unit, in vitro drug release behaviour and results were compared with marketed formulation Lamictal tablets. Results: The release profile of marketed product Lamictal tablets and developed lamotrigine oral suspension shows a complete release profile throughout physiological pH in all three media (0.1N hydrochloric acid, 4.5 pH acetate buffer and 6.8 pH phosphate buffer) and shows similar release as a marketed product. Microscopic observation clearly indicates the stability of the suspension (no aggregation of suspended particles) during the storage period of 12 months. The content uniformity of suspension was found well within the specified limits. Conclusion: Lamotrigine oral suspension was developed successfully and found a suitable alternative for a commercially available tablet for the treatment of epilepsy in children and geriatric patients.","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75446725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of PUO in diabetes mellitus 糖尿病合并PUO 1例

Current medicine research and practice Pub Date : 2022-05-01 DOI: 10.4103/cmrp.cmrp_2_22

P. Agarwal, Shipra Gulati, A. Garg, Sunila Jain

引用次数: 0

Effects of COVID-19 pandemic on medical equipment's/devices supply chain COVID-19大流行对医疗设备/器械供应链的影响

Current medicine research and practice Pub Date : 2022-05-01 DOI: 10.4103/cmrp.cmrp_84_20

Abid Haleem, M. Javaid, Shahbaz Khan

引用次数: 0

Intraoral biosensors: A promising diagnostic tool 口腔内生物传感器:一种有前途的诊断工具

Current medicine research and practice Pub Date : 2022-05-01 DOI: 10.4103/cmrp.cmrp_25_22

Shefali Dogra, Pankaj Dhawan, S. Tomar, Ashish Kakar, Era Kakar

{"title":"Intraoral biosensors: A promising diagnostic tool","authors":"Shefali Dogra, Pankaj Dhawan, S. Tomar, Ashish Kakar, Era Kakar","doi":"10.4103/cmrp.cmrp_25_22","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_25_22","url":null,"abstract":"The article encompasses a research on intraoral biosensors, which was conducted using keywords such as “Intraoral biosensors,” “health care monitoring devices,” “biomarkers”, “cloud servers,” “Internet of dental things (IoDT)” and “wireless sensors” in the databases of PubMed/Medline and Google Scholar between 1990 and 2020. Biomedical devices such as intraoral biosensors that are involved in continuous healthcare monitoring have garnered the attention of several researchers across the world. These devices function as an interconnecting link between the human systems and the outer environment. Recently, chair-side monitoring and early diagnostic tests are highly valuable for periodic monitoring and treatment planning for patients. These devices use biological reactions to detect and measure a particular chemical compound substance and then send an electronic signal. The chief advantages of these ubiquitous devices are high sensitivity and fast response. Intraoral biosensors integrate various materials and devices on one unique chip, hence functioning as the latest analytical and diagnostic tool of dentistry. This review highlights the basic concepts, principles and role of intraoral biosensors in the diagnosis of caries, periodontitis, oral cancer and dental fluorosis.","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86188582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0