Current medicine research and practice最新文献

{"title":"Coronavirus fear assessment using the modified COVID-19 fear scale among Indian dentists practicing in the Delhi NCR region","authors":"Harsimran Kaur, Nikita Karabale, Pankaj Dhawan, Era Kakar, Ashish Kakar","doi":"10.4103/cmrp.cmrp_40_22","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_40_22","url":null,"abstract":"Background: Recently, numerous surveys have been conducted amongst different communities to assess the fear of coronavirus diseases-2019 (COVID-19), using the Fear of COVID-19 Scale (FCV-19) scale. Currently, there is a spot within the literature published regarding fear of COVID-19 amongst dentists, and hence, we conducted a questionnaire-based survey to assess the fear of COVID-19 amongst dentists practicing in India. Aim: Assessment of coronavirus fear amongst Indian dentists practicing in the Delhi NCR region using the modified FCV-19. Materials and Methods: A questionnaire was formulated using FCV-19S, which gathered the demographic data and fear in relation to COVID-19. Except for the seven-item FCV-19S, three questions were formulated for dentists particularly. The responses were recorded on a five-point Likert scale, starting from strongly disagree to strongly agree. Dentists residing in the Delhi NCR region and above 18 years old were included in the study. Results: A total of 202 responses were obtained, which were considered for the survey analysis. The results obtained after the compilation of the information were subjected to one-way analysis of variance test, and post-hoc Tukey Bonferroni tests were used for multiple comparisons. The study population comprised 65.8% of females and 34.2% of males, with approximately 68.3% belonging to the 18–30 years age group. The t-test for total fear and gender shows total fear score was 18.85 with standard deviation = 6.23. Conclusion: The study suggests that the population associated with healthcare showed lower levels of fear and anxiety than the general population. The fear of COVID-19 has reduced over a period of time due to the awareness of the disease and vaccination. Media plays a significant role in the psychological aspect of the person, irrespective of the profession, which leads to certain disturbances like lack of sleep. More than 50% of dentists agree that the use of precautionary protocols in our dental practice can reduce the risk of getting infected.","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84645223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative evaluation in geriatric patients – Response","authors":"B. Sharma","doi":"10.4103/cmrp.cmrp_71_23","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_71_23","url":null,"abstract":"","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78972750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving epidemiology and chemical analysis of urinary stones: A retrospective analysis","authors":"P. Singla, A. Manocha, S. Bhargava, M. Kankra, Anisha K. Sharma","doi":"10.4103/cmrp.cmrp_91_22","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_91_22","url":null,"abstract":"Background: Renal stones are a painful urological disorder resulting from the combined influence of epidemiological, biochemical and genetic risk factors. A high recurrence risk has been reported for renal stones, and 0.6%–3.2% cases may progress to end stage renal disease. Modern lifestyle, sedentary habits and unhealthy dietary practices are primary promoters of the stone boom in this millennium. Aims and Objectives: The aim of the present study is to evaluate the percentage of the stone type according to chemical composition and their association with epidemiological factors like sex and age. A retrospective analysis of the chemical composition of the stone samples received was done. Material and Methods: Stones samples were processed by Stone Analysis Set (BIOLABO S A, France). Qualitative chemical analysis was done for calcium, phosphorus, ammonium ion, oxalate, cystine, magnesium, carbonate and uric acid. Results: Type of renal stone and its incidence with age and sex have been evaluated. The total number of patients reporting to the hospital with renal stones was 123. Of these, 69.11% were male and 30.89% were female, with a male to female ratio of 2.23:1. The maximum occurrence was in the third and fourth decade of life. On analysis, 72.35% of total stones comprised calcium oxalate and 23.57% of nonoxalate (phosphate, magnesium, carbonate, ammonium ion) stones, whereas uric acid was positive in 4.06%. Conclusion: The occurrence of renal stones according to epidemiological factors such as age and sex in our study are similar to those reported in studies from developed countries. The data on urinary stones indicate that 98% were located in the upper urinary tract. Oxalate stones represent the main form of urolithiasis, affecting males more than females. The most important cause studied for renal stone formation is metabolic disturbances, but the genetic factors associated with the occurrence and recurrence of stone and mineral homeostasis of ions in kidney of stone formers should be further evaluated.","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83384690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human papillomavirus vaccine: An update on recent developments and review of real world data on efficacy","authors":"S. Rajaram, Ipshita Sahoo, Ayush Heda, Lakhwinder Singh","doi":"10.4103/cmrp.cmrp_28_23","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_28_23","url":null,"abstract":"Cervical cancer is the fourth most common cancer in women worldwide and is a significant public health problem. Currently, there are three bivalent human papillomavirus (HPV) vaccines targeting high-risk HPV types (16, 18), two quadrivalent vaccines targeting two high risk HPV types (16,18) and two low risk types (6,11) and one nonavalent vaccine against HPV 16,18, 31, 33, 45, 52, 58, 6 and 11. All are WHO approved vaccines and show excellent seropositivity (>95%) even at 5–10 years' post-vaccination irrespective of dosing schedule. These vaccines are relatively safe with minor local side effects. The WHO recommends two dosage vaccination schedule for girls aged 9–14 years with an off-label recommendation for a single-dose schedule. HPV vaccination has shown efficacy against the reduction of cervical intraepithelial neoplasia, invasive cervical cancer, anogenital warts and vulvovaginal intraepithelial neoplasia in numerous population/registry-based cohort studies worldwide. Countries such as Australia and Sweden where vaccination began as early as 2006–2008 have seen a major reduction in the incidence of cervical cancer in the vaccinated cohorts. Model based projection studies have also indicated significant vaccine efficacy with two doses and single dose in catch-up programmes. In this article, we provide an update on the vaccine recommendations, immunogenicity and efficacy data derived from registry-based cohort studies and trials published mostly in the last 5 years.","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78921692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The obituary, Dr. V. P. Kumra","authors":"B. Sharma","doi":"10.4103/cmrp.cmrp_68_23","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_68_23","url":null,"abstract":"","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75173890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical cytology and HPV in cervical cancer screening: Current and future perspectives","authors":"P. Bakshi, P. Agarwal, Gunjan Mangla","doi":"10.4103/cmrp.cmrp_29_23","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_29_23","url":null,"abstract":"Cervical cancer remains a health burden in our country and is the 2nd most common cancer in Indian women. Effective screening can reduce the incidence as well as the morbidity and mortality of this disease. Cervical cytology and the more recent human papilloma virus (HPV) DNA test are the two main pillars of screening. Liquid based cytology has improved the cytological preparations and has shown certain advantages while advancements in molecular techniques for detection of high-risk HPV DNA/RNA has opened up new frontiers. These technological advancements have led to the changes in screening practices and paradigms and are evolving at a rapid pace. This article gives an overview of the screening modalities currently available, the technological advancements, recent updates of the screening guidelines and the future directions.","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82251924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of attitude and behaviour of healthcare professionals towards the patients in an Emergency Department during the COVID-19 pandemic","authors":"Nitesh Vaishnav, Bharat Kumar, A. Misra, M. Garg","doi":"10.4103/cmrp.cmrp_88_22","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_88_22","url":null,"abstract":"Background: COVID-19 outbreak is known to have a psychological impact on patients. Background and Objective: The main aim of the study was a to study the attitude and behavior of health care professionals (HCPs) in the emergency department towards chronic patients during COVID-19 pandemic and also the accessibility of healthcare system during COVID-19 period and to compare it with the pre-COVID period. Materials and Methods: A random sampling technique was used, and a pre-designed questionnaire named the Brief Emergency Department Patients' Satisfaction Scale was adopted to record the patient's satisfaction with the healthcare services. Results: The patients admitted to the emergency ward felt that the nursing and physicians' care in the emergency department was highly satisfactory in the pre-COVID period. In the COVID period, the same set of patients who got admitted felt that there was a deterioration in the behaviour and attitude of the HCPs towards them. In the COVID period, 30% of the patients felt that there was a marked deterioration in the general services in the emergency department. It was also observed in the study, that there was a marked change in the attitude and behaviour of the HCPs in the emergency department at the time of the COVID pandemic. Conclusion: COVID-19 has significantly changed the attitude and behaviour of HCPs. The disease has critically transformed the working environment and the approach of HCPs to treat the patients. It is imperative to employ productive strategies to care for the health of our HCP.","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82184250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cancer genome atlas - TCGA molecular classification: A changing paradigm in the management of endometrial cancers","authors":"Rahul A. Modi","doi":"10.4103/cmrp.cmrp_125_22","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_125_22","url":null,"abstract":"Conventionally, endometrial cancers have been risk-stratified as per the clinco-pathological factors. The Cancer Genome Atlas project identified four distinct molecular subtypes within endometrial cancers which further lead to the clinical validation of molecular classification by various research groups. The molecular classification has influenced the risk stratification, thereby impacting adjuvant treatment decisions and prognostication. Molecular classification has paved the precision oncology in gynaecological cancers further strengthening the ongoing advances in targeted therapies and immunotherapy. This review elaborately presents the development of a new molecular classification of endometrial cancers; its evidence-based clinical utility with a brief overview of future perspectives.","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87605361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human papillomavirus self-sampling for cervical cancer screening: Review on the acceptance, accuracy, feasibility and incorporation in the National Screening Programme of India","authors":"Amey Oak, K. Sivaranjini, Ruchi Pathak, R. Dikshit","doi":"10.4103/cmrp.cmrp_12_23","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_12_23","url":null,"abstract":"Screening along with treatment is the foremost tool for cervical cancer elimination in addition to vaccination strategies. At present, India lacks a comprehensive screening programme. There are huge issues in terms of feasibility, acceptability and implementation of the existing cervical screening programme in the country. Less than 2% (Urban-2.2% and Rural-1.7%) of women in India have been screened. The current strategy recommended by Ministry of Health and Family Welfare is Visual Inspection with Acetic Acid (VIA) every 5 years for women aged between 30 and 65 years. A significant improvement in terms of decreasing incidence and mortality of cervical cancer has been seen in two randomized controlled trials conducted in India. However, VIA lacks sensitivity, requires extensive training to be given to the medical staff for accurate diagnosis, has substantial operator variability and has less acceptability among women when compared to the newer methods of cervical cancer screening such as human papillomavirus (HPV) self-sampling. HPV self-sampling is a more sensitive, accurate and more acceptable method of cervical cancer screening for women in India and abroad. It can help the existing VIA-based strategy of cervical screening by increasing participation resulting in more population being screened in the various geographical regions and populations in India. However, VIA-based screening should also be continued because of its affordability and cost-effectiveness in India where there is a significant population belonging to low socio-economic background. There are numerous evidences such as systematic reviews, meta-analyses, randomised controlled trials of India and abroad that have been used as sources in this review article to come to the conclusion that HPV self-sampling is an acceptable, accurate and sensitive method that can be used as a primary screening tool in cervical cancer screening programmes globally and in India. It can also be used as an effective triage test for prioritising high-risk populations who require urgent and effective treatment for cervical pre-cancer and cancer. To conclude, HPV self-sampling should be integrated and implemented by the government and private sector in addition to VIA-based screening strategies for achieving the goal of cervical cancer elimination in India.","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86062619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gearing up for implementation of self-sampled HPV-DNA screening test for cervical cancer in India","authors":"L. Kant","doi":"10.4103/cmrp.cmrp_75_23","DOIUrl":"https://doi.org/10.4103/cmrp.cmrp_75_23","url":null,"abstract":"","PeriodicalId":72736,"journal":{"name":"Current medicine research and practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87732890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}